RGD Reference Report - Complement factors C3a and C5a have distinct hemodynamic effects in the rat. - Rat Genome Database

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Complement factors C3a and C5a have distinct hemodynamic effects in the rat.

Authors: Proctor, LM  Moore, TA  Monk, PN  Sanderson, SD  Taylor, SM  Woodruff, TM 
Citation: Proctor LM, etal., Int Immunopharmacol. 2009 Jun;9(6):800-6. Epub 2009 Mar 12.
RGD ID: 5129696
Pubmed: PMID:19285573   (View Abstract at PubMed)
DOI: DOI:10.1016/j.intimp.2009.03.002   (Journal Full-text)

In the rat, C5a infusion mediates well-defined effects including hypotension and neutropenia. Conversely, the comparative effect of C3a in the rat is not yet defined. In the current study, we have investigated C3a receptor (C3aR) activation in the rat, using recombinant human C3a, the C3aR agonist WWGKKYRASKLGLAR, which is a C-terminal analogue of C3a, and a nonpeptide C3aR antagonist SB-290157, as pharmacological tools. In vitro, C3a and WWGKKYRASKLGLAR selectively bound to C3aRs and induced degranulation of C3aR-transfected RBL-2H3 cells. C3a or WWGKKYRASKLGLAR-induced degranulation was dose-dependently antagonized in a surmountable fashion by the nonpeptide C3aR antagonist. Intravenous infusion of C3a and WWGKKYRASKLGLAR to rats induced a rapid, transient and concentration-dependent hypertensive response, which was mediated by C3aR-induced prostanoid release. C3a and WWGKKYRASKLGLAR caused a small drop in circulating neutrophils, but a rise in circulating neutrophils was evident after 90-120 min. In contrast to C3a, C5a infusion resulted in hypotension, and rapid and transient neutropenia. These results demonstrate that C3a and C5a mediate distinct effects on blood pressure and circulating polymorphonuclear leukocytes in the rat.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of blood pressure  IDA 5129696 RGD 

Objects Annotated

Genes (Rattus norvegicus)
C3ar1  (complement C3a receptor 1)


Additional Information