Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) - Rat Genome Database

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Gene: Ugt1a1 (UDP glucuronosyltransferase family 1 member A1) Rattus norvegicus
Analyze
Symbol: Ugt1a1 (Ensembl: Ugt1a5)
Name: UDP glucuronosyltransferase family 1 member A1 (Ensembl:UDP glucuronosyltransferase family 1 member A5)
RGD ID: 3935
Description: Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular response to estradiol stimulus; and cellular response to ethanol. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1); PARTICIPATES IN axitinib pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1 family member 1; UDP-glucuronosyltransferase 1 family, member 1; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1A1; Udpgt; UDPGT 1-1; Ugt1; UGT1*1; UGT1-01; UGT1.1
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: Ugt1a1j  
Genetic Models: Gunn-Ugt1a1j/BluHsd Gunn-Ugt1a1j/BluHsdRrrc
Is Marker For: Strains:   WIST/Nhg   SD.Gunn-Ugt1a1j/Aon   W.Gunn-Ugt1a1j/Aon  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,249,143 - 96,256,264 (+)NCBIGRCr8
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,225,245 - 97,232,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,361,437 - 102,368,552 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,729,538 - 100,736,659 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Ugt1a1RatAcute Liver Failure treatmentISOUgt1a1 (Mus musculus)14402051 RGD 
Ugt1a1Ratbilirubin metabolic disorder susceptibilityISOUGT1A1 (Homo sapiens)10769337associated with Beta-Thalassemia and DNA:repeat:promoter:(TA)RGD 
Ugt1a1Ratbilirubin metabolic disorder  IAGP 1354702 RGD 
Ugt1a1Ratbilirubin metabolic disorder severityISOUGT1A1 (Homo sapiens)6482855associated with HIV Infection and DNA:mutation: :p.G71R (human)RGD 
Ugt1a1Ratbilirubin metabolic disorder  ISOUGT1A1 (Homo sapiens)6482854associated with Arthritis more ...RGD 
Ugt1a1Ratbreast cancer  ISOUGT1A1 (Homo sapiens)2301047 RGD 
Ugt1a1RatChemical and Drug Induced Liver Injury susceptibilityISOUGT1A1 (Homo sapiens)14694824DNA:SNP:exon (rs4148323)(human)RGD 
Ugt1a1Ratcholecystolithiasis susceptibilityISOUGT1A1 (Homo sapiens)10768868associated with Anemia more ...RGD 
Ugt1a1Ratcholelithiasis susceptibilityISOUGT1A1 (Homo sapiens)10768828associated with Beta-Thalassemia more ...RGD 
Ugt1a1Ratcholelithiasis susceptibilityISOUGT1A1 (Homo sapiens)10769341associated with Alpha-Thalassemia and DNA:repeat:promoter:(TA)RGD 
Ugt1a1Ratcholelithiasis susceptibilityISOUGT1A1 (Homo sapiens)6482853associated with Spherocytosis more ...RGD 
Ugt1a1Ratcholestasis treatmentISOUgt1a1 (Mus musculus)14694823 RGD 
Ugt1a1RatCrigler-Najjar syndrome treatmentISOUGT1A1 (Homo sapiens)10769340 RGD 
Ugt1a1RatCrigler-Najjar syndrome treatmentIMP 10769363 RGD 
Ugt1a1RatCrigler-Najjar syndrome  ISOUGT1A1 (Homo sapiens)13432067 RGD 
Ugt1a1RatCrigler-Najjar syndrome  ISOUGT1A1 (Homo sapiens)6482856 RGD 
Ugt1a1RatCrigler-Najjar syndrome  ISOUgt1a1 (Mus musculus) and UGT1A1 (Homo sapiens)6482851 RGD 
Ugt1a1RatCrigler-Najjar syndrome susceptibilityISOUGT1A1 (Homo sapiens)1600438DNA:splice-site mutationsRGD 
Ugt1a1RatCrohn's disease  ISOUGT1A1 (Homo sapiens)6482850DNA:polymorphism:promoterRGD 
Ugt1a1RatDrug-induced Neutropenia susceptibilityISOUGT1A1 (Homo sapiens)10769334associated with Adenocarcinoma more ...RGD 
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Ugt1a1Ratbilirubin metabolic disorder  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: HyperbilirubinemiaClinVarPMID:10975608 more ...
Ugt1a1RatCrigler Najjar Syndrome, Type 1  ISOUGT1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10412811 more ...
Ugt1a1RatCrigler Najjar Syndrome, Type 2  ISOUGT1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10412811 more ...
Ugt1a1RatCrigler-Najjar syndrome  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Crigler-Najjar syndromeClinVarPMID:11013440 more ...
Ugt1a1Ratgenetic disease  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11182932 more ...
Ugt1a1RatGilbert syndrome  ISOUGT1A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10412811 more ...
Ugt1a1RatHyperbilirubinemia, Transient Familial Neonatal  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Transient familial neonatal hyperbilirubinemiaClinVarPMID:10412811 more ...
Ugt1a1RatJoubert syndrome 22  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Joubert syndrome 22ClinVarPMID:28492532
