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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621083
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd2
Name: cyclin D2
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd2multiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA]PMID:17510244
Ccnd2decreases expressionISOCCND2 (Homo sapiens)6480464CTDSirolimus results in decreased expression of CCND2 proteinPMID:15070696
Ccnd2multiple interactionsISOCCND2 (Homo sapiens)6480464CTD[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]PMID:15778701
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