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Gene: C3ar1 (complement C3a receptor 1) Rattus norvegicus

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Symbol:

C3ar1

Name:

complement C3a receptor 1

RGD ID:

620537

Description:

Enables complement component C3a binding activity and complement component C3a receptor activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of cell population proliferation; and tolerance induction to nonself antigen. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study adult respiratory distress syndrome. Biomarker of asthma and lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

C3a anaphylatoxin chemotactic receptor; C3a-R; C3AR; complement component 3a receptor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C3AR1 (complement C3a receptor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	C3ar1 (complement component 3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	C3ar1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C3AR1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C3AR1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C3ar1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C3AR1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C3AR1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C3ar1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	C3ar1 (complement C3a receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	COX4I1 (cytochrome c oxidase subunit 4I1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	C3ar1 (complement component 3a receptor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	C3AR1 (complement C3a receptor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c3ar1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c3ar1	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Oia7

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,747,419 - 157,756,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,746,089 - 157,776,323 (-)	Ensembl				GRCr8
mRatBN7.2	4	156,074,747 - 156,084,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	156,075,389 - 156,084,701 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	162,347,387 - 162,354,238 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	158,130,613 - 158,137,464 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,775,694 - 156,782,545 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,681,767 - 155,691,240 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,684,029 - 155,690,869 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,702,646 - 222,711,738 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	159,326,402 - 159,333,433 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,898,053 - 144,904,840 (-)	NCBI		Celera
RGSC_v3.1	4	159,571,333 - 159,578,369 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (IMP)

asthma (IEP,ISO)

atypical hemolytic-uremic syndrome (ISO)

bacterial pneumonia (ISO)

COVID-19 (ISO)

lung disease (IEP,ISO)

pneumonia (ISO)

prostate cancer (ISO)

Reperfusion Injury (IMP)

rhinitis (ISO)

systemic lupus erythematosus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cytarabine (ISO)

deoxynivalenol (ISO)

dextran sulfate (ISO)

dioxygen (ISO)

doxorubicin (ISO)

Echimidine (EXP)

ethanol (ISO)

fenvalerate (EXP)

flavonoids (EXP)

folic acid (ISO)

gentamycin (EXP)

Heliotrine (EXP)

indinavir (ISO)

irinotecan (ISO)

L-methionine (ISO)

lamivudine (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methylmercury chloride (EXP)

nickel atom (ISO)

nicotine (ISO)

Octicizer (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylarsine oxide (ISO)

pirinixic acid (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

saquinavir (ISO)

SB 290157 (ISO)

senecionine (EXP)

Senkirkine (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

tributyl phosphate (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tris(2-chloroethyl) phosphate (ISO)

vinclozolin (EXP)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (IEA,ISO)

calcium-mediated signaling (ISO)

chemotaxis (IEA)

complement component C5a signaling pathway (IEA)

complement receptor mediated signaling pathway (IBA,IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

inflammatory response (IBA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IBA)

positive regulation of angiogenesis (IEA,ISO)

positive regulation of cell migration (IEA,IMP)

positive regulation of cytosolic calcium ion concentration (IBA,IDA)

positive regulation of DNA biosynthetic process (IMP)

positive regulation of glomerular mesangial cell proliferation (IMP)

positive regulation of immune system process (IEA)

positive regulation of macrophage chemotaxis (IEA,ISO)

positive regulation of neutrophil chemotaxis (IEA,ISO)

positive regulation of smooth muscle cell proliferation (IMP)

positive regulation of vascular endothelial growth factor production (IEA,ISO)

regulation of blood pressure (IDA)

signal transduction (IEA)

tolerance induction to nonself antigen (IMP)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

complement component C3a binding (IDA)

complement component C3a receptor activity (IBA,IDA,IEA,IPI,ISO)

complement component C5a receptor activity (IBA)

complement receptor activity (IEA)

