F10 (coagulation factor X) - Rat Genome Database

Name: F10
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: F10 (coagulation factor X) Rattus norvegicus

Analyze

Symbol:

F10

Name:

coagulation factor X

RGD ID:

61850

Description:

Predicted to enable phospholipid binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of TOR signaling. Predicted to be active in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

coagulation factor 10; MGC108722; stuart factor

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	F10 (coagulation factor X)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	F10 (coagulation factor X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	F10 (coagulation factor X)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	F10 (coagulation factor X)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	f10 (coagulation factor X)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	f10	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Allele / Splice:

F10^m1Mcwi F10^m2Mcwi

Genetic Models:

FHH-F10^m1Mcwi FHH-F10^m2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	83,170,973 - 83,190,280 (-)	NCBI		GRCr8
mRatBN7.2	16	76,468,834 - 76,488,141 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,468,838 - 76,488,141 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,749,382 - 81,768,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	85,201,959 - 85,221,266 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,451,223 - 80,470,556 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,803,169 - 81,822,476 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,803,110 - 81,822,716 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	81,288,536 - 81,307,842 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,327,237 - 81,346,544 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,327,502 - 81,346,809 (-)	NCBI
Celera	16	74,274,866 - 74,294,173 (-)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

blood coagulation disease (ISO)

breast cancer (ISO)

factor VII deficiency (ISO)

factor X deficiency (ISO)

Familial Amyloid Polyneuropathies (ISO)

genetic disease (ISO)

Hemorrhage (ISO)

hemorrhagic disease (ISO)

hyperhomocysteinemia (IDA)

myocardial infarction (ISO)

Peritoneal Fibrosis (IEP)

thrombocytopenia (ISO)

thrombosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2,4-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-Chloro-ortho-phenylenediamine (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acenocoumarol (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

aspalathin (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

calcium dichloride (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

chlorogenic acid (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

cyproconazole (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

Difethialone (EXP)

dioxygen (EXP)

epoxiconazole (ISO)

estriol (ISO)

ethyl biscoumacetate (EXP)

Ethyl icosapentate (EXP)

ethylparaben (ISO)

felbamate (EXP)

fenthion (ISO)

ferroheme b (ISO)

flutamide (EXP)

fondaparinux (ISO)

fumonisin B1 (ISO)

furan (EXP)

gabapentin (EXP)

gentamycin (EXP)

gestodene (ISO)

heme b (ISO)

heparin (EXP,ISO)

iron(2+) sulfate (anhydrous) (ISO)

iron(III) citrate (ISO)

kojic acid (ISO)

lead(0) (ISO)

lidocaine (EXP)

mangiferin (ISO)

menadione (EXP)

menaquinone (EXP)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (ISO)

methidathion (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (ISO)

nefazodone (EXP)

nickel atom (ISO)

niclosamide (ISO)

nimesulide (EXP)

nitrofen (EXP)

norethisterone (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP)

phenprocoumon (EXP)

phenytoin (EXP)

pioglitazone (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

propiconazole (ISO)

quercetin (ISO)

rivaroxaban (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

sunitinib (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tremolite asbestos (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

varespladib (ISO)

venom (ISO)

vitamin E (ISO)

warfarin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

positive regulation of leukocyte chemotaxis (IEA)

positive regulation of TOR signaling (IEA,ISO)

proteolysis (IEA)

Cellular Component

extracellular space (IBA,IEA)

Molecular Function

calcium ion binding (IEA)

phospholipid binding (IEA,ISO)

protein binding (ISO)

serine-type endopeptidase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acenocoumarol pharmacodynamics pathway (ISO)

alteplase pharmacodynamics pathway (ISO)

aminocaproic acid pharmacodynamics pathway (ISO)

anistreplase pharmacodynamics pathway (ISO)

aprotinin pharmacodynamics pathway (ISO)

argatroban pharmacodynamics pathway (ISO)

bivalirudin pharmacodynamics pathway (ISO)

coagulation cascade pathway (IDA,IEA,ISO)

complement system pathway (IEA)

