Pak3 (p21 (RAC1) activated kinase 3)

Gene: Pak3 (p21 (RAC1) activated kinase 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Pak3

Name:

p21 (RAC1) activated kinase 3

RGD ID:

12503914

Description:

ENCODES a protein that exhibits GTPase binding (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular response to organic cyclic compound (ortholog); dendritic spine development (ortholog); positive regulation of dendritic spine morphogenesis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); developmental and epileptic encephalopathy 36 (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); postsynaptic density (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein kinase PAK 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	83,329,189 - 83,584,851 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	4,079,103 - 4,188,774 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936499	4,079,127 - 4,328,580 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

developmental and epileptic encephalopathy 36 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

microcephaly (ISO)

non-syndromic X-linked intellectual disability (ISO)

non-syndromic X-linked intellectual disability 30 (ISO)

retinal degeneration (ISO)

schizophrenia (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonogenesis (IEA)

cellular response to organic cyclic compound (IEA,ISO)

dendrite development (IEA)

dendritic spine development (IEA,ISO)

dendritic spine morphogenesis (IEA)

intracellular signal transduction (IEA)

MAPK cascade (IEA)

positive regulation of dendritic spine morphogenesis (ISO)

positive regulation of DNA biosynthetic process (ISO)

positive regulation of fibroblast migration (ISO)

positive regulation of neuron apoptotic process (ISO)

protein phosphorylation (ISO)

regulation of actin cytoskeleton organization (IEA,ISO)

regulation of actin filament polymerization (IEA)

regulation of axonogenesis (IEA)

regulation of MAPK cascade (IEA)

regulation of neuron projection development (ISO)

regulation of postsynapse organization (IEA)

Cellular Component

cytoplasm (IEA)

endosome (ISO)

glutamatergic synapse (IEA,ISO)

postsynaptic density (IEA,ISO)

Molecular Function

ATP binding (IEA)

catalytic activity (IEA)

GTPase binding (ISO)

MAP kinase kinase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA,ISO)

small GTPase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	83,329,189 - 83,584,851 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936499	4,079,103 - 4,188,774 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936499	4,079,127 - 4,328,580 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	110,944,397 - 111,227,361 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	110,944,285 - 111,227,361 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	110,187,625 - 110,470,589 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	110,226,256 - 110,350,816 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	110,145,744 - 110,270,305	NCBI
Celera	X	110,667,132 - 110,943,790 (+)	NCBI		Celera
Cytogenetic Map	X	q23	NCBI
HuRef	X	99,807,691 - 100,086,683 (+)	NCBI		HuRef
CHM1_1	X	110,098,857 - 110,375,673 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	109,392,559 - 109,675,560 (+)	NCBI		T2T-CHM13v2.0

Pak3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	142,301,370 - 142,580,792 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	142,301,587 - 142,580,792 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	143,518,366 - 143,797,796 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	143,518,591 - 143,797,796 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	140,127,830 - 140,226,347 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	138,912,113 - 139,038,179 (+)	NCBI		MGSCv36	mm8
Celera	X	127,648,772 - 127,747,962 (+)	NCBI		Celera
Cytogenetic Map	X	F2	NCBI
cM Map	X	64.5	NCBI

Pak3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	111,912,967 - 112,171,037 (+)	NCBI		GRCr8
mRatBN7.2	X	107,116,308 - 107,374,342 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	107,260,898 - 107,368,314 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	109,398,307 - 109,506,166 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	112,897,991 - 113,005,870 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	110,452,018 - 110,559,437 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	114,784,452 - 115,042,683 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	114,929,029 - 115,036,669 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	113,227,320 - 113,495,881 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	34,734,814 - 34,842,093 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	34,788,282 - 34,895,562 (-)	NCBI
Celera	X	106,660,352 - 106,767,478 (+)	NCBI		Celera
Cytogenetic Map	X	q33	NCBI

Pak3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955490	4,545,457 - 4,662,862 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955490	4,538,933 - 4,833,851 (-)	NCBI	ChiLan1.0	ChiLan1.0

PAK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	110,434,847 - 110,720,349 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	110,438,452 - 110,723,954 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	100,060,647 - 100,345,491 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	110,672,659 - 110,804,815 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	110,672,664 - 110,797,992 (+)	Ensembl	panpan1.1		panPan2

PAK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	84,074,146 - 84,335,699 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	84,074,001 - 84,329,951 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	70,164,167 - 70,430,936 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	85,871,706 - 85,997,455 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	83,206,488 - 83,474,638 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	84,896,488 - 85,157,976 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	84,724,769 - 84,986,483 (+)	NCBI		UU_Cfam_GSD_1.0

PAK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	90,942,077 - 91,238,565 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	90,941,976 - 91,244,331 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PAK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	98,743,525 - 99,031,056 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	98,911,447 - 99,027,769 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	24,135,627 - 24,263,134 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pak3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624803	4,392,511 - 4,513,101 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624803	4,386,035 - 4,700,450 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021725207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284285	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040284317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000009470 ⟹ ENSSTOP00000008494

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936499	4,079,628 - 4,188,774 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000027433 ⟹ ENSSTOP00000015144

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936499	4,079,133 - 4,161,940 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000036341 ⟹ ENSSTOP00000026466

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936499	4,079,103 - 4,188,774 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000037475 ⟹ ENSSTOP00000028069

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936499	4,079,162 - 4,188,771 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000041499 ⟹ ENSