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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620029 Species: Rattus norvegicus RGD Object: Gene Symbol: Nr4a1 Name: nuclear receptor subfamily 4, group A, member 1

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:732752	6480464	CTD	bisphenol A results in increased expression of NR4A1 mRNA	PMID:20826375 PMID:12021184
affects expression	ISO	RGD:732751	6480464	CTD	bisphenol A affects the expression of NR4A1 mRNA	PMID:20170705
increases expression	ISO	RGD:732752	6480464	CTD	bisphenol A results in increased expression of NR4A1 mRNA	PMID:12021184 PMID:20826375
multiple interactions	ISO	RGD:732752	6480464	CTD	[bisphenol A results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of NR4A1 mRNA [bisphenol A results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of NR4A1 mRNA JUN protein promotes the reaction [bisphenol A results in increased expression of NR4A1 mRNA] N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased expression of NR4A1 mRNA] PD 98059 inhibits the reaction [bisphenol A results in increased expression of NR4A1 mRNA] NR4A1 protein mutant form inhibits the reaction [bisphenol A results in increased abundance of Progesterone] NR4A1 protein promotes the reaction [bisphenol A results in increased abundance of Progesterone]	PMID:12021184