RGD Reference Report - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - Rat Genome Database

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Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

Authors: Li, Y  Wang, K  Yu, T  Zhao, B  Li, J  Zhang, S  Zhao, X 
Citation: Li Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2001 Jun;9(3):172-4.
RGD ID: 2317026
Pubmed: PMID:11412396   (View Abstract at PubMed)

OBJECTIVE: To investigate whether ethanol and isopentanol could modulate the drug metabolism by regulating uridine diphosphate glucuronosyltransferase (UGT) expression in rat livers and cultured rat hepatocytes. METHODS: Rat livers and primary rat hepatocyte cultures have been used to determine the mRNA levels of five UGT isoenzymes following treatment with ethanol and isopentanol. RESULTS: Following treatment with alcohol in rats, UGT1A1 mRNA and UGT1A5 mRNA were increased to a mean of 177% and 166% of control, respectively. The mRNA levels of UGT2B1 and UGT2B3 were also increased in alcohol-treated rats to 178% and 132% of control, respectively. Incubation of hepatocytes with ethanol and isopentanol significantly increased the mRNA expression of UGT1A1, UGT1A5, UGT2B1 and UGT2B3 mRNA. CONCLUSIONS: The expression of UGT can be regulated by ethanol and isopentanol. As a result, chronic alcohol consumption may modify the metabolism of numerous endogenous and exogenous compounds, in particular some drugs, which are substrates of these UGT isoenzymes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to ethanol  IEP 2317026; 2317026; 2317026; 2317026 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ugt1a1  (UDP glucuronosyltransferase family 1 member A1)
Ugt1a5  (UDP glucuronosyltransferase family 1 member A5)
Ugt2b1  (UDP glucuronosyltransferase 2 family, polypeptide B1)
Ugt2b15  (UDP glucuronosyltransferase family 2 member B15)


Additional Information