Tfpi (tissue factor pathway inhibitor) - Rat Genome Database

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Gene: Tfpi (tissue factor pathway inhibitor) Rattus norvegicus
Analyze
Symbol: Tfpi
Name: tissue factor pathway inhibitor
RGD ID: 61914
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Located in extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor); PARTICIPATES IN coagulation cascade pathway; syndecan signaling pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EPI; extrinsic pathway inhibitor; LACI; lipoprotein-associated coagulation inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,939,862 - 89,989,253 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl389,939,868 - 89,980,742 (-)EnsemblGRCr8
mRatBN7.2369,533,156 - 69,582,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,533,156 - 69,576,880 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx372,915,327 - 72,959,162 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,513,992 - 81,557,826 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,267,881 - 79,311,569 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,852,738 - 71,902,127 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,852,744 - 71,893,618 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,373,808 - 78,423,115 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,654,389 - 67,697,178 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera368,890,124 - 68,933,788 (-)NCBICelera
RGSC_v3.1367,550,760 - 67,593,550 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bisphenol Z  (ISO)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
chenodeoxycholic acid  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clomiphene  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
estrone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
fluvastatin  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
hexestrol  (ISO)
indole-3-methanol  (EXP)
irbesartan  (EXP)
irinotecan  (ISO)
isobutanol  (ISO)
Lasiocarpine  (ISO)
lead(0)  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thiram  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (ISO)
cell surface  (ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Decreased anticoagulant response to tissue factor pathway inhibitor in patients with venous thromboembolism and otherwise no evidence of hereditary or acquired thrombophilia. Bombeli T, etal., Thromb Haemost. 2004 Jan;91(1):80-6.
2. The effect of two-domain tissue factor pathway inhibitor on endotoxin-induced disseminated intravascular coagulation in rabbits. Bregengard C, etal., Blood Coagul Fibrinolysis. 1993 Oct;4(5):699-706.
3. Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor. Carlsson K, etal., Eur J Biochem. 2003 Jun;270(12):2576-82.
4. Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma. Castoldi E, etal., J Thromb Haemost. 2010 Feb;8(2):294-300. doi: 10.1111/j.1538-7836.2009.03712.x. Epub 2009 Nov 30.
5. Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation. Choi G, etal., Eur Respir J. 2007 Sep;30(3):423-8. Epub 2007 May 30.
6. Low levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis. Dahm A, etal., Blood. 2003 Jun 1;101(11):4387-92. Epub 2003 Jan 30.
7. Association analysis of tissue factor pathway inhibitor polymorphisms and haplotypes with osteonecrosis of the femoral head in the Korean population. Dai XL, etal., Mol Cells. 2008 Nov 30;26(5):490-5.
8. Localization of tissue factor pathway inhibitor to lipid rafts is not required for inhibition of factor VIIa/tissue factor activity. Dietzen DJ, etal., Thromb Haemost. 2003 Jan;89(1):65-73.
9. Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency. Duckers C, etal., Blood. 2008 Nov 1;112(9):3615-23. doi: 10.1182/blood-2008-06-162453. Epub 2008 Aug 11.
10. Total tissue factor pathway inhibitor is an independent risk factor for symptomatic paediatric venous thromboembolism and stroke. Duering C, etal., Thromb Haemost. 2004 Oct;92(4):707-12.
11. Effects of recombinant human tissue factor pathway inhibitor on thrombus formation and its in vivo distribution in a rat DIC model. Elsayed YA, etal., Am J Clin Pathol. 1996 Nov;106(5):574-83.
12. cDNA cloning and expression of rat tissue factor pathway inhibitor (TFPI). Enjyoji K, etal., J Biochem (Tokyo) 1992 May;111(5):681-7.
13. Recombinant tissue factor pathway inhibitor prevents lipopolysaccharide-induced systemic hypotension in rats by inhibiting excessive production of nitric oxide. Enkhbaatar P, etal., Thromb Haemost. 2001 Dec;86(6):1573-7.
