Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) - Rat Genome Database

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Gene: Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) Rattus norvegicus
Analyze
Symbol: Ywhaq
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
RGD ID: 3979
Description: Enables 14-3-3 protein binding activity and transmembrane transporter binding activity. Involved in negative regulation of monoatomic ion transmembrane transport. Part of protein-containing complex. Is active in synapse. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3t; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,664,358 - 46,694,875 (-)NCBIGRCr8
mRatBN7.2640,935,714 - 40,966,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,257,806 - 41,288,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,572,495 - 41,602,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,005,763 - 41,036,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,463,294 - 43,493,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,331,003 - 60,361,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,945,769 - 41,976,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,948,894 - 41,979,249 (-)NCBI
Celera640,222,774 - 40,252,668 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YwhaqRattemporal lobe epilepsy  ISOYWHAQ (Homo sapiens)1625714protein:decreased expression:mitochondria and hippocampusRGD 
Object Symbol
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Qualifier
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Reference
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Original Reference(s)
YwhaqRatNEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, NYSTAGMUS, AND SEIZURES  ISOYWHAQ (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with microcephaly more ...ClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YwhaqRatosteoarthritis  ISOYWHAQ (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YwhaqRat1,2-dimethylhydrazine multiple interactionsISOYwhaq (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of YWHAQ mRNACTDPMID:22206623
YwhaqRat17alpha-ethynylestradiol multiple interactionsISOYwhaq (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YWHAQ mRNACTDPMID:17942748
YwhaqRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of YWHAQ mRNACTDPMID:17108234
YwhaqRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOYwhaq (Mus musculus)64804642 more ...CTDPMID:30294300
YwhaqRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOYwhaq (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YWHAQ mRNACTDPMID:17942748
YwhaqRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of YWHAQ mRNACTDPMID:34747641
YwhaqRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOYwhaq (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of YWHAQ mRNACTDPMID:21570461
YwhaqRat2,6-dimethoxyphenol multiple interactionsISOYWHAQ (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of and affects the localization of YWHAQ proteinCTDPMID:38598786
YwhaqRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of YWHAQ mRNACTDPMID:21346803
YwhaqRat3,3'-Dichlorobenzidine affects expressionISOYWHAQ (Homo sapiens)64804643 and 3'-Dichlorobenzidine affects the expression of YWHAQ proteinCTDPMID:24604609
YwhaqRat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of YWHAQ mRNACTDPMID:19162173
YwhaqRat4,4'-sulfonyldiphenol increases expressionISOYWHAQ (Homo sapiens)6480464bisphenol S results in increased expression of YWHAQ proteinCTDPMID:34186270
YwhaqRat4-hydroxyphenyl retinamide affects localizationISOYWHAQ (Homo sapiens)6480464Fenretinide affects the localization of YWHAQ proteinCTDPMID:17110918
YwhaqRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of YWHAQ mRNACTDPMID:30047161
YwhaqRatacetylsalicylic acid increases expressionISOYWHAQ (Homo sapiens)6480464Aspirin results in increased expression of YWHAQ mRNACTDPMID:15928584
YwhaqRatacrolein multiple interactionsISOYWHAQ (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased oxidation of YWHAQ mRNACTDPMID:32845096
YwhaqRatacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of YWHAQ mRNACTDPMID:28959563
YwhaqRatAICA ribonucleotide multiple interactionsISOYWHAQ (Homo sapiens)6480464AICA ribonucleotide promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein] and AICA ribonucleotide promotes the reaction [XPO1 protein binds to YWHAQ protein]CTDPMID:33070465
YwhaqRataminoglutethimide increases expressionISOYWHAQ (Homo sapiens)6480464Aminoglutethimide results in increased expression of YWHAQ proteinCTDPMID:26102013
YwhaqRatamitrole increases expressionEXP 6480464Amitrole results in increased expression of YWHAQ mRNACTDPMID:30047161