Ugt1a1RatPerlman syndrome  ISOUGT1A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Perlman syndromeClinVarPMID:28492532
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Ugt1a1Ratacute kidney failure  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:3864191
Ugt1a1Ratautism spectrum disorder  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Ugt1a1Ratbilirubin metabolic disorder  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20194756 more ...
Ugt1a1Ratcontact dermatitis  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Ugt1a1RatCrigler Najjar Syndrome, Type 2  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ugt1a1RatCrigler-Najjar syndrome  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25370011
Ugt1a1RatDrug-Related Side Effects and Adverse Reactions  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:19931604
Ugt1a1RatGilbert syndrome  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10421657 more ...
Ugt1a1RatHodgkin's lymphoma  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18768784
Ugt1a1RatHyperbilirubinemia, Transient Familial Neonatal  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ugt1a1Ratkernicterus  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20194756 and PMID:28167773
Ugt1a1RatNeonatal Hyperbilirubinemia  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28167773
Ugt1a1Ratneutropenia  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17549067
Ugt1a1Ratsmall cell carcinoma  ISOUGT1A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20946520
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Ugt1a1Rat(+)-catechin decreases activityISOUGT1A1 (Homo sapiens)6480464Catechin results in decreased activity of UGT1A1 proteinCTDPMID:35868516
Ugt1a1Rat(+)-taxifolin multiple interactionsISOUGT1A1 (Homo sapiens)6480464AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]CTDPMID:29584932
Ugt1a1Rat(+)-taxifolin increases expressionISOUGT1A1 (Homo sapiens)6480464taxifolin results in increased expression of UGT1A1 mRNACTDPMID:29584932
Ugt1a1Rat(1->4)-beta-D-glucan multiple interactionsISOUgt1a1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UGT1A1 mRNACTDPMID:36331819
Ugt1a1Rat(5Z,8Z,11Z,13E)-15-HETE increases glucuronidationISOUGT1A1 (Homo sapiens)6480464UGT1A1 protein results in increased glucuronidation of 15-hydroxy-5 more ...CTDPMID:15231852
Ugt1a1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA]CTDPMID:22389237
Ugt1a1Rat(S)-naringenin increases glucuronidationISOUGT1A1 (Homo sapiens)6480464UGT1A1 protein results in increased glucuronidation of naringeninCTDPMID:14557274
Ugt1a1Rat(S)-naringenin increases expressionISOUgt1a1 (Mus musculus)6480464naringenin results in increased expression of UGT1A1 mRNACTDPMID:31621310
Ugt1a1Rat(Z)-ligustilide increases expressionISOUgt1a1 (Mus musculus)6480464ligustilide results in increased expression of UGT1A1 proteinCTDPMID:23441843
Ugt1a1Rat(Z)-ligustilide increases expressionISOUGT1A1 (Homo sapiens)6480464ligustilide results in increased expression of UGT1A1 mRNACTDPMID:30243965
Ugt1a1Rat1,4-dioxane decreases expressionISOUgt1a1 (Mus musculus)64804641 and 4-dioxane results in decreased expression of UGT1A1 mRNACTDPMID:33693819
Ugt1a1Rat1-Hydroxypyrene increases glucuronidationISOUGT1A1 (Homo sapiens)6480464UGT1A1 protein results in increased glucuronidation of 1-hydroxypyreneCTDPMID:15802387
Ugt1a1Rat1-naphthyl isothiocyanate decreases expressionISOUgt1a1 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of UGT1A1 proteinCTDPMID:32976922
Ugt1a1Rat1-naphthyl isothiocyanate multiple interactionsEXP 6480464ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA] more ...CTDPMID:32198087
Ugt1a1Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of UGT1A1 proteinCTDPMID:32198087
Ugt1a1Rat1-naphthyl isothiocyanate increases expressionISOUgt1a1 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of UGT1A1 proteinCTDPMID:28549656
Ugt1a1Rat1-naphthyl isothiocyanate multiple interactionsISOUgt1a1 (Mus musculus)6480464Chenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA] more ...CTDPMID:32976922
Ugt1a1Rat17alpha-ethynylestradiol multiple interactionsISOUGT1A1 (Homo sapiens)6480464chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]CTDPMID:10950852
Ugt1a1Rat17alpha-ethynylestradiol decreases expressionISOUgt1a1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of UGT1A1 mRNACTDPMID:27818225
Ugt1a1Rat17alpha-ethynylestradiol increases glucuronidationEXP 6480464UGT1A1 protein results in increased glucuronidation of Ethinyl EstradiolCTDPMID:15921999