G protein-coupled receptor activity (IBA,IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

Staphylococcus aureus infection pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death.	Benard M, etal., J Biol Chem. 2004 Oct 15;279(42):43487-96. Epub 2004 Aug 2.
2.	Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.	Benard M, etal., Mol Immunol. 2008 Aug;45(14):3767-74. Epub 2008 Jul 16.
3.	Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma.	Fregonese L, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1148-54.
4.	Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation.	Fukuoka Y, etal., Biochem Biophys Res Commun 1998 Jan 26;242(3):663-8.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats.	Han Y, etal., Am J Hypertens. 2012 Mar;25(3):284-9. doi: 10.1038/ajh.2011.214. Epub 2011 Nov 17.
7.	Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma.	Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
8.	Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.	Ikeda K, etal., Clin Exp Hypertens. 2013 May 28.
9.	Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis.	Jun SW, etal., J Allergy Clin Immunol. 2008 Jul;122(1):119-25. Epub 2008 Jun 5.
10.	Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.	Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
11.	C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression.	Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia.	Mueller-Ortiz SL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L157-65. Epub 2006 Feb 3.
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
16.	Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury.	Proctor LM, etal., Br J Pharmacol. 2004 Jun;142(4):756-64. Epub 2004 May 24.
17.	Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats.	Proctor LM, etal., Int Immunopharmacol. 2006 Aug;6(8):1224-32. Epub 2006 Apr 3.
18.	Complement factors C3a and C5a have distinct hemodynamic effects in the rat.	Proctor LM, etal., Int Immunopharmacol. 2009 Jun;9(6):800-6. Epub 2009 Mar 12.
19.	Biomarkers of acute respiratory allergen exposure: screening for sensitization potential.	Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4.
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.	Sohn JH, etal., Nat Med. 2003 Feb;9(2):206-12. Epub 2003 Jan 6.
24.	Complement Inhibition Alleviates Paraquat-Induced Acute Lung Injury.	Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18.
25.	Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation.	Tschernig T, etal., Exp Toxicol Pathol. 2007 Aug;58(6):419-25. Epub 2007 Jun 1.

Additional References at PubMed

PMID:10571060	PMID:16452172	PMID:22099750	PMID:23940034	PMID:25422985	PMID:32617860	PMID:36871753

Genomics

Comparative Map Data

C3ar1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,747,419 - 157,756,609 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	157,746,089 - 157,776,323 (-)	Ensembl				GRCr8
mRatBN7.2	4	156,074,747 - 156,084,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	156,075,389 - 156,084,701 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	162,347,387 - 162,354,238 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	158,130,613 - 158,137,464 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,775,694 - 156,782,545 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,681,767 - 155,691,240 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,684,029 - 155,690,869 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	222,702,646 - 222,711,738 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	159,326,402 - 159,333,433 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	144,898,053 - 144,904,840 (-)	NCBI		Celera
RGSC_v3.1	4	159,571,333 - 159,578,369 (-)	NCBI
Cytogenetic Map	4	q42	NCBI

C3AR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	8,056,844 - 8,066,359 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	8,056,844 - 8,066,374 (-)	Ensembl			hg38	GRCh38
GRCh37	12	8,209,440 - 8,218,955 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	8,102,186 - 8,110,222 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	8,102,185 - 8,110,222	NCBI
Celera	12	9,787,991 - 9,796,026 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	8,022,647 - 8,030,683 (-)	NCBI		HuRef
CHM1_1	12	8,210,143 - 8,218,179 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	8,070,449 - 8,079,963 (-)	NCBI		T2T-CHM13v2.0

C3ar1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,824,099 - 122,833,116 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,824,097 - 122,833,120 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	122,847,140 - 122,856,157 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,847,138 - 122,856,161 (-)	Ensembl			mm10	GRCm38
MGSCv37	6	122,797,158 - 122,806,175 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,813,577 - 122,821,624 (-)	NCBI		MGSCv36	mm8
Celera	6	124,649,306 - 124,658,328 (-)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	57.93	NCBI

