Gene:	Mapk10 ( Rattus norvegicus ) mitogen activated protein kinase 10
Description:	a stress-activated protein kinase
Synonyms:	Jnk3; Serk2; SAPKC; SAPb; Stress activated protein kinase beta;
ArrayIDs:	5807682; 5760106; 1369102_at; 5837850; 5941829; 6072167; 6505138; L27128_at; 6356667; 1377059_at; A_43_P11572; 5859926; 5676075; 6248339; 6630596; 5880773; 6113212; 6054120; 5968097; A_44_P482281; 6556630; 6017655; 6225405; 6364208; GE19978; 5988101;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: MAPK10     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Mapk10     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Mapk10 genome assembly 3.1 14 7719594 - 8010694     Rat Celera Assembly 14 6636702 - 6918635     RGSC genome assembly v3.4 14 7719595 - 8010694     Cytogenetic 14 p22 Mus musculus Mapk10 Mouse genome assembly build 36.1 5 103336967 - 103640353     Cytogenetic 5 5 E5 Homo sapiens MAPK10 human genome assembly 4 87294810 - 87632922     Human genome assembly build 36.2 4 87156656 - 87593307     Cytogenetic 4 q22.1-q23   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology JUN kinase activity,  protein binding,  nucleotide binding ...  (details...)
Biological Process	Gene Ontology JNK cascade,  protein amino acid phosphorylation (details...)
Cellular Component	Gene Ontology mitochondrion,  cytoplasm,  plasma membrane (details...)
Pathway	Ontology mitogen activated protein kinase signaling pathway,  c-Jun N-terminal kinases MAPK signaling pathway,  Wnt signaling pathway ...  (details...)
Regulation	Note Reference activated by cellular stress, sphingomyelinase and tumour necrosis factor (TNF)-alpha 729029
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: MAPK IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI0001B7A678 IPI UNIPARC: UPI0000DC1312 IPI UNIPARC: UPI000012F17C IPI KEGG Report: rno:25272 ENTREZGENE HomoloGene Group ID: 56439 ENTREZGENE Germonline: 3663 Pfam: Pkinase IPI KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04622 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE InterPro: Kinase-like_dom. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: MAP_kinase_CS. IPI InterPro: JNK_MAPK. IPI Ensembl Protein: ENSRNOP00000057862 IPI Ensembl Protein: ENSRNOP00000060904 IPI Ensembl Protein: ENSRNOP00000002855 IPI IPI: IPI00780268 IPI IPI: IPI00191810 IPI IPI: IPI00952018 IPI Entrez Gene: Mapk10 ENTREZGENE TIGR: TC235746 UniProt: MK10_RAT IPI UniProt: B0VXR6_RAT IPI Ensembl Genes: ENSRNOG00000002079 IPI RatMap: 41156 ENTREZGENE Superfamily-SCOP: Kinase_like IPI PRINTS: JNKMAPKINASE. IPI
Sequences	Nucleotide: CH474022 Get FASTA Search GEO Profiles Nucleotide: L27128 Get FASTA Search GEO Profiles Nucleotide: DQ377224 Get FASTA Search GEO Profiles Nucleotide: NM_012806 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_036938 Get FASTA Protein: EDL99526 Get FASTA Protein: EDL99527 Get FASTA Protein: ABD24063 Get FASTA Protein: AAA42110 Get FASTA Protein: P49187 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 9911
References
Curated References	10 references in RGD related to Mapk10
Other References	8 other references at PubMed related to Mapk10
Database Information
RGD ID	3663
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-APR-03: Mapk10 mitogen activated protein kinase 10 Serk2 Stress activated protein kinase beta APPROVED Symbol and Name updated 629477 10-JUN-02: Serk2 Stress activated protein kinase beta APPROVED Symbol and Name status set to approved 70586