Gene:	Ppp3ca ( Rattus norvegicus ) protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
Description:	catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase; mediates activities of transcription factors and ion channels; involved in regulation of T-cell activation
Synonyms:	calcineurin subunit A alpha; protein phosphatase 3, catalytic subunit, alpha isoform; Calna1;
ArrayIDs:	5993972; 6734214; D90035_s_at; 6100331; 1398506_at; 6194275; 1368277_at; 1373479_at; A_43_P11790; 6073220; 6017803; 5976982; 5792245; 6151961; 6064013; 6465462; rc_AI043636_at; 5801462; 5722716; 6270877; 5804439; 6284891; 6406764; 5707923; 6343445;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PPP3CA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ppp3ca     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ppp3ca genome assembly 3.1 2 234116915 - 234395972     Rat Celera Assembly 2 217359756 - 217630340     RGSC genome assembly v3.4 2 234130176 - 234409232     Cytogenetic 2 q43 Mus musculus Ppp3ca Mouse genome assembly build 36.1 3 136333734 - 136598743     Cytogenetic 3 3 G3 Homo sapiens PPP3CA human genome assembly 4 102301764 - 102625531     Human genome assembly build 36.2 4 102163610 - 102487376     Cytogenetic 4 q21-q24   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference serine/threonine phosphatase 628556 Gene Ontology protein serine/threonine phosphatase activity,  protein binding,  phosphoprotein phosphatase activity ...  (details...)
Biological Process	Note Reference may play an important role in glomerular hypertrophy and extracellular matrix accumulation in deabetic nephropathy 628556 mediates T cell signal transduction 628556 mediates hypertropic response of muscle cells 628556 catalytic and calmodulin binding phosphatase subunit is activated by intracellular calcium anions 628398 increases phosphatase activity by binding to calcium and calmodulin   Gene Ontology response to amphetamine,  regulation of synaptic transmission,  G1/S transition of mitotic cell cycle ...  (details...)
Cellular Component	Gene Ontology nucleus,  mitochondrion,  soluble fraction ...  (details...)
Disease	Note Reference inhibition results in whole kidney hypertrophy and abolishes glomerular hypertrophy in diabetic rats 628556 Ontology Hypertrophy, Right Ventricular,  Hypertrophy, Left Ventricular,  Cardiomegaly ...  (details...)
Phenotype	Ontology cardiac hypertrophy,  abnormal long term object recognition memory (details...)
Pathway	Ontology mitogen activated protein kinase signaling pathway,  Wnt signaling pathway,  calcineurin signaling pathway ...  (details...)
Protein	Note Reference alpha:beta and CaN:substrate ratios may determine the levels of phosphatase activity toward specific substrates 729536 heterodimer of 58-64 kDa 628398
Regulation	Note Reference activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) 628556
Drugs	Note Reference cyclosporin acts as a inhibitor partially blocking the muscle size 628556 cyclosporin A affects protein accumulation and activity 628556
External Links
Databases	DATABASE ID SOURCE SMART: PP2Ac IPI PROSITE: SER_THR_PHOSPHATASE IPI UNIPARC: UPI00000E721C IPI UNIPARC: UPI0000028792 IPI KEGG Report: rno:24674 ENTREZGENE HomoloGene Group ID: 55497 ENTREZGENE Germonline: 3382 Pfam: Metallophos IPI KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE KEGG Pathway: 05014 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: Ser/Thr-sp_prot-phosphatase. IPI InterPro: M-pesterase. IPI IPI: IPI00559849 IPI IPI: IPI00201410 IPI Ensembl Protein: ENSRNOP00000013305 IPI Ensembl Protein: ENSRNOP00000049674 IPI Entrez Gene: Ppp3ca ENTREZGENE UniProt: PP2BA_RAT IPI UniProt: PP2BA_RAT IPI Ensembl Genes: ENSRNOG00000009882 IPI RatMap: 34319 ENTREZGENE PANTHER: T_phtase_apaH IPI PRINTS: STPHPHTASE. IPI
Sequences	Nucleotide: AY724517 Get FASTA Search GEO Profiles Nucleotide: M29275 Get FASTA Search GEO Profiles Nucleotide: D90035 Get FASTA Search GEO Profiles Nucleotide: X57115 Get FASTA Search GEO Profiles Nucleotide: CH473952 Get FASTA Search GEO Profiles Nucleotide: NM_017041 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: CAA40398 Get FASTA Protein: P63329 Get FASTA Protein: EDL82282 Get FASTA Protein: BAA14083 Get FASTA Protein: EDL82283 Get FASTA Protein: NP_058737 Get FASTA Protein: EDL82280 Get FASTA Protein: EDL82281 Get FASTA Protein: AAA40940 Get FASTA (View all 9 Protein Accessions)
Clusters	UniGene: 6866
References
Curated References	21 references in RGD related to Ppp3ca
Other References	21 other references at PubMed related to Ppp3ca
Database Information
RGD ID	3382
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-DEC-08: Ppp3ca protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 24-OCT-01: Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform APPROVED Name updated to reflect Human and Mouse nomenclature 68913