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Biological Process
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Ugt1a1Ratacute-phase response  IEP 6482857 RGD 
Ugt1a1Ratanimal organ regeneration  IEP 2317021 RGD 
Ugt1a1Ratbilirubin conjugation  TAS 70480 RGD 
Ugt1a1Ratbilirubin conjugation acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
Ugt1a1Ratbiphenyl catabolic process  IDA 1600442 RGD 
Ugt1a1Ratcanonical NF-kappaB signal transduction acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
Ugt1a1Ratcell activation acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
Ugt1a1Ratcellular response to estradiol stimulus  IEP 10769353 RGD 
Ugt1a1Ratcellular response to ethanol  IEP 2317026 RGD 
Ugt1a1Ratcellular response to glucocorticoid stimulus  IEP 2317062 RGD 
Ugt1a1Ratcellular response to hormone stimulus  IEP 2317062triiodothyronine T3RGD 
Ugt1a1Ratcellular response to xenobiotic stimulus  IEP 10769355 RGD 
Ugt1a1Ratconnective tissue replacement acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
Ugt1a1Ratdigestive tract development acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:36720308RGDPMID:36720308
Ugt1a1RatDNA damage response acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
Ugt1a1Ratestrogen metabolic process involved_inISOUGT1A1 (Homo sapiens)1624291 PMID:15472229 more ...RGDPMID:15472229 more ...
Ugt1a1Ratflavone metabolic process involved_inISOUGT1A1 (Homo sapiens)1624291 PMID:18052087RGDPMID:18052087
Ugt1a1Ratflavonoid metabolic process  IDA 10769352 RGD 
Ugt1a1Ratflavonoid metabolic process involved_inISOUGT1A1 (Homo sapiens)1624291 PMID:20056724RGDPMID:20056724
Ugt1a1Ratgene expression acts_upstream_of_or_withinISOUgt1a1 (Mus musculus)1624291 PMID:33961837RGDPMID:33961837
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Cellular Component
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Ugt1a1Ratcytochrome complex  IDA 2317073 RGD 
Ugt1a1Ratendoplasmic reticulum located_inISOUGT1A1 (Homo sapiens)1624291 PMID:17179145RGDPMID:17179145
Ugt1a1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Ugt1a1Ratendoplasmic reticulum is_active_inIBAMGI:98898 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ugt1a1Ratendoplasmic reticulum located_inIDA 1580664PMID:14561759HGNC-UCL 
Ugt1a1Ratendoplasmic reticulum chaperone complex part_ofISOUgt1a1 (Mus musculus)1624291 PMID:12475965RGDPMID:12475965
Ugt1a1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Ugt1a1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Ugt1a1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Ugt1a1Ratmembrane located_inIEAUniRule:UR0001508021600115GO_REF:0000104UniProtGO_REF:0000104
Ugt1a1Ratplasma membrane located_inISOUgt1a1 (Mus musculus)1624291 PMID:12951053RGDPMID:12951053
Ugt1a1Ratprotein-containing complex part_ofISOUgt1a1 (Mus musculus)1624291 PMID:32093886RGDPMID:32093886
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Molecular Function
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Ugt1a1Ratenzyme binding enablesISOUGT1A1 (Homo sapiens)1624291UniProtKB:O60656 more ...RGDPMID:17179145
Ugt1a1Ratenzyme binding  IDA 2317073Cyp2c11 or Cyp2c13RGD 
Ugt1a1Ratenzyme binding enablesIBAPANTHER:PTN002630028 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ugt1a1Ratenzyme binding enablesISOUGT1A1 (Homo sapiens) and UniProtKB:P22309-21624291UniProtKB:O60656-1 more ...RGDPMID:20610558
Ugt1a1Ratenzyme inhibitor activity enablesISOUGT1A1 (Homo sapiens)1624291 PMID:19996319RGDPMID:19996319
Ugt1a1Ratglucuronosyltransferase activity  IDA 70480 RGD 
Ugt1a1Ratglucuronosyltransferase activity enablesIEARHEA:210321600115GO_REF:0000116RHEAGO_REF:0000116
Ugt1a1Ratglucuronosyltransferase activity enablesIEAEC:2.4.1.171600115GO_REF:0000003UniProtGO_REF:0000003
Ugt1a1Ratglucuronosyltransferase activity enablesISOUGT1A1 (Homo sapiens)1624291 PMID:15231852 more ...RGDPMID:15231852 more ...
Ugt1a1Ratglucuronosyltransferase activity enablesISOUgt1a1 (Mus musculus)1624291 PMID:32093886RGDPMID:32093886
Ugt1a1Ratglycosyltransferase activity enablesIEAUniProtKB-KW:KW-03281600115GO_REF:0000043UniProtGO_REF:0000043
Ugt1a1Ratprotein binding enablesISOUGT1A1 (Homo sapiens) and UniProtKB:P22309-11624291UniProtKB:P22309-2 more ...RGDPMID:20610558 and PMID:27025983
Ugt1a1Ratprotein binding enablesISOUGT1A1 (Homo sapiens)1624291UniProtKB:Q9BSJ8 and PMID:33961781RGDPMID:33961781
Ugt1a1Ratprotein binding enablesISOUGT1A1 (Homo sapiens) and UniProtKB:P22309-21624291UniProtKB:O60656-1 more ...RGDPMID:20610558 more ...
Ugt1a1Ratprotein heterodimerization activity enablesISOUGT1A1 (Homo sapiens) and UniProtKB:P22309-21624291UniProtKB:O60656-1 more ...RGDPMID:20610558
Ugt1a1Ratprotein heterodimerization activity enablesISOUGT1A1 (Homo sapiens) and UniProtKB:P22309-11624291UniProtKB:O60656-2 more ...RGDPMID:20610558
Ugt1a1Ratprotein homodimerization activity enablesISOUGT1A1 (Homo sapiens)1624291 PMID:17179145RGDPMID:17179145
Ugt1a1Ratretinoic acid binding enablesISOUGT1A1 (Homo sapiens)1624291 PMID:20308471RGDPMID:20308471
Ugt1a1Ratsteroid binding enablesISOUGT1A1 (Homo sapiens)1624291 PMID:19996319RGDPMID:19996319
Ugt1a1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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Imported Annotations - KEGG (archival)

