Hnrnpd (heterogeneous nuclear ribonucleoprotein D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hnrnpd (heterogeneous nuclear ribonucleoprotein D) Rattus norvegicus
Analyze
Symbol: Hnrnpd
Name: heterogeneous nuclear ribonucleoprotein D
RGD ID: 620365
Description: Enables several functions, including histone deacetylase binding activity; mRNA 3'-UTR AU-rich region binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to nitric oxide; and positive regulation of macromolecule metabolic process. Is active in glutamatergic synapse and postsynaptic density. Used to study uremia. Biomarker of hepatocellular carcinoma. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; Auf1; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; Hnrpd; RNA binding protein p45AUF1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,918,630 - 9,938,072 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,919,739 - 9,938,066 (+)EnsemblGRCr8
mRatBN7.2149,615,375 - 9,638,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,615,479 - 9,633,786 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,586,928 - 9,605,215 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,886,767 - 10,905,061 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,583,376 - 9,601,670 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,256,163 - 11,274,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,256,268 - 11,274,578 (+)Ensemblrn6Rnor6.0
Rnor_5.01411,200,186 - 11,218,696 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,917,674 - 10,935,989 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,716,133 - 9,734,433 (+)NCBICelera
RGSC_v3.11410,917,909 - 10,935,760 (+)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3',5'-cyclic UMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
adenine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
dexamethasone  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dihydroartemisinin  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrates  (ISO)
nobiletin  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
piroxicam  (ISO)
putrescine  (EXP)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
glutamatergic synapse  (EXP,IDA,IEP)
mCRD-mediated mRNA stability complex  (IEA,ISO)
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IEA)
postsynaptic density  (EXP,IDA,IEP)
ribonucleoprotein complex  (IEA,ISO,ISS)
synapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A+U-rich-element RNA-binding factor 1/heterogeneous nuclear ribonucleoprotein D gene expression is regulated by oestrogen in the rat uterus. Arao Y, etal., Biochem J 2002 Jan 1;361(Pt 1):125-32.
2. Stability of A+U-rich element binding factor 1 (AUF1)-binding messenger ribonucleic acid correlates with the subcellular relocalization of AUF1 in the rat uterus upon estrogen treatment. Arao Y, etal., Mol Endocrinol 2004 Sep;18(9):2255-67. Epub 2004 Jun 10.
3. Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA. Blum JL, etal., Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2543-50. Epub 2005 Aug 19.
4. Nitric oxide-sensitive guanylyl cyclase is differentially regulated by nuclear and non-nuclear estrogen pathways in anterior pituitary gland. Cabilla JP, etal., PLoS One. 2011;6(12):e29402. doi: 10.1371/journal.pone.0029402. Epub 2011 Dec 28.
5. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
6. Characterization of cDNAs encoding the murine A+U-rich RNA-binding protein AUF1. Ehrenman K, etal., Gene 1994 Nov 18;149(2):315-9.
7. Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues. Faura M, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):554-60.
8. Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. Frau M, etal., Hepatology. 2012 Jul;56(1):165-75. doi: 10.1002/hep.25643. Epub 2012 Jun 5.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors. Hambardzumyan D, etal., J Neurosci Res. 2009 May 1;87(6):1296-309. doi: 10.1002/jnr.21957.
12. NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells. Jurado S, etal., J Cell Sci. 2006 Apr 15;119(Pt 8):1622-31. Epub 2006 Mar 28.
13. Identification of AUF1 as a rapamycin-responsive binding protein to the 5'-terminal oligopyrimidine element of mRNAs. Kakegawa T, etal., Arch Biochem Biophys. 2007 Sep 1;465(1):274-81. Epub 2007 Jun 9.
14. Effect of chronic contractile activity on mRNA stability in skeletal muscle. Lai RY, etal., Am J Physiol Cell Physiol. 2010 Jul;299(1):C155-63. doi: 10.1152/ajpcell.00523.2009. Epub 2010 Apr 7.
15. Members of the NuRD chromatin remodeling complex interact with AUF1 in developing cortical neurons. Lee C, etal., Cereb Cortex. 2008 Dec;18(12):2909-19. doi: 10.1093/cercor/bhn051. Epub 2008 Apr 15.
16. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: correlation with posttranslational modification of the trans acting factor AUF1. Levi R, etal., J Am Soc Nephrol. 2006 Jan;17(1):107-12. Epub 2005 Nov 16.
17. AUF-1 mediates inhibition by nitric oxide of lipopolysaccharide-induced matrix metalloproteinase-9 expression in cultured astrocytes. Liu W, etal., J Neurosci Res. 2006 Aug 1;84(2):360-9.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. Nechama M, etal., FASEB J. 2008 Oct;22(10):3458-68. doi: 10.1096/fj.08-107250. Epub 2008 Jun 26.
22. Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex. Rao JS, etal., Pharmacogenomics J. 2006 Nov-Dec;6(6):413-20. Epub 2006 Apr 25.
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Vazquez-Chantada M, etal., Gastroenterology. 2010 May;138(5):1943-53. doi: 10.1053/j.gastro.2010.01.032. Epub 2010 Jan 25.
25. RNA binding proteins accumulate at the postsynaptic density with synaptic activity. Zhang G, etal., J Neurosci. 2012 Jan 11;32(2):599-609. doi: 10.1523/JNEUROSCI.2463-11.2012.
26. Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1. Zou T, etal., Mol Cell Biol. 2010 Nov;30(21):5021-32. doi: 10.1128/MCB.00807-10. Epub 2010 Aug 30.
Additional References at PubMed
PMID:8321232   PMID:14976220   PMID:15514034   PMID:16219914   PMID:16452087   PMID:16603688   PMID:16769718   PMID:17289661   PMID:18789946   PMID:22633954   PMID:22658674   PMID:22681889  
PMID:23106098   PMID:23376485   PMID:24423872   PMID:24625528   PMID:26316108   PMID:27034373   PMID:28986222   PMID:29476059   PMID:35352799  


Genomics

Comparative Map Data
Hnrnpd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,918,630 - 9,938,072 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,919,739 - 9,938,066 (+)EnsemblGRCr8
mRatBN7.2149,615,375 - 9,638,975 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl149,615,479 - 9,633,786 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx149,586,928 - 9,605,215 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,886,767 - 10,905,061 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,583,376 - 9,601,670 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01411,256,163 - 11,274,684 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1411,256,268 - 11,274,578 (+)Ensemblrn6Rnor6.0
Rnor_5.01411,200,186 - 11,218,696 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,917,674 - 10,935,989 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,716,133 - 9,734,433 (+)NCBICelera
RGSC_v3.11410,917,909 - 10,935,760 (+)NCBI
Cytogenetic Map14p22NCBI
HNRNPD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38482,352,498 - 82,373,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl482,351,523 - 82,374,543 (-)Ensemblhg38GRCh38
GRCh37483,273,651 - 83,295,144 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36483,493,491 - 83,514,173 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34483,631,645 - 83,652,328NCBI
Celera480,565,274 - 80,585,965 (-)NCBICelera
Cytogenetic Map4q21.22NCBI
HuRef479,014,546 - 79,035,236 (-)NCBIHuRef
CHM1_1483,250,972 - 83,271,667 (-)NCBICHM1_1
T2T-CHM13v2.0485,681,761 - 85,703,272 (-)NCBIT2T-CHM13v2.0
Hnrnpd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,103,794 - 100,126,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,103,794 - 100,126,797 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38599,955,935 - 99,979,130 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl599,955,935 - 99,978,938 (-)Ensemblmm10GRCm38
MGSCv375100,384,955 - 100,407,957 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365100,201,309 - 100,218,851 (-)NCBIMGSCv36mm8
Celera597,269,494 - 97,292,491 (-)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.46NCBI
Hnrnpd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554336,454,454 - 6,469,904 (-)Ensembl
ChiLan1.0NW_0049554336,452,931 - 6,470,209 (-)NCBIChiLan1.0ChiLan1.0
HNRNPD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2347,690,517 - 47,713,374 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1447,882,558 - 47,902,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0441,825,518 - 41,846,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1447,675,382 - 47,696,894 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl447,676,599 - 47,696,894 (+)EnsemblpanPan2panpan1.1
HNRNPD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,323,444 - 6,341,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,323,469 - 6,341,166 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3235,539,639 - 35,557,456 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0326,346,646 - 6,364,470 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,346,649 - 6,364,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,376,955 - 6,394,761 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,283,881 - 6,301,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03233,661,515 - 33,679,335 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hnrnpd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,934,255 - 5,953,306 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367382,096,370 - 2,113,604 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367382,096,370 - 2,115,135 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8135,844,487 - 135,862,626 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18135,844,492 - 135,862,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28145,204,594 - 145,218,439 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1730,729,697 - 30,749,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl730,731,175 - 30,749,876 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660379,284,119 - 9,304,361 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247578,531,601 - 8,549,835 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247578,532,373 - 8,549,840 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hnrnpd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11110,215,403 - 10,233,593 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hnrnpd
218 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:969
Count of miRNA genes:188
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000003158, ENSRNOT00000003173, ENSRNOT00000047840
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH136938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2149,633,559 - 9,633,742 (+)MAPPERmRatBN7.2
Rnor_6.01411,274,350 - 11,274,532NCBIRnor6.0
Rnor_5.01411,218,373 - 11,218,555UniSTSRnor5.0
RGSC_v3.41410,935,756 - 10,935,938UniSTSRGSC3.4
Celera149,734,200 - 9,734,382UniSTS
RH 3.4 Map14130.09UniSTS
Cytogenetic Map14p22UniSTS
MARC_23646-23647:1029444341:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2149,627,896 - 9,628,952 (+)MAPPERmRatBN7.2
Rnor_6.01411,268,685 - 11,269,742NCBIRnor6.0
Rnor_5.01411,212,708 - 11,213,765UniSTSRnor5.0
RGSC_v3.41410,930,091 - 10,931,148UniSTSRGSC3.4
Celera149,728,550 - 9,729,607UniSTS
Cytogenetic Map14p22UniSTS
MARC_23650-23651:1029445581:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2149,632,621 - 9,633,574 (+)MAPPERmRatBN7.2
Rnor_6.01411,273,412 - 11,274,364NCBIRnor6.0
Rnor_5.01411,217,435 - 11,218,387UniSTSRnor5.0
RGSC_v3.41410,934,818 - 10,935,770UniSTSRGSC3.4
Celera149,733,262 - 9,734,214UniSTS
Cytogenetic Map14p22UniSTS
Hnrnpd  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X35,476,861 - 35,477,120 (+)Marker Load Pipeline
mRatBN7.2X31,845,062 - 31,845,321 (+)MAPPERmRatBN7.2
Rnor_6.0X33,580,661 - 33,580,919NCBIRnor6.0
Rnor_5.0X33,927,890 - 33,928,148UniSTSRnor5.0
RGSC_v3.4X52,600,676 - 52,600,934UniSTSRGSC3.4
CeleraX32,149,434 - 32,149,692UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001082539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001082540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001082541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005493015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_359351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB046616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB046617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB046618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB798484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO560068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO567918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003158   ⟹   ENSRNOP00000003158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,919,739 - 9,938,066 (+)Ensembl
mRatBN7.2 Ensembl149,615,479 - 9,633,786 (+)Ensembl
Rnor_6.0 Ensembl1411,256,268 - 11,274,578 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000003173   ⟹   ENSRNOP00000003173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,919,757 - 9,938,065 (+)Ensembl
mRatBN7.2 Ensembl149,615,479 - 9,633,786 (+)Ensembl
Rnor_6.0 Ensembl1411,256,268 - 11,274,578 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047840   ⟹   ENSRNOP00000046491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,919,757 - 9,938,065 (+)Ensembl
mRatBN7.2 Ensembl149,615,479 - 9,633,786 (+)Ensembl
Rnor_6.0 Ensembl1411,256,268 - 11,274,578 (+)Ensembl
RefSeq Acc Id: NM_001082539   ⟹   NP_001076008
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,919,757 - 9,938,072 (+)NCBI
mRatBN7.2149,615,479 - 9,633,793 (+)NCBI
Rnor_6.01411,256,268 - 11,274,583 (+)NCBI
Rnor_5.01411,200,186 - 11,218,696 (+)NCBI
RGSC_v3.41410,917,674 - 10,935,989 (+)RGD
Celera149,716,133 - 9,734,433 (+)RGD
Sequence:
RefSeq Acc Id: NM_001082540   ⟹   NP_001076009