C3ar1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	6,707,689 - 6,715,689 (-)	Ensembl
ChiLan1.0	NW_004955413	6,707,003 - 6,715,689 (-)	NCBI	ChiLan1.0	ChiLan1.0

C3AR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	13,614,735 - 13,622,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	13,611,497 - 13,619,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	8,178,064 - 8,186,206 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	8,220,505 - 8,228,480 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	8,220,933 - 8,222,381 (-)	Ensembl			panPan2	panpan1.1

C3AR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,431,745 - 37,439,858 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,433,792 - 37,435,246 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,176,099 - 9,184,204 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,785,758 - 37,793,862 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,785,991 - 37,793,787 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	37,660,414 - 37,668,519 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,701,675 - 37,709,781 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	8,662,656 - 8,670,749 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

C3ar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	99,162,915 - 99,170,683 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936892	347,842 - 349,296 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936892	347,547 - 355,143 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C3AR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,088,778 - 63,098,750 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	63,088,778 - 63,098,750 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

C3AR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	8,128,192 - 8,135,517 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	8,128,620 - 8,130,062 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666089	222,592 - 230,801 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C3ar1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	5,197,619 - 5,199,043 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624860	5,196,621 - 5,204,686 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

C3ar1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	24,251,703 - 24,253,209 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in C3ar1
174 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	50
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000012216
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	146370897	184426481	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	134095016	179095016	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	149763204	169799698	Rat
61446	Coreg2	Compensatory renal growth QTL 2	3.5		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	4	150095743	159267220	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	146370897	184426481	Rat
6478757	Anxrr44	Anxiety related response QTL 44		0.01087	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
1358364	Sradr4	Stress Responsive Adrenal Weight QTL 4	4.92		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	131384565	176384565	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	123870974	168870974	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	117559384	162559384	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	140059299	181024663	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	157292416	184426481	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	94638356	168870820	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	106848959	168870974	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	127263297	172263297	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	126334185	171334185	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	147299608	184426481	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
6478782	Anxrr52	Anxiety related response QTL 52		0.02091	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	124700988	169700988	Rat
6478720	Alc23	Alcohol consumption QTL 23		0.00509	drinking behavior trait (VT:0001422)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	155834926	184426481	Rat
6478785	Anxrr53	Anxiety related response QTL 53		0.01397	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	100752691	179366077	Rat
1581566	Eae21	Experimental allergic encephalomyelitis QTL 21	6.2		body mass (VT:0001259)	maximum body weight loss to initial body weight ratio (CMO:0001400)	4	137447185	182447185	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	137430611	182430611	Rat
6478728	Anxrr36	Anxiety related response QTL 36		0.01061	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	86709649	168870974	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	134199006	168870974	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	148121375	176967367	Rat
6478733	Anxrr37	Anxiety related response QTL 37		0.00095	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	123870974	168870974	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	140059299	184426481	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478737	Anxrr38	Anxiety related response QTL 38		0.00159	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	155834926	184426481	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	116184844	161184844	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	146370897	184426481	Rat
12798525	Anxrr57	Anxiety related response QTL 57	3.21	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	148834094	168870974	Rat

Markers in Region

D4Got128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	4	157,757,348 - 157,757,491 (+)	Marker Load Pipeline
mRatBN7.2	4	156,085,418 - 156,085,563 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	155,691,688 - 155,691,830	NCBI	Rnor6.0
Rnor_5.0	4	222,712,454 - 222,712,596	UniSTS	Rnor5.0
RGSC_v3.4	4	159,334,251 - 159,334,394	RGD	RGSC3.4
RGSC_v3.4	4	159,334,252 - 159,334,394	UniSTS	RGSC3.4
Celera	4	144,905,659 - 144,905,801	UniSTS
RGSC_v3.1	4	159,579,188 - 159,579,330	RGD
RH 3.4 Map	4	998.8	UniSTS
RH 3.4 Map	4	998.8	RGD
Cytogenetic Map	4	q42	UniSTS

RH138462

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	156,077,849 - 156,077,978 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	155,684,124 - 155,684,252	NCBI	Rnor6.0
Rnor_5.0	4	222,705,003 - 222,705,131	UniSTS	Rnor5.0
RGSC_v3.4	4	159,326,499 - 159,326,627	UniSTS	RGSC3.4
Celera	4	144,898,150 - 144,898,278	UniSTS
RH 3.4 Map	4	1001.5	UniSTS
Cytogenetic Map	4	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	354	192	11	144	79	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_032060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U86379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012216 ⟹ ENSRNOP00000012216

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,746,089 - 157,756,741 (-)	Ensembl
mRatBN7.2 Ensembl	4	156,075,389 - 156,084,701 (-)	Ensembl
Rnor_6.0 Ensembl	4	155,684,029 - 155,690,869 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106930 ⟹ ENSRNOP00000094051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,746,089 - 157,756,741 (-)	Ensembl
mRatBN7.2 Ensembl	4	156,075,389 - 156,084,701 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135206 ⟹ ENSRNOP00000112598

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,749,886 - 157,753,365 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153946 ⟹ ENSRNOP00000104182

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	157,749,904 - 157,776,323 (-)	Ensembl

RefSeq Acc Id:

NM_032060 ⟹ NP_114449

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,749,684 - 157,756,530 (-)	NCBI
mRatBN7.2	4	156,077,753 - 156,084,600 (-)	NCBI
Rnor_6.0	4	155,684,027 - 155,690,869 (-)	NCBI
Rnor_5.0	4	222,702,646 - 222,711,738 (-)	NCBI
RGSC_v3.4	4	159,326,402 - 159,333,433 (-)	RGD
Celera	4	144,898,053 - 144,904,840 (-)	RGD

Sequence:

show sequence

TGTCGAGTAAGCACTCAGCAACTAGTCCAACATCCTCCACGGCGGCTGGACCAGATAGGATTTG
TTGGTGGCTCACAGATCATCAGTCCTGGAGCCTTCTGATCCCACCTCAGTGCTCTTGACTGAGC
AATGGAGTCTTTCACTGCTGACACCAACTCAACTGACCTACACTCACGGCCTCTGTTTAAACCC
CAAGACATTGCCTCCATGGTCATTCTCAGTCTCACGTGTTTATTGGGACTGCCAGGCAATGGGC
TGGTGCTGTGGGTCGCTGGCGTAAAGATGAAGAGGACCGTGAACACAGTCTGGTTCCTCCACCT
CACCCTGGCCGATTTCCTCTGCTGCCTCTCCTTGCCCTTCTCCGTGGCTCACCTGATTCTCCGA
GGACACTGGCCCTATGGCTTGTTCCTGTGCAAACTTATCCCGTCCGTCATTATCCTCAACATGT
TTGCCAGTGTCTTCCTGCTTACTGCCATTAGCCTGGACCGCTGTCTGATGGTGCACAAGCCGAT
CTGGTGCCAGAACCATCGGAGCGTGAGAACAGCCTTCGCCGTCTGTGGATGCGTCTGGGTGGTA
ACCTTTGTGATGTGTATACCGGTATTTGTATACCGTGATCTGCTCGTTGTGGATGATTACAGTG
TATGTGGCTATAACTTTGATTCCTCCAGGGCATATGATTATTGGGACTACATGTACAATTCACA
TCTACCAGAAATCAACCCTCCTGACAACTCCACTGGACATGTGGATGACAGGACAGCTCCTTCC
TCCTCTGTACCAGCAAGGGACCTTTGGACAGCTACCACTGCTCTCCAGTCACAAACGTTCCACA
CATCTCCTGAAGACCCATTCTCTCAAGACTCAGCAAGTCAGCAACCCCATTATGGGGGGAAGCC
TCCTACTGTGCTCATAGCCACCATACCCGGCGGGTTTCCTGTTGAAGATCATAAATCCAACACA
CTGAACACTGGTGCTTTTCTCTCTGCCCACACAGAGCCGTCCCTCACTGCTTCTAGCAGTCCTT
TATACGCCCATGATTTCCCGGATGATTATTTTGACCAACTGATGTATGGCAATCACGCGTGGAC
ACCTCAGGTGGCAATCACCATCTCGAGGCTGGTGGTGGGCTTCCTGGTGCCCTTTTTCATCATG
ATAACCTGTTACAGCCTCATCGTCTTCAGAATGCGAAAAACCAACCTCACCAAGTCGAGGAACA
AAACCCTTCGGGTGGCCGTGGCGGTGGTCACCGTCTTTTTTGTCTGCTGGATTCCATACCATAT
TGTTGGAATCCTGTTAGTGATTACTGACCAAGAAAGCGCCTTGAGAGAAGTTGTGCTACCCTGG
GACCACATGTCCATTGCTTTAGCATCTGCCAATAGTTGTTTCAACCCTTTCCTTTATGCCCTCT
TGGGAAAAGACTTCAGGAAGAAAGCAAGACAGTCCGTAAAGGGCATTCTGGAAGCAGCCTTCAG
CGAAGAGCTCACGCACTCTACCAGTTGTACCCAGGACAAAGCCCCCTCAAAAAGAAACCATATG
AGTACGGATGTGTGAAGATGCTGCACTGGGGACCTAAGCAGATGTTCTGAGGTGAATACTGGTG
ATGGGTGACCTGTGAGCGGGACACCTTAGACAGCCTGGCCACCCTCAGAGAAAGGTCTCTTATT
GACATCAGCATCATTTGAAAACACTAAAGGCACAAAATTTCAAGCCCCATCCCAGATGTTTGAC
TCCGAATCTCTGGCCCGTGGGGACCAATGTCTTAACAGGCCCCCTTGTTTCCACCAATGTTAAG
TTTTATTCAACTCATTTTATTCCCATCCCTGAATCGGCCATGTGCAATGAATAACGTCTTCATC
TGTTTCCAGTATTAATCTCTTCTTGCATAGCATCATTTAAATCCTTTAGTTTGTGCGGGAGGCT
GCTATTGTCCAGAGTGAAAGATATTTTTTTATTGAACATTTGTGTGGTGGTAGCAGTGATTTTT
TAGTGGGGAGGCAGGGGAGAAAGACACAGAAATAAAAGGTTTTTGGAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAGAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006237314 ⟹ XP_006237376

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	157,747,419 - 157,756,609 (-)	NCBI
mRatBN7.2	4	156,074,747 - 156,084,680 (-)	NCBI
Rnor_6.0	4	155,681,767 - 155,691,240 (-)	NCBI
Rnor_5.0	4	222,702,646 - 222,711,738 (-)	NCBI

Sequence:

show sequence

CCCAACACCCACGTTACATTGCAGTATCAAGAGATCTAGCATCCCCTCTTGGCCTCTCTGAGCA
ACCACAGATGGCACACACATACTTATAAAAGATAAAACAAAATAAATTTAAAAAGAAAAAAAAA
CTCACTGTAGCACAGACAAACCTTGAACTTTCTGCCTGCCTGCCTGTGTCTCGGCATTTCATAG
CTAGGATGGCAGGTTCCTGCAGGACATATCTGCGCCCTGATCGTCCTCCTCCACCCGCCCTCCT
CTGTCCTTCTGCTTTTCTTATCTACGCTGGCTAATTTAAGAGGTGACTCATGGAAAAGCCCTTC
CTGTGCAGTCAGATAGCAGTCTCGATCCCGAGTTCCCTTTACTCTGGGAAAAGTAAGCACTCAG
CAACTAGTCCAACATCCTCCACGGCGGCTGGACCAGATAGGATTTGTTGGTGGCTCACAGATCA
TCAGTCCTGGAGCCTTCTGATTCCACCTCAGTGCTCTTGACTGAGCAATGGAGTCTTTCACTGC
TGACACCAACTCAACTGACCTACACTCACGGCCTCTGTTTAAACCCCAAGACATTGCCTCCATG
GTCATTCTCAGTCTCACGTGTTTATTGGGACTGCCAGGCAATGGGCTGGTGCTGTGGGTCGCTG
GCGTAAAGATGAAGAGGACCGTGAACACAGTCTGGTTCCTCCACCTCACCCTGGCCGATTTCCT
CTGCTGCCTCTCCTTGCCCTTCTCCGTGGCTCACCTGATTCTCCGAGGACACTGGCCCTATGGC
TTGTTCCTGTGCAAACTTATCCCGTCCGTCATTATCCTCAACATGTTTGCCAGTGTCTTCCTGC
TTACTGCCATTAGCCTGGACCGCTGTCTGATGGTGCACAAGCCGATCTGGTGCCAGAACCATCG
GAGCGTGAGAACAGCCTTCGCCGTCTGTGGATGCGTCTGGGTGGTAGCCTTTGTGATGTGTATA
CCGGTATTTGTATACCGTGATCTGCTCGTTGTGGATGATTACAGTGTATGTGGCTATAACTTTG
ATTCCTCCAGGGCATATGATTATTGGGACTACATGTACAATTCACATCTACCAGAAATCAACCC
TCCTGACAACTCCACTGGACATGTGGATGACAGGACAGCTCCTTCCTCTGTACCAGCAAGGGAC
CTTTGGACAGCTACCACTGCTCTCCAGTCACAAACGTTCCACACATCTCCTGAAGACCCATTCT
CTCAAGACTCAGCAAGTCAGCAACCCCATTATGGGGGGAAGCCTCCTACTGTGCTCATAGCCAC
CATACCCGGCGGGTTTCCTGTTGAAGATCATAAATCCAACACACTGAACACTGGTGCTTTTCTC
TCTGCCCACACAGAGCCGTCCCTCACTGCTTCTAGCAGTCCTTTATACGCCCATGATTTCCCGG
ATGATTATTTTGACCAACTGATGTATGGCAATCACGCGTGGACACCTCAGGTGGCAATCACCAT
CTCGAGGCTGGTGGTGGGCTTCCTGGTGCCCTTTTTCATCATGATAACCTGTTACAGCCTCATC
GTCTTCAGAATGCGAAAAACCAACCTCACCAAGTCGAGGAACAAAACCCTTCGGGTGGCCGTGG
CGGTGGTCACCGTCTTTTTTGTCTGCTGGATTCCATACCATATTGTTGGAATCCTGTTAGTGAT
TACTGACCAAGAAAGCGCCTTGAGAGAAGTTGTGCTACCCTGGGACCACATGTCCATTGCTTTA
GCATCTGCCAATAGTTGTTTCAACCCTTTCCTTTATGCCCTCTTGGGAAAAGACTTCAGGAAGA
AAGCAAGACAGTCCGTAAAGGGCATTCTGGAAGCAGCCTTCAGCGAAGAGCTCACGCACTCTAC
CAGTTGTACCCAGGACAAAGCCCCCTCAAAAAGAAACCATATGAGTACGGATGTGTGAAGATGC
TGCACTGGGGACCTAAGCAGATGTTCTGAGGATCTTGCCATCTCCTGCTGTGGTTAGGAGTGTG
CAGCACATACCCGGCCCCGCCTTCTTCTTCGGCTTTTCCTGCGAGACTTTGTGCCTCACATAAA
ACAAGACAGTACTCTAAACGTACCTTTCCTTTCTCTCCAAACTCATGTCAAACAGAAGGAGGAT
