Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) - Rat Genome Database

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Gene: Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) Rattus norvegicus
Analyze
Symbol: Ywhaq
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
RGD ID: 3979
Description: Enables 14-3-3 protein binding activity and transmembrane transporter binding activity. Involved in negative regulation of monoatomic ion transmembrane transport. Part of protein-containing complex. Is active in synapse. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3t; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,664,358 - 46,694,875 (-)NCBIGRCr8
mRatBN7.2640,935,714 - 40,966,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,257,806 - 41,288,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,572,495 - 41,602,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,005,763 - 41,036,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,463,294 - 43,493,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,331,003 - 60,361,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,945,769 - 41,976,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,948,894 - 41,979,249 (-)NCBI
Celera640,222,774 - 40,252,668 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3'-Dichlorobenzidine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
AICA ribonucleotide  (ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bromobenzene  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (EXP)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nonanoic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
PCB138  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
poly(propylene imine) macromolecule  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
Thiotepa  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (ISO)
protein-containing complex  (IDA,ISO)
synapse  (IDA,IEP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. Choi SJ, etal., Nucleic Acids Res. 2001 Jul 1;29(13):2836-42.
2. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. Fan J, etal., Int J Neurosci. 2012 Nov;122(11):665-74. doi: 10.3109/00207454.2012.707714. Epub 2012 Aug 21.
3. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. Fox TE, etal., J Biol Chem. 2007 Apr 27;282(17):12450-7. Epub 2007 Feb 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. 14-3-3theta is a binding partner of rat Eag1 potassium channels. Hsu PH, etal., PLoS One. 2012;7(7):e41203. doi: 10.1371/journal.pone.0041203. Epub 2012 Jul 20.
7. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
17. Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury. Yu F, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):44-52. Epub 2007 Apr 25.
Additional References at PubMed
PMID:9211421   PMID:10854065   PMID:11984006   PMID:12446771   PMID:12650640   PMID:15163635   PMID:15489334   PMID:15677482   PMID:17085597   PMID:19056867   PMID:19199708   PMID:19946888  
PMID:20458337   PMID:21423176   PMID:21618583   PMID:22797923   PMID:22871113   PMID:22926577   PMID:23432726   PMID:25002582   PMID:29476059   PMID:31505169   PMID:32357304   PMID:35352799  
PMID:36717938  


Genomics

Comparative Map Data
Ywhaq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,664,358 - 46,694,875 (-)NCBIGRCr8
mRatBN7.2640,935,714 - 40,966,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,257,806 - 41,288,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,572,495 - 41,602,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,005,763 - 41,036,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,463,294 - 43,493,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,331,003 - 60,361,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,945,769 - 41,976,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,948,894 - 41,979,249 (-)NCBI
Celera640,222,774 - 40,252,668 (-)NCBICelera
Cytogenetic Map6q16NCBI
YWHAQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3829,583,967 - 9,630,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,583,967 - 9,630,997 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,724,096 - 9,771,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,641,557 - 9,688,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,674,703 - 9,721,704NCBI
Celera29,635,980 - 9,682,954 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,569,609 - 9,616,664 (-)NCBIHuRef
CHM1_129,653,476 - 9,700,564 (-)NCBICHM1_1
T2T-CHM13v2.029,609,000 - 9,656,011 (-)NCBIT2T-CHM13v2.0
Ywhaq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,440,330 - 21,467,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,440,072 - 21,467,638 (-)EnsemblGRCm39 Ensembl
GRCm381221,390,329 - 21,417,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,390,071 - 21,417,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,396,190 - 21,423,297 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,636,819 - 21,663,926 (-)NCBIMGSCv36mm8
Celera1219,483,848 - 19,511,370 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.31NCBI
Ywhaq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,230,506 - 5,263,752 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,229,485 - 5,263,749 (-)NCBIChiLan1.0ChiLan1.0
YWHAQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,895,271 - 116,943,104 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,899,244 - 116,946,787 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,573,413 - 9,620,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,735,448 - 9,772,074 (-)NCBIpanpan1.1PanPan1.1panPan2
YWHAQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,660,504 - 6,697,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,588,178 - 6,625,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,759,032 - 6,796,562 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,758,751 - 6,796,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,651,427 - 6,688,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,653,706 - 6,691,132 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,667,564 - 6,705,013 (-)NCBIUU_Cfam_GSD_1.0
Ywhaq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,176,636 - 51,199,301 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365325,931,677 - 5,938,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,738,862 - 126,772,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,738,795 - 126,772,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,245,481 - 135,278,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,017,300 - 98,064,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604514,257,939 - 14,305,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhaq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624969167,676 - 199,963 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969167,635 - 199,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ywhaq
194 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:532
Count of miRNA genes:270
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000011501
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63569161857730540Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat

Markers in Region
RH143719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,959,183 - 40,959,320 (+)MAPPERmRatBN7.2
Rnor_6.0643,486,758 - 43,486,894NCBIRnor6.0
Rnor_5.0660,354,186 - 60,354,322UniSTSRnor5.0
RGSC_v3.4641,969,065 - 41,969,201UniSTSRGSC3.4
Celera640,245,612 - 40,245,748UniSTS
RH 3.4 Map6236.6UniSTS
Cytogenetic Map6q16UniSTS
Ywhaq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,556,250 - 78,556,859 (+)MAPPERmRatBN7.2
Rnor_6.0479,229,061 - 79,229,669NCBIRnor6.0
Rnor_5.04143,910,762 - 143,911,370UniSTSRnor5.0
Celera473,476,716 - 73,477,324UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000077786   ⟹   ENSRNOP00000072011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,936,003 - 40,965,826 (-)Ensembl
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115392   ⟹   ENSRNOP00000077932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)Ensembl
RefSeq Acc Id: NM_013053   ⟹   NP_037185
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8646,664,358 - 46,694,875 (-)NCBI
mRatBN7.2640,935,714 - 40,966,240 (-)NCBI
Rnor_6.0643,463,294 - 43,493,816 (-)NCBI
Rnor_5.0660,331,003 - 60,361,242 (-)NCBI
RGSC_v3.4641,945,769 - 41,976,123 (-)RGD
Celera640,222,774 - 40,252,668 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62409 (Get FASTA)   NCBI Sequence Viewer  
  BAA04533 (Get FASTA)   NCBI Sequence Viewer  
  EDM03173 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072011.2
  ENSRNOP00000077932.1
  ENSRNOP00055007100
  ENSRNOP00060011509
  ENSRNOP00065012614
GenBank Protein P68255 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037185   ⟸   NM_013053
- UniProtKB: P68255 (UniProtKB/Swiss-Prot),   A6HAW8 (UniProtKB/TrEMBL),   A0A8L2R4Y2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072011   ⟸   ENSRNOT00000077786
Ensembl Acc Id: ENSRNOP00000077932   ⟸   ENSRNOT00000115392
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68255-F1-model_v2 AlphaFold P68255 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694518
Promoter ID:EPDNEW_R5041
Type:initiation region
Name:Ywhaq_2
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, theta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5042  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,493,371 - 43,493,431EPDNEW
RGD ID:13694519
Promoter ID:EPDNEW_R5042
Type:initiation region
Name:Ywhaq_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, theta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5041  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,493,803 - 43,493,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3979 AgrOrtholog
BioCyc Gene G2FUF-38031 BioCyc
Ensembl Genes ENSRNOG00000051650 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005734 UniProtKB/Swiss-Prot
  ENSRNOG00060008854 UniProtKB/Swiss-Prot
  ENSRNOG00065010266 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077786.2 UniProtKB/TrEMBL
  ENSRNOT00000115392.1 UniProtKB/Swiss-Prot
  ENSRNOT00055009259 UniProtKB/Swiss-Prot
  ENSRNOT00060014863 UniProtKB/Swiss-Prot
  ENSRNOT00065016571 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623850 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25577 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72512 IMAGE-MGC_LOAD
NCBI Gene 25577 ENTREZGENE
PANTHER 14-3-3 PROTEIN THETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ywhaq PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051650 RatGTEx
  ENSRNOG00055005734 RatGTEx
  ENSRNOG00060008854 RatGTEx
  ENSRNOG00065010266 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC203972
UniProt 1433T_RAT UniProtKB/Swiss-Prot
  A0A8L2R4Y2 ENTREZGENE, UniProtKB/TrEMBL
  A6HAW8 ENTREZGENE, UniProtKB/TrEMBL
  P68255 ENTREZGENE
UniProt Secondary P35216 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhaq  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta  Ywhaq  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ywhaq  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in cerebellar cortex and the hippocampus 727985
gene_protein 245 amino acids 727985