Gene: PAK3 (p21 protein (Cdc42/Rac)-activated kinase 3)  Homo sapiens
Symbol: PAK3
Name: p21 protein (Cdc42/Rac)-activated kinase 3
Description: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-PAK; bPAK; CDKN1A; hPAK3; MRX30; MRX47; oligophrenin-3; OPHN3; OTTHUMP00000023855; OTTHUMP00000023856; OTTHUMP00000226621; OTTHUMP00000226622; p21 (CDKN1A)-activated kinase 3; p21-activated kinase 3; PAK-3; PAK3beta; serine/threonine-protein kinase PAK 3
Orthologs: Mus musculus : Pak3 (p21 protein (Cdc42/Rac)-activated kinase 3)  MGI
Rattus norvegicus : Pak3 (p21 protein (Cdc42/Rac)-activated kinase 3)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_1X110,167,583 - 110,444,231+NCBI
Human Genome Assembly HuRefX99,807,691 - 100,086,683+NCBI
Human Genome Assembly GRCh37X110,187,513 - 110,464,173+NCBI
Human Genome Assembly Build 36X110,226,256 - 110,350,816+NCBI
Human Cytogenetic MapXq23 NCBI
Human Genome AssemblyX110,145,744 - 110,270,305 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
  
More on PAK3
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
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Vista
Vista + UCSC

RGD Object Information
RGD ID: 731864
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-05-28
Status: ACTIVE



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