Rock1 (Rho-associated coiled-coil containing protein kinase 1) - Rat Genome Database

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Gene: Rock1 (Rho-associated coiled-coil containing protein kinase 1) Rattus norvegicus
Analyze
Symbol: Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
RGD ID: 620424
Description: Enables small GTPase binding activity. Involved in cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Is active in synapse. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1); PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver regeneration-related protein LRRG199; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; P160Rock; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; ROCK-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,387,360 - 1,509,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl181,387,360 - 1,509,147 (-)EnsemblGRCr8
mRatBN7.2181,114,532 - 1,236,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx181,332,915 - 1,454,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,120,746 - 2,242,546 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0181,334,812 - 1,456,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,273,490 - 1,390,790 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,316,022 - 1,433,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,391,751 - 1,511,865 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,001,677 - 1,120,847 (-)NCBICelera
RGSC_v3.1181,391,824 - 1,511,866 (-)NCBI
Cytogenetic Map18p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,8-cineole  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
fasudil  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
Ginkgoic acid  (ISO)
glucose  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
hyaluronic acid  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
maneb  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (ISO)
ouabain  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
pamidronate  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (ISO)
pyridaben  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
Sanggenon C  (EXP)
scoparone  (ISO)
SHP099  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (EXP)
spiromesifen  (ISO)
streptozocin  (EXP)
succimer  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
Torularhodin  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
Y-27632  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actomyosin structure organization  (IBA)
aortic valve morphogenesis  (ISO)
apical constriction  (ISO)
apoptotic process  (IEA)
bleb assembly  (ISO)
blood vessel diameter maintenance  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cortical actin cytoskeleton organization  (IBA)
cytoskeleton organization  (IEA,IMP)
embryonic morphogenesis  (IBA)
epithelial to mesenchymal transition  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
leukocyte cell-cell adhesion  (IEA,ISO)
leukocyte migration  (IEA,ISO)
leukocyte tethering or rolling  (IEA,ISO)
membrane to membrane docking  (IEA,ISO)
mitotic cytokinesis  (IBA)
mRNA destabilization  (IEA,ISO)
myoblast migration  (IEA,ISO,ISS)
negative regulation of amyloid precursor protein catabolic process  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of bicellular tight junction assembly  (IEA,ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neuron projection arborization  (IEA,ISO)
neuron projection development  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
podocyte cell migration  (IEA,ISO,ISS)
positive regulation of amyloid-beta clearance  (IEA,ISO)
positive regulation of autophagy  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of connective tissue replacement  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of protein localization to nucleus  (ISO)
protein localization to plasma membrane  (IEA,ISO)
regulation of actin cytoskeleton organization  (IBA,IEA,ISO,ISS)
regulation of actin filament-based process  (ISO)
regulation of angiotensin-activated signaling pathway  (IEA,ISO)
regulation of cell junction assembly  (IBA)
regulation of cell migration  (IEA,ISO,ISS)
regulation of establishment of endothelial barrier  (IEA,ISO)
regulation of keratinocyte differentiation  (IEA,ISO)
regulation of microtubule cytoskeleton organization  (IEA,ISO,ISS)
regulation of neuron differentiation  (IEA,ISO)
regulation of synapse maturation  (IEA,ISO)
regulation of synaptic vesicle endocytosis  (IEA,ISO)
response to angiotensin  (IEA,ISO)
response to transforming growth factor beta  (IEA,IGI,ISO)
Rho protein signal transduction  (IBA,IEA,IMP,ISO)
signal transduction  (IEA)