14. A link between a hemostatic disorder and preterm PROM: a role for tissue factor and tissue factor pathway inhibitor. Erez O, etal., J Matern Fetal Neonatal Med. 2008 Oct;21(10):732-44. doi: 10.1080/14767050802361807.
15. Changes in the concentration and distribution of tissue factor pathway inhibitor in Behcet's disease and systemic lupus erythematosus: effect on the prethrombotic state. Ertenli I, etal., Ann Rheum Dis. 2001 Dec;60(12):1149-51.
16. Tissue factor pathway inhibitor in paediatric patients with nephrotic syndrome. Farid FA, etal., SAJCH. 2011 Dec;5(4):107-111.
17. Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis. Fujii M, etal., Thromb Res. 2000 Jul 15;99(2):111-7.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype. Ghrib F, etal., Thromb Haemost 2002 Jun;87(6):1051-6.
20. Involvement of tissue factor pathway inhibitor in the coronary circulation of patients with acute coronary syndromes. Golino P, etal., Circulation. 2003 Dec 9;108(23):2864-9. Epub 2003 Dec 1.
21. Structural requirements for TFPI-mediated inhibition of neointimal thickening after balloon injury in the rat. Han X, etal., Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2563-7.
22. Expressions of tissue factor and tissue factor pathway inhibitor in patients with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Hao J, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):697-700. doi: 10.1007/s11596-009-0604-4. Epub 2009 Dec 29.
23. Expression of tissue factor and tissue factor pathway inhibitor in rats lungs with lipopolysaccharide-induced disseminated intravascular coagulation. Hara S, etal., Lab Invest. 1997 Dec;77(6):581-9.
24. Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism. Hoke M, etal., Thromb Haemost. 2005 Oct;94(4):787-90.
25. Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Huang ZF, etal., Blood. 1997 Aug 1;90(3):944-51.
26. Elevated plasma levels of the factor Xa-TFPI complex in cancer patients. Iversen N, etal., Thromb Res. 2002 Jan 1;105(1):33-6.
27. Production of tissue factor pathway inhibitor in cardiomyocytes and its upregulation by interleukin-1. Kereveur A, etal., Thromb Haemost 2001 Nov;86(5):1314-9.
28. Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis. Kijiyama N, etal., Biochem Biophys Res Commun. 2006 Jan 27;339(4):1113-9. Epub 2005 Dec 5.
29. Decreased plasma tissue factor pathway inhibitor levels in patients with thrombotic thrombocytopenic purpura. Kobayashi M, etal., Thromb Haemost. 1995 Jan;73(1):10-4.
30. Caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface. Lupu C, etal., J Biol Chem. 2005 Jun 10;280(23):22308-17. Epub 2005 Apr 6.
31. Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition. Maroney SA, etal., J Thromb Haemost. 2008 Jan;6(1):111-7. Epub 2007 Oct 25.
32. Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia. Maroney SA, etal., Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3927-31. doi: 10.1073/pnas.1119858109. Epub 2012 Feb 21.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Deranged blood coagulation equilibrium as a factor of massive liver necrosis following endotoxin administration in partially hepatectomized rats. Mochida S, etal., Hepatology. 1999 May;29(5):1532-40.
35. Effect of nitric oxide deficiency on tissue-type plasminogen activator expression in the umbilical cord in a pregnancy-induced hypertension rat model. Mukai Y and Sato S, Pregnancy Hypertens. 2012 Jan;2(1):53-8. doi: 10.1016/j.preghy.2011.10.002. Epub 2011 Oct 21.
36. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
37. Changes in tissue factor and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats. Niiro M, etal., Thromb Res. 2008;122(2):247-55. Epub 2007 Dec 11.
38. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
39. Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor. Ogiwara K, etal., Int J Hematol. 2014;99(5):577-87. doi: 10.1007/s12185-014-1572-4. Epub 2014 Apr 1.