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Biological Process
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Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YwhaqRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
YwhaqRatcytoplasm located_inIEAUniProtKB:P27348 and ensembl:ENSP000002380811600115GO_REF:0000107EnsemblGO_REF:0000107
YwhaqRatcytoplasm is_active_inIBAFB:FBgn0020238 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
YwhaqRatcytoplasm located_inISOYWHAQ (Homo sapiens)1624291 PMID:15163635 and PMID:31906564RGDPMID:15163635 and PMID:31906564
YwhaqRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
YwhaqRatnucleus located_inISOYWHAQ (Homo sapiens)1624291 PMID:31906564RGDPMID:31906564
YwhaqRatnucleus located_inIEAUniProtKB:P27348 and ensembl:ENSP000002380811600115GO_REF:0000107EnsemblGO_REF:0000107
YwhaqRatprotein-containing complex part_ofISOYWHAQ (Homo sapiens)1624291 PMID:22797923RGDPMID:22797923
YwhaqRatprotein-containing complex  IDA 2307106 RGD 
YwhaqRatprotein-containing complex part_ofIEAUniProtKB:P27348 and ensembl:ENSP000002380811600115GO_REF:0000107EnsemblGO_REF:0000107
YwhaqRatsynapse is_active_inIDA 9693692PMID:22911758SynGO 
YwhaqRatsynapse is_active_inIEP 9693692PMID:22911758SynGO 
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Molecular Function
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Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
YwhaqRatcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
YwhaqRatneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. Choi SJ, etal., Nucleic Acids Res. 2001 Jul 1;29(13):2836-42.
2. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. Fan J, etal., Int J Neurosci. 2012 Nov;122(11):665-74. doi: 10.3109/00207454.2012.707714. Epub 2012 Aug 21.
3. Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains. Fox TE, etal., J Biol Chem. 2007 Apr 27;282(17):12450-7. Epub 2007 Feb 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. 14-3-3theta is a binding partner of rat Eag1 potassium channels. Hsu PH, etal., PLoS One. 2012;7(7):e41203. doi: 10.1371/journal.pone.0041203. Epub 2012 Jul 20.
7. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy. Schindler CK, etal., J Neurochem. 2006 Oct;99(2):561-9. Epub 2006 Sep 18.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
18. Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury. Yu F, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):44-52. Epub 2007 Apr 25.
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PMID:9211421   PMID:10854065   PMID:11984006   PMID:12446771   PMID:12650640   PMID:15163635   PMID:15489334   PMID:15677482   PMID:17085597   PMID:19056867   PMID:19199708   PMID:19946888  
PMID:20458337   PMID:21423176   PMID:21618583   PMID:22797923   PMID:22871113   PMID:22926577   PMID:23432726   PMID:25002582   PMID:29476059   PMID:31505169   PMID:32357304   PMID:35352799  
PMID:36717938  



Ywhaq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,664,358 - 46,694,875 (-)NCBIGRCr8
mRatBN7.2640,935,714 - 40,966,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,257,806 - 41,288,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,572,495 - 41,602,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,005,763 - 41,036,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,463,294 - 43,493,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,331,003 - 60,361,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,945,769 - 41,976,123 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,948,894 - 41,979,249 (-)NCBI
Celera640,222,774 - 40,252,668 (-)NCBICelera
Cytogenetic Map6q16NCBI
YWHAQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3829,583,967 - 9,630,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,583,967 - 9,630,997 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,724,096 - 9,771,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,641,557 - 9,688,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,674,703 - 9,721,704NCBI
Celera29,635,980 - 9,682,954 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,569,609 - 9,616,664 (-)NCBIHuRef
CHM1_129,653,476 - 9,700,564 (-)NCBICHM1_1
T2T-CHM13v2.029,609,000 - 9,656,011 (-)NCBIT2T-CHM13v2.0
Ywhaq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,440,330 - 21,467,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,440,072 - 21,467,638 (-)EnsemblGRCm39 Ensembl
GRCm381221,390,329 - 21,417,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,390,071 - 21,417,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,396,190 - 21,423,297 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,636,819 - 21,663,926 (-)NCBIMGSCv36mm8
Celera1219,483,848 - 19,511,370 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.31NCBI
Ywhaq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,230,506 - 5,263,752 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,229,485 - 5,263,749 (-)NCBIChiLan1.0ChiLan1.0
YWHAQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,895,271 - 116,943,104 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,899,244 - 116,946,787 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,573,413 - 9,620,495 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,735,448 - 9,772,074 (-)NCBIpanpan1.1PanPan1.1panPan2
YWHAQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,660,504 - 6,697,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,588,178 - 6,625,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,759,032 - 6,796,562 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,758,751 - 6,796,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,651,427 - 6,688,863 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,653,706 - 6,691,132 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,667,564 - 6,705,013 (-)NCBIUU_Cfam_GSD_1.0
Ywhaq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,176,636 - 51,199,301 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365325,931,677 - 5,938,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,738,862 - 126,772,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,738,795 - 126,772,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,245,481 - 135,278,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,017,300 - 98,064,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604514,257,939 - 14,305,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhaq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624969167,676 - 199,963 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969167,635 - 199,963 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ywhaq
194 total Variants

Predicted Target Of
Summary Value
Count of predictions:532
Count of miRNA genes:270
Interacting mature miRNAs:334
Transcripts:ENSRNOT00000011501
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63432335751121479Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63330954957730294Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat

1 to 10 of 34 rows
RH143719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2640,959,183 - 40,959,320 (+)MAPPERmRatBN7.2
Rnor_6.0643,486,758 - 43,486,894NCBIRnor6.0
Rnor_5.0660,354,186 - 60,354,322UniSTSRnor5.0
RGSC_v3.4641,969,065 - 41,969,201UniSTSRGSC3.4
Celera640,245,612 - 40,245,748UniSTS
RH 3.4 Map6236.6UniSTS
Cytogenetic Map6q16UniSTS
Ywhaq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,556,250 - 78,556,859 (+)MAPPERmRatBN7.2
Rnor_6.0479,229,061 - 79,229,669NCBIRnor6.0
Rnor_5.04143,910,762 - 143,911,370UniSTSRnor5.0
Celera473,476,716 - 73,477,324UniSTS
Cytogenetic Map6q16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000077786   ⟹   ENSRNOP00000072011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,936,003 - 40,965,826 (-)Ensembl
Rnor_6.0 Ensembl643,463,294 - 43,493,816 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115392   ⟹   ENSRNOP00000077932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl640,935,949 - 40,966,273 (-)Ensembl
RefSeq Acc Id: NM_013053   ⟹   NP_037185
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8646,664,358 - 46,694,875 (-)NCBI
mRatBN7.2640,935,714 - 40,966,240 (-)NCBI
Rnor_6.0643,463,294 - 43,493,816 (-)NCBI
Rnor_5.0660,331,003 - 60,361,242 (-)NCBI
RGSC_v3.4641,945,769 - 41,976,123 (-)RGD
Celera640,222,774 - 40,252,668 (-)RGD
Sequence:
Protein RefSeqs NP_037185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62409 (Get FASTA)   NCBI Sequence Viewer  
  BAA04533 (Get FASTA)   NCBI Sequence Viewer  
  EDM03173 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072011
  ENSRNOP00000077932.1
GenBank Protein P68255 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037185   ⟸   NM_013053
- UniProtKB: P68255 (UniProtKB/Swiss-Prot),   A6HAW8 (UniProtKB/TrEMBL),   A0A8L2R4Y2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072011   ⟸   ENSRNOT00000077786
Ensembl Acc Id: ENSRNOP00000077932   ⟸   ENSRNOT00000115392
14-3-3

Name Modeler Protein Id AA Range Protein Structure
AF-P68255-F1-model_v2 AlphaFold P68255 1-245 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694518
Promoter ID:EPDNEW_R5041
Type:initiation region
Name:Ywhaq_2
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, theta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5042  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,493,371 - 43,493,431EPDNEW
RGD ID:13694519
Promoter ID:EPDNEW_R5042
Type:initiation region
Name:Ywhaq_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, theta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5041  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,493,803 - 43,493,863EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38031 BioCyc
Ensembl Genes ENSRNOG00000051650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077786 ENTREZGENE
  ENSRNOT00000115392.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623850 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot
  14-3-3_CS UniProtKB/Swiss-Prot
  14-3-3_dom_sf UniProtKB/Swiss-Prot
  14-3-3_domain UniProtKB/Swiss-Prot
  14-3-3_theta UniProtKB/Swiss-Prot
KEGG Report rno:25577 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72512 IMAGE-MGC_LOAD
NCBI Gene 25577 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot
Pfam 14-3-3 UniProtKB/Swiss-Prot
PhenoGen Ywhaq PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot
PRINTS 1433ZETA UniProtKB/Swiss-Prot
PROSITE 1433_1 UniProtKB/Swiss-Prot
  1433_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051650 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot
TIGR TC203972
UniProt 1433T_RAT UniProtKB/Swiss-Prot
  A0A8L2R4Y2 ENTREZGENE, UniProtKB/TrEMBL
  A6HAW8 ENTREZGENE, UniProtKB/TrEMBL
  P68255 ENTREZGENE
UniProt Secondary P35216 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhaq  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta  Ywhaq  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ywhaq  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression highly expressed in cerebellar cortex and the hippocampus 727985
gene_protein 245 amino acids 727985