Pak3 Rat Gene (p21 protein (Cdc42/Rac)-activated kinase 3)

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Keyword

Gene:
Pak3 ( Rattus norvegicus )
p21 protein (Cdc42/Rac)-activated kinase 3
Description: displays GTP-p21 mediated protein kinase activity
Synonyms: p21 (CDKN1A)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); beta-PAK;
ArrayIDs: A_43_P11979; 6263558; A_44_P208304; 5692938; U33314_at; 5926553; 5760596; 5706820; 6312625; 5918893; 5735272; 1368902_at; 6551649; 6596304; GE20586; 5936640; GE1278171; 6394776; 6269970; 5620977; 5770558; 6117542; 5996242; rc_AA997367_s_at; 5937484; 6495247;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: PAK3     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Pak3     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Pak3 genome assembly 3.1 X 34788282 - 34895562
Rat Celera Assembly X 106660352 - 106767478
RGSC genome assembly v3.4 X 34734814 - 34842093
Cytogenetic X q14
Mus musculus Pak3 Mouse genome assembly build 36.1 X 140127830 - 140226347
Cytogenetic X X F2
Homo sapiens PAK3 human genome assembly X 110145744 - 110270305
Human genome assembly build 36.2 X 110226256 - 110350816
Cytogenetic X q22.3

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Note Reference

phosphorylates protein serine/threonine residues 61685, 70317

Gene Ontology

protein kinase activity,  Rho GTPase binding,  nucleotide binding ... (details...)
Biological Process

Gene Ontology

protein kinase cascade,  multicellular organismal development,  protein amino acid phosphorylation (details...)
Product

Note Reference

mitogen activated protein kinase kinase kinase family member 61685, 70317

Protein

Note Reference

65 kDa 61685, 70317

External Links
Databases
DATABASE ID SOURCE
SMART: S_TKc IPI
SMART: PBD IPI
PROSITE: PROTEIN_KINASE_ATP IPI
PROSITE: PROTEIN_KINASE_DOM IPI
PROSITE: PROTEIN_KINASE_ST IPI
PROSITE: CRIB IPI
UNIPARC: UPI0000131225 IPI
UNIPARC: UPI0001B7AF56 IPI
UNIPARC: UPI000021E9CB IPI
KEGG Report: rno:29433 ENTREZGENE
HomoloGene Group ID: 55664 ENTREZGENE
Germonline: 3251
Pfam: Pkinase IPI
Pfam: PBD IPI
KEGG Pathway: 04360 ENTREZGENE
KEGG Pathway: 04510 ENTREZGENE
KEGG Pathway: 05211 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04810 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
InterPro: Kinase-like_dom. IPI
InterPro: Prot_kinase_cat_dom. IPI
InterPro: PAK_box_Rho_bd. IPI
InterPro: Protein_kinase_ATP_BS. IPI
InterPro: Se/Thr_prot_kinase-like_dom. IPI
InterPro: Ser/Thr_kinase_Pak-rel. IPI
InterPro: Ser/Thr_prot_kinase_AS. IPI
InterPro: Ser/Thr_prot_kinase_dom. IPI
IPI: IPI00390962 IPI
IPI: IPI00947961 IPI
IPI: IPI00327030 IPI
Ensembl Protein: ENSRNOP00000006459 IPI
Ensembl Protein: ENSRNOP00000029906 IPI
Ensembl Protein: ENSRNOP00000058831 IPI
Entrez Gene: Pak3 ENTREZGENE
TIGR: TC220638
UniProt: PAK3_RAT IPI
Ensembl Genes: ENSRNOG00000004676 IPI
Superfamily-SCOP: Kinase_like IPI
PANTHER: Pak_like IPI
Sequences
Nucleotide: U33314 Get FASTA Search GEO Profiles
Nucleotide: NM_019210 Get FASTA Search GEO Profiles
Nucleotide: CH474047 Get FASTA Search GEO Profiles
(View all 3 Nucleotide Accessions)
Protein: EDL85196 Get FASTA
Protein: EDL85197 Get FASTA
Protein: NP_062083 Get FASTA
Protein: AAC52268 Get FASTA
Protein: Q62829 Get FASTA
(View all 5 Protein Accessions)
Clusters
UniGene: 10128

References
Curated References
8 references in RGD related to Pak3

Other References
9 other references at PubMed related to Pak3

Database Information
RGD ID 3251
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

27-MAY-09: Pak3 p21 protein (Cdc42/Rac)-activated kinase 3 Pak3 p21 (CDKN1A)-activated kinase 3 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

10-JUN-02: Pak3 p21 (CDKN1A)-activated kinase 3 APPROVED Symbol and Name status set to approved 70586