Gene:	Zap70 ( Rattus norvegicus ) zeta-chain (TCR) associated protein kinase
Description:	human homolog is a cytoplasmic tyrosine kinase involved in T-cell activation; often expressed in chronic lymphocytic leukemia
Synonyms:	zap70_mapped; syk-related protein tyrosine kinase; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70; MGC108902; zeta-chain (TCR) associated protein kinase 70 (mapped); Srk; Zap70_mapped; zeta-chain (tcr) associated protein kinase 70 (mapped);  (details...)
ArrayIDs:	5745867; 1394306_at; 6317600; 5639368; 6333545; 6499800; 5788468; rc_AI012530_at; 6553874; A_42_P728121; 6025569; 5969134; 1393400_at; 6633317; 5972730; A_44_P994692; 6047021; 6252912; GE1116294; 5746316; 6103828;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: ZAP70     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Zap70     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Zap70 Rat Celera Assembly 9 36755106 - 36777088     Cytogenetic 9 q21     RGSC genome assembly v3.4 9 35693089 - 35715071     Cytogenetic 9 q21 Mus musculus Zap70 Mouse genome assembly build 36.1 1 36818706 - 36839661     Cytogenetic 1 1 A4-C1 Homo sapiens ZAP70 human genome assembly 2 97809386 - 97814841     Human genome assembly build 36.2 2 97696463 - 97722755     Cytogenetic 2 q12   View comparative maps:      NCBI MapViewer
Genome
View:
Annotation
Molecular Function	Gene Ontology protein kinase activity,  nucleotide binding,  protein binding ...  (details...)
Biological Process	Gene Ontology thymic T cell selection,  positive regulation of alpha-beta T cell differentiation,  positive regulation of calcium-mediated signaling ...  (details...)
Cellular Component	Gene Ontology immunological synapse,  cytoplasm,  T cell receptor complex ...  (details...)
Disease	Ontology Severe Combined Immunodeficiency (details...)
External Links
Databases	DATABASE ID SOURCE UNIPARC: UPI0001B7A8F1 IPI KEGG Report: rno:301348 ENTREZGENE HomoloGene Group ID: 839 ENTREZGENE Germonline: 3983 KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 05340 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE IPI: IPI00357886 IPI Ensembl Protein: ENSRNOP00000023036 IPI IMAGE_CLONE: IMAGE:7380367 IMAGE-MGC_LOAD Entrez Gene: Zap70 ENTREZGENE MGC_CLONE: MGC:108902 IMAGE-MGC_LOAD UniProt: Q5FVN9_RAT IPI Ensembl Genes: ENSRNOG00000016995 IPI RatMap: 34928 ENTREZGENE
Sequences	Nucleotide: NM_001012002 Get FASTA Search GEO Profiles Nucleotide: BC089855 Get FASTA Search GEO Profiles (View all 2 Nucleotide Accessions) Protein: AAH89855 Get FASTA Protein: NP_001012002 Get FASTA Protein: Q5FVN9 Get FASTA (View all 3 Protein Accessions)
Clusters	UniGene: 17862
References
Curated References	4 references in RGD related to Zap70
Other References	1 other references at PubMed related to Zap70
Database Information
RGD ID	3983
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 27-JUN-08: Zap70 zeta-chain (TCR) associated protein kinase Zap70 zeta-chain (TCR) associated protein kinase 70 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-FEB-07: Zap70 zeta-chain (TCR) associated protein kinase 70 Zap70_mapped zeta-chain (TCR) associated protein kinase 70 (mapped) PROVISIONAL Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 19-NOV-06: Zap70 zeta-chain (TCR) associated protein kinase 70 (mapped) PROVISIONAL Symbol and Name status set to provisional 70820 17-NOV-05: Zap70_mapped zeta-chain (TCR) associated protein kinase 70 (mapped) Zap70 zeta-chain (TCR) associated protein kinase 70kDa APPROVED Symbol and Name updated 1556543 09-APR-03: Zap70 zeta-chain (TCR) associated protein kinase 70kDa APPROVED Name updated 629478 11-MAR-03: zeta-chain (TCR) associated protein kinase 70kDa Zap70 zeta-chain (TCR) associated protein kinase PROVISIONAL Name updated to reflect Human and Mouse nomenclature 61478 10-JUN-02: Zap70 zeta-chain (TCR) associated protein kinase APPROVED Name updated 70584 23-JUL-01: Zap70 zeta-chain (TCR) associated protein kinase (70kD) APPROVED Name updated to reflect Human and Mouse nomenclature 67952 09-JUL-01: Zap70 Syk-related protein tyrosine kinase WITHDRAWN Name withdrawn 67952