dicoumarol pharmacodynamics pathway (ISO)

enoxaparin pharmacodynamics pathway (ISO)

fondaparinux pharmacodynamics pathway (ISO)

heparin pharmacodynamics pathway (ISO)

phenindione pharmacodynamics pathway (ISO)

protease mediated signaling via protease-activated receptor 2 (ISO)

reteplase pharmacodynamics pathway (ISO)

tranexamic acid pharmacodynamics pathway (ISO)

warfarin pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II.	Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40.
2.	Cross Talk Pathways Between Coagulation and Inflammation.	Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	The inhibitors of the tissue factor:factor VII pathway.	Golino P Thromb Res. 2002 May 1;106(3):V257-65.
5.	Severe factor X deficiency in three unrelated Palestinian patients is caused by homozygosity for the mutation c302delG-correlation with thrombin generation and thromboelastometry.	Livnat T, etal., Blood Coagul Fibrinolysis. 2011 Dec;22(8):673-9. doi: 10.1097/MBC.0b013e32834ad785.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats.	Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
9.	Blood coagulation.	Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	Molecular characterization of human factor XSan Antonio.	Reddy SV, etal., Blood. 1989 Oct;74(5):1486-90.
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Tissue factor and factor v involvement in rat peritoneal fibrosis.	Saito H, etal., Perit Dial Int. 2009 May-Jun;29(3):340-51.
19.	How it all starts: Initiation of the clotting cascade.	Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
20.	Evidence for competition between vitamin K-dependent clotting factors for intracellular processing by the vitamin K-dependent gamma-carboxylase.	Stanton C, etal., Thromb Res 1995 Oct 1;80(1):63-73.
21.	Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy.	Takahashi R, etal., Amyloid. 2012 Sep;19(3):129-32. doi: 10.3109/13506129.2012.691918. Epub 2012 May 25.
22.	Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study.	Tinholt M, etal., BMC Cancer. 2014 Nov 19;14:845. doi: 10.1186/1471-2407-14-845.
23.	Intracellular proteolytic processing of the two-chain vitamin K-dependent coagulation factor X.	Wallin R, etal., Thromb Res. 1994 Mar 15;73(6):395-403.

Additional References at PubMed

PMID:8168596	PMID:12477932	PMID:12574802	PMID:14570897	PMID:15489334	PMID:17469850	PMID:18612547	PMID:20664909	PMID:22999414

Genomics

Comparative Map Data

F10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	83,170,973 - 83,190,280 (-)	NCBI		GRCr8
mRatBN7.2	16	76,468,834 - 76,488,141 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	76,468,838 - 76,488,141 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	81,749,382 - 81,768,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	85,201,959 - 85,221,266 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	80,451,223 - 80,470,556 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,803,169 - 81,822,476 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,803,110 - 81,822,716 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	81,288,536 - 81,307,842 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	81,327,237 - 81,346,544 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	81,327,502 - 81,346,809 (-)	NCBI
Celera	16	74,274,866 - 74,294,173 (-)	NCBI		Celera
Cytogenetic Map	16	q12.5	NCBI

F10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,122,799 - 113,149,529 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,122,799 - 113,149,529 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	113,777,113 - 113,803,843 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	112,825,114 - 112,851,844 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	13	112,825,145 - 112,851,842	NCBI
Celera	13	94,603,103 - 94,629,507 (+)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	94,215,823 - 94,242,228 (+)	NCBI		HuRef
CHM1_1	13	113,745,235 - 113,771,639 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	13	112,374,457 - 112,401,188 (+)	NCBI		T2T-CHM13v2.0

F10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,087,308 - 13,106,676 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,087,308 - 13,106,676 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	13,037,308 - 13,056,676 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,037,308 - 13,056,676 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	13,037,308 - 13,056,216 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,037,344 - 13,055,877 (+)	NCBI		MGSCv36	mm8
Celera	8	13,205,092 - 13,223,990 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	5.73	NCBI

F10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	666,165 - 682,538 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955404	666,142 - 682,598 (-)	NCBI	ChiLan1.0	ChiLan1.0

