Map2k2 (mitogen activated protein kinase kinase 2) - Rat Genome Database

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Gene: Map2k2 (mitogen activated protein kinase kinase 2) Rattus norvegicus
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Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
RGD ID: 61888
Description: Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression and response to ischemia. Located in cell cortex. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; MEK2; Prkmk2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,241,449 - 9,264,216 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,241,310 - 9,260,940 (-)EnsemblGRCr8
mRatBN7.278,590,729 - 8,610,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,580,905 - 8,610,243 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,475,464 - 11,494,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,350,953 - 13,370,301 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,217,425 - 11,236,805 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,458,971 - 11,478,520 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,458,967 - 11,478,489 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,626,294 - 11,645,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,074,654 - 10,094,003 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,778,257 - 6,797,606 (-)NCBICelera
RGSC_v3.1710,074,657 - 10,094,003 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(Z)-PUGNAc  (ISO)
1,2-dimethylhydrazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,5-dimethylcelecoxib  (ISO)
2,6-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (EXP)
3',5'-cyclic GMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-mangostin  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (EXP)
Antrocin  (ISO)
aristolochic acid A  (ISO)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-mannitol  (EXP)
dabrafenib  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fenthion  (ISO)
finasteride  (EXP)
fipronil  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP,ISO)
heparin  (EXP)
heptachlor  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
ketamine  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
ochratoxin A  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH772984  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
sorafenib  (EXP,ISO)
sulfadimethoxine  (EXP)
tartrazine  (ISO)
tetrahydropalmatine  (ISO)
Theaflavin 3,3'-digallate  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
wogonin  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IDA,IEA)
cell-cell junction  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic side of plasma membrane  (IEA,ISO)
cytosol  (IEA,ISO,TAS)
early endosome  (IEA,TAS)
endoplasmic reticulum  (IEA,ISO)
focal adhesion  (IEA,TAS)
Golgi apparatus  (IEA,ISO,TAS)
late endosome  (IEA,TAS)
membrane  (IEA)
microtubule  (IEA,ISO)
mitochondrion  (IEA,TAS)
nucleus  (TAS)
perinuclear region of cytoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Blasco RB, etal., Cancer Cell. 2011 May 17;19(5):652-63. doi: 10.1016/j.ccr.2011.04.002. Epub 2011 Apr 21.
2. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Chen J, etal., Physiol Rep. 2017 Sep;5(18). pii: 5/18/e13441. doi: 10.14814/phy2.13441.
3. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Duan RD, etal., Am J Physiol. 1995 Jun;268(6 Pt 1):G1060-5.
4. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. Estep AL, etal., PLoS ONE. 2007 Dec 5;2(12):e1279.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment. He H, etal., Cell Mol Immunol. 2016 Sep;13(5):658-68. doi: 10.1038/cmi.2015.46. Epub 2015 Jul 20.
7. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. McKillop IH, etal., Hepatology. 1997 Dec;26(6):1484-91. doi: 10.1002/hep.510260615.
8. Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion. Mizukami Y and Yoshida Ki, Biochem J. 1997 May 1;323 ( Pt 3)(Pt 3):785-90. doi: 10.1042/bj3230785.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Isolation of two members of the rat MAP kinase kinase gene family. Otsu M, etal., FEBS Lett 1993 Apr 12;320(3):246-50.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations. Rauen KA, etal.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. Salh B, etal., Anticancer Res. 1999 Jan-Feb;19(1B):731-40.
20. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
21. Evidence for elevated (LIMK2 and CFL1) and suppressed (ICAM1, EZR, MAP2K2, and NOS3) gene expressions in metabolic syndrome. Tabur S, etal., Endocrine. 2016 Aug;53(2):465-70. doi: 10.1007/s12020-016-0910-0. Epub 2016 Mar 8.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. Voisin L, etal., BMC Cancer. 2008 Nov 17;8:337. doi: 10.1186/1471-2407-8-337.
24. Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle. Wu J, etal., Biochem J 1992 Aug 1;285 ( Pt 3):701-5.
25. Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. Wu J, etal., Mol Cell Biol 1993 Aug;13(8):4539-48.
26. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Wu J, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):173-7.
27. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. Xu J, etal., J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.
