RGD Reference Report - Total tissue factor pathway inhibitor is an independent risk factor for symptomatic paediatric venous thromboembolism and stroke. - Rat Genome Database

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Total tissue factor pathway inhibitor is an independent risk factor for symptomatic paediatric venous thromboembolism and stroke.

Authors: Duering, C  Kosch, A  Langer, C  Thedieck, S  Nowak-Gottl, U 
Citation: Duering C, etal., Thromb Haemost. 2004 Oct;92(4):707-12.
RGD ID: 11341677
Pubmed: PMID:15467899   (View Abstract at PubMed)
DOI: DOI:10.1160/TH04-05-0293   (Journal Full-text)

Tissue factor pathway inhibitor (TFPI) plays an important role in inhibiting tissue factor-induced coagulation by a factor Xadependent pathway of the activated tissue-factor VIIa complex. Decreased values of the latter inhibitor have been recently reported in adult patients with venous thrombosis (VT) or ischaemic stroke (IS). The present case-control study was therefore performed to evaluate whether a decreased TFPI concentration is also involved in paediatric symptomatic thromboembolism (ST). Total TFPI concentrations were measured along with established prothrombotic risk factors six to twelve months after the acute thrombotic onset in 144 Caucasian children aged 0.6 to 18 years (VT: n=80; IS: n=64). The cut-off values defined as age-dependent 10(th) percentiles were obtained from 244 healthy controls. Median (range) values of TFPI were significantly lower in patients compared with control subjects [50.0(20.0-132.3) ng/ml vs. 59.5(25.4-117.4) ng/ml; p-value < 0.0001]. In addition, 42 of the 144 patients (29.2%) compared with 25 of the 244 controls (10.2%) showed TFPI concentrations below the 10(th) age-dependent percentiles. Compared to baseline values 78.6% of children with total TFPI Ag < 10(th) percentiles showed a low response to enoxaparin administration, whereas in children with normal baseline TFPI values 30% show a low TFPI release (p = 0.007). Multivariate analysis adjusted for the presence of established prothrombotic risk factors showed a significantly increased odds ratio (OR) and 95% confidence interval (CI) for patients with ST [OR/CI: 3.8/2.2-6.6; p < 0.0001]. Data shown here give evidence that total TFPI concentrations below the 10(th) age-dependent percentiles independently increase the risk of ST in Caucasian children 3.8-fold.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Embolism and Thrombosis  IEP 11341677 RGD 
Embolism and Thrombosis  ISOTFPI (Homo sapiens)11341677; 11341677 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tfpi  (tissue factor pathway inhibitor)

Genes (Mus musculus)
Tfpi  (tissue factor pathway inhibitor)

Genes (Homo sapiens)
TFPI  (tissue factor pathway inhibitor)


Additional Information