Ccl3 (C-C motif chemokine ligand 3) - Rat Genome Database

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Gene: Ccl3 (C-C motif chemokine ligand 3) Rattus norvegicus
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Symbol: Ccl3
Name: C-C motif chemokine ligand 3
RGD ID: 3647
Description: Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3); PARTICIPATES IN interleukin-12 signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 3; chemokine (C-C motif) ligand 3; macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; MIP-1-alpha; MIP-1a; Scya3; small inducible cytokine A3; small-inducible cytokine A3
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp300 Eau9
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,948,889 - 68,950,439 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,948,889 - 68,950,439 (-)EnsemblGRCr8
mRatBN7.21068,451,388 - 68,452,938 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,451,388 - 68,452,938 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1073,071,388 - 73,072,938 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,576,405 - 72,577,955 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01068,040,825 - 68,042,375 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,869,516 - 70,871,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,869,513 - 70,871,066 (-)Ensemblrn6Rnor6.0
Rnor_5.01070,501,119 - 70,502,669 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,744,559 - 71,746,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,390,853 - 67,392,403 (-)NCBICelera
RGSC_v3.11071,758,928 - 71,760,479 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(Z)-ligustilide  (ISO)
1,4-benzoquinone  (ISO)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (ISO)
abexinostat  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
albendazole  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (ISO)
AM6545  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amprenavir  (ISO)
Ancriviroc  (ISO)
antimycin A  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
atazanavir sulfate  (ISO)
ATP  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
betamethasone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
budesonide  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium silicate  (EXP)
calcium(0)  (ISO)
cannabigerol  (EXP)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carrageenan  (ISO)
catechol  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorobenzene  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
citronellol  (EXP)
cobalt atom  (EXP)
cocaine  (ISO)
cordycepin  (ISO)
corn oil  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
dapsone  (ISO)
deoxynivalenol  (ISO)
dequalinium  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dihydroxyacetone  (ISO)
diiodine  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dobutamine  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
emetine  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fludrocortisone  (ISO)
flumequine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
graphite  (EXP,ISO)
heme b  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
indinavir  (ISO)
indometacin  (ISO)
iodixanol  (ISO)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lidocaine  (EXP)
lipid As  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lopinavir  (ISO)
losartan  (EXP)
malathion  (ISO)
maraviroc  (ISO)
meclocycline  (ISO)
MeIQx  (ISO)
menadione  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (ISO)
mercury(0)  (EXP,ISO)
mesalamine  (ISO)
metam  (ISO)
methadone  (EXP)
methionine sulfoximine  (ISO)
methotrexate  (ISO)
methyl salicylate  (ISO)
Methylbenzethonium chloride  (ISO)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
naproxen  (EXP)
naringin  (ISO)
nelfinavir  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
NSC 23766  (ISO)
o-anisidine  (ISO)
octadecanoic acid  (ISO)
oxaliplatin  (EXP)
oxytetracycline  (ISO)
ozone  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (ISO)
parathion  (EXP)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (EXP)
phenanthridone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisolone  (ISO)
progesterone  (EXP)
propanal  (ISO)
propidium  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rifaximin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
roflumilast  (ISO)
rolipram  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
styrene  (ISO)
succimer  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
terameprocol  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
thiostrepton  (ISO)
tigecycline  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (IBA)
astrocyte cell migration  (IEA,ISO,ISS)
calcium ion transport  (ISO,ISS)
calcium-mediated signaling  (ISO,ISS)
cell activation  (ISO,ISS)
cell chemotaxis  (IBA)
cell-cell signaling  (ISO,ISS)