F10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	114,625,296 - 114,651,858 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	113,310,076 - 113,337,459 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	94,263,202 - 94,289,612 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	113,332,124 - 113,358,660 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	113,332,124 - 113,358,660 (+)	Ensembl	panpan1.1		panPan2

F10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	60,585,563 - 60,597,027 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	60,571,822 - 60,597,024 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,297,960 - 60,309,413 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,211,249 - 61,222,710 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,211,250 - 61,222,699 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	60,709,507 - 60,721,052 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	60,711,813 - 60,723,235 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	60,742,888 - 60,754,688 (+)	NCBI		UU_Cfam_GSD_1.0

F10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,449,719 - 195,476,829 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	475,333 - 502,377 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936472	475,851 - 502,341 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

F10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,521,598 - 78,538,258 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	11	78,521,760 - 78,538,256 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,197,298 - 86,215,095 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,125,097 - 91,154,000 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,124,766 - 91,157,376 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666046	48,141,434 - 48,190,001 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	762,330 - 778,282 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624793	762,306 - 777,511 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in F10
106 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	154
Count of miRNA genes:	116
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000026677
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	35288870	80288870	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	37752156	82752156	Rat
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	37752156	82752156	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	42396345	84729064	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	52726464	84729064	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	52726464	84729064	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	52726464	84729064	Rat
631525	Pia14	Pristane induced arthritis QTL 14	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	16	55711087	83402471	Rat

Genetic Models

This gene F10 is modified in the following models/strains:

FHH-F10^m1Mcwi FHH-F10^m2Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			41	41		41					1
Low	2	2	12		19		2	2	18	5	26	8	2
Below cutoff	1	41	4				5	6	48	28	12	3	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D21215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X79807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026677 ⟹ ENSRNOP00000026677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	76,468,838 - 76,488,141 (-)	Ensembl
Rnor_6.0 Ensembl	16	81,803,110 - 81,822,716 (-)	Ensembl

RefSeq Acc Id:

NM_017143 ⟹ NP_058839

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	83,170,973 - 83,190,280 (-)	NCBI
mRatBN7.2	16	76,468,834 - 76,488,141 (-)	NCBI
Rnor_6.0	16	81,803,169 - 81,822,476 (-)	NCBI
Rnor_5.0	16	81,288,536 - 81,307,842 (-)	NCBI
RGSC_v3.4	16	81,327,237 - 81,346,544 (-)	RGD
Celera	16	74,274,866 - 74,294,173 (-)	RGD

Sequence:

show sequence

ATCAGAAGGCTGAGATAAGCAGACTGACCATGGCCACCTGGGGCCTAGGGTGAGTGAACCTTGC
CCCATGCCTGTCACAGCAGCTGCTGTCCTTGACCACATCATGGAGAGCCCGGTGCGACTCAGCC
TTCTCTATGTTGTCCTGGCCAGCCTCCTGCTCCCGGGGAGAAGTGTGTTTATTAACCGGGAACG
AGCCAACAACGTCCTGCAGAGGATTCGGAGAGCAAACTCATTTTTTGAGGAGATAAAGAAAGGA
AATCTGGAAAGGGAGTGTGTGGAAGAAATTTGTTCTTTTGAAGAGGCCCGCGAAGTCTTTGAGG
ACAATGAGAAGACGACAGAATTCTGGAACAAATATGAAGATGGTGACCAGTGTGAGAGCAGTCC
TTGCCAGAACCAAGGCGAGTGTCGAGATGGCCTTGGGAGTTATACATGCACCTGCACGGAGGGA
TTCGAAGGCAAAAACTGTGAACTCTTTGTTCGGAAACTCTGCAGCCTAGACAACGGAGACTGCG
ACCAGTTCTGCCGTGAGGAGCAGAACTCAGTGGTGTGCTCCTGTGCCAAGGGTTACTTCCTGGG
TAATGACGGCAAGTCCTGCCTCTCCACAGCTCCCTTCCCCTGTGGAAAAACCAATAAAGGACGC
GCGAAGAGGTCTGTGGCCCTAAATACCAGCAACAGTGAACCTGACCCTGAAGACCTCATGCCTG
ATGCAGATATTCTATATCCTACTGAGAGTCCTTCTGAACTGCTCAATCTCAACAAGACAGAGCC
TGAAGCAAACAGTGATGACGTTATTCGGATTGTGGGTGGCCAAGAATGCAAGAGAGGAGAATGT
CCTTGGCAGGCTCTGCTCTTTAGCGACGAAGAGACTGATGGGTTCTGTGGGGGCACCATCTTGA
ATGAGTTCTACATCCTCACTGCCGCCCATTGTCTCCATCAAGCCAAGCGATTCAAGGTGAGGGT
AGGGGACCTGAACACGGAACAGGAAGACGGCGGCGAGATGGTGCACGAGGTGGATATGATCATC
AAGCACAACAAGTTTCAGAGGGACACCTACGACTTCGACATTGCCATGCTGAGGCTGAAGACCC
CCATCACGTTCCGCGAGAACGTGGCCCCTGCCTGCTTGCCTCAGAAAGACTGGGCCGAGGCCAC
ACTGATGACGCAAAAGACAGGCATCGTGAGCGGGTTTGGACGCACGCACGAGAAGGGCCGCCAG
TCCAAAGTCCTGAAGATGATGGAGGTGCCCTATGTGGACCGCAACACCTGCAGGCTCTCCACCA
GCTTCAGCATTACGCAGAATATGTTCTGCGCAGGCTATGACGCCAAGCAAGAGGACGCCTGCCA
GGGGGACAGCGGTGGCCCTCACGTCACACGATTCAAAGACACCTACTTTGTGACCGGCATCGTC
AGCTGGGGAGAGGGGTGTGCAAGGAAAGGGAAATACGGCATCTACACGAAGGTCACGGCCTTCC
TCAAATGGATTGACAGGTCCATGAAAGCCAGGGTGGGGCCCACCTCTGAGACCCCAAGGTTAAC
CCATCCACCCTATTAAAGCAGTCCTTCTCCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_058839	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88151	(Get FASTA)	NCBI Sequence Viewer
	BAA04756	(Get FASTA)	NCBI Sequence Viewer
	CAA56202	(Get FASTA)	NCBI Sequence Viewer
	EDM08870	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026677
	ENSRNOP00000026677.5
GenBank Protein	Q63207	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058839 ⟸ NM_017143
- Peptide Label:	precursor
- UniProtKB:	Q63207 (UniProtKB/Swiss-Prot), A0A0H2UHR6 (UniProtKB/TrEMBL), A6IWK2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSF EEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKL CSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSE PDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETD GFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFD IAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVD RNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYG IYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY hide sequence

RefSeq Acc Id:

ENSRNOP00000026677 ⟸ ENSRNOT00000026677

Protein Domains

EGF-like Gla Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63207-F1-model_v2	AlphaFold	Q63207	1-482	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61850	AgrOrtholog
BioCyc Gene	G2FUF-10698	BioCyc
Ensembl Genes	ENSRNOG00000033444	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026677	ENTREZGENE
	ENSRNOT00000026677.7	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.740.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7383301	IMAGE-MGC_LOAD
InterPro	Coagulation_fac-like_Gla_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLA-like_dom_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLA_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_S1A_FX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29243	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108722	IMAGE-MGC_LOAD
NCBI Gene	29243	ENTREZGENE
PANTHER	COAGULATION FACTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COAGULATION FACTOR X	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FXa_inhibition	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Gla	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Trypsin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	F10	RGD
PhenoGen	F10	PhenoGen
PIRSF	Factor_X	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGFBLOOD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLABLOOD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033444	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57630	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UHR6	ENTREZGENE, UniProtKB/TrEMBL
	A6IWK2	ENTREZGENE, UniProtKB/TrEMBL
	FA10_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	F10	coagulation factor X		coagulation factor 10	Name updated	1299863	APPROVED
2002-06-10	F10	coagulation factor 10			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	vitamin K-dependent	61577

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)