40. Increased plasma levels of tissue factor pathway inhibitor-activated factor X complex in patients with disseminated intravascular coagulation. Okugawa Y, etal., Am J Hematol. 2000 Nov;65(3):210-4.
41. Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion. Park JB, etal., PLoS One. 2011;6(11):e28327. doi: 10.1371/journal.pone.0028327. Epub 2011 Nov 29.
42. Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor VIII: studies of spatial dynamics of fibrin clot formation in hemophilia A. Parunov LA, etal., Thromb Res. 2014 Jan;133(1):112-9. doi: 10.1016/j.thromres.2013.10.036. Epub 2013 Nov 1.
43. Heparanase role in the treatment of avascular necrosis of femur head. Peled E, etal., Thromb Res. 2013 Jan;131(1):94-8. doi: 10.1016/j.thromres.2012.09.018. Epub 2012 Oct 9.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Decreased tissue factor pathway inhibitor (TFPI)-dependent anticoagulant capacity in patients with cirrhosis who have decreased protein S but normal TFPI plasma levels. Potze W, etal., Br J Haematol. 2013 Sep;162(6):819-26. doi: 10.1111/bjh.12462. Epub 2013 Jul 11.
47. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Rancourt RC, etal., Toxicol Appl Pharmacol. 2013 Oct 1;272(1):86-95. doi: 10.1016/j.taap.2013.05.020. Epub 2013 May 30.
48. Tissue factor pathway inhibitor and thrombin activatable fibrinolytic inhibitor plasma levels following burn and septic injuries in rats. Ravindranath TM, etal., Clin Appl Thromb Hemost. 2004 Oct;10(4):379-85.
49. GOA pipeline RGD automated data pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Hypercoagulability, high tissue factor and low tissue factor pathway inhibitor levels in severe ovarian hyperstimulation syndrome: possible association with clinical outcome. Rogolino A, etal., Blood Coagul Fibrinolysis. 2003 Apr;14(3):277-82.
53. Analysis of behaviors of plasma tissue factor and tissue factor pathway inhibitor in patients with various diseases Saito M, etal., Rinsho Ketsueki. 1996 Sep;37(9):794-8.
54. Hemostatic variables as independent predictors for fetal growth retardation in preeclampsia. Schjetlein R, etal., Acta Obstet Gynecol Scand. 1999 Mar;78(3):191-7.
55. Increased levels of tissue factor activity and procoagulant phospholipids during treatment of children with acute lymphoblastic leukaemia. Schneider P, etal., Br J Haematol. 2010 Feb;148(4):582-92. doi: 10.1111/j.1365-2141.2009.07958.x. Epub 2009 Oct 28.
56. Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat. Shirk RA, etal., J Steroid Biochem Mol Biol. 2005 Mar;94(4):361-8.
57. Tissue factor pathway inhibitor relates to fibrin degradation in patients with acute deep venous thrombosis. Sidelmann JJ, etal., Blood Coagul Fibrinolysis. 2008 Jul;19(5):405-9. doi: 10.1097/MBC.0b013e3283049639.
58. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
59. Tissue factor pathway inhibitor on circulating microparticles in acute myocardial infarction. Steppich B, etal., Thromb Haemost. 2005 Jan;93(1):35-9.
60. [Analysis of the dynamic change of TF, TFPI and IL-1beta in plasma of patients with acute leukemia]. Sun Y, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):493-6.
61. TFPI resistance related to inherited or acquired protein S deficiency. Tardy-Poncet B, etal., Thromb Res. 2012 Dec;130(6):925-8. doi: 10.1016/j.thromres.2012.07.025. Epub 2012 Oct 15.
62. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
63. The role of tissue factor in renal ischemic reperfusion injury of the rat. Ushigome H, etal., J Surg Res. 2002 Feb;102(2):102-9.
64. Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice. Westrick RJ, etal., Circulation. 2001 Jun 26;103(25):3044-6.
65. Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria. Yamashita T, etal., Circulation 2003 Nov 18;108(20):2450-2. Epub 2003 Nov 10.
66. The effect of tissue factor pathway inhibitor on hepatic ischemic reperfusion injury of the rat. Yoshimura N, etal., Transplantation. 1999 Jan 15;67(1):45-53.
67. Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction. Yu J, etal., Heart Vessels. 2011 Nov;26(6):646-53. doi: 10.1007/s00380-010-0106-0. Epub 2011 Jan 13.
68. [Levels of plasma TF and TFPI activities in patients with acute leukemia]. Zhu Y, etal., Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):401-2, 405.
Additional References at PubMed
PMID:12477932   PMID:18368493   PMID:19065458   PMID:19581412   PMID:21868574   PMID:24006456   PMID:25931508   PMID:34876522  


Genomics

Comparative Map Data
Tfpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,939,862 - 89,989,253 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl389,939,868 - 89,980,742 (-)EnsemblGRCr8
mRatBN7.2369,533,156 - 69,582,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,533,156 - 69,576,880 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx372,915,327 - 72,959,162 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,513,992 - 81,557,826 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,267,881 - 79,311,569 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,852,738 - 71,902,127 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,852,744 - 71,893,618 (-)Ensemblrn6Rnor6.0
Rnor_5.0378,373,808 - 78,423,115 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4367,654,389 - 67,697,178 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera368,890,124 - 68,933,788 (-)NCBICelera
RGSC_v3.1367,550,760 - 67,593,550 (-)NCBI
Cytogenetic Map3q24NCBI
TFPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382187,464,230 - 187,554,435 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2187,463,823 - 187,565,846 (-)Ensemblhg38GRCh38
GRCh372188,328,957 - 188,419,162 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362188,037,202 - 188,127,464 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342188,156,790 - 188,244,556NCBI
Celera2181,925,068 - 182,015,356 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2180,188,532 - 180,278,959 (-)NCBIHuRef
CHM1_12188,334,627 - 188,424,881 (-)NCBICHM1_1
T2T-CHM13v2.02187,953,180 - 188,043,364 (-)NCBIT2T-CHM13v2.0
Tfpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,263,199 - 84,307,119 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,263,199 - 84,307,119 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38284,432,855 - 84,476,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,432,855 - 84,476,775 (-)Ensemblmm10GRCm38
MGSCv37284,273,017 - 84,316,932 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36284,233,699 - 84,275,013 (-)NCBIMGSCv36mm8
Celera286,041,007 - 86,084,914 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.41NCBI
Tfpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540310,924,893 - 11,004,284 (+)Ensembl
ChiLan1.0NW_00495540310,925,155 - 11,004,229 (+)NCBIChiLan1.0ChiLan1.0
TFPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21390,129,678 - 90,219,981 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B90,144,776 - 90,234,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B74,744,154 - 74,834,338 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B192,541,881 - 192,631,867 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B192,541,881 - 192,581,384 (-)EnsemblpanPan2panpan1.1
TFPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13629,457,131 - 29,546,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3629,459,371 - 29,511,310 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3629,358,584 - 29,410,512 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03629,680,362 - 29,769,683 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,680,366 - 29,734,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,744,554 - 29,796,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,679,616 - 29,731,462 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,848,287 - 29,900,234 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tfpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303146,663,997 - 146,734,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,103,139 - 10,171,863 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,103,120 - 10,172,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1592,345,075 - 92,409,905 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11592,345,083 - 92,409,962 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215102,535,224 - 102,694,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11073,004,762 - 73,105,772 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1073,002,522 - 73,105,858 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040126,397,666 - 126,498,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248992,406,282 - 2,473,883 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248992,401,861 - 2,473,762 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tfpi