28. The ERK signaling cascade--views from different subcellular compartments. Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
29. Development and External Validation of a Novel Immune Checkpoint-Related Gene Signature for Prediction of Overall Survival in Hepatocellular Carcinoma. Zhao E, etal., Front Mol Biosci. 2021 Jan 21;7:620765. doi: 10.3389/fmolb.2020.620765. eCollection 2020.
Additional References at PubMed
PMID:7565670   PMID:8026469   PMID:8388392   PMID:8397117   PMID:10409742   PMID:12477932   PMID:14963006   PMID:15753041   PMID:17380122   PMID:18006605   PMID:18270979   PMID:18793415  
PMID:18952847   PMID:19047410   PMID:19447520   PMID:20179103   PMID:21525035   PMID:21615688   PMID:22871113   PMID:23626836   PMID:23920377   PMID:24375836   PMID:24610459   PMID:24733831  
PMID:25100655   PMID:29433126  


Genomics

Comparative Map Data
Map2k2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,241,449 - 9,264,216 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,241,310 - 9,260,940 (-)EnsemblGRCr8
mRatBN7.278,590,729 - 8,610,279 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,580,905 - 8,610,243 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,475,464 - 11,494,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,350,953 - 13,370,301 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,217,425 - 11,236,805 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,458,971 - 11,478,520 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,458,967 - 11,478,489 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,626,294 - 11,645,884 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,074,654 - 10,094,003 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,778,257 - 6,797,606 (-)NCBICelera
RGSC_v3.1710,074,657 - 10,094,003 (-)NCBI
Cytogenetic Map7q11NCBI
MAP2K2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,090,321 - 4,124,122 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,090,317 - 4,124,216 (-)Ensemblhg38GRCh38
GRCh37194,090,319 - 4,124,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,041,319 - 4,075,126 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34194,041,321 - 4,075,126NCBI
Celera194,029,762 - 4,063,598 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,854,052 - 3,888,086 (-)NCBIHuRef
CHM1_1194,089,923 - 4,123,692 (-)NCBICHM1_1
T2T-CHM13v2.0194,073,480 - 4,107,423 (-)NCBIT2T-CHM13v2.0
Map2k2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,941,749 - 80,960,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,941,749 - 80,969,809 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381081,105,913 - 81,124,697 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,105,915 - 81,133,975 (+)Ensemblmm10GRCm38
MGSCv371080,568,692 - 80,587,442 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,509,092 - 80,527,465 (+)NCBIMGSCv36mm8
Celera1082,126,303 - 82,145,053 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Map2k2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,695,768 - 4,722,098 (+)Ensembl
ChiLan1.0NW_0049554954,695,239 - 4,718,380 (+)NCBIChiLan1.0ChiLan1.0
MAP2K2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,488,392 - 8,523,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,718,541 - 7,752,382 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,114,445 - 3,148,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,064,626 - 4,097,933 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,064,626 - 4,097,933 (-)EnsemblpanPan2panpan1.1
MAP2K2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,465,460 - 55,487,629 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,465,212 - 55,487,641 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2055,191,875 - 55,213,954 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02056,128,646 - 56,148,204 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12055,182,690 - 55,204,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,664,143 - 55,686,194 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,862,931 - 55,885,022 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map2k2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,457,693 - 215,496,652 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,336,858 - 2,377,090 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,338,127 - 2,377,090 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,626,783 - 74,651,348 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1274,626,739 - 74,651,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,170,854 - 75,195,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,848,441 - 3,881,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,848,401 - 3,881,412 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660814,347,082 - 4,394,579 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,488,814 - 5,511,445 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248285,489,085 - 5,511,166 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map2k2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,764,327 - 153,784,203 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map2k2
150 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000027272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