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,919,757 - 9,938,072 (+)NCBI
mRatBN7.2149,615,479 - 9,633,793 (+)NCBI
Rnor_6.01411,256,268 - 11,274,583 (+)NCBI
Rnor_5.01411,200,186 - 11,218,696 (+)NCBI
RGSC_v3.41410,917,674 - 10,935,989 (+)RGD
Celera149,716,133 - 9,734,433 (+)RGD
Sequence:
RefSeq Acc Id: NM_001082541   ⟹   NP_001076010
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,919,757 - 9,938,072 (+)NCBI
mRatBN7.2149,615,479 - 9,633,793 (+)NCBI
Rnor_6.01411,256,268 - 11,274,583 (+)NCBI
Rnor_5.01411,200,186 - 11,218,696 (+)NCBI
RGSC_v3.41410,917,674 - 10,935,989 (+)RGD
Celera149,716,133 - 9,734,433 (+)RGD
Sequence:
RefSeq Acc Id: NM_024404   ⟹   NP_077380
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,919,757 - 9,938,072 (+)NCBI
mRatBN7.2149,615,479 - 9,633,793 (+)NCBI
Rnor_6.01411,256,268 - 11,274,583 (+)NCBI
Rnor_5.01411,200,186 - 11,218,696 (+)NCBI
RGSC_v3.41410,917,674 - 10,935,989 (+)RGD
Celera149,716,133 - 9,734,433 (+)RGD
Sequence:
RefSeq Acc Id: XM_063273661   ⟹   XP_063129731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,918,630 - 9,938,072 (+)NCBI
RefSeq Acc Id: XR_005493015
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,918,630 - 9,938,072 (+)NCBI
mRatBN7.2149,615,375 - 9,638,975 (+)NCBI
RefSeq Acc Id: XR_359351
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,918,630 - 9,938,072 (+)NCBI
mRatBN7.2149,615,375 - 9,638,975 (+)NCBI
Rnor_6.01411,256,163 - 11,274,684 (+)NCBI
Rnor_5.01411,200,186 - 11,218,696 (+)NCBI
Sequence:
RefSeq Acc Id: NP_077380   ⟸   NM_024404
- Peptide Label: isoform a
- UniProtKB: Q9JJ52 (UniProtKB/Swiss-Prot),   Q9JJ51 (UniProtKB/Swiss-Prot),   P17132 (UniProtKB/Swiss-Prot),   G3V9G2 (UniProtKB/Swiss-Prot),   Q9JJ53 (UniProtKB/Swiss-Prot),   Q9JJ54 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001076010   ⟸   NM_001082541
- Peptide Label: isoform d
- UniProtKB: A6K625 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001076008   ⟸   NM_001082539
- Peptide Label: isoform b
- UniProtKB: A6K623 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001076009   ⟸   NM_001082540
- Peptide Label: isoform c
- UniProtKB: A6K622 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046491   ⟸   ENSRNOT00000047840
Ensembl Acc Id: ENSRNOP00000003173   ⟸   ENSRNOT00000003173
Ensembl Acc Id: ENSRNOP00000003158   ⟸   ENSRNOT00000003158
RefSeq Acc Id: XP_063129731   ⟸   XM_063273661
- Peptide Label: isoform X1
- UniProtKB: A6K623 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ54-F1-model_v2 AlphaFold Q9JJ54 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699199
Promoter ID:EPDNEW_R9723
Type:initiation region
Name:Hnrnpd_1
Description:heterogeneous nuclear ribonucleoprotein D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01411,256,247 - 11,256,307EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620365 AgrOrtholog
BioCyc Gene G2FUF-16388 BioCyc
Ensembl Genes ENSRNOG00000002292 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003158 ENTREZGENE
  ENSRNOT00000003158.7 UniProtKB/Swiss-Prot
  ENSRNOT00000003173 ENTREZGENE
  ENSRNOT00000003173.8 UniProtKB/Swiss-Prot
  ENSRNOT00000047840 ENTREZGENE
  ENSRNOT00000047840.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro CARG-binding_factor_N UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:79256 UniProtKB/Swiss-Prot
NCBI Gene 79256 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 UniProtKB/Swiss-Prot
  RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN UniProtKB/Swiss-Prot
Pfam CBFNT UniProtKB/Swiss-Prot
  RRM_1 UniProtKB/Swiss-Prot
PhenoGen Hnrnpd PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002292 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A6K622 ENTREZGENE, UniProtKB/TrEMBL
  A6K623 ENTREZGENE, UniProtKB/TrEMBL
  A6K625 ENTREZGENE, UniProtKB/TrEMBL
  G3V9G2 ENTREZGENE
  HNRPD_RAT UniProtKB/Swiss-Prot
  P17132 ENTREZGENE
  Q9JJ51 ENTREZGENE
  Q9JJ52 ENTREZGENE
  Q9JJ53 ENTREZGENE
  Q9JJ54 ENTREZGENE
UniProt Secondary G3V9G2 UniProtKB/Swiss-Prot
  P17132 UniProtKB/Swiss-Prot
  Q9JJ51 UniProtKB/Swiss-Prot
  Q9JJ52 UniProtKB/Swiss-Prot
  Q9JJ53 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-04 Hnrnpd  heterogeneous nuclear ribonucleoprotein D  Hnrpd  heterogeneous nuclear ribonucleoprotein D  Symbol changed 629549 APPROVED
2005-01-20 Hnrpd  heterogeneous nuclear ribonucleoprotein D    RNA binding protein p45AUF1  Name updated 1299863 APPROVED
2002-08-07 Hnrpd  RNA binding protein p45AUF1      Symbol and Name status set to provisional 70820 PROVISIONAL