cellular response to interleukin-1  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
chemokine-mediated signaling pathway  (IBA)
chemotaxis  (IEA,ISO,ISS)
cytoskeleton organization  (ISO,ISS)
eosinophil chemotaxis  (ISO,ISS)
eosinophil degranulation  (ISO,ISS)
exocytosis  (ISO,ISS)
granulocyte chemotaxis  (ISO,ISS)
host-mediated suppression of viral transcription  (ISS)
immune response  (IEA)
inflammatory response  (IBA,IEA,ISO)
intracellular calcium ion homeostasis  (ISO,ISS)
leukocyte chemotaxis  (IDA)
lymphocyte chemotaxis  (ISO,ISS)
macrophage chemotaxis  (IEA,ISO,ISS)
MAPK cascade  (ISO)
monocyte chemotaxis  (ISO,ISS)
negative regulation of bone mineralization  (ISO)
negative regulation of gene expression  (ISO,ISS)
negative regulation of osteoclast differentiation  (ISO,ISS)
neutrophil chemotaxis  (IDA,ISO)
osteoblast differentiation  (ISO,ISS)
positive chemotaxis  (IEA)
positive regulation of calcium ion transport  (ISO,ISS)
positive regulation of calcium-mediated signaling  (ISO,ISS)
positive regulation of cell migration  (IBA,ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of inflammatory response  (IEA,ISO,ISS)
positive regulation of interleukin-1 beta production  (IEA,ISO,ISS)
positive regulation of natural killer cell chemotaxis  (ISO,ISS)
positive regulation of neuron apoptotic process  (IEA,ISO,ISS)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
regulation of behavior  (ISO,ISS)
regulation of cell shape  (IEA,ISO,ISS)
regulation of programmed cell death  (IMP)
regulation of sensory perception of pain  (ISO,ISS)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO,ISS)
response to cholesterol  (ISO,ISS)
response to toxic substance  (ISO,ISS)
response to xenobiotic stimulus  (IEP)
signaling  (ISO,ISS)
T cell chemotaxis  (ISO,ISS)

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (ISO,ISS)
extracellular region  (IEA,ISO)
extracellular space  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli. Bennett MR, etal., Nephron Exp Nephrol. 2007;107(1):e30-40. Epub 2007 Aug 6.
2. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
3. Expression and regulation of the macrophage inflammatory protein-1 alpha gene by nicotine in rat alveolar macrophages. Chong IW, etal., Eur Cytokine Netw 2002 Apr-Jun;13(2):242-9.
4. An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Codullo V, etal., Ann Rheum Dis. 2011 Jun;70(6):1115-21. Epub 2011 Feb 1.
5. Probabilistic (Bayesian) modeling of gene expression in transplant glomerulopathy. Elster EA, etal., J Mol Diagn. 2010 Sep;12(5):653-63. doi: 10.2353/jmoldx.2010.090101. Epub 2010 Aug 5.
6. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Fisher NC, etal., Gut. 1999 Sep;45(3):416-20. doi: 10.1136/gut.45.3.416.
7. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Time course of chemokine expression in acutely rejecting rat kidneys. Grau V, etal., Transplant Proc 1999 May;31(3):1571.
12. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
13. Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. Huang L, etal., Exp Neurol. 2018 Feb;300:41-50. doi: 10.1016/j.expneurol.2017.10.024. Epub 2017 Oct 27.
14. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
15. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1alpha and VEGF. Kaur J and Sanyal SN, Mol Carcinog. 2011 Jan 25. doi: 10.1002/mc.20736.
16. Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome. Keepers TR, etal., Infect Immun. 2007 Mar;75(3):1229-36. Epub 2007 Jan 12.
17. Early up-regulation of chemokine expression in fulminant hepatic failure. Leifeld L, etal., J Pathol. 2003 Mar;199(3):335-44. doi: 10.1002/path.1298.
18. Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study. Liangos O, etal., Biomarkers. 2010 Aug;15(5):436-45.
19. Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. Manczak M, etal., J Autoimmun. 2002 Jun;18(4):259-70.
20. Expression of the chemokine receptor CCR1 in human renal allografts. Mayer V, etal., Nephrol Dial Transplant. 2007 Jun;22(6):1720-9. Epub 2007 Feb 13.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Influence of irbesartan on the urinary excretion of cytokines in patients with chronic kidney disease. Ni J, etal., Chin Med J (Engl). 2012 Mar;125(6):1147-52.
24. Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients. Nordoy I, etal., J Infect Dis. 1999 Jul;180(1):195-8.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats. Peake JM, etal., Mol Nutr Food Res. 2011 Mar;55(3):400-10. doi: 10.1002/mnfr.201000195. Epub 2010 Oct 28.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. Rachid MA, etal., Microbes Infect. 2006 Jul;8(8):2113-9. Epub 2006 Jun 6.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. RANTES release contributes to the protective action of PACAP38 against sodium nitroprusside in cortical neurons. Sanchez A, etal., Neuropeptides. 2009 Aug;43(4):315-20. Epub 2009 Jun 3.
