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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620029
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Acc ID: CHEBI:47495
Term: N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
Definition: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N(1)-[3-(4-bromophenyl)prop-2-en-1-yl]ethane-1,2-diamine. It is a protein kinase A inhibitor.
Chemical ID: MESH:C063509
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr4a1multiple interactionsISONR4A1 (Homo sapiens)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [cadmium acetate results in increased expression of NR4A1 protein]PMID:15016657
Nr4a1multiple interactionsISONr4a1 (Mus musculus)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased expression of NR4A1 mRNA]PMID:12021184
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