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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (R)-noradrenaline | multiple interactions | ISO | RGD:61993 | 6480464 | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; more ... | CTD | PMID:16714034 | (R)-noradrenaline | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] | CTD | PMID:16714034 PMID:19225867 | (R)-noradrenaline | increases expression | ISO | RGD:61993 | 6480464 | Norepinephrine results in increased expression of PLCB3 mRNA | CTD | PMID:19225867 PMID:16714034 | (R)-noradrenaline | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] | CTD | PMID:19225867 PMID:16714034 | (R)-noradrenaline | increases expression | ISO | RGD:61993 | 6480464 | Norepinephrine results in increased expression of PLCB3 protein | CTD | PMID:16714034 | (R)-noradrenaline | increases expression | ISO | RGD:61993 | 6480464 | Norepinephrine results in increased expression of PLCB3 mRNA | CTD | PMID:16714034 PMID:19225867 | (R)-noradrenaline | increases activity | ISO | RGD:61993 | 6480464 | Norepinephrine results in increased activity of PLCB3 protein | CTD | PMID:16714034 | (R)-noradrenaline | multiple interactions | ISO | RGD:61993 | 6480464 | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; more ... | CTD | PMID:19225867 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:61993 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLCB3 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLCB3 mRNA | CTD | PMID:21570461 | 2-ethoxyethanol | increases expression | ISO | RGD:61993 | 6480464 | 2-ethoxyethanol results in increased expression of PLCB3 mRNA | CTD | PMID:19643169 | 2-methoxyethanol | increases expression | ISO | RGD:61993 | 6480464 | methyl cellosolve results in increased expression of PLCB3 mRNA | CTD | PMID:19643169 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PLCB3 mRNA | CTD | PMID:18648102 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of PLCB3 mRNA | CTD | PMID:16604517 | ammonium chloride | affects expression | ISO | RGD:61993 | 6480464 | Ammonium Chloride affects the expression of PLCB3 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PLCB3 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of PLCB3 mRNA | CTD | PMID:22228805 | capsaicin | decreases expression | ISO | RGD:61993 | 6480464 | Capsaicin results in decreased expression of PLCB3 mRNA | CTD | PMID:20349343 | cobalt dichloride | decreases expression | ISO | RGD:731269 | 6480464 | cobaltous chloride results in decreased expression of PLCB3 mRNA | CTD | PMID:19320972 | ethanol | increases expression | ISO | RGD:61993 | 6480464 | Ethanol results in increased expression of PLCB3 mRNA | CTD | PMID:20655511 | hypochlorous acid | decreases expression | EXP | | 6480464 | Hypochlorous Acid results in decreased expression of PLCB3 mRNA | CTD | PMID:19376150 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PLCB3 mRNA | CTD | PMID:22776087 | oxytocin | affects localization | EXP | | 6480464 | Oxytocin affects the localization of PLCB3 protein | CTD | PMID:11579162 | ozone | decreases expression | ISO | RGD:61993 | 6480464 | Ozone results in decreased expression of PLCB3 mRNA | CTD | PMID:16330353 | paraquat | increases expression | ISO | RGD:61993 | 6480464 | Paraquat results in increased expression of PLCB3 mRNA | CTD | PMID:18198484 | phenylephrine | increases expression | ISO | RGD:61993 | 6480464 | Phenylephrine results in increased expression of PLCB3 mRNA | CTD | PMID:16714034 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of PLCB3 mRNA | CTD | PMID:17426115 | prazosin | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein] | CTD | PMID:19225867 | prazosin | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] | CTD | PMID:19225867 PMID:16714034 | prazosin | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] | CTD | PMID:16714034 | prazosin | multiple interactions | ISO | RGD:61993 | 6480464 | Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA] | CTD | PMID:16714034 PMID:19225867 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:61993 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of PLCB3 mRNA | CTD | PMID:19162173 | resveratrol | multiple interactions | ISO | RGD:731269 | 6480464 | resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of PLCB3 protein modified form] | CTD | PMID:18291361 | trans-resveratrol | multiple interactions | ISO | RGD:731269 | 6480464 | resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of PLCB3 protein modified form] | CTD | PMID:18291361 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of PLCB3 mRNA | CTD | PMID:20546886 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | African trypanosomiasis |