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1561,841,747 - 61,891,430 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tfpi
196 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:113
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000006787, ENSRNOT00000057685
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH131998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,540,449 - 69,540,630 (+)MAPPERmRatBN7.2
Rnor_6.0371,860,031 - 71,860,211NCBIRnor6.0
Rnor_5.0378,381,101 - 78,381,281UniSTSRnor5.0
RGSC_v3.4367,661,676 - 67,661,856UniSTSRGSC3.4
Celera368,897,411 - 68,897,591UniSTS
Cytogenetic Map3q24UniSTS
RH142666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,545,338 - 69,545,527 (+)MAPPERmRatBN7.2
Rnor_6.0371,864,920 - 71,865,108NCBIRnor6.0
Rnor_5.0378,385,990 - 78,386,178UniSTSRnor5.0
RGSC_v3.4367,666,565 - 67,666,753UniSTSRGSC3.4
Celera368,902,300 - 68,902,488UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D10926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006787   ⟹   ENSRNOP00000006787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl389,939,868 - 89,980,724 (-)Ensembl
mRatBN7.2 Ensembl369,533,156 - 69,576,818 (-)Ensembl
Rnor_6.0 Ensembl371,852,744 - 71,893,600 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057685   ⟹   ENSRNOP00000054493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl389,947,106 - 89,980,742 (-)Ensembl
mRatBN7.2 Ensembl369,540,401 - 69,574,037 (-)Ensembl
Rnor_6.0 Ensembl371,859,982 - 71,893,618 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100291   ⟹   ENSRNOP00000078992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl389,939,868 - 89,980,724 (-)Ensembl
mRatBN7.2 Ensembl369,533,156 - 69,576,880 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105382   ⟹   ENSRNOP00000076793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,540,401 - 69,574,037 (-)Ensembl
RefSeq Acc Id: NM_001177321   ⟹   NP_001170792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,543 (-)NCBI
mRatBN7.2369,540,400 - 69,576,838 (-)NCBI
Rnor_6.0371,859,981 - 71,896,419 (-)NCBI
Rnor_5.0378,373,808 - 78,423,115 (-)NCBI
Celera368,897,361 - 68,933,788 (-)NCBI
Sequence:
RefSeq Acc Id: NM_017200   ⟹   NP_058896
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,868 - 89,980,724 (-)NCBI
mRatBN7.2369,533,162 - 69,574,019 (-)NCBI
Rnor_6.0371,852,744 - 71,893,600 (-)NCBI
Rnor_5.0378,373,808 - 78,423,115 (-)NCBI
RGSC_v3.4367,654,389 - 67,697,178 (-)RGD
Celera368,890,124 - 68,930,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234440   ⟹   XP_006234502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,983,624 (-)NCBI
mRatBN7.2369,533,156 - 69,577,044 (-)NCBI
Rnor_6.0371,852,738 - 71,896,641 (-)NCBI
Rnor_5.0378,373,808 - 78,423,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234441   ⟹   XP_006234503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,981,239 (-)NCBI
mRatBN7.2369,533,156 - 69,575,123 (-)NCBI
Rnor_6.0371,852,738 - 71,895,103 (-)NCBI
Rnor_5.0378,373,808 - 78,423,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234444   ⟹   XP_006234506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,981,234 (-)NCBI
mRatBN7.2369,533,156 - 69,575,124 (-)NCBI
Rnor_6.0371,852,738 - 71,895,103 (-)NCBI
Rnor_5.0378,373,808 - 78,423,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761980   ⟹   XP_008760202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,983,625 (-)NCBI
mRatBN7.2369,533,156 - 69,577,060 (-)NCBI
Rnor_6.0371,852,738 - 71,896,660 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761981   ⟹   XP_008760203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,989,253 (-)NCBI
mRatBN7.2369,533,156 - 69,582,547 (-)NCBI
Rnor_6.0371,852,738 - 71,902,127 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761982   ⟹   XP_008760204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,983,648 (-)NCBI
mRatBN7.2369,533,156 - 69,577,112 (-)NCBI