RH143912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,590,487 - 8,590,707 (+)MAPPERmRatBN7.2
Rnor_6.0711,458,732 - 11,458,951NCBIRnor6.0
Rnor_5.0711,626,096 - 11,626,315UniSTSRnor5.0
RGSC_v3.4710,074,404 - 10,074,623UniSTSRGSC3.4
Celera76,778,007 - 6,778,226UniSTS
RH 3.4 Map716.4UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027272   ⟹   ENSRNOP00000027272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,241,453 - 9,260,940 (-)Ensembl
mRatBN7.2 Ensembl78,580,905 - 8,610,243 (-)Ensembl
Rnor_6.0 Ensembl711,458,967 - 11,478,489 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096038   ⟹   ENSRNOP00000085974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,241,310 - 9,260,940 (-)Ensembl
mRatBN7.2 Ensembl78,590,856 - 8,610,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102006   ⟹   ENSRNOP00000092750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,242,981 - 9,260,940 (-)Ensembl
mRatBN7.2 Ensembl78,590,740 - 8,610,206 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102029   ⟹   ENSRNOP00000080213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,591,413 - 8,610,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107951   ⟹   ENSRNOP00000092716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,590,599 - 8,607,875 (-)Ensembl
RefSeq Acc Id: NM_133283   ⟹   NP_579817
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,241,449 - 9,260,798 (-)NCBI
mRatBN7.278,590,738 - 8,610,090 (-)NCBI
Rnor_6.0711,458,982 - 11,478,331 (-)NCBI
Rnor_5.0711,626,294 - 11,645,884 (-)NCBI
RGSC_v3.4710,074,654 - 10,094,003 (-)RGD
Celera76,778,257 - 6,797,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240987   ⟹   XP_006241049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,241,449 - 9,264,216 (-)NCBI
mRatBN7.278,590,733 - 8,610,269 (-)NCBI
Rnor_6.0711,458,971 - 11,478,520 (-)NCBI
Rnor_5.0711,626,294 - 11,645,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079809   ⟹   XP_038935737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,241,581 - 9,264,216 (-)NCBI
mRatBN7.278,590,729 - 8,610,279 (-)NCBI
RefSeq Acc Id: XM_063264176   ⟹   XP_063120246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,242,251 - 9,264,216 (-)NCBI
RefSeq Acc Id: XM_063264177   ⟹   XP_063120247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,242,251 - 9,264,216 (-)NCBI
RefSeq Acc Id: NP_579817   ⟸   NM_133283
- UniProtKB: A0JN15 (UniProtKB/Swiss-Prot),   P36506 (UniProtKB/Swiss-Prot),   A6K8C5 (UniProtKB/TrEMBL),   A0A8I6A1A4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241049   ⟸   XM_006240987
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QEI7 (UniProtKB/TrEMBL),   A0A8I6A1A4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027272   ⟸   ENSRNOT00000027272
RefSeq Acc Id: XP_038935737   ⟸   XM_039079809
- Peptide Label: isoform X4
- UniProtKB: A6K8C1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080213   ⟸   ENSRNOT00000102029
Ensembl Acc Id: ENSRNOP00000092750   ⟸   ENSRNOT00000102006
Ensembl Acc Id: ENSRNOP00000085974   ⟸   ENSRNOT00000096038
Ensembl Acc Id: ENSRNOP00000092716   ⟸   ENSRNOT00000107951
RefSeq Acc Id: XP_063120247   ⟸   XM_063264177
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPN3 (UniProtKB/TrEMBL),   A6K8C1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120246   ⟸   XM_063264176
- Peptide Label: isoform X1
- UniProtKB: A6K8C1 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36506-F1-model_v2 AlphaFold P36506 1-400 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694989
Promoter ID:EPDNEW_R5514
Type:initiation region
Name:Map2k2_1
Description:mitogen activated protein kinase kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,478,475 - 11,478,535EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61888 AgrOrtholog
BioCyc Gene G2FUF-34994 BioCyc
Ensembl Genes ENSRNOG00000020005 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027272 ENTREZGENE
  ENSRNOT00000096038 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8376547 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase_kinase UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:58960 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156599 IMAGE-MGC_LOAD
NCBI Gene 58960 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN UniProtKB/Swiss-Prot
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAP2K2 RGD
PhenoGen Map2k2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020005 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC228409
UniProt A0A8I5ZPN3 ENTREZGENE
  A0A8I6A1A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AW22_RAT UniProtKB/TrEMBL
  A0A8L2QEI7 ENTREZGENE, UniProtKB/TrEMBL
  A0JN15 ENTREZGENE
  A6K8C1 ENTREZGENE, UniProtKB/TrEMBL
  A6K8C3_RAT UniProtKB/TrEMBL
  A6K8C4_RAT UniProtKB/TrEMBL
  A6K8C5 ENTREZGENE, UniProtKB/TrEMBL
  A6K8C6_RAT UniProtKB/TrEMBL
  MP2K2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JN15 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Map2k2  mitogen activated protein kinase kinase 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates both threonine and tyrosine residues on Mapk kinases 61657
gene_regulation regulated by a protooncogene cRaf-1 729046