Nr4a1 (nuclear receptor subfamily 4, group A, member 1) - Rat Genome Database

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Gene: Nr4a1 (nuclear receptor subfamily 4, group A, member 1) Rattus norvegicus
Analyze
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
RGD ID: 620029
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including neurotransmitter secretion involved in regulation of skeletal muscle contraction; response to amphetamine; and response to lipopolysaccharide. Predicted to be located in chromatin; cytosol; and mitochondrion. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Used to study Parkinson's disease and chronic kidney disease. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HMR; immediate early gene transcription factor NGFI-B; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; Ngfi-b; nuclear receptor subfamily 4 group A member 1; Nur77; Orphan nuclear receptor HMR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nr4a1m1Mcwi
Genetic Models: FHH-Nr4a1m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,247,153 - 134,268,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,247,192 - 134,268,041 (+)EnsemblGRCr8
mRatBN7.27132,368,399 - 132,389,300 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,374,840 - 132,389,297 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,182,933 - 134,190,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,412,449 - 136,420,349 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,322,869 - 136,330,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,899,358 - 142,920,216 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,905,758 - 142,920,216 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,700,242 - 140,721,073 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,012,807 - 140,020,590 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,846,928 - 128,854,640 (+)NCBICelera
RGSC_v3.17140,089,243 - 140,097,024 (+)NCBI
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-pantothenic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-hydroxymethylfurfural  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
8-OH-DPAT  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (EXP)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
bellidifolin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-butoxyethyl)phthalate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP,ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
carbachol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
Chorionic gonadotropin  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-penicillamine  (EXP)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dapsone  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl hydrogen phosphate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
dipentyl phthalate  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
febuxostat  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glycerol  (ISO)
glycidol  (EXP)
glycitein  (ISO)
glycitin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
Ibotenic acid  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
ketorolac  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
potassium atom  (EXP)
potassium chloride  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
proanthocyanidin  (ISO)
progesterone  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
rotenone  (EXP)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
scopolamine  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
styrene  (ISO)
succinic acid  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triazolam  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO,ISS)
cytosol  (IEA,ISO,ISS)
fibrillar center  (IEA,ISO)
mitochondrion  (IEA,ISO,ISS)
nuclear membrane  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
presynapse  (IEA)
transcription regulator complex  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
Experimental Data Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. Balasubramanian S, etal., J Am Soc Nephrol. 2012 Apr;23(4):674-86. doi: 10.1681/ASN.2011070646. Epub 2012 Feb 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Interaction between corticotropin-releasing factor and nitric oxide in mediating the response of the rat hypothalamus to immune and non-immune stimuli. Lee S and Rivier C, Brain Res Mol Brain Res. 1998 Jun 1;57(1):54-62.
5. Systemic endotoxin increases steady-state gene expression of hypothalamic nitric oxide synthase: comparison with corticotropin-releasing factor and vasopressin gene transcripts. Lee S, etal., Brain Res. 1995 Dec 24;705(1-2):136-48. doi: 10.1016/0006-8993(95)01142-0.
6. Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways. Liu M, etal., Environ Toxicol. 2022 Oct;37(10):2419-2433. doi: 10.1002/tox.23607. Epub 2022 Jun 28.
7. Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Maira M, etal., Mol Cell Biol. 1999 Nov;19(11):7549-57.
8. Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor. Martens C, etal., Mol Endocrinol. 2005 Apr;19(4):885-97. Epub 2004 Dec 9.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Milbrandt J Neuron 1988 May;1(3):183-8.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. Rambaud J, etal., J Biol Chem. 2009 May 22;284(21):14147-56. doi: 10.1074/jbc.M809023200. Epub 2009 Mar 25.
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease. Rouillard C, etal., Exp Neurol. 2018 Jun;304:143-153. doi: 10.1016/j.expneurol.2018.03.008. Epub 2018 Mar 9.
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Nkx6.1 regulates islet beta-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Tessem JS, etal., Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.
19. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Westbrook L, etal., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10.
20. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Xu JH, etal., Cell Tissue Res. 2006 Oct;326(1):159-68. doi: 10.1007/s00441-006-0214-4. Epub 2006 May 31.
