Gene:	Rock1 ( Rattus norvegicus ) Rho-associated coiled-coil containing protein kinase 1
Description:	protein serine/threonine kinase; involved in intracellular signaling
Synonyms:	Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated coiled-coil forming kinase 1; P160Rock;
ArrayIDs:	5641200; 6571995; 6559887; 5973586; 5838419; rc_AI137331_at; 5665957; 5770324; 5784910; 5650215; U61266_at; 5860142; 5688509; 6312441; 5970475; 5857769; 5965015; 1368932_at; 6675974; 6298334; 6093314; 5820230; 6628457; 6451498; 6744804; 6114198; 5758358; 6467154; 6270105; 6290902; 6457620; 6291864; 6566352; 6564005; 6010118; 6610411; 5811312; 6691592; 5803313; 6587132; 6095363; 6329125; 6216075; 5978710; 5892432;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: ROCK1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Rock1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Rock1 genome assembly 3.1 18 1391824 - 1511866     Rat Celera Assembly 18 1001715 - 1120847     RGSC genome assembly v3.4 18 1391825 - 1511865     Cytogenetic 18 p13 Mus musculus Rock1 Mouse genome assembly build 36.1 18 10064399 - 10181790     Cytogenetic 18 18 A2 Homo sapiens ROCK1 human genome assembly 18 16787532 - 16944869     Human genome assembly build 36.2 18 16787533 - 16944869     Cytogenetic 18 q11.1   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology identical protein binding,  protein serine/threonine kinase activity,  GTP-Rho binding (details...)
Biological Process	Note Reference involved in GATA-4-dependent endothelin-1 transcription 619546 Gene Ontology leukocyte migration,  membrane to membrane docking,  leukocyte tethering or rolling ...  (details...)
Cellular Component	Gene Ontology cytosol (details...)
Disease	Ontology Hypertrophy, Left Ventricular,  Neoplasms, Germ Cell and Embryonal (details...)
Protein	Note Reference molecular mass of 160 kDa 633784
Regulation	Note Reference MEK induces down-regulation of ROCK expression 633785
Physical interaction	Note Reference binds RhoA, RhoB, and RhoC but not Rac1 and Cdc42 633784
External Links
Databases	DATABASE ID SOURCE SMART: C1 IPI SMART: PH IPI PROSITE: ZF_DAG_PE_2 IPI PROSITE: PH_DOMAIN IPI UNIPARC: UPI0001B79BA3 IPI UNIPARC: UPI0000367824 IPI UNIPARC: UPI0001B79BA1 IPI UNIPARC: UPI0001B79BA2 IPI KEGG Report: rno:81762 ENTREZGENE HomoloGene Group ID: 55899 ENTREZGENE Germonline: 620424 Pfam: C1_1 IPI Pfam: Rho_Binding IPI Pfam: PH IPI KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04270 ENTREZGENE KEGG Pathway: 04350 ENTREZGENE InterPro: Rho_bd. IPI InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI InterPro: Pleckstrin_homology. IPI InterPro: Rho-assoc_coiled-coil_kin-like. IPI IPI: IPI00211045 IPI IPI: IPI00418087 IPI IPI: IPI00951118 IPI IPI: IPI00568616 IPI Ensembl Protein: ENSRNOP00000058491 IPI Ensembl Protein: ENSRNOP00000049511 IPI Ensembl Protein: ENSRNOP00000047378 IPI Gene3D-CATH: Rho_bd IPI Entrez Gene: Rock1 ENTREZGENE UniProt: ROCK1_RAT IPI UniProt: ROCK1_RAT IPI Ensembl Genes: ENSRNOG00000031092 IPI PANTHER: Rho_kinase IPI
Sequences	Nucleotide: CH474073 Get FASTA Search GEO Profiles Nucleotide: AY325220 Get FASTA Search GEO Profiles Nucleotide: U61266 Get FASTA Search GEO Profiles Nucleotide: NM_031098 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: Q63644 Get FASTA Protein: AAB37571 Get FASTA Protein: AAP92621 Get FASTA Protein: NP_112360 Get FASTA Protein: EDL86665 Get FASTA Protein: EDL86664 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 89756
References
Curated References	11 references in RGD related to Rock1
Other References	34 other references at PubMed related to Rock1
Database Information
RGD ID	620424
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 25-FEB-08: Rock1 Rho-associated coiled-coil containing protein kinase 1 Rock1 Rho-associated coiled-coil forming kinase 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-JAN-05: Rock1 Rho-associated coiled-coil forming kinase 1 Rho-associated kinase beta APPROVED Name updated 1299863 07-AUG-02: Rock1 Rho-associated kinase beta PROVISIONAL Symbol and Name status set to provisional 70820