GGGATGGGTGAAGCTACAATTCTTCAATTCACTGCACACTCCGACAGCAGTATCAAAGGATTTT
AAACCTGAGTCTAGGTATTTTACATGCCAAACGTGTCAGGCACACTCTCTTTGGGATTTTTTTT
TTCAAATTAATTTTTTTTCGGGACCATGGTACTATAAAGTACTATATACACCCAATTTTAAAGG
AACTAGTTAATAATGAAATGCAGAAGGGCTGGTTCTCCAGCACCCAGTAATTCCCATCTCTCCC
TACTTCCAAGAGATAACCTTTGCAAGAATTTTAGCTGTTTCTTCTGATACATGATGTGCCTAAG
ACATGTGCCCACGCTGCTGGTCACTGTAGATATGAAGAAAAGGTTGTCTCGAAAGATTTTACCT
GCTTACCTACTTTCATATTTGCGCCCGGCATCCCAGGGTTGACTGGTATCATGTTTTAATCTGT
TCGTGACCGTTCCACTTTTTTTTTCCTTCCTTTTGTTGTCAGGTTTTGCTTGGCTTTGTTCCAG
GGTCTCTGGGTAGCACAGTCTAGCCTCAGACTCACAGGTTTCTTGTTACAGTACCAGAGCTGAG
CACCGCCACCACCACCACCCCCAGCTGACTACACAATTTTCCTGTCAACACATTTCAATAGCAT
ACAGCTTCTCTTCTGCCCTCTTACTTCGCATGCTAACATATATTCATTGTACATATTAGGAAGG
TTCGACATGACTGATCCGTACATGCACACAACATTCACACGTCCACCCCAGACTCTTCCTAATC
ATTCTTCTTCTTACTGGTTGACTTTTAAAAAAGGGGGTGGGGGGCACTGGAGAGGTGGCTCAGA
GGTTAAAAGCACCAACTGTTCTTCCAGAGGTTCTAGTTCAACTCCCAGCAACTACATGGTGGCT
CACAACCATCTGTAATGGGAGCCGATGCCCTCTTCTGGTGTGTCTGAAGACAGCTACAATGTTA
TTCGTGTACATTAAATAAAAATTCTTTAAAAAAAATAGGTCTTAAGAATCCCACACTGGCCTCA
AGATTATTATGCAACCAAAAATGACTTTGAAATTCAAATCCCCCTGCCTCCACCTCCTATTGGC
TGGGATCATAGGCAGGGAACACTATGCCCAGTCTTATGTGGTACTGGGAATCAAAGCCAGGGCT
TCGTGCACGGTAATTAAGCATCCTGTCAACTAAGCTACTACCCTAGCCTGCTCAGGTTGACGTG
TCTGGCCCTCAGATATGAGACTGCATGGCACTTCTGCGTCCACTCACATAATGTCCCCGTCATC
CACCCAACTATTAACCAACGCCTCAGCAGACTCTGTACCGTAGCTATTATACATAGTACTACAC
TCAACCCTTGGTTTAAAAAAGGAAAACCAGCAATCTCCCACCATAACCTATCCTCGTGCGTACA
TGTCCATGTGTTAAATCCCTGAGAAGTCAAGCTTGTTTGCGTAAGTGGGCATGTCCAAGATGAA
TGAGTTAATCTACATAGACAGAAGATGGAATGTAGATCAGTCTTGTGATACATGCCTTCTGTCG
TCGAGGGAAGGACCTTAGGCTACAACTGCTGTACGAACTATTATGCAGAAATTTCAAATCACTA
AAAAGATCTTTTTTGTGGTGAGGTATTTTGAGCGTAAGACTGCAGTTCCGCCTTTCCAGTGTAA
GCTGTTTATCTATTCCCCATGAATAAATGCTTTTATCTACAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_114449	(Get FASTA)	NCBI Sequence Viewer
	XP_006237376	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC40071	(Get FASTA)	NCBI Sequence Viewer
	EDM01978	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012216
	ENSRNOP00000094051
GenBank Protein	O55197	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114449 ⟸ NM_032060

