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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd2
Name: cyclin D2
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd2decreases expressionISOCcnd2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of CCND2 mRNAPMID:19874833 PMID:31211961
Ccnd2increases expressionISOCcnd2 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of CCND2 mRNAPMID:25701202
Ccnd2multiple interactionsISOCcnd2 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CCND2 mRNA; Estradiol inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CCND2 mRNA]PMID:19874833 PMID:28013214
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