Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) - Rat Genome Database

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Gene: Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) Rattus norvegicus
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Symbol: Ugt1a1 (Ensembl: Ugt1a5)
Name: UDP glucuronosyltransferase family 1 member A1 (Ensembl:UDP glucuronosyltransferase family 1 member A5)
RGD ID: 3935
Description: Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular response to estradiol stimulus; and cellular response to ethanol. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1); PARTICIPATES IN axitinib pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1; Udpgt; UDPGT 1-1; Ugt1; UGT1*1; UGT1-01; UGT1.1
RGD Orthologs
Human
Mouse
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ugt1a1j
Genetic Models: Gunn-Ugt1a1j/BluHsd ; Gunn-Ugt1a1j/BluHsdRrrc
Is Marker For: Strains:   WIST/Nhg   SD.Gunn-Ugt1a1j/Aon   W.Gunn-Ugt1a1j/Aon  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,249,143 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,225,245 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,361,437 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,729,538 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,362,434 - 86,369,556 (+)NCBICelera
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-taxifolin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (ISO)
(Z)-ligustilide  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,4-dioxane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',4,4',6'-tetrahydroxychalcone  (ISO)
2',5'-Dihydroxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4,6-Triphenyl-1-hexene  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxychalcone  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxyestrone  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (EXP)
20-HETE  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3-Hydroxybenzo[a]pyrene  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-hydroxyestrone  (ISO)
4-hydroxyphenytoin  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-nitrophenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Epidiosbulbin E acetate  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
alizarin  (ISO)
all-trans-retinol  (EXP)
alpha-tocotrienol  (ISO)
amentoflavone  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
androsterone  (ISO)
Anetholtrithion  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthraflavic acid  (ISO)
anthrarobin  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamidoxime  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bergomottin  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
beta-tocotrienol  (ISO)
bilirubin IXalpha  (EXP,ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Boldine  (EXP)
brequinar  (ISO)
Bropirimine  (ISO)
buprenorphine  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (EXP,ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chalcones  (EXP)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chrysen-6-ol  (EXP)
chrysin  (EXP,ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (ISO)
Clofop  (ISO)
clomipramine  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
coumarins  (EXP,ISO)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (EXP)
delta-tocopherol  (EXP)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicyclanil  (ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
diquat  (ISO)
doxorubicin  (EXP)
drometrizole  (ISO)
emodin  (ISO)
endosulfan  (ISO)
entacapone  (ISO)
epoxiconazole  (EXP)
equol  (ISO)
Erucin  (ISO)
estragole  (ISO)
estriol  (ISO)
estrone  (ISO)
ethoxyquin  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
ezetimibe  (ISO)
farnesol  (ISO)
felbamate  (EXP)
fenofibrate  (ISO)
fenthion  (ISO)
fipronil  (EXP,ISO)
fipronil-sulfone  (EXP)
fisetin  (ISO)
flavanone  (ISO)
flavonoids  (ISO)
flumequine  (ISO)
flunitrazepam  (ISO)
flurbiprofen  (ISO)
formononetin  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
fusidic acid  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (EXP)
glabridin  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Grepafloxacin  (ISO)
griseofulvin  (ISO)
hexadecanoic acid  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
imipramine  (EXP)
imperatorin  (EXP,ISO)
indometacin  (ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
irinotecan  (EXP,ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP,ISO)
ketoprofen  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP)
labetalol  (ISO)
lansoprazole  (EXP)
leflunomide  (ISO)
Licochalcone A  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
masoprocol  (ISO)
Meclizine  (ISO)
MeIQx  (ISO)
metazachlor  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
MK 571  (ISO)
morin  (ISO)
morphine  (ISO)
moxifloxacin  (ISO)
Muraglitazar  (ISO)
myricetin  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (ISO)
Niflumic acid  (ISO)
nilotinib  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ofloxacin  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
opicapone  (ISO)
ortho-Aminoazotoluene  (ISO)
osimertinib  (ISO)
oxycodone  (EXP)
paclitaxel  (ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pectolinarigenin  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenylbutazone  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
Picroside ii  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
plumbagin  (ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propacetamol  (ISO)
propiconazole  (EXP)
prostaglandin B1  (ISO)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
pterostilbene  (ISO)
puerarin  (ISO)
pyrene  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinizarin  (ISO)
rabeprazole  (EXP)
raloxifene  (ISO)
ranirestat  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
robinetin  (ISO)
SB 203580  (ISO)
scopoletin  (ISO)
selumetinib  (ISO)
sevoflurane  (EXP)
Shikonin  (EXP,ISO)
silibinin  (EXP,ISO)
Sitafloxacin  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium propionate  (ISO)
spironolactone  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tangeretin  (ISO)
taurine  (EXP)
tebuconazole  (ISO)
tert-butyl ethyl ether  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thyroxine  (EXP)
ticlopidine  (ISO)
tienilic acid  (ISO)
trans-caffeic acid  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifluralin  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2. Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Borgna-Pignatti C, etal., Haematologica. 2003 Oct;88(10):1106-9.
3. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. Bortolussi G, etal., FASEB J. 2012 Mar;26(3):1052-63. Epub 2011 Nov 17.
4. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Boyd MA, etal., Pharmacogenet Genomics. 2006 May;16(5):321-9.
5. Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats. Braun L, etal., Biochem J. 1998 Dec 15;336 ( Pt 3):587-92.
6. Evolution of the activity of UGT1A1 throughout the development and adult life in a rat. Bustamante N, etal., Life Sci. 2006 Mar 6;78(15):1688-95. Epub 2005 Nov 28.
7. The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin. Call NB and Tisher CC, J Clin Invest 1975 Feb;55(2):319-29.
8. Hereditary Acholuric Jaundice In The Rat Canadian Medical Association Journal
9. UGT1A1*28 polymorphism in ovarian cancer patients. Cecchin E, etal., Oncol Rep. 2004 Aug;12(2):457-62.
10. Risk of hyperbilirubinemia in breast-fed infants. Chang PF, etal., J Pediatr. 2011 Oct;159(4):561-5. doi: 10.1016/j.jpeds.2011.03.042. Epub 2011 May 18.
11. Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. D'Andrea V, etal., Life Sci. 2005 Jun 24;77(6):683-92. Epub 2005 Feb 25.
12. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
13. A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease. de Vries HS, etal., J Crohns Colitis. 2011 Dec 16.
14. Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. del Giudice EM, etal., Blood. 1999 Oct 1;94(7):2259-62.
15. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Deming SL, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):563-70.
16. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Embola CW, etal., Food Chem Toxicol 2002 Jun;40(6):841-4.
17. Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Emi Y, etal., Arch Biochem Biophys 2002 Sep 15;405(2):163-9.
18. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Emi Y, etal., J Biol Chem. 1996 Feb 16;271(7):3952-8.
19. Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. Galanello R, etal., Haematologica. 1999 Feb;84(2):103-5.
20. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Gantla S, etal., Am J Hum Genet. 1998 Mar;62(3):585-92.
21. Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients. Gao J, etal., Med Oncol. 2013;30(3):630. doi: 10.1007/s12032-013-0630-8. Epub 2013 Jun 20.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Glimelius B, etal., Pharmacogenomics J. 2011 Feb;11(1):61-71. doi: 10.1038/tpj.2010.10. Epub 2010 Feb 23.
24. Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. Haberkorn V, etal., Br J Nutr. 2001 Mar;85(3):289-97.
25. Vitamin A modulates the effects of thyroid hormone on UDP-glucuronosyltransferase expression and activity in rat liver. Haberkorn V, etal., Mol Cell Endocrinol 2002 Apr 25;190(1-2):167-75.
26. 9-cis-Retinoic acid regulation of four UGT isoforms in hepatocytes from rats with various thyroid states. Haberkorn V, etal., Pharm Res. 2003 Oct;20(10):1568-73.
27. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. Han JY, etal., J Clin Oncol. 2006 May 20;24(15):2237-44. Epub 2006 Apr 24.
28. UGT1A1 variation and gallstone formation in sickle cell disease. Haverfield EV, etal., Blood. 2005 Feb 1;105(3):968-72. Epub 2004 Sep 23.
29. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. Innocenti F, etal., J Clin Oncol. 2004 Apr 15;22(8):1382-8. Epub 2004 Mar 8.
30. Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. Ishii Y, etal., Drug Metab Pharmacokinet. 2007 Oct;22(5):367-76.
31. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). Iyanagi T J Biol Chem 1991 Dec 15;266(35):24048-52.
32. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. Iyanagi T, etal., J Biol Chem 1989 Dec 15;264(35):21302-7.
33. In vitro induction of bilirubin conjugation in primary rat hepatocyte culture. Jemnitz K, etal., Biochem Biophys Res Commun 2002 Feb 15;291(1):29-33.
34. Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle. Jia Z and Danko I, Mol Ther. 2005 Nov;12(5):860-6. Epub 2005 Jul 12.
35. Ethanol-dependent induction of bilirubin UDP-glucuronosyl-transferase in rat liver is mediated by Kupffer cells. Kardon T, etal., Life Sci. 2002 Jan 25;70(10):1205-12.
36. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Kessler FK, etal., Drug Metab Dispos 2002 Mar;30(3):324-30.
37. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
38. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1. King CD, etal., Arch Biochem Biophys. 1996 Aug 1;332(1):92-100.
39. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, etal., Biochem Biophys Res Commun. 2008 Dec 19;377(3):815-9. Epub 2008 Oct 18.
40. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Li Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):172-4.
41. The effect of hormones on the expression of five isoforms of UDP-glucuronosyltransferase in primary cultures of rat hepatocytes. Li YQ, etal., Pharm Res. 1999 Feb;16(2):191-7.
42. Follicle-stimulating hormone, testosterone, and hypoxia differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat sertoli and peritubular myoid cells. Magnanti M, etal., J Steroid Biochem Mol Biol. 2000 Oct;74(3):149-55.
43. Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. Martins R, etal., J Hum Genet. 2008;53(6):524-8. doi: 10.1007/s10038-008-0281-3. Epub 2008 Apr 5.
44. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV. Montenegro-Miranda PS, etal., Gene Ther. 2014 Feb;21(2):168-74. doi: 10.1038/gt.2013.69. Epub 2013 Nov 28.
47. Tocilizumab-induced hyperbilirubinemia in Japanese patients with rheumatoid arthritis: its association with UDP glucuronosyltransferase 1A1 gene polymorphisms. Mori S, etal., Mod Rheumatol. 2011 Oct 13.
48. Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of in patients with gynecological cancers. Moriya H, etal., Oncol Lett. 2014 Jun;7(6):2035-2040. Epub 2014 Apr 8.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
51. Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer. Otsuka H, etal., Breast Cancer. 2015 Jul;22(4):335-42. doi: 10.1007/s12282-013-0483-1. Epub 2013 Jul 5.
52. Sustained reduction of hyperbilirubinemia in Gunn rats after adeno-associated virus-mediated gene transfer of bilirubin UDP-glucuronosyltransferase isozyme 1A1 to skeletal muscle. Pastore N, etal., Hum Gene Ther. 2012 Oct;23(10):1082-9. doi: 10.1089/hum.2012.018. Epub 2012 Aug 27.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
55. Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT). Radominska A, etal., Drug Metab Dispos. 1997 Jul;25(7):889-92.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Richardson TA, etal., Drug Metab Dispos. 2006 Mar;34(3):351-3. Epub 2005 Dec 8.
60. [Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women]. Shatalova EG, etal., Mol Biol (Mosk). 2006 Mar-Apr;40(2):263-70.
61. Association between severe toxicity of nilotinib and UGT1A1 polymorphisms in Japanese patients with chronic myelogenous leukemia. Shibata T, etal., Int J Clin Oncol. 2014 Apr;19(2):391-6. doi: 10.1007/s10147-013-0562-5. Epub 2013 Apr 23.
62. Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response. Strasser SI, etal., J Gastroenterol Hepatol. 1998 Jan;13(1):88-94.
63. Sex hormones differentially regulate isoforms of UDP-glucuronosyltransferase. Strasser SI, etal., Pharm Res. 1997 Sep;14(9):1115-21.
64. Genetic Polymorphisms of SLCO1B1, CYP2E1 and UGT1A1 and Susceptibility to Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Chinese Population-Based Prospective Case-Control Study. Sun Q, etal., Clin Drug Investig. 2017 Dec;37(12):1125-1136. doi: 10.1007/s40261-017-0572-6.
65. Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study. Takano M, etal., Oncology. 2009;76(5):315-21. Epub 2009 Mar 20.
66. Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. Tankanitlert J, etal., Eur J Haematol. 2008 Apr;80(4):351-5. Epub 2007 Dec 10.
67. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, etal., Pharm Res. 2005 Dec;22(12):2007-15. Epub 2005 Oct 21.
68. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Toietta G, etal., Proc Natl Acad Sci U S A 2005 Mar 15;102(11):3930-5. Epub 2005 Mar 7.
69. Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. Tsai MS, etal., Toxicol Lett. 2018 Jun 15;290:97-109. doi: 10.1016/j.toxlet.2018.03.024. Epub 2018 Mar 21.
70. Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. van der Wegen P, etal., Mol Ther. 2006 Feb;13(2):374-81. Epub 2005 Dec 5.
71. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR and Klaassen CD, Drug Metab Dispos. 2002 Mar;30(3):240-6.
72. The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. Vasavda N, etal., Br J Haematol. 2007 Jul;138(2):263-70.
73. Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon. Wang X, etal., Hepatology. 2009 Sep;50(3):815-24. doi: 10.1002/hep.23060.
74. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes. Xie H, etal., Drug Metab Pharmacokinet. 2013;28(5):427-34. Epub 2013 Apr 2.
75. Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters. Yi YX, etal., Front Pharmacol. 2018 May 15;9:510. doi: 10.3389/fphar.2018.00510. eCollection 2018.
76. Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat. Yokota H, etal., J Biochem (Tokyo) 2002 Aug;132(2):265-70.
77. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Yu WG, etal., Environ Toxicol Chem. 2009 May;28(5):990-6.
78. Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China. Zhang C, etal., J Int Med Res. 2018 Feb;46(2):739-751. doi: 10.1177/0300060517730174. Epub 2017 Sep 20.
79. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
Additional References at PubMed
PMID:1898728   PMID:7603447   PMID:7608130   PMID:7986077   PMID:8554318   PMID:8999837   PMID:9271076   PMID:9488689   PMID:11437649   PMID:12475965   PMID:12477932   PMID:12951053  
PMID:16141793   PMID:17179145   PMID:18004212   PMID:18052087   PMID:19996319   PMID:20056724   PMID:20308471   PMID:20610558   PMID:22447239   PMID:22579593   PMID:23230277   PMID:28479355  
PMID:29131354  


Genomics

Comparative Map Data
Ugt1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,249,143 - 96,256,264 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl996,144,786 - 96,256,264 (+)EnsemblGRCr8
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx997,225,245 - 97,232,360 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,361,437 - 102,368,552 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,729,538 - 100,736,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera986,362,434 - 86,369,556 (+)NCBICelera
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Cytogenetic Map9q35NCBI
UGT1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,760,270 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,760,270 - 233,773,300 (+)Ensemblhg38GRCh38
GRCh372234,668,916 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,333,658 - 234,346,684 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342234,450,918 - 234,463,945NCBI
Celera2228,389,552 - 228,402,577 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,468,768 - 226,481,779 (+)NCBIHuRef
CHM1_12234,674,733 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,248,901 - 234,261,929 (+)NCBIT2T-CHM13v2.0
Ugt1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,139,681 - 88,147,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,139,681 - 88,146,719 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38188,211,959 - 88,220,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,211,959 - 88,218,997 (+)Ensemblmm10GRCm38
MGSCv37190,108,534 - 90,116,577 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36190,043,130 - 90,050,148 (+)NCBIMGSCv36mm8
Celera191,173,026 - 91,181,062 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.55NCBI
Ugt1a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14160,244,579 - 160,251,687 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ugt1a1
49 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8996,255,939 - 96,256,140 (+)Marker Load Pipeline
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


Related Rat Strains
The following Strains have been annotated to Ugt1a1
SD.Gunn-Ugt1a1j/Aon     W.Gunn-Ugt1a1j/Aon     WIST/Nhg    


Genetic Models
This gene Ugt1a1 is modified in the following models/strains:
Gunn-Ugt1a1j/BluHsd     Gunn-Ugt1a1j/BluHsdRrrc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 6 54 34 30 18 31 18 6 125 49 50 45 51 12 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000025045   ⟹   ENSRNOP00000025045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,801,339 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,295,701 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025291   ⟹   ENSRNOP00000025292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,762,249 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,256,627 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025652   ⟹   ENSRNOP00000025652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,739,577 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,202,632 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000032634   ⟹   ENSRNOP00000030374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,747,213 - 88,808,463 (+)Ensembl
Rnor_6.0 Ensembl995,241,609 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045163   ⟹   ENSRNOP00000046507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,780,328 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,274,707 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000063853   ⟹   ENSRNOP00000062958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,791,216 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,285,592 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066839   ⟹   ENSRNOP00000063634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,221,474 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071003   ⟹   ENSRNOP00000075547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,233,957 - 95,302,810 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071200   ⟹   ENSRNOP00000066773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,727,092 - 88,808,453 (+)Ensembl
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077416   ⟹   ENSRNOP00000070501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,241,626 - 95,302,816 (+)Ensembl
RefSeq Acc Id: NM_012683   ⟹   NP_036815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,249,143 - 96,256,264 (+)NCBI
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0995,295,701 - 95,302,822 (+)NCBI
Rnor_5.0994,982,916 - 94,990,037 (+)NCBI
RGSC_v3.4987,091,241 - 87,098,362 (+)RGD
Celera986,362,434 - 86,369,556 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036815 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52219 (Get FASTA)   NCBI Sequence Viewer  
  AAL67852 (Get FASTA)   NCBI Sequence Viewer  
  AAR95629 (Get FASTA)   NCBI Sequence Viewer  
  BAA07260 (Get FASTA)   NCBI Sequence Viewer  
  EDL92105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025045.4
  ENSRNOP00000108039
GenBank Protein Q64550 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036815   ⟸   NM_012683
- Peptide Label: precursor
- UniProtKB: Q64635 (UniProtKB/Swiss-Prot),   Q64550 (UniProtKB/Swiss-Prot),   Q5DT04 (UniProtKB/TrEMBL),   Q547Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046507   ⟸   ENSRNOT00000045163
Ensembl Acc Id: ENSRNOP00000062958   ⟸   ENSRNOT00000063853
Ensembl Acc Id: ENSRNOP00000075547   ⟸   ENSRNOT00000071003
Ensembl Acc Id: ENSRNOP00000070501   ⟸   ENSRNOT00000077416
Ensembl Acc Id: ENSRNOP00000030374   ⟸   ENSRNOT00000032634
Ensembl Acc Id: ENSRNOP00000066773   ⟸   ENSRNOT00000071200
Ensembl Acc Id: ENSRNOP00000025292   ⟸   ENSRNOT00000025291
Ensembl Acc Id: ENSRNOP00000025652   ⟸   ENSRNOT00000025652
Ensembl Acc Id: ENSRNOP00000063634   ⟸   ENSRNOT00000066839
Ensembl Acc Id: ENSRNOP00000025045   ⟸   ENSRNOT00000025045

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64550-F1-model_v2 AlphaFold Q64550 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696846
Promoter ID:EPDNEW_R7370
Type:multiple initiation site
Name:Ugt1a7c_3
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7367  EPDNEW_R7368  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,295,686 - 95,295,746EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3935 AgrOrtholog
BioCyc Gene G2FUF-26816 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025045.7 UniProtKB/Swiss-Prot
  ENSRNOT00000153691 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report rno:24861 UniProtKB/Swiss-Prot
NCBI Gene 24861 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PharmGKB UGT1A1 RGD
PhenoGen Ugt1a1 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018740 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt F7EKA4_RAT UniProtKB/TrEMBL
  Q547Q8 ENTREZGENE, UniProtKB/TrEMBL
  Q5DT04 ENTREZGENE, UniProtKB/TrEMBL
  Q64550 ENTREZGENE
  Q64635 ENTREZGENE
  UD11_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64635 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt1a1  UDP glucuronosyltransferase family 1 member A1  Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Ugt1  UDP-glucuronosyltransferase 1 family, member 1  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt1  UDP-glucuronosyltransferase 1 family, member 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver hepatocytes 70480
gene_process functions in glucuronidation and excretion of bilirubin 70480
gene_transcript each variable exon is preceded by a promoter region which may be used for tissue specific gene expression 1302827