- UniProtKB:

O55197 (UniProtKB/Swiss-Prot), G3V759 (UniProtKB/TrEMBL), A6ILG1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHL
TLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPI
WCQNHRSVRTAFAVCGCVWVVTFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYDYWDYMYNSH
LPEINPPDNSTGHVDDRTAPSSSVPARDLWTATTALQSQTFHTSPEDPFSQDSASQQPHYGGKP
PTVLIATIPGGFPVEDHKSNTLNTGAFLSAHTEPSLTASSSPLYAHDFPDDYFDQLMYGNHAWT
PQVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHI
VGILLVITDQESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFS
EELTHSTSCTQDKAPSKRNHMSTDV

hide sequence

RefSeq Acc Id:	XP_006237376 ⟸ XM_006237314
- Peptide Label:	isoform X1
- UniProtKB:	O55197 (UniProtKB/Swiss-Prot), G3V759 (UniProtKB/TrEMBL), A6ILG1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHL TLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPI WCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYDYWDYMYNSH LPEINPPDNSTGHVDDRTAPSSVPARDLWTATTALQSQTFHTSPEDPFSQDSASQQPHYGGKPP TVLIATIPGGFPVEDHKSNTLNTGAFLSAHTEPSLTASSSPLYAHDFPDDYFDQLMYGNHAWTP QVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIV GILLVITDQESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFSE ELTHSTSCTQDKAPSKRNHMSTDV hide sequence

Ensembl Acc Id:

ENSRNOP00000012216 ⟸ ENSRNOT00000012216

Ensembl Acc Id:

ENSRNOP00000094051 ⟸ ENSRNOT00000106930

Ensembl Acc Id:

ENSRNOP00000104182 ⟸ ENSRNOT00000153946

Ensembl Acc Id:

ENSRNOP00000112598 ⟸ ENSRNOT00000135206

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O55197-F1-model_v2	AlphaFold	O55197	1-473	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693372

Promoter ID:

EPDNEW_R3897

Type:

single initiation site

Name:

C3ar1_1

Description:

complement C3a receptor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	155,690,918 - 155,690,978	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620537	AgrOrtholog
BioCyc Gene	G2FUF-43141	BioCyc
Ensembl Genes	ENSRNOG00000009211	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000012216	ENTREZGENE
	ENSRNOT00000106930	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	Anaphtx_C3AR1	UniProtKB/Swiss-Prot
	Anphylx_rcpt	UniProtKB/Swiss-Prot
	Formyl_rcpt-rel	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	rno:84007	UniProtKB/Swiss-Prot
NCBI Gene	84007	ENTREZGENE
PANTHER	PTHR24225	UniProtKB/Swiss-Prot
	PTHR24225:SF28	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	C3ar1	PhenoGen
PRINTS	ANPHYLATOXNR	UniProtKB/Swiss-Prot
	C3ANPHYLTXNR	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009211	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A6ILG1	ENTREZGENE, UniProtKB/TrEMBL
	C3AR_RAT	UniProtKB/Swiss-Prot
	G3V759	ENTREZGENE, UniProtKB/TrEMBL
	O55197	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	C3ar1	complement C3a receptor 1	C3ar1	complement component 3a receptor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	C3ar1	complement component 3a receptor 1			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	C3ar1	complement component 3a receptor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	ubiquitously expressed	724614
gene_process	important mediator of inflammation and potent chemotactic factor for eosinophils and mast cells	724614
gene_product	member of the G-protein coupled receptor family	724614

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)