| Alzheimer's disease | |
| Amoebiasis | |
| Calcium signaling pathway | |
| Chagas disease (American trypanosomiasis) | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Circadian entrainment | |
| Dopaminergic synapse | |
| Endocrine and other factor-regulated calcium reabsorption | |
| Gap junction | |
| Gastric acid secretion | |
| Glutamatergic synapse | |
| GnRH signaling pathway | |
| Huntington's disease | |
| Inositol phosphate metabolism | |
| Long-term depression | |
| Long-term potentiation | |
| Melanogenesis | |
| Metabolic pathways | |
| Pancreatic secretion | |
| Phosphatidylinositol signaling system | |
| Retrograde endocannabinoid signaling | |
| Salivary secretion | |
| Serotonergic synapse | |
| Vascular smooth muscle contraction | |
| Wnt signaling pathway | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
| Endothelins (PID:200005) | |
| IL8- and CXCR1-mediated signaling events (PID:200199) | |
| IL8- and CXCR2-mediated signaling events (PID:200167) | |
| LPA receptor mediated events (PID:200013) | |
| Nongenotropic Androgen signaling (PID:200170) | |
| PAR1-mediated thrombin signaling events (PID:200189) | |
| Plasma membrane estrogen receptor signaling (PID:200034) | |
Phenotype Annotations
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References - curated| 1. |
Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29. |
| 2. |
Ju H, etal., Circulation. 1998 Mar 10;97(9):892-9. |
| 3. |
MGD and Homologene mouse data transfer |
| 4. |
MGD data from the GO Consortium |
| 5. |
MGD IEA |
| 6. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated import pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Rhee SG Annu Rev Biochem. 2001;70:281-312. |
| 12. |
Tappia PS, etal., Mol Cell Biochem. 2004 Jun;261(1-2):193-9. |
| 13. |
Wang S, etal., FEBS Lett 1998 Dec 18;441(2):261-5. |
References - uncurated| PubMed | 10349636 |
| 10468617 | |
| 10501973 | |
| 10609087 | |
| 10669417 | |
| 11042159 | |
| 11076861 | |
| 11145744 | |
| 11217851 | |
| 12477932 | |
| 12823437 | |
| 14610273 | |
| 14681479 | |
| 15174099 | |
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| 16141072 | |
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| 16314422 | |
| 16566000 | |
| 17114052 | |
| 17298601 | |
| 17675482 | |
| 17921328 | |
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| 18287559 | |
| 18411281 | |
| 18468998 | |
| 18799693 | |
| 19020012 | |
| 19564617 | |
| 19647226 | |
| 2033248 | |
| 20579885 | |
| 20858858 | |
| 21683628 | |
| 22674805 | |
| 22728827 | |
| 7587389 | |
| 8672127 | |
| 8687404 | |
| 8739298 | |
| 9211987 | |
| 9305844 | |
| 9457670 | |
| 9714794 | |
| 9753089 |
RGD Disease Portals| Plcb3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Plcb3 (Mus musculus) |
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| PLCB3 (Homo sapiens) |
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| Plcb3 (Rattus norvegicus) |
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Position Markers| Plcb3 |
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| PLCB3sts2 |
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| Plcb3 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_008874 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01141437 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC120557 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF022803 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK047029 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK146793 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK159679 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK164300 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK180722 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK184792 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK187376 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK196090 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK198938 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK201210 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK205096 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK220180 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC035928 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466612 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HB877174 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HB895808 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HC934583 | (Get FASTA) | Search GEO for Microarray Profiles | |