Rnor_6.0371,852,738 - 71,896,693 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761983   ⟹   XP_008760205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,981,237 (-)NCBI
mRatBN7.2369,533,156 - 69,575,886 (-)NCBI
Rnor_6.0371,852,738 - 71,895,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761984   ⟹   XP_008760206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,981,237 (-)NCBI
mRatBN7.2369,533,156 - 69,575,886 (-)NCBI
Rnor_6.0371,852,738 - 71,895,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761985   ⟹   XP_008760207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,625 (-)NCBI
mRatBN7.2369,540,400 - 69,577,078 (-)NCBI
Rnor_6.0371,859,981 - 71,896,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761986   ⟹   XP_008760208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,625 (-)NCBI
mRatBN7.2369,540,400 - 69,577,071 (-)NCBI
Rnor_6.0371,859,981 - 71,896,650 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104441   ⟹   XP_038960369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,989,233 (-)NCBI
mRatBN7.2369,533,156 - 69,577,112 (-)NCBI
RefSeq Acc Id: XM_039104442   ⟹   XP_038960370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,625 (-)NCBI
mRatBN7.2369,540,400 - 69,577,053 (-)NCBI
RefSeq Acc Id: XM_063283202   ⟹   XP_063139272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,989,251 (-)NCBI
RefSeq Acc Id: XM_063283203   ⟹   XP_063139273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,939,862 - 89,989,222 (-)NCBI
RefSeq Acc Id: XM_063283204   ⟹   XP_063139274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,989,253 (-)NCBI
RefSeq Acc Id: XM_063283205   ⟹   XP_063139275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,981,238 (-)NCBI
RefSeq Acc Id: XM_063283206   ⟹   XP_063139276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,649 (-)NCBI
RefSeq Acc Id: XM_063283207   ⟹   XP_063139277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,981,238 (-)NCBI
RefSeq Acc Id: XM_063283208   ⟹   XP_063139278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,989,252 (-)NCBI
RefSeq Acc Id: XM_063283209   ⟹   XP_063139279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,981,236 (-)NCBI
RefSeq Acc Id: XM_063283210   ⟹   XP_063139280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,983,646 (-)NCBI
RefSeq Acc Id: XM_063283211   ⟹   XP_063139281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8389,947,105 - 89,981,236 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001170792 (Get FASTA)   NCBI Sequence Viewer  
  NP_058896 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234502 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234503 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234506 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760202 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760203 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760204 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760205 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760206 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760207 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760208 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960369 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960370 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139272 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139273 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139274 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139275 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139276 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139277 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139278 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139279 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139280 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139281 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87020 (Get FASTA)   NCBI Sequence Viewer  
  BAA01724 (Get FASTA)   NCBI Sequence Viewer  
  EDL79301 (Get FASTA)   NCBI Sequence Viewer  
  EDL79302 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006787
  ENSRNOP00000054493
  ENSRNOP00000078992
  ENSRNOP00000078992.1
GenBank Protein Q02445 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058896   ⟸   NM_017200
- Peptide Label: isoform 1 precursor
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001170792   ⟸   NM_001177321
- Peptide Label: isoform 2 precursor
- UniProtKB: Q5PQU8 (UniProtKB/TrEMBL),   A0A8I5Y6C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234502   ⟸   XM_006234440
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234503   ⟸   XM_006234441
