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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Acc ID: CHEBI:16336
Term: hyaluronic acid
Definition: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
Chemical ID: MESH:D006820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rock1increases phosphorylationISOROCK1 (Homo sapiens)6480464CTDHyaluronic Acid results in increased phosphorylation of ROCK1 proteinPMID:16864594
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