MAPK10 (mitogen-activated protein kinase 10) - Rat Genome Database

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Gene: MAPK10 (mitogen-activated protein kinase 10) Pan paniscus
Analyze
Symbol: MAPK10
Name: mitogen-activated protein kinase 10
RGD ID: 12042006
Description: ENCODES a protein that exhibits ATP binding (ortholog); JUN kinase activity (ortholog); INVOLVED IN cellular hyperosmotic response (ortholog); JNK cascade (ortholog); JUN phosphorylation (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); congestive heart failure (ortholog); Generalized Epilepsy (ortholog); FOUND IN glutamatergic synapse (ortholog); mitochondrion (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2384,040,153 - 84,470,878 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1484,304,836 - 84,732,991 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0478,326,129 - 78,756,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1489,056,754 - 89,392,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl489,059,579 - 89,392,196 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2384,040,153 - 84,470,878 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1484,304,836 - 84,732,991 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0478,326,129 - 78,756,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1489,056,754 - 89,392,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl489,059,579 - 89,392,196 (-)Ensemblpanpan1.1panPan2
MAPK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38486,010,405 - 86,594,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl485,990,007 - 86,594,625 (-)EnsemblGRCh38hg38GRCh38
GRCh37486,931,558 - 87,374,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36487,156,656 - 87,593,307 (-)NCBINCBI36Build 36hg18NCBI36
Build 34487,294,810 - 87,632,922NCBI
Celera484,225,414 - 84,570,629 (-)NCBICelera
Cytogenetic Map4q21.3NCBI
HuRef482,680,152 - 83,118,708 (-)NCBIHuRef
CHM1_1486,912,970 - 87,350,773 (-)NCBICHM1_1
T2T-CHM13v2.0489,339,877 - 89,923,587 (-)NCBIT2T-CHM13v2.0
Mapk10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395103,056,413 - 103,359,200 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5103,055,814 - 103,359,200 (-)EnsemblGRCm39 Ensembl
GRCm385102,908,547 - 103,212,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5102,907,948 - 103,211,334 (-)EnsemblGRCm38mm10GRCm38
MGSCv375103,336,967 - 103,640,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365103,152,671 - 103,451,379 (-)NCBIMGSCv36mm8
Celera5100,221,882 - 100,523,871 (-)NCBICelera
Cytogenetic Map5E5NCBI
cM Map549.61NCBI
Mapk10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,802,247 - 7,094,103 (+)NCBIGRCr8
mRatBN7.2146,497,662 - 6,790,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,497,707 - 6,786,201 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx146,475,683 - 6,751,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,775,937 - 8,052,130 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0146,467,375 - 6,743,050 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,079,955 - 8,371,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,080,275 - 8,368,254 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,053,697 - 8,344,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,719,595 - 8,010,694 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,719,594 - 8,010,694 (+)NCBI
Celera146,636,411 - 6,919,118 (+)NCBICelera
Cytogenetic Map14p22NCBI
Mapk10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554743,624,679 - 3,772,458 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554743,451,656 - 3,772,405 (+)NCBIChiLan1.0ChiLan1.0
MAPK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,584,437 - 9,889,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,575,492 - 9,884,325 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3232,059,481 - 32,299,296 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,607,730 - 9,912,898 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,597,455 - 9,907,345 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,698,411 - 10,025,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,545,360 - 9,851,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03230,098,318 - 30,403,778 (+)NCBIUU_Cfam_GSD_1.0
Mapk10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052852,447,490 - 2,761,815 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936896230,494 - 540,071 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936896228,908 - 539,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8132,298,299 - 132,776,820 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18132,445,818 - 132,751,575 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28141,972,691 - 142,138,440 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1734,394,600 - 34,725,658 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl734,399,544 - 34,564,212 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603713,051,033 - 13,392,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248722,461,362 - 2,825,161 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248722,460,308 - 2,830,569 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063377   ⟹   ENSPPAP00000040461
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,059,579 - 89,231,867 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063396   ⟹   ENSPPAP00000040480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,060,521 - 89,231,867 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063425   ⟹   ENSPPAP00000040509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,061,691 - 89,392,196 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063458   ⟹   ENSPPAP00000040541
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,061,691 - 89,231,860 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063465   ⟹   ENSPPAP00000040548
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,061,691 - 89,196,943 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063480   ⟹   ENSPPAP00000040563
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,061,822 - 89,387,136 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063481   ⟹   ENSPPAP00000040564
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,069,749 - 89,231,860 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063490   ⟹   ENSPPAP00000040573
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,104,706 - 89,145,355 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000063492   ⟹   ENSPPAP00000040575
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl489,136,547 - 89,231,860 (-)Ensembl
RefSeq Acc Id: XM_003811245   ⟹   XP_003811293
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,377,790 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,639,907 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,663,752 (-)NCBI
PanPan1.1489,056,754 - 89,392,758 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003811246   ⟹   XP_003811294
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,377,791 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,639,908 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,663,753 (-)NCBI
PanPan1.1489,056,754 - 89,392,972 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963618   ⟹   XP_008961866
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,375,497 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,637,598 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,661,340 (-)NCBI
PanPan1.1489,060,935 - 89,390,257 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963620   ⟹   XP_008961868
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,376,050 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,638,154 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,661,970 (-)NCBI
PanPan1.1489,060,935 - 89,390,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963621   ⟹   XP_008961869
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,216,562 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,478,741 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,663,755 (-)NCBI
PanPan1.1489,056,754 - 89,392,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963625   ⟹   XP_008961873
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,216,562 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,478,741 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,663,754 (-)NCBI
PanPan1.1489,056,754 - 89,392,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008963626   ⟹   XP_008961874
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,216,562 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,478,741 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,663,756 (-)NCBI
PanPan1.1489,059,579 - 89,392,980 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958876   ⟹   XP_034814767
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,470,844 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,732,954 (-)NCBI
Mhudiblu_PPA_v0478,326,129 - 78,756,794 (-)NCBI
RefSeq Acc Id: XM_055111579   ⟹   XP_054967554
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,470,878 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,732,991 (-)NCBI
RefSeq Acc Id: XM_055111580   ⟹   XP_054967555
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2384,040,153 - 84,377,790 (-)NCBI
NHGRI_mPanPan1484,304,836 - 84,639,908 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008961874   ⟸   XM_008963626
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CES1 (UniProtKB/TrEMBL),   A0A2R9CF85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961869   ⟸   XM_008963621
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961873   ⟸   XM_008963625
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CF85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003811294   ⟸   XM_003811246
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003811293   ⟸   XM_003811245
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CEV4 (UniProtKB/TrEMBL),   A0A2R9CF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961868   ⟸   XM_008963620
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961866   ⟸   XM_008963618
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CF30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034814767   ⟸   XM_034958876
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CF30 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000040480   ⟸   ENSPPAT00000063396
RefSeq Acc Id: ENSPPAP00000040461   ⟸   ENSPPAT00000063377
RefSeq Acc Id: ENSPPAP00000040548   ⟸   ENSPPAT00000063465
RefSeq Acc Id: ENSPPAP00000040541   ⟸   ENSPPAT00000063458
RefSeq Acc Id: ENSPPAP00000040509   ⟸   ENSPPAT00000063425
RefSeq Acc Id: ENSPPAP00000040563   ⟸   ENSPPAT00000063480
RefSeq Acc Id: ENSPPAP00000040564   ⟸   ENSPPAT00000063481
RefSeq Acc Id: ENSPPAP00000040575   ⟸   ENSPPAT00000063492
RefSeq Acc Id: ENSPPAP00000040573   ⟸   ENSPPAT00000063490
RefSeq Acc Id: XP_054967554   ⟸   XM_055111579
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054967555   ⟸   XM_055111580
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CEV4 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042829 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063377.1 UniProtKB/TrEMBL
  ENSPPAT00000063396.1 UniProtKB/TrEMBL
  ENSPPAT00000063425.1 UniProtKB/TrEMBL
  ENSPPAT00000063458.1 UniProtKB/TrEMBL
  ENSPPAT00000063465.1 UniProtKB/TrEMBL
  ENSPPAT00000063481.1 UniProtKB/TrEMBL
  ENSPPAT00000063490.1 UniProtKB/TrEMBL
  ENSPPAT00000063492.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report pps:100984173 UniProtKB/TrEMBL
NCBI Gene MAPK10 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 10 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS JNKMAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9CES1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CEV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CEZ5_PANPA UniProtKB/TrEMBL
  A0A2R9CF30 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CF54_PANPA UniProtKB/TrEMBL
  A0A2R9CF85 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CHP0_PANPA UniProtKB/TrEMBL
  A0A2R9CHR8_PANPA UniProtKB/TrEMBL