Cellular Component
bleb  (IEA)
centriole  (IEA)
cytoplasm  (IBA,IEA)
cytoplasmic stress granule  (IBA,IEA,ISO)
cytoskeleton  (IBA,IEA,ISO,ISS)
Golgi membrane  (IEA)
lamellipodium  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
ruffle  (IEA,ISO,ISS)
Schaffer collateral - CA1 synapse  (IEA,ISO)
synapse  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability. Da Silva JS, etal., J Cell Biol 2003 Sep 29;162(7):1267-79.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Endogenous Rho-kinase signaling maintains synaptic strength by stabilizing the size of the readily releasable pool of synaptic vesicles. González-Forero D, etal., J Neurosci. 2012 Jan 4;32(1):68-84. doi: 10.1523/JNEUROSCI.3215-11.2012.
6. RhoA activation promotes transendothelial migration of monocytes via ROCK. Honing H, etal., J Leukoc Biol 2004 Mar;75(3):523-8. Epub 2003 Nov 21.
7. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. Jeon S, etal., J Biol Chem 2002 May 10;277(19):16576-84.
8. The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour. Kamai T, etal., BJU Int. 2002 Mar;89(4):449-53.
9. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Leung T, etal., Mol Cell Biol 1996 Oct;16(10):5313-27.
10. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
14. MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. Pawlak G and Helfman DM, J Biol Chem 2002 Jul 26;277(30):26927-33.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Shimizu T, etal., JCI Insight. 2017 Jul 6;2(13). pii: 93187. doi: 10.1172/jci.insight.93187.
20. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. Yanazume T, etal., J Biol Chem 2002 Mar 8;277(10):8618-25.
Additional References at PubMed
PMID:9353125   PMID:10652353   PMID:11018042   PMID:11956230   PMID:12082081   PMID:15071095   PMID:15336547   PMID:15476589   PMID:15834419   PMID:15857906   PMID:15865439   PMID:15988321  
PMID:16249236   PMID:16322374   PMID:16390872   PMID:16396994   PMID:16741948   PMID:16890527   PMID:16904666   PMID:17065553   PMID:17071121   PMID:17135244   PMID:17177859   PMID:17220176  
PMID:17554619   PMID:17654484   PMID:18316075   PMID:18356698   PMID:18469113   PMID:18573880   PMID:18599801   PMID:18640982   PMID:18694941   PMID:18819929   PMID:19036714   PMID:19052484  
PMID:19080536   PMID:19106222   PMID:19131646   PMID:19181962   PMID:19427347   PMID:19524675   PMID:19746421   PMID:19782753   PMID:19799911   PMID:19915157   PMID:19942308   PMID:19997641  
PMID:20086008   PMID:20665664   PMID:20724941   PMID:20970835   PMID:21297020   PMID:21385940   PMID:21685893   PMID:21920940   PMID:22031832   PMID:22215561   PMID:22235829   PMID:22566503  
PMID:22883550   PMID:22987919   PMID:23093407   PMID:23258382   PMID:23325464   PMID:23402758   PMID:23826343   PMID:23899007   PMID:24305806   PMID:24398620   PMID:24637663   PMID:24792035  
PMID:24982890   PMID:25121106   PMID:25150189   PMID:25264049   PMID:25460182   PMID:25695625   PMID:25712270   PMID:25807302   PMID:25816133   PMID:25911094   PMID:25922200   PMID:26010004  
PMID:26169356   PMID:26194354   PMID:26342084   PMID:26377600   PMID:26391686   PMID:26634652   PMID:27075764   PMID:27094551   PMID:27160703   PMID:27333569   PMID:27351828   PMID:27430620  
PMID:27760762   PMID:27853422   PMID:28054559   PMID:28131915   PMID:28277985   PMID:28300565   PMID:28656263   PMID:28820400   PMID:28821742   PMID:29029794   PMID:29219181   PMID:29353861  
PMID:29383848   PMID:29791873   PMID:29795210   PMID:30132575   PMID:30212830   PMID:30546117   PMID:31078707   PMID:31625671   PMID:31904090   PMID:31940260   PMID:31970784   PMID:32031069  
PMID:32308124   PMID:32813542   PMID:33283391   PMID:33450132   PMID:33495839   PMID:33538509   PMID:34294375   PMID:35432725   PMID:37003483   PMID:37874190  


Genomics

Comparative Map Data
Rock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,387,360 - 1,509,218 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl181,387,360 - 1,509,147 (-)EnsemblGRCr8
mRatBN7.2181,114,532 - 1,236,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx181,332,915 - 1,454,715 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,120,746 - 2,242,546 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0181,334,812 - 1,456,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,273,490 - 1,390,790 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)Ensemblrn6Rnor6.0
Rnor_5.0181,316,022 - 1,433,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,391,751 - 1,511,865 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,001,677 - 1,120,847 (-)NCBICelera
RGSC_v3.1181,391,824 - 1,511,866 (-)NCBI
Cytogenetic Map18p13NCBI
ROCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381820,946,906 - 21,111,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1820,944,612 - 21,111,813 (-)Ensemblhg38GRCh38
GRCh371818,526,867 - 18,691,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361816,783,699 - 16,945,810 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341816,787,532 - 16,944,869NCBI
Celera1815,335,539 - 15,497,459 (-)NCBICelera
Cytogenetic Map18q11.1NCBI
HuRef1815,376,598 - 15,538,887 (-)NCBIHuRef
CHM1_11818,456,721 - 18,618,879 (-)NCBICHM1_1
T2T-CHM13v2.01821,131,976 - 21,296,884 (-)NCBIT2T-CHM13v2.0
Rock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,064,401 - 10,182,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)Ensemblmm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBIMGSCv36mm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
Rock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)Ensembl
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBIChiLan1.0ChiLan1.0
ROCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21738,369,318 - 38,529,836 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11824,061,911 - 24,221,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,192,293 - 14,352,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,831,594 - 17,991,039 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,833,047 - 17,990,086 (-)EnsemblpanPan2panpan1.1
ROCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,862,614 - 67,001,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,941,517 - 63,085,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936550733,239 - 874,601 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936550730,462 - 874,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,163,989 - 106,314,944 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16106,163,899 - 106,314,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,710,281 - 98,860,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,384,822 - 59,538,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,384,944 - 59,540,070 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605034,174,637 - 34,329,252 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477010,592,304 - 10,731,640 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rock1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11533,941,444 - 34,059,491 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rock1
520 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:196
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000051362, ENSRNOT00000061777
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat

Markers in Region
RH127505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,120,397 - 1,120,573 (+)MAPPERmRatBN7.2
Rnor_6.0181,279,266 - 1,279,441NCBIRnor6.0
Rnor_5.0181,321,700 - 1,321,875UniSTSRnor5.0
RGSC_v3.4181,396,306 - 1,396,481UniSTSRGSC3.4
Celera181,006,194 - 1,006,369UniSTS
RH 3.4 Map1832.2UniSTS
Cytogenetic Map18p13UniSTS
Cytogenetic Map4q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001389239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_171200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB861944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC112592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U61266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000051362   ⟹   ENSRNOP00000047378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl181,387,360 - 1,509,147 (-)Ensembl
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)Ensembl
Rnor_6.0 Ensembl181,276,391 - 1,389,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061777   ⟹   ENSRNOP00000058491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,115,905 - 1,200,920 (-)Ensembl
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)Ensembl
RefSeq Acc Id: NM_001389239   ⟹   NP_001376168
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,387,360 - 1,509,147 (-)NCBI
mRatBN7.2181,114,532 - 1,236,324 (-)NCBI
RefSeq Acc Id: NR_171200
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,387,360 - 1,509,147 (-)NCBI
mRatBN7.2181,114,532 - 1,236,324 (-)NCBI
RefSeq Acc Id: XM_006254401   ⟹   XP_006254463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,387,360 - 1,509,218 (-)NCBI
mRatBN7.2181,114,532 - 1,236,345 (-)NCBI
Rnor_6.0181,273,584 - 1,390,790 (-)NCBI
Rnor_5.0181,316,022 - 1,433,175 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001376168 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB37571 (Get FASTA)   NCBI Sequence Viewer  
  AAP92621 (Get FASTA)   NCBI Sequence Viewer  
  EDL86664 (Get FASTA)   NCBI Sequence Viewer  
  EDL86665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047378
GenBank Protein Q63644 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_006254463   ⟸   XM_006254401
- Peptide Label: isoform X1
- UniProtKB: D4A5S0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047378   ⟸   ENSRNOT00000051362
Ensembl Acc Id: ENSRNOP00000058491   ⟸   ENSRNOT00000061777
RefSeq Acc Id: NP_001376168   ⟸   NM_001389239
- UniProtKB: D4A5S0 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   PH   Phorbol-ester/DAG-type   Protein kinase   REM-1   RhoBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63644-F1-model_v2 AlphaFold Q63644 1-1369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620424 AgrOrtholog
BioCyc Gene G2FUF-8421 BioCyc
Ensembl Genes ENSRNOG00000031092 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051362 ENTREZGENE
Gene3D-CATH 1.20.5.340 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  HR1_rho-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Rho-assoc_Ser/Thr_Kinase UniProtKB/Swiss-Prot
  Rho-bd_dom UniProtKB/Swiss-Prot
  ROCK1/ROCK2 UniProtKB/Swiss-Prot
  ROCK1_HR1 UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 81762 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/Swiss-Prot
  RHO-ASSOCIATED PROTEIN KINASE 1 UniProtKB/Swiss-Prot
Pfam PH_MRCK UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Rho_Binding UniProtKB/Swiss-Prot
PhenoGen Rock1 PhenoGen
PIRSF Rho_kinase UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  REM_1 UniProtKB/Swiss-Prot
  RHO_BD UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031092 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP G protein-binding domain UniProtKB/Swiss-Prot
  Myosin rod fragments UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
UniProt A6KND9_RAT UniProtKB/TrEMBL
  A6KNE0_RAT UniProtKB/TrEMBL
  D4A5S0 ENTREZGENE, UniProtKB/TrEMBL
  Q63644 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q7TP31 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Rock1  Rho-associated coiled-coil containing protein kinase 1  Rock1  Rho-associated coiled-coil forming kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rock1  Rho-associated coiled-coil forming kinase 1    Rho-associated kinase beta  Name updated 1299863 APPROVED
2002-08-07 Rock1  Rho-associated kinase beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds RhoA, RhoB, and RhoC but not Rac1 and Cdc42 633784
gene_process involved in GATA-4-dependent endothelin-1 transcription 619546
gene_protein molecular mass of 160 kDa 633784
gene_regulation MEK induces down-regulation of ROCK expression 633785