Gene:	Ccnd2 ( Rattus norvegicus ) cyclin D2
Description:	a cell cycle protein involved in the regulation of cell proliferation; associated with many cancers and other diseases
Synonyms:	LOC297611;
ArrayIDs:	rc_AA899106_at; 1370810_at; D16308_at; 5694536; 6530230; rc_AA946145_at; 6140661; GE19605; 6229889; GE21575; 6288341; A_44_P477768;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Ept5 - Estrogen-induced pituitary tumorigenesis QTL 5
Homologs
Homo sapiens: CCND2     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ccnd2     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ccnd2 Rat Celera Assembly 4 148681937 - 148704301     RGSC genome assembly v3.4 4 163523817 - 163546501     Cytogenetic 4 q42     genome assembly 3.1 4 163768752 - 163791437 Mus musculus Ccnd2 Mouse genome assembly build 36.1 6 127075726 - 127101066     Cytogenetic 6 6 F3 Homo sapiens CCND2 human genome assembly 12 4253198 - 4284777     Human genome assembly build 36.2 12 4253199 - 4284777     Cytogenetic 12 p13   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  protein kinase binding (details...)
Biological Process	Gene Ontology response to cAMP,  positive regulation of cell proliferation,  regulation of cell cycle ...  (details...)
Cellular Component	Gene Ontology nucleus,  cyclin-dependent protein kinase holoenzyme complex,  cellular_component (details...)
Disease	Ontology Ovarian Neoplasms,  Seminoma,  Neoplasm Metastasis ...  (details...)
Regulation	Note Reference dihydrotestosterone (DHT), a 5-alpha reduced metabolite of testosterone, decreases mRNA expression and results in cell cyle arrest at G1 phase of granulosa cells 625716 expression altered by integration of proviruses in the Vin-1 common site of integration in retrovirus-induced rodent T-cell leukemias 724623
External Links
Databases	DATABASE ID SOURCE SMART: CYCLIN IPI PROSITE: CYCLINS IPI UNIPARC: UPI00001275C6 IPI KEGG Report: rno:64033 ENTREZGENE HomoloGene Group ID: 37525 ENTREZGENE Germonline: 1308987 Pfam: Cyclin_N IPI Pfam: Cyclin_C IPI KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04110 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04115 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE InterPro: Cyclin_A_B_D_E. IPI InterPro: Cyclin_C. IPI InterPro: Cyclin_N. IPI InterPro: Cyclin_related. IPI InterPro: Cyclin-like. IPI InterPro: CycD. IPI InterPro: Cyclin. IPI IPI: IPI00189816 IPI Ensembl Protein: ENSRNOP00000027084 IPI Gene3D-CATH: Cyclin_related IPI Entrez Gene: Ccnd2 ENTREZGENE PIRSF: Cyclin_A_B_D_E IPI UniProt: Q6LC41_RAT IPI UniProt: CCND2_RAT IPI Ensembl Genes: ENSRNOG00000019939 IPI Superfamily-SCOP: Cyclin_like IPI PANTHER: CycD IPI
Sequences	Nucleotide: U87099 Get FASTA Search GEO Profiles Nucleotide: NM_022267 Get FASTA Search GEO Profiles Nucleotide: D16308 Get FASTA Search GEO Profiles Nucleotide: L09752 Get FASTA Search GEO Profiles Nucleotide: CH473964 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: EDM01811 Get FASTA Protein: EDM01812 Get FASTA Protein: EDM01813 Get FASTA Protein: EDM01814 Get FASTA Protein: EDM01815 Get FASTA Protein: AAD10953 Get FASTA Protein: BAA03815 Get FASTA Protein: AAA41010 Get FASTA Protein: Q04827 Get FASTA Protein: EDM01810 Get FASTA Protein: NP_071603 Get FASTA Protein: Q6LC41 Get FASTA (View all 12 Protein Accessions)
Clusters	UniGene: 96083
References
Curated References	36 references in RGD related to Ccnd2
Other References	17 other references at PubMed related to Ccnd2
Database Information
RGD ID	621083
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 24-JAN-08: Ccnd2 cyclin D2 Ccnd2_predicted cyclin D2 (predicted) APPROVED Data Merged 737654 12-JAN-05: Ccnd2_predicted cyclin D2 (predicted) APPROVED Symbol and Name status set to approved 70820 26-FEB-04: Ccnd2 cyclin D2 APPROVED Symbol and Name status set to approved 625702 07-AUG-02: Ccnd2 cyclin D2 PROVISIONAL Symbol and Name status set to provisional 70820