Gene:	Rhoa ( Rattus norvegicus ) ras homolog gene family, member A
Description:	small GTPase; involved in multiple intracellular signaling pathways
Synonyms:	Arha2; Arha; plysia ras-related homolog A2; MGC72339; RhoA;  (details...)
ArrayIDs:	5761653; D84477_at; 1399027_at; 5751823; 6430685; rc_AI179356_at; 1370130_at; 5911277; 6546078;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: RHOA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Rhoa     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Rhoa Rat Celera Assembly 16 108304937 - 108328661     Cytogenetic 16 q12.5 Mus musculus Rhoa Mouse genome assembly build 36.1 9 108208536 - 108240265     Cytogenetic 9 9 F2 Homo sapiens RHOA human genome assembly 3 49371584 - 49424530     Human genome assembly build 36.2 3 49371582 - 49424530     Cytogenetic 3 p21.3   View comparative maps:
Genome
View:
Annotation
Molecular Function	Gene Ontology GTP binding,  protein binding,  nucleotide binding ...  (details...)
Biological Process	Note Reference decreases both expression levels and activities of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642 regulates actin cytoskeleton 628348 Gene Ontology negative regulation of neuron differentiation,  cell morphogenesis,  positive regulation of smooth muscle contraction ...  (details...)
Cellular Component	Gene Ontology nucleus,  mitochondrion,  soluble fraction ...  (details...)
Disease	Note Reference be involved in the cerebral vascular pathogenesis 632250 Ontology Myocardial Reperfusion Injury,  Hypertrophy, Left Ventricular,  Ovarian Neoplasms ...  (details...)
Expression	Note Reference expressed in 804G rat bladder carcinoma cells 628348
Pathway	Ontology Rho/Rac/Cdc42 mediated signaling pathway,  the planar cell polarity Wnt signaling pathway (details...)
Regulation	Note Reference transiently activated by the CNF1 toxin produced by uropathogenic Escherichia coli (UPEC) strains; this restricted activation is a direct consequence of the cell-mediated degradation of the toxin-activated forms 628348 expression level modulated by release of NO in vascular smooth muscle cells 1304269
External Links
Databases	DATABASE ID SOURCE SMART: RHO IPI IPI: IPI00201699 IPI PROSITE: RHO IPI Entrez Gene: Rhoa ENTREZGENE IMAGE_CLONE: IMAGE:5598621 IMAGE-MGC_LOAD UNIPARC: UPI00000009E3 IPI MGC_CLONE: MGC:72339 IMAGE-MGC_LOAD UniProt: O35791_RAT IPI UniProt: RHOA_RAT IPI Germonline: 619921 TIGRFAMs: small_GTP IPI Pfam: Ras IPI InterPro: GTPase_Rho. IPI InterPro: Ras. IPI InterPro: Ras_GTPase. IPI InterPro: Small_GTP_bd. IPI PRINTS: RASTRNSFRMNG. IPI
Sequences	Nucleotide: AY026069 Get FASTA Search GEO Profiles Nucleotide: BC061732 Get FASTA Search GEO Profiles Nucleotide: D84477 Get FASTA Search GEO Profiles Nucleotide: AY026068 Get FASTA Search GEO Profiles Nucleotide: NM_057132 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: AAK11718 Get FASTA Protein: AAH61732 Get FASTA Protein: O35791 Get FASTA Protein: AAK11717 Get FASTA Protein: NP_476473 Get FASTA Protein: BAA20863 Get FASTA Protein: P61589 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 107401
References
Curated References	56 references in RGD related to Rhoa
Other References	106 other references at PubMed related to Rhoa
Database Information
RGD ID	619921
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 30-MAR-06: Rhoa ras homolog gene family, member A APPROVED Symbol and Name status set to approved 1299863 14-JUL-05: Rhoa ras homolog gene family, member A PROVISIONAL Symbol and Name status set to provisional 70820 25-FEB-05: ras homolog gene family, member A Rhoa plysia ras-related homolog A2 APPROVED Name updated to reflect Human and Mouse nomenclature 1299863 10-SEP-04: Rhoa plysia ras-related homolog A2 Arha2 APPROVED Symbol and Name updated 1299863 07-AUG-02: Arha2 plysia ras-related homolog A2 PROVISIONAL Symbol and Name status set to provisional 70820