Additional References at PubMed
PMID:1314418   PMID:8227042   PMID:8395013   PMID:8961274   PMID:9155013   PMID:10331876   PMID:12030839   PMID:12477932   PMID:12770726   PMID:12815108   PMID:14657025   PMID:14769794  
PMID:15016657   PMID:15155786   PMID:15358368   PMID:15486232   PMID:15525348   PMID:15701640   PMID:15707695   PMID:15716272   PMID:16951544   PMID:17032584   PMID:17416458   PMID:17434920  
PMID:17550977   PMID:18059339   PMID:18163434   PMID:18292087   PMID:18388149   PMID:18945812   PMID:18987158   PMID:18996961   PMID:19150624   PMID:19270309   PMID:19359610   PMID:19412742  
PMID:19447175   PMID:19789410   PMID:20375114   PMID:20411306   PMID:21048074   PMID:21357543   PMID:21442465   PMID:21505978   PMID:21908547   PMID:22097717   PMID:22128883   PMID:22147266  
PMID:22427340   PMID:22525717   PMID:23028064   PMID:23197407   PMID:23663895   PMID:24047441   PMID:24584059   PMID:24680679   PMID:25957997   PMID:26003139   PMID:26008781   PMID:26195821  
PMID:26276525   PMID:26465200   PMID:26497037   PMID:26498924   PMID:26884829   PMID:27221116   PMID:27765761   PMID:29295823   PMID:29850786   PMID:30006349   PMID:31273046   PMID:31939452  
PMID:31993850   PMID:32919804   PMID:33562500   PMID:34688693   PMID:35311465   PMID:36307672   PMID:37108481   PMID:38310251   PMID:38836656  


Genomics

Comparative Map Data
Nr4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,247,153 - 134,268,044 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,247,192 - 134,268,041 (+)EnsemblGRCr8
mRatBN7.27132,368,399 - 132,389,300 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,374,840 - 132,389,297 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,182,933 - 134,190,833 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,412,449 - 136,420,349 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,322,869 - 136,330,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,899,358 - 142,920,216 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,905,758 - 142,920,216 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,700,242 - 140,721,073 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47140,012,807 - 140,020,590 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,846,928 - 128,854,640 (+)NCBICelera
RGSC_v3.17140,089,243 - 140,097,024 (+)NCBI
Cytogenetic Map7q36NCBI
NR4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,022,832 - 52,059,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,022,832 - 52,059,509 (+)Ensemblhg38GRCh38
GRCh371252,416,616 - 52,453,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,731,458 - 50,739,554 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341250,723,762 - 50,736,019NCBI
Celera1251,247,867 - 51,255,961 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,449,770 - 49,486,519 (+)NCBIHuRef
CHM1_11252,382,884 - 52,419,560 (+)NCBICHM1_1
T2T-CHM13v2.01251,986,402 - 52,023,082 (+)NCBIT2T-CHM13v2.0
Nr4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,151,783 - 101,172,676 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,152,150 - 101,172,676 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,253,902 - 101,274,795 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,254,269 - 101,274,795 (+)Ensemblmm10GRCm38
MGSCv3715101,097,277 - 101,105,226 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,094,896 - 101,102,826 (+)NCBIMGSCv36mm8
Celera15103,414,983 - 103,422,853 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.64NCBI
Nr4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,404,532 - 2,431,050 (+)Ensembl
ChiLan1.0NW_0049555472,404,532 - 2,426,882 (+)NCBIChiLan1.0ChiLan1.0
NR4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,136,340 - 42,158,166 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,133,103 - 42,154,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,703,903 - 36,740,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,480,300 - 37,498,290 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,480,300 - 37,501,188 (-)EnsemblpanPan2panpan1.1
NR4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,947,729 - 2,965,045 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,891,053 - 2,955,655 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2743,300,499 - 43,308,433 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,944,790 - 2,966,939 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,939,797 - 2,965,600 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,961,332 - 2,969,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,947,820 - 2,955,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,698,715 - 43,706,655 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nr4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,656,496 - 63,678,740 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,499,754 - 9,508,423 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,486,096 - 9,508,338 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,208,354 - 48,232,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,208,587 - 48,233,063 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,859,302 - 197,884,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816267,303 - 293,227 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624816271,345 - 288,265 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nr4a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,816,890 - 261,837,125 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nr4a1
