Rock1 (Rho associated coiled-coil containing protein kinase 1) - Rat Genome Database

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Gene: Rock1 (Rho associated coiled-coil containing protein kinase 1) Chinchilla lanigera
Analyze
Symbol: Rock1
Name: Rho associated coiled-coil containing protein kinase 1
RGD ID: 8928197
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); Rho-dependent protein serine/threonine kinase activity (ortholog); small GTPase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); aortic valve morphogenesis (ortholog); apical constriction (ortholog); PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Breast Neoplasms (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic stress granule (ortholog); cytoskeleton (ortholog); lamellipodium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
aortic valve morphogenesis  (ISO)
apical constriction  (ISO)
bleb assembly  (ISO)
blood vessel diameter maintenance  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cortical actin cytoskeleton organization  (ISO)
cytoskeleton organization  (ISO)
epithelial to mesenchymal transition  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO)
leukocyte tethering or rolling  (ISO)
membrane to membrane docking  (ISO)
motor neuron apoptotic process  (ISO)
mRNA destabilization  (ISO)
myoblast migration  (ISO)
negative regulation of amyloid precursor protein catabolic process  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of bicellular tight junction assembly  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of motor neuron apoptotic process  (ISO)
negative regulation of phosphorylation  (ISO)
neuron projection arborization  (ISO)
neuron projection development  (ISO)
podocyte cell migration  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of connective tissue replacement  (ISO)
positive regulation of dephosphorylation  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of protein localization to nucleus  (ISO)
protein localization to plasma membrane  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of actin filament-based process  (ISO)
regulation of angiotensin-activated signaling pathway  (ISO)
regulation of cell migration  (ISO)
regulation of establishment of endothelial barrier  (ISO)
regulation of keratinocyte differentiation  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of neuron differentiation  (ISO)
regulation of synapse maturation  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
response to angiotensin  (ISO)
response to transforming growth factor beta  (ISO)
Rho protein signal transduction  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBIChiLan1.0ChiLan1.0
ROCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381820,946,906 - 21,111,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1820,944,612 - 21,111,813 (-)EnsemblGRCh38hg38GRCh38
GRCh371818,526,867 - 18,691,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361816,783,699 - 16,945,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341816,787,532 - 16,944,869NCBI
Celera1815,335,539 - 15,497,459 (-)NCBICelera
Cytogenetic Map18q11.1NCBI
HuRef1815,376,598 - 15,538,887 (-)NCBIHuRef
CHM1_11818,456,721 - 18,618,879 (-)NCBICHM1_1
T2T-CHM13v2.01821,131,976 - 21,296,884 (-)NCBIT2T-CHM13v2.0
Rock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,064,401 - 10,182,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm39 Ensembl
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBIMGSCv36mm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
Rock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,387,360 - 1,509,218 (-)NCBIGRCr8
mRatBN7.2181,114,532 - 1,236,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,332,915 - 1,454,715 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,120,746 - 2,242,546 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0181,334,812 - 1,456,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,273,490 - 1,390,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,316,022 - 1,433,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,391,751 - 1,511,865 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,391,824 - 1,511,866 (-)NCBI
Celera181,001,677 - 1,120,847 (-)NCBICelera
Cytogenetic Map18p13NCBI
ROCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21738,369,318 - 38,529,836 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11824,061,911 - 24,221,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,192,293 - 14,352,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,831,594 - 17,991,039 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,833,047 - 17,990,086 (-)Ensemblpanpan1.1panPan2
ROCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,862,614 - 67,001,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBIUU_Cfam_GSD_1.0
Rock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,941,517 - 63,085,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936550733,239 - 874,601 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936550730,462 - 874,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,163,989 - 106,314,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,163,899 - 106,314,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,710,281 - 98,860,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,384,822 - 59,538,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,384,944 - 59,540,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605034,174,637 - 34,329,252 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477010,592,304 - 10,731,640 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000018486   ⟹   ENSCLAP00000018307
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000018487   ⟹   ENSCLAP00000018308
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554029,754,988 - 9,864,049 (-)Ensembl
RefSeq Acc Id: XM_005372684   ⟹   XP_005372741
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005372741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018307
  ENSCLAP00000018307.1
  ENSCLAP00000018308.1
Reference Protein Sequences
RefSeq Acc Id: XP_005372741   ⟸   XM_005372684
- UniProtKB: A0A8C2VNS8 (UniProtKB/TrEMBL),   A0A8C2VVZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000018308   ⟸   ENSCLAT00000018487
RefSeq Acc Id: ENSCLAP00000018307   ⟸   ENSCLAT00000018486
Protein Domains
AGC-kinase C-terminal   PH   Phorbol-ester/DAG-type   Protein kinase   REM-1   RhoBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000018486 ENTREZGENE
  ENSCLAT00000018486.1 UniProtKB/TrEMBL
  ENSCLAT00000018487.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  ROCK1/ROCK2 UniProtKB/TrEMBL
  ROCK1_HR1 UniProtKB/TrEMBL
  ROCK_Rho-bd_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Rock1 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/TrEMBL
  RHO-ASSOCIATED PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Rho_Binding UniProtKB/TrEMBL
PIRSF Rho_kinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  REM_1 UniProtKB/TrEMBL
  RHO_BD UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP G protein-binding domain UniProtKB/TrEMBL
  Myosin rod fragments UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C2VNS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VVZ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Rock1  Rho associated coiled-coil containing protein kinase 1    Rho-associated, coiled-coil containing protein kinase 1  Symbol and/or name change 5135510 APPROVED