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Reference Title
Reference Citation
1. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Alkharfy KM, etal., Drug Metab Lett. 2008 Dec;2(4):248-55.
2. Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Borgna-Pignatti C, etal., Haematologica. 2003 Oct;88(10):1106-9.
3. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. Bortolussi G, etal., FASEB J. 2012 Mar;26(3):1052-63. Epub 2011 Nov 17.
4. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Boyd MA, etal., Pharmacogenet Genomics. 2006 May;16(5):321-9.
5. Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats. Braun L, etal., Biochem J. 1998 Dec 15;336 ( Pt 3):587-92.
6. Evolution of the activity of UGT1A1 throughout the development and adult life in a rat. Bustamante N, etal., Life Sci. 2006 Mar 6;78(15):1688-95. Epub 2005 Nov 28.
7. The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin. Call NB and Tisher CC, J Clin Invest 1975 Feb;55(2):319-29.
8. Hereditary Acholuric Jaundice In The Rat Canadian Medical Association Journal
9. UGT1A1*28 polymorphism in ovarian cancer patients. Cecchin E, etal., Oncol Rep. 2004 Aug;12(2):457-62.
10. Risk of hyperbilirubinemia in breast-fed infants. Chang PF, etal., J Pediatr. 2011 Oct;159(4):561-5. doi: 10.1016/j.jpeds.2011.03.042. Epub 2011 May 18.
11. Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. D'Andrea V, etal., Life Sci. 2005 Jun 24;77(6):683-92. Epub 2005 Feb 25.
12. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
13. A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease. de Vries HS, etal., J Crohns Colitis. 2011 Dec 16.
14. Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. del Giudice EM, etal., Blood. 1999 Oct 1;94(7):2259-62.
15. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Deming SL, etal., Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):563-70.
16. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Embola CW, etal., Food Chem Toxicol 2002 Jun;40(6):841-4.
17. Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Emi Y, etal., Arch Biochem Biophys 2002 Sep 15;405(2):163-9.
18. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. Emi Y, etal., J Biol Chem. 1996 Feb 16;271(7):3952-8.
19. Co-inherited Gilbert's syndrome: a factor determining hyperbilirubinemia in homozygous beta-thalassemia. Galanello R, etal., Haematologica. 1999 Feb;84(2):103-5.
20. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Gantla S, etal., Am J Hum Genet. 1998 Mar;62(3):585-92.
1 to 20 of 79 rows
PMID:1898728   PMID:7603447   PMID:7608130   PMID:7986077   PMID:8554318   PMID:8999837   PMID:9271076   PMID:9488689   PMID:11437649   PMID:12475965   PMID:12477932   PMID:12951053  
PMID:16141793   PMID:17179145   PMID:18004212   PMID:18052087   PMID:19996319   PMID:20056724   PMID:20308471   PMID:20610558   PMID:22447239   PMID:22579593   PMID:23230277   PMID:28479355  
PMID:29131354  