34. [The behavior of intra-leukocyte peroxidase after irradiation with radar microwaves in intra-articular exudates]. Santolini BM, etal., Minerva Ortop. 1971 Dec;22(12):459-62.
35. Macrophage-inflammatory protein-1alpha regulates preosteoclast differentiation in vitro. Scheven BA, etal., Biochem Biophys Res Commun. 1999 Jan 27;254(3):773-8.
36. Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats. Shanley TP, etal., J Immunol 1995 May 1;154(9):4793-802.
37. Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages. Shi MM, etal., Biochem Biophys Res Commun 1995 Jun 6;211(1):289-95.
38. Rat macrophage inflammatory protein-1alpha, a CC chemokine, acts as a neutrophil chemoattractant in vitro and in vivo. Takano K, etal., Inflammation. 1999 Oct;23(5):411-24.
39. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. Microarray analysis of glomerular gene expression in murine lupus nephritis. Teramoto K, etal., J Pharmacol Sci. 2008 Jan;106(1):56-67. Epub 2008 Jan 11.
41. CCR5 deficiency aggravates crescentic glomerulonephritis in mice. Turner JE, etal., J Immunol. 2008 Nov 1;181(9):6546-56.
42. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
43. Sustained monocyte activation in clinical remission of systemic vasculitis. Wikman A, etal., Inflammation. 2008 Dec;31(6):384-90. doi: 10.1007/s10753-008-9089-8.
44. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. Wu Y, etal., J Immunol. 2008 Nov 1;181(9):6384-93.
45. Deletion of macrophage-inflammatory protein 1 alpha retards neurodegeneration in Sandhoff disease mice. Wu YP and Proia RL, Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8425-30. Epub 2004 May 20.
46. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
47. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
48. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
49. Characterization of the expression of macrophage inflammatory protein-1alpha (MIP-1alpha) and C-C chemokine receptor 5 (CCR5) after kainic acid-induced status epilepticus (SE) in juvenile rats. Zhu XB, etal., Neuropathol Appl Neurobiol. 2012 Oct;38(6):602-16. doi: 10.1111/j.1365-2990.2012.01251.x.
Additional References at PubMed
PMID:7545673   PMID:7594543   PMID:8607872   PMID:8699119   PMID:9407497   PMID:10072545   PMID:10660125   PMID:10679098   PMID:10706735   PMID:10734056   PMID:10841574   PMID:12032188  
PMID:12899200   PMID:14583384   PMID:15001559   PMID:15764707   PMID:16804970   PMID:17218081   PMID:18272692   PMID:19139201   PMID:19523456   PMID:20041150   PMID:20167378   PMID:20959807  
PMID:21051067   PMID:21147091   PMID:21162127   PMID:21317391   PMID:21403648   PMID:21535896   PMID:21731074   PMID:21784977   PMID:22791363   PMID:22960654   PMID:23460747   PMID:24589480  
PMID:25127716   PMID:26178913   PMID:26550961   PMID:28677732   PMID:32306124  


Genomics

Comparative Map Data
Ccl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,948,889 - 68,950,439 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,948,889 - 68,950,439 (-)EnsemblGRCr8
mRatBN7.21068,451,388 - 68,452,938 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,451,388 - 68,452,938 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1073,071,388 - 73,072,938 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,576,405 - 72,577,955 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01068,040,825 - 68,042,375 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,869,516 - 70,871,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,869,513 - 70,871,066 (-)Ensemblrn6Rnor6.0
Rnor_5.01070,501,119 - 70,502,669 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,744,559 - 71,746,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1067,390,853 - 67,392,403 (-)NCBICelera
RGSC_v3.11071,758,928 - 71,760,479 (-)NCBI
Cytogenetic Map10q26NCBI
CCL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,088,256 - 36,090,143 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1736,088,256 - 36,090,169 (-)Ensemblhg38GRCh38
GRCh371734,415,602 - 34,417,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,439,715 - 31,441,619 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341731,439,717 - 31,441,600NCBI
Celera1731,325,155 - 31,327,059 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,600,149 - 30,602,053 (-)NCBIHuRef
CHM1_11734,479,827 - 34,481,731 (-)NCBICHM1_1
T2T-CHM13v2.01737,036,142 - 37,038,029 (-)NCBIT2T-CHM13v2.0
Ccl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,538,669 - 83,540,204 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,538,670 - 83,540,181 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381183,647,843 - 83,649,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,647,844 - 83,649,355 (-)Ensemblmm10GRCm38