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234506   ⟸   XM_006234444
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760203   ⟸   XM_008761981
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760204   ⟸   XM_008761982
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760202   ⟸   XM_008761980
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760205   ⟸   XM_008761983
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760206   ⟸   XM_008761984
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2B4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760207   ⟸   XM_008761985
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760208   ⟸   XM_008761986
- Peptide Label: isoform X5
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054493   ⟸   ENSRNOT00000057685
Ensembl Acc Id: ENSRNOP00000006787   ⟸   ENSRNOT00000006787
RefSeq Acc Id: XP_038960369   ⟸   XM_039104441
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960370   ⟸   XM_039104442
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076793   ⟸   ENSRNOT00000105382
Ensembl Acc Id: ENSRNOP00000078992   ⟸   ENSRNOT00000100291
RefSeq Acc Id: XP_063139272   ⟸   XM_063283202
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139273   ⟸   XM_063283203
- Peptide Label: isoform X2
- UniProtKB: Q02445 (UniProtKB/Swiss-Prot),   A6HMQ1 (UniProtKB/TrEMBL),   A0A8L2Q2B4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139274   ⟸   XM_063283204
- Peptide Label: isoform X4
- UniProtKB: Q5PQU8 (UniProtKB/TrEMBL),   A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139278   ⟸   XM_063283208
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139276   ⟸   XM_063283206
- Peptide Label: isoform X4
- UniProtKB: Q5PQU8 (UniProtKB/TrEMBL),   A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139280   ⟸   XM_063283210
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139275   ⟸   XM_063283205
- Peptide Label: isoform X4
- UniProtKB: Q5PQU8 (UniProtKB/TrEMBL),   A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139277   ⟸   XM_063283207
- Peptide Label: isoform X4
- UniProtKB: Q5PQU8 (UniProtKB/TrEMBL),   A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139279   ⟸   XM_063283209
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139281   ⟸   XM_063283211
- Peptide Label: isoform X6
- UniProtKB: A0A8I5Y6C8 (UniProtKB/TrEMBL)
Protein Domains
BPTI/Kunitz inhibitor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02445-F1-model_v2 AlphaFold Q02445 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61914 AgrOrtholog
BioCyc Gene G2FUF-49181 BioCyc
Ensembl Genes ENSRNOG00000005039 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006787 ENTREZGENE
  ENSRNOT00000057685 ENTREZGENE
  ENSRNOT00000100291 ENTREZGENE
  ENSRNOT00000100291.1 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.410.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192382 IMAGE-MGC_LOAD
InterPro Kunitz-type_SerProtInhib UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot
  TFPI-like UniProtKB/Swiss-Prot
KEGG Report rno:29436 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93499 IMAGE-MGC_LOAD
NCBI Gene 29436 ENTREZGENE
PANTHER KUNITZ-TYPE PROTEASE INHIBITOR-RELATED UniProtKB/Swiss-Prot
  TISSUE FACTOR PATHWAY INHIBITOR UniProtKB/Swiss-Prot
Pfam Kunitz_BPTI UniProtKB/Swiss-Prot
PhenoGen Tfpi PhenoGen
PIRSF TFPI UniProtKB/Swiss-Prot
PRINTS BASICPTASE UniProtKB/Swiss-Prot
PROSITE BPTI_KUNITZ_1 UniProtKB/Swiss-Prot
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005039 RatGTEx
SMART SM00131 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57362 UniProtKB/Swiss-Prot
TIGR TC206777
UniProt A0A8I5Y6C8 ENTREZGENE
  A0A8L2Q2B4 ENTREZGENE, UniProtKB/TrEMBL
  A6HMQ1 ENTREZGENE, UniProtKB/TrEMBL
  Q02445 ENTREZGENE
  Q5PQU8 ENTREZGENE, UniProtKB/TrEMBL
  TFPI1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Tfpi  tissue factor pathway inhibitor  Tfpi  tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Tfpi  tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  Tfpi  tissue factor pathway inhibitor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tfpi  tissue factor pathway inhibitor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease downregulation in atrial endocardium may contribute to coagulation imbalance in atrial fibrillation 1299121
gene_expression expressed is increased in synthetic (neo-intimal) smooth muscle cells 1299120
gene_process production by synthetic (neo-intimal) smooth muscle cells may be involved in neo-intima formation 1299120
gene_regulation expression in cardiomyocytes is increased upon treatment with IL-1beta 727341