Ugt1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8996,249,143 - 96,256,264 (+)NCBIGRCr8
mRatBN7.2988,801,344 - 88,808,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx997,225,245 - 97,232,360 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,361,437 - 102,368,552 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,729,538 - 100,736,659 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0995,295,701 - 95,302,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0994,982,916 - 94,990,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4987,091,241 - 87,098,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1987,277,121 - 87,284,238 (+)NCBI
Celera986,362,434 - 86,369,556 (+)NCBICelera
Cytogenetic Map9q35NCBI
UGT1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,760,270 - 233,773,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,760,270 - 233,773,300 (+)EnsemblGRCh38hg38GRCh38
GRCh372234,668,916 - 234,681,946 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,333,658 - 234,346,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,450,918 - 234,463,945NCBI
Celera2228,389,552 - 228,402,577 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,468,768 - 226,481,779 (+)NCBIHuRef
CHM1_12234,674,733 - 234,682,899 (+)NCBICHM1_1
T2T-CHM13v2.02234,248,901 - 234,261,929 (+)NCBIT2T-CHM13v2.0
Ugt1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39188,139,681 - 88,147,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl188,139,681 - 88,146,719 (+)EnsemblGRCm39 Ensembl
GRCm38188,211,959 - 88,220,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl188,211,959 - 88,218,997 (+)EnsemblGRCm38mm10GRCm38
MGSCv37190,108,534 - 90,116,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36190,043,130 - 90,050,148 (+)NCBIMGSCv36mm8
Celera191,173,026 - 91,181,062 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.55NCBI

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Variants in Ugt1a1
41 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
9 95295888 95295889 G A snv CDR View more Information


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat

1 to 10 of 21 rows
RH94830  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8996,255,939 - 96,256,140 (+)Marker Load Pipeline
mRatBN7.2988,808,140 - 88,808,341 (+)MAPPERmRatBN7.2
Rnor_6.0995,302,498 - 95,302,698NCBIRnor6.0
Rnor_5.0994,989,713 - 94,989,913UniSTSRnor5.0
RGSC_v3.4987,098,038 - 87,098,238UniSTSRGSC3.4
Celera986,369,232 - 86,369,432UniSTS
Cytogenetic Map9q35UniSTS
Cytogenetic Map9q35-q36UniSTS


The following Strains have been annotated to Ugt1a1
SD.Gunn-Ugt1a1j/Aon     W.Gunn-Ugt1a1j/Aon     WIST/Nhg    


This gene Ugt1a1 is modified in the following models/strains:
Gunn-Ugt1a1j/BluHsd     Gunn-Ugt1a1j/BluHsdRrrc    