117 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:337
Count of miRNA genes:193
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000010171
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Genetic Models
This gene Nr4a1 is modified in the following models/strains:
FHH-Nr4a1m1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010171   ⟹   ENSRNOP00000010171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,247,192 - 134,268,041 (+)Ensembl
mRatBN7.2 Ensembl7132,381,391 - 132,389,297 (+)Ensembl
Rnor_6.0 Ensembl7142,912,316 - 142,920,216 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078663   ⟹   ENSRNOP00000070558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,259,764 - 134,268,041 (+)Ensembl
mRatBN7.2 Ensembl7132,374,840 - 132,385,097 (+)Ensembl
Rnor_6.0 Ensembl7142,905,758 - 142,916,017 (+)Ensembl
RefSeq Acc Id: NM_024388   ⟹   NP_077364
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,260,138 - 134,268,044 (+)NCBI
mRatBN7.27132,381,391 - 132,389,300 (+)NCBI
Rnor_6.07142,912,309 - 142,920,216 (+)NCBI
Rnor_5.07140,700,242 - 140,721,073 (+)NCBI
RGSC_v3.47140,012,807 - 140,020,590 (+)RGD
Celera7128,846,928 - 128,854,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242358   ⟹   XP_006242420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,253,494 - 134,268,044 (+)NCBI
mRatBN7.27132,374,841 - 132,389,300 (+)NCBI
Rnor_6.07142,905,064 - 142,920,216 (+)NCBI
Rnor_5.07140,700,242 - 140,721,073 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595130   ⟹   XP_017450619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,247,153 - 134,268,044 (+)NCBI
mRatBN7.27132,368,399 - 132,389,300 (+)NCBI
Rnor_6.07142,899,358 - 142,920,216 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063264287   ⟹   XP_063120357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,247,265 - 134,268,044 (+)NCBI
RefSeq Acc Id: NP_077364   ⟸   NM_024388
- UniProtKB: Q4V8M4 (UniProtKB/Swiss-Prot),   P22829 (UniProtKB/Swiss-Prot),   A6KCN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242420   ⟸   XM_006242358
- Peptide Label: isoform X1
- UniProtKB: Q4V8M4 (UniProtKB/Swiss-Prot),   P22829 (UniProtKB/Swiss-Prot),   A6KCN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450619   ⟸   XM_017595130
- Peptide Label: isoform X1
- UniProtKB: Q4V8M4 (UniProtKB/Swiss-Prot),   P22829 (UniProtKB/Swiss-Prot),   A6KCN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010171   ⟸   ENSRNOT00000010171
Ensembl Acc Id: ENSRNOP00000070558   ⟸   ENSRNOT00000078663
RefSeq Acc Id: XP_063120357   ⟸   XM_063264287
- Peptide Label: isoform X1
- UniProtKB: Q4V8M4 (UniProtKB/Swiss-Prot),   P22829 (UniProtKB/Swiss-Prot),   A6KCN9 (UniProtKB/TrEMBL)
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22829-F1-model_v2 AlphaFold P22829 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695673
Promoter ID:EPDNEW_R6191
Type:single initiation site
Name:Nr4a1_2
Description:nuclear receptor subfamily 4, group A, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6192  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,905,759 - 142,905,819EPDNEW
RGD ID:13695667
Promoter ID:EPDNEW_R6192
Type:multiple initiation site
Name:Nr4a1_1
Description:nuclear receptor subfamily 4, group A, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6191  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,912,303 - 142,912,363EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620029 AgrOrtholog
BioCyc Gene G2FUF-31993 BioCyc
Ensembl Genes ENSRNOG00000007607 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010171 ENTREZGENE
  ENSRNOT00000010171.5 UniProtKB/Swiss-Prot
  ENSRNOT00000078663 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458540 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nuc_orp_HMR_rcpt UniProtKB/Swiss-Prot
  Nuc_orph_rcpt UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:79240 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114310 IMAGE-MGC_LOAD
NCBI Gene 79240 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
  NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 1 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr4a1 PhenoGen
PRINTS HMRNUCRECPTR UniProtKB/Swiss-Prot
  NUCLEARECPTR UniProtKB/Swiss-Prot
  STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007607 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A0G2JY86_RAT UniProtKB/TrEMBL
  A6KCN9 ENTREZGENE, UniProtKB/TrEMBL
  NR4A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4V8M4 ENTREZGENE
UniProt Secondary Q4V8M4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nr4a1  nuclear receptor subfamily 4, group A, member 1    immediate early gene transcription factor NGFI-B  Name updated 1299863 APPROVED
2002-08-07 Nr4a1  immediate early gene transcription factor NGFI-B      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by NGF in PC12 cells 728970