ROCK1 (Rho associated coiled-coil containing protein kinase 1) - Rat Genome Database

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Gene: ROCK1 (Rho associated coiled-coil containing protein kinase 1) Canis lupus familiaris
Analyze
Symbol: ROCK1
Name: Rho associated coiled-coil containing protein kinase 1
RGD ID: 12423133
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); aortic valve morphogenesis (ortholog); apical constriction (ortholog); PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Breast Neoplasms (ortholog); genetic disease (ortholog); FOUND IN amyloid-beta complex (ortholog); Schaffer collateral - CA1 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho-associated protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,862,614 - 67,001,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actomyosin structure organization  (IEA)
aortic valve morphogenesis  (ISO)
apical constriction  (IEA,ISO)
bleb assembly  (IEA,ISO)
blood vessel diameter maintenance  (IEA)
canonical NF-kappaB signal transduction  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cortical actin cytoskeleton organization  (IEA)
cytoskeleton organization  (ISO)
embryonic morphogenesis  (IEA)
epithelial to mesenchymal transition  (IEA)
leukocyte cell-cell adhesion  (IEA)
leukocyte migration  (IEA)
leukocyte tethering or rolling  (IEA)
membrane to membrane docking  (IEA)
mitotic cytokinesis  (IEA)
motor neuron apoptotic process  (IEA,ISO)
mRNA destabilization  (IEA)
myoblast migration  (IEA)
negative regulation of amyloid precursor protein catabolic process  (IEA)
negative regulation of amyloid-beta formation  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of bicellular tight junction assembly  (IEA)
negative regulation of biomineral tissue development  (ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of phosphorylation  (IEA)
neuron projection arborization  (IEA)
neuron projection development  (IEA)
podocyte cell migration  (IEA)
positive regulation of amyloid-beta clearance  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of connective tissue replacement  (IEA)
positive regulation of dephosphorylation  (IEA)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of protein localization to nucleus  (ISO)
protein localization to plasma membrane  (IEA)
regulation of actin cytoskeleton organization  (IEA)
regulation of actin filament-based process  (IEA,ISO)
regulation of angiotensin-activated signaling pathway  (IEA)
regulation of cell junction assembly  (IEA)
regulation of cell migration  (IEA)
regulation of establishment of endothelial barrier  (IEA)
regulation of keratinocyte differentiation  (IEA)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of neuron differentiation  (IEA)
regulation of synapse maturation  (IEA)
regulation of synaptic vesicle endocytosis  (IEA)
response to angiotensin  (IEA)
response to transforming growth factor beta  (IEA)
Rho protein signal transduction  (IEA,ISO)
signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16448388   PMID:21685893   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ROCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,862,614 - 67,001,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBIUU_Cfam_GSD_1.0
ROCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381820,946,906 - 21,111,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1820,944,612 - 21,111,813 (-)EnsemblGRCh38hg38GRCh38
GRCh371818,526,867 - 18,691,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361816,783,699 - 16,945,810 (-)NCBINCBI36Build 36hg18NCBI36
Build 341816,787,532 - 16,944,869NCBI
Celera1815,335,539 - 15,497,459 (-)NCBICelera
Cytogenetic Map18q11.1NCBI
HuRef1815,376,598 - 15,538,887 (-)NCBIHuRef
CHM1_11818,456,721 - 18,618,879 (-)NCBICHM1_1
T2T-CHM13v2.01821,131,976 - 21,296,884 (-)NCBIT2T-CHM13v2.0
Rock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,064,401 - 10,182,225 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm39 Ensembl
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,064,401 - 10,182,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBIMGSCv36mm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
Rock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,387,360 - 1,509,218 (-)NCBIGRCr8
mRatBN7.2181,114,532 - 1,236,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,115,905 - 1,235,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx181,332,915 - 1,454,715 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,120,746 - 2,242,546 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0181,334,812 - 1,456,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,273,490 - 1,390,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,273,453 - 1,390,190 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,316,022 - 1,433,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,391,751 - 1,511,865 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,391,824 - 1,511,866 (-)NCBI
Celera181,001,677 - 1,120,847 (-)NCBICelera
Cytogenetic Map18p13NCBI
Rock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,750,730 - 9,864,317 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,752,101 - 9,864,317 (-)NCBIChiLan1.0ChiLan1.0
ROCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21738,369,318 - 38,529,836 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11824,061,911 - 24,221,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,192,293 - 14,352,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,831,594 - 17,991,039 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,833,047 - 17,990,086 (-)Ensemblpanpan1.1panPan2
Rock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,941,517 - 63,085,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936550733,239 - 874,601 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936550730,462 - 874,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,163,989 - 106,314,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,163,899 - 106,314,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,710,281 - 98,860,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,384,822 - 59,538,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,384,944 - 59,540,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605034,174,637 - 34,329,252 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477010,592,304 - 10,731,640 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ROCK1
1129 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 12 6 6 6 10 4
Low 5 10 6 6 6 6 8 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005623022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005623023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022421535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022421536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038482257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038482258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038482259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038543693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038543694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038543695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038607818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038607819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038607820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038672499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038672500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038672501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MT636893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000029058   ⟹   ENSCAFP00000027021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,862,608 - 66,999,990 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076478   ⟹   ENSCAFP00000044119
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000088322   ⟹   ENSCAFP00000059976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,862,608 - 66,994,290 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089215   ⟹   ENSCAFP00000050426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,862,608 - 67,035,525 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089687   ⟹   ENSCAFP00000051252
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl766,862,608 - 67,142,853 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002501   ⟹   ENSCAFP00845001988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl766,927,171 - 67,066,030 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002571   ⟹   ENSCAFP00845002048
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl766,927,171 - 67,065,342 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002586   ⟹   ENSCAFP00845002058
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl766,927,171 - 67,064,546 (+)Ensembl
RefSeq Acc Id: XM_005623022   ⟹   XP_005623079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1766,862,614 - 67,001,538 (+)NCBI
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005623023   ⟹   XP_005623080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1766,862,614 - 67,001,538 (+)NCBI
Dog10K_Boxer_Tasha766,316,405 - 66,455,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022421535   ⟹   XP_022277243
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1766,863,462 - 67,001,538 (+)NCBI
Dog10K_Boxer_Tasha766,317,285 - 66,455,341 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038482257   ⟹   XP_038338185
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBI
RefSeq Acc Id: XM_038482258   ⟹   XP_038338186
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1766,593,144 - 66,730,420 (+)NCBI
RefSeq Acc Id: XM_038482259   ⟹   XP_038338187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1766,592,264 - 66,730,420 (+)NCBI
RefSeq Acc Id: XM_038543693   ⟹   XP_038399621
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBI
RefSeq Acc Id: XM_038543694   ⟹   XP_038399622
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0766,918,825 - 67,056,895 (+)NCBI
RefSeq Acc Id: XM_038543695   ⟹   XP_038399623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0766,917,945 - 67,056,895 (+)NCBI
RefSeq Acc Id: XM_038607818   ⟹   XP_038463746
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBI
RefSeq Acc Id: XM_038607819   ⟹   XP_038463747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0766,617,130 - 66,754,480 (+)NCBI
RefSeq Acc Id: XM_038607820   ⟹   XP_038463748
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0766,616,250 - 66,754,480 (+)NCBI
RefSeq Acc Id: XM_038672499   ⟹   XP_038528427
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBI
RefSeq Acc Id: XM_038672500   ⟹   XP_038528428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0766,928,066 - 67,066,094 (+)NCBI
RefSeq Acc Id: XM_038672501   ⟹   XP_038528429
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0766,927,186 - 67,066,094 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005623079   ⟸   XM_005623022
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NIR0 (UniProtKB/TrEMBL),   A0A8P0NJG9 (UniProtKB/TrEMBL),   A0A8C0RLW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005623080   ⟸   XM_005623023
- Peptide Label: isoform X3
- UniProtKB: A0A8C0RLW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022277243   ⟸   XM_022421535
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MEB5 (UniProtKB/TrEMBL),   A0A8C0RLW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000059976   ⟸   ENSCAFT00000088322
RefSeq Acc Id: ENSCAFP00000027021   ⟸   ENSCAFT00000029058
RefSeq Acc Id: ENSCAFP00000044119   ⟸   ENSCAFT00000076478
RefSeq Acc Id: ENSCAFP00000050426   ⟸   ENSCAFT00000089215
RefSeq Acc Id: ENSCAFP00000051252   ⟸   ENSCAFT00000089687
RefSeq Acc Id: XP_038338185   ⟸   XM_038482257
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038338187   ⟸   XM_038482259
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038338186   ⟸   XM_038482258
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038463746   ⟸   XM_038607818
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038463748   ⟸   XM_038607820
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038463747   ⟸   XM_038607819
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038528427   ⟸   XM_038672499
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NIR0 (UniProtKB/TrEMBL),   A0A8P0NJG9 (UniProtKB/TrEMBL),   A0A8C0RLW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528429   ⟸   XM_038672501
- Peptide Label: isoform X3
- UniProtKB: A0A8C0RLW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038528428   ⟸   XM_038672500
- Peptide Label: isoform X2
- UniProtKB: A0A8I3MEB5 (UniProtKB/TrEMBL),   A0A8C0RLW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399621   ⟸   XM_038543693
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NIR0 (UniProtKB/TrEMBL),   A0A8C0RLW4 (UniProtKB/TrEMBL),   A0A8P0NJG9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399623   ⟸   XM_038543695
- Peptide Label: isoform X3
- UniProtKB: A0A8C0RLW4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038399622   ⟸   XM_038543694
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RLW4 (UniProtKB/TrEMBL),   A0A8I3MEB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845002058   ⟸   ENSCAFT00845002586
RefSeq Acc Id: ENSCAFP00845002048   ⟸   ENSCAFT00845002571
RefSeq Acc Id: ENSCAFP00845001988   ⟸   ENSCAFT00845002501
Protein Domains
AGC-kinase C-terminal   PH   Phorbol-ester/DAG-type   Protein kinase   REM-1   RhoBD

Promoters
RGD ID:13684088
Promoter ID:EPDNEW_C2155
Type:initiation region
Name:ROCK1_1
Description:Rho associated coiled-coil containing protein kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1766,862,628 - 66,862,688EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018282 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030016668 UniProtKB/TrEMBL
  ENSCAFG00040000908 UniProtKB/TrEMBL
  ENSCAFG00845001454 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029058.5 UniProtKB/TrEMBL
  ENSCAFT00000076478.2 UniProtKB/TrEMBL
  ENSCAFT00000089687.2 UniProtKB/TrEMBL
  ENSCAFT00030030790.1 UniProtKB/TrEMBL
  ENSCAFT00030030844.1 UniProtKB/TrEMBL
  ENSCAFT00030031110.1 UniProtKB/TrEMBL
  ENSCAFT00030031349.1 UniProtKB/TrEMBL
  ENSCAFT00030031655.1 UniProtKB/TrEMBL
  ENSCAFT00030031895.1 UniProtKB/TrEMBL
  ENSCAFT00040001639.1 UniProtKB/TrEMBL
  ENSCAFT00040001692.1 UniProtKB/TrEMBL
  ENSCAFT00040001738.1 UniProtKB/TrEMBL
  ENSCAFT00040001788.1 UniProtKB/TrEMBL
  ENSCAFT00040001805.1 UniProtKB/TrEMBL
  ENSCAFT00845002501 ENTREZGENE
  ENSCAFT00845002501.1 UniProtKB/TrEMBL
  ENSCAFT00845002571 ENTREZGENE
  ENSCAFT00845002571.1 UniProtKB/TrEMBL
  ENSCAFT00845002586 ENTREZGENE
  ENSCAFT00845002586.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  ROCK1/ROCK2 UniProtKB/TrEMBL
  ROCK1_HR1 UniProtKB/TrEMBL
  ROCK_Rho-bd_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene ROCK1 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/TrEMBL
  RHO-ASSOCIATED PROTEIN KINASE UniProtKB/TrEMBL
  RHO-ASSOCIATED PROTEIN KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Rho_Binding UniProtKB/TrEMBL
PIRSF Rho_kinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  REM_1 UniProtKB/TrEMBL
  RHO_BD UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP G protein-binding domain UniProtKB/TrEMBL
  Myosin rod fragments UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A7M3U3T1_CANLF UniProtKB/TrEMBL
  A0A8C0NIR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NLH8_CANLF UniProtKB/TrEMBL
  A0A8C0NUV8_CANLF UniProtKB/TrEMBL
  A0A8C0PWD7_CANLF UniProtKB/TrEMBL
  A0A8C0PZU5_CANLF UniProtKB/TrEMBL
  A0A8C0RLW4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RUX3_CANLF UniProtKB/TrEMBL
  A0A8C0RUY1_CANLF UniProtKB/TrEMBL
  A0A8I3MEB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MHP7_CANLF UniProtKB/TrEMBL
  A0A8I3MJ13_CANLF UniProtKB/TrEMBL
  A0A8P0NJG9 ENTREZGENE
UniProt Secondary A0A8P0NJG9 UniProtKB/TrEMBL
VGNC ID VGNC:45688 ENTREZGENE