| HC953217 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U43144 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X95345 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_008874 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_032900 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_032900 | (Get FASTA) |
| GenBank Protein | AAA85199 | (Get FASTA) |
| AAD01751 | (Get FASTA) | |
| AAH35928 | (Get FASTA) | |
| BAC32944 | (Get FASTA) | |
| BAD90365 | (Get FASTA) | |
| BAE27436 | (Get FASTA) | |
| BAE35282 | (Get FASTA) | |
| BAE37725 | (Get FASTA) | |
| CAA64638 | (Get FASTA) | |
| CBF62936 | (Get FASTA) | |
| CBF74670 | (Get FASTA) | |
| CBU87812 | (Get FASTA) | |
| CBU96759 | (Get FASTA) | |
| EDL33267 | (Get FASTA) | |
| EDL33268 | (Get FASTA) | |
| P51432 | (Get FASTA) |
Promoters| RGD ID: | 6847578 | ||||||||||
| Promoter ID: | MM_ACW:25923 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney, Lung | ||||||||||
| Transcripts: | PLCB3.DSEP07, PLCB3.GSEP07, PLCB3.ISEP07 | ||||||||||
| Position: |
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| RGD ID: | 6830314 | ||||||||||
| Promoter ID: | MM_KWN:26226 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_4Hour | ||||||||||
| Transcripts: | UC008GJP.1 | ||||||||||
| Position: |
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| RGD ID: | 6830313 | ||||||||||
| Promoter ID: | MM_KWN:26227 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | NM_008874, UC008GJR.1 | ||||||||||
| Position: |
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| RGD ID: | 6891460 | ||||||||||
| Promoter ID: | EPDNEW_M9180 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Plcb3_1 | ||||||||||
| Description: | phospholipase C, beta 3 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000024960 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000025912 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000025912 | ENTREZGENE |
| Entrez Gene | 18797 | ENTREZGENE |
| Gene3D-CATH | 9.30 | UniProtKB/TrEMBL |
| EF-Hand_type | UniProtKB/Swiss-Prot | |
| PLC-like_Pdiesterase_TIM-brl | UniProtKB/Swiss-Prot | |
| Germonline | ENSMUSG00000024960 | |
| HomoloGene Group ID | 47960 | ENTREZGENE |
| InterPro | C2_Ca-dep | UniProtKB/Swiss-Prot |
| C2_Ca/lipid-bd_dom_CaLB | UniProtKB/Swiss-Prot | |
| C2_membr_targeting | UniProtKB/Swiss-Prot | |
| EF-hand-like_dom | UniProtKB/Swiss-Prot | |
| PH_like_dom | UniProtKB/TrEMBL | |
| Pinositol_PLipase_C | UniProtKB/Swiss-Prot | |
| PLC-beta | UniProtKB/Swiss-Prot | |
| PLC-beta_C | UniProtKB/Swiss-Prot | |
| PLC-beta_CS | UniProtKB/Swiss-Prot | |
| PLC-like_Pdiesterase_TIM-brl | UniProtKB/Swiss-Prot | |
| PLipase_C_EF-hand-like | UniProtKB/Swiss-Prot | |
| PLipase_C_PInositol-sp_X_dom | UniProtKB/Swiss-Prot | |
| PLipase_C_Pinositol-sp_Y | UniProtKB/Swiss-Prot | |
| IPI | IPI00311203 | UniProtKB/Swiss-Prot |
| KEGG Report | mmu:18797 | ENTREZGENE, UniProtKB/TrEMBL |
| MGD | MGI:104778 | ENTREZGENE |
| PANTHER | PTHR10336 | UniProtKB/Swiss-Prot |
| Pfam | DUF1154 | UniProtKB/Swiss-Prot |
| efhand_like | UniProtKB/Swiss-Prot | |
| PF00168 | UniProtKB/Swiss-Prot | |
| PI-PLC-X | UniProtKB/Swiss-Prot | |
| PI-PLC-Y | UniProtKB/Swiss-Prot | |
| PLC-beta_C | UniProtKB/Swiss-Prot | |
| PIRSF | PLC-beta | UniProtKB/Swiss-Prot |
| PRINTS | PHPHLIPASEC | UniProtKB/Swiss-Prot |
| PROSITE | PIPLC_X_DOMAIN | UniProtKB/Swiss-Prot |
| PIPLC_Y_DOMAIN | UniProtKB/Swiss-Prot | |
| PS50004 | UniProtKB/Swiss-Prot | |
| SMART | PLCXc | UniProtKB/Swiss-Prot |
| PLCYc | UniProtKB/Swiss-Prot | |
| SM00239 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | C2_CaLB | UniProtKB/Swiss-Prot |
| PLC-like_Pdiesterase_TIM-brl | UniProtKB/Swiss-Prot | |
| UniGene | Mm.273204 | ENTREZGENE |
| UniProt | PLCB3_MOUSE | UniProtKB/Swiss-Prot |
| Q3TPL1_MOUSE | UniProtKB/TrEMBL | |
| Q3TWI4_MOUSE | UniProtKB/TrEMBL | |
| Q571K9_MOUSE | UniProtKB/TrEMBL | |
| Q62076_MOUSE | UniProtKB/TrEMBL | |
| Q8CI86_MOUSE | UniProtKB/TrEMBL | |
| Q9R1Y4_MOUSE | UniProtKB/TrEMBL |
| More on Plcb3 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62285 |
| Created: | 2001-04-11 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