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12



Ensembl Acc Id: ENSRNOT00000025045   ⟹   ENSRNOP00000025045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,801,339 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,295,701 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025291   ⟹   ENSRNOP00000025292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,762,249 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,256,627 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025652   ⟹   ENSRNOP00000025652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,739,577 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,202,632 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000032634   ⟹   ENSRNOP00000030374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,747,213 - 88,808,463 (+)Ensembl
Rnor_6.0 Ensembl995,241,609 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045163   ⟹   ENSRNOP00000046507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,780,328 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,274,707 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000063853   ⟹   ENSRNOP00000062958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,791,216 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,285,592 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066839   ⟹   ENSRNOP00000063634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,713,184 - 88,808,465 (+)Ensembl
Rnor_6.0 Ensembl995,221,474 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071003   ⟹   ENSRNOP00000075547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,233,957 - 95,302,810 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071200   ⟹   ENSRNOP00000066773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,727,092 - 88,808,453 (+)Ensembl
Rnor_6.0 Ensembl995,161,157 - 95,302,822 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077416   ⟹   ENSRNOP00000070501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl995,241,626 - 95,302,816 (+)Ensembl
RefSeq Acc Id: NM_012683   ⟹   NP_036815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8996,249,143 - 96,256,264 (+)NCBI
mRatBN7.2988,801,344 - 88,808,465 (+)NCBI
Rnor_6.0995,295,701 - 95,302,822 (+)NCBI
Rnor_5.0994,982,916 - 94,990,037 (+)NCBI
RGSC_v3.4987,091,241 - 87,098,362 (+)RGD
Celera986,362,434 - 86,369,556 (+)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_036815 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52219 (Get FASTA)   NCBI Sequence Viewer  
  AAL67852 (Get FASTA)   NCBI Sequence Viewer  
  AAR95629 (Get FASTA)   NCBI Sequence Viewer  
  BAA07260 (Get FASTA)   NCBI Sequence Viewer  
  EDL92105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025045.4
  ENSRNOP00000108039
GenBank Protein Q64550 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_036815   ⟸   NM_012683
- Peptide Label: precursor
- UniProtKB: Q64635 (UniProtKB/Swiss-Prot),   Q64550 (UniProtKB/Swiss-Prot),   Q5DT04 (UniProtKB/TrEMBL),   Q547Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046507   ⟸   ENSRNOT00000045163
Ensembl Acc Id: ENSRNOP00000062958   ⟸   ENSRNOT00000063853
Ensembl Acc Id: ENSRNOP00000075547   ⟸   ENSRNOT00000071003
Ensembl Acc Id: ENSRNOP00000070501   ⟸   ENSRNOT00000077416

Name Modeler Protein Id AA Range Protein Structure
AF-Q64550-F1-model_v2 AlphaFold Q64550 1-535 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696846
Promoter ID:EPDNEW_R7370
Type:multiple initiation site
Name:Ugt1a7c_3
Description:UDP glucuronosyltransferase 1 family, polypeptide A7C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7366  EPDNEW_R7367  EPDNEW_R7368  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0995,295,686 - 95,295,746EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-26816 BioCyc
Ensembl Genes ENSRNOG00000018740 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025045.7 UniProtKB/Swiss-Prot
  ENSRNOT00000153691 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report rno:24861 UniProtKB/Swiss-Prot
NCBI Gene 24861 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1 UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PharmGKB UGT1A1 RGD
PhenoGen Ugt1a1 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018740 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt F7EKA4_RAT UniProtKB/TrEMBL
  Q547Q8 ENTREZGENE, UniProtKB/TrEMBL
  Q5DT04 ENTREZGENE, UniProtKB/TrEMBL
  Q64550 ENTREZGENE
  Q64635 ENTREZGENE
  UD11_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64635 UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt1a1  UDP glucuronosyltransferase family 1 member A1  Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ugt1a1  UDP glucuronosyltransferase 1 family, polypeptide A1  Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ugt1a1  UDP glycosyltransferase 1 family, polypeptide A1  Ugt1  UDP-glucuronosyltransferase 1 family, member 1  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt1  UDP-glucuronosyltransferase 1 family, member 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in liver hepatocytes 70480
gene_process functions in glucuronidation and excretion of bilirubin 70480
gene_transcript each variable exon is preceded by a promoter region which may be used for tissue specific gene expression 1302827