MGSCv371183,461,345 - 83,462,880 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361183,464,040 - 83,465,552 (-)NCBIMGSCv36mm8
Celera1193,252,227 - 93,253,762 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.04NCBI
LOC480600
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,708,561 - 37,710,209 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,676,966 - 37,710,209 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha936,932,297 - 36,933,945 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0938,518,874 - 38,520,522 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,487,223 - 38,520,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,300,458 - 37,302,106 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,587,667 - 37,589,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,674,911 - 37,676,559 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CCL3L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,491,914 - 39,493,774 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11239,491,999 - 39,493,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,061,465 - 41,062,811 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242767
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,887,799 - 29,897,664 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1629,887,883 - 29,897,544 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666075412,551 - 414,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl3
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000015139
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
AI323804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,451,655 - 68,451,752 (+)MAPPERmRatBN7.2
Rnor_6.01070,869,784 - 70,869,880NCBIRnor6.0
Rnor_5.01070,501,387 - 70,501,483UniSTSRnor5.0
RGSC_v3.41071,744,827 - 71,744,923UniSTSRGSC3.4
Celera1067,391,121 - 67,391,217UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 67 157 91 90 59 92 59 6 352 189 10 137 81 89 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000015139   ⟹   ENSRNOP00000015139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,948,889 - 68,950,439 (-)Ensembl
mRatBN7.2 Ensembl1068,451,388 - 68,452,938 (-)Ensembl
Rnor_6.0 Ensembl1070,869,513 - 70,871,066 (-)Ensembl
RefSeq Acc Id: NM_013025   ⟹   NP_037157
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,948,889 - 68,950,439 (-)NCBI
mRatBN7.21068,451,388 - 68,452,938 (-)NCBI
Rnor_6.01070,869,516 - 70,871,066 (-)NCBI
Rnor_5.01070,501,119 - 70,502,669 (-)NCBI
RGSC_v3.41071,744,559 - 71,746,109 (-)RGD
Celera1067,390,853 - 67,392,403 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA80608 (Get FASTA)   NCBI Sequence Viewer  
  AAA96498 (Get FASTA)   NCBI Sequence Viewer  
  ABL63433 (Get FASTA)   NCBI Sequence Viewer  
  ABL63434 (Get FASTA)   NCBI Sequence Viewer  
  EDM05492 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015139
  ENSRNOP00000015139.1
GenBank Protein P50229 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037157   ⟸   NM_013025
- Peptide Label: precursor
- UniProtKB: A1EC87 (UniProtKB/Swiss-Prot),   P50229 (UniProtKB/Swiss-Prot),   A6HHI7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015139   ⟸   ENSRNOT00000015139
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50229-F1-model_v2 AlphaFold P50229 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697536
Promoter ID:EPDNEW_R8061
Type:single initiation site
Name:Ccl3_1
Description:C-C motif chemokine ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,871,077 - 70,871,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3647 AgrOrtholog
BioCyc Gene G2FUF-23864 BioCyc
Ensembl Genes ENSRNOG00000011205 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015139 ENTREZGENE
  ENSRNOT00000015139.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25542 UniProtKB/Swiss-Prot
NCBI Gene 25542 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 3 UniProtKB/Swiss-Prot
  PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl3 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011205 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
TIGR TC213067
UniProt A1EC87 ENTREZGENE
  A6HHI7 ENTREZGENE, UniProtKB/TrEMBL
  CCL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1EC87 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl3  C-C motif chemokine ligand 3  Ccl3  chemokine (C-C motif) ligand 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ccl3  chemokine (C-C motif) ligand 3   Scya3  small inducible cytokine A3  Symbol and Name updated 629477 APPROVED
2002-06-10 Scya3  small inducible cytokine A3      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Scya3  Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)      Name withdrawn 67952 WITHDRAWN
2001-07-23 Scya3  small inducible cytokine A3      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED