Plcb3 Rat Gene (phospholipase C, beta 3 (phosphatidylinositol-specific))

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Keyword

Gene:
Plcb3 ( Rattus norvegicus )
phospholipase C, beta 3 (phosphatidylinositol-specific)
Description: phospholipase C isozyme activated by Gq class G proteins
ArrayIDs: A_42_P707369; 6222375; 6448951; 5624938; 6686726; M99567_g_at; 1388156_at; 6184470; M99567_at; 6264392; 6255133; 6673105; rc_AA859210_at; 6143783; 5943176; 6441802; 6551831; 6045190; 6300357; 6027810; 6739030; 6476743; 5634213; 5976601; 6468544; 6479068; 6171772; 6104356; 5922780; 6538291; 5860360; 6617220; 5866543; 5972245; 6187867; 6007636; 6474638; 5718621; A_44_P438090; 1394522_at; 6743878; 5893780;  (details...)
Gene Type: protein-coding

Additional Data

Curated Variants: Plcb3^{Tn(sb-T2/Bart3)2.69Mcwi}

primer pair: 635093

Homologs
Homo sapiens: PLCB3     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Plcb3     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Plcb3 Rat Celera Assembly 1 201678898 - 201694162
RH 3.4 1 1521
RGSC genome assembly v3.4 1 209628425 - 209643694
Cytogenetic 1 q43
genome assembly 3.1 1 209786729 - 209802063
Mus musculus Plcb3 Mouse genome assembly build 36.1 19 7028203 - 7044242
Cytogenetic 19 19 B
Homo sapiens PLCB3 human genome assembly 11 63775697 - 63791604
Human genome assembly build 36.2 11 63775698 - 63791604
Cytogenetic 11 q13

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

signal transducer activity,  protein binding,  phospholipase C activity ... (details...)
Biological Process

Gene Ontology

G-protein coupled receptor protein signaling pathway,  post-Golgi vesicle-mediated transport,  lipid catabolic process ... (details...)
Cellular Component

Gene Ontology

sarcolemma,  cytosol (details...)
Disease

Ontology

Skin Ulcer,  Diabetes Mellitus, Experimental,  Myocardial Infarction (details...)
Phenotype

Ontology

prenatal lethality (details...)
Pathway

Ontology

inositol phosphate metabolic pathway,  Wnt signaling pathway (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: C2 IPI
SMART: PLCXc IPI
SMART: PLCYc IPI
PROSITE: PIPLC_Y_DOMAIN IPI
PROSITE: C2 IPI
PROSITE: PIPLC_X_DOMAIN IPI
UNIPARC: UPI00001CEB50 IPI
KEGG Report: rno:29322 ENTREZGENE
HomoloGene Group ID: 47960 ENTREZGENE
Germonline: 61993
Pfam: PLC-beta_C IPI
Pfam: PI-PLC-Y IPI
Pfam: PI-PLC-X IPI
Pfam: C2 IPI
Pfam: efhand_like IPI
KEGG Pathway: 04062 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04270 ENTREZGENE
KEGG Pathway: 04070 ENTREZGENE
KEGG Pathway: 01100 ENTREZGENE
KEGG Pathway: 04916 ENTREZGENE
KEGG Pathway: 04720 ENTREZGENE
KEGG Pathway: 04730 ENTREZGENE
KEGG Pathway: 00562 ENTREZGENE
KEGG Pathway: 05016 ENTREZGENE
KEGG Pathway: 04912 ENTREZGENE
KEGG Pathway: 04540 ENTREZGENE
KEGG Pathway: 05010 ENTREZGENE
KEGG Pathway: 04020 ENTREZGENE
InterPro: Phospholipase_C_EF-hand-like. IPI
InterPro: Phospholipase_C_Pinositol-sp_C. IPI
InterPro: Phospholipase_C_Pinositol-sp_X. IPI
InterPro: Phospholipase_C_Pinositol-sp_Y. IPI
InterPro: PLC-beta. IPI
InterPro: PLC-beta_C. IPI
InterPro: PLC-like_Pdiesterase_TIM-brl. IPI
InterPro: EF-Hand_type. IPI
InterPro: C2_Ca-dep. IPI
InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI
InterPro: C2_membr_targeting. IPI
Ensembl Protein: ENSRNOP00000028720 IPI
IPI: IPI00209033 IPI
Gene3D-CATH: PLC-like_Pdiesterase_TIM-brl IPI
Gene3D-CATH: EF-Hand_type IPI
Entrez Gene: Plcb3 ENTREZGENE
PIRSF: PLC-beta IPI
TIGR: TC207503
UniProt: PLCB3_RAT IPI
UniProt: Q45QJ4_RAT IPI
Ensembl Genes: ENSRNOG00000021150 IPI
Superfamily-SCOP: C2_CaLB IPI
Superfamily-SCOP: PLC-like_Pdiesterase_TIM-brl IPI
PRINTS: PHPHLIPASEC. IPI
Sequences
Nucleotide: CH473953 Get FASTA Search GEO Profiles
Nucleotide: DQ120508 Get FASTA Search GEO Profiles
Nucleotide: NM_033350 Get FASTA Search GEO Profiles
Nucleotide: M99567 Get FASTA Search GEO Profiles
Nucleotide: U41411 Get FASTA Search GEO Profiles
Nucleotide: DQ120507 Get FASTA Search GEO Profiles
(View all 6 Nucleotide Accessions)
Protein: NP_203501 Get FASTA
Protein: EDM12633 Get FASTA
Protein: AAC53366 Get FASTA
Protein: AAZ23846 Get FASTA
Protein: AAZ23847 Get FASTA
Protein: AAK14906 Get FASTA
Protein: Q45QJ4 Get FASTA
Protein: Q99JE6 Get FASTA
(View all 8 Protein Accessions)
Clusters
UniGene: 16983

References
Curated References
13 references in RGD related to Plcb3

Other References
5 other references at PubMed related to Plcb3

Database Information
RGD ID 61993
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Plcb3 phospholipase C, beta 3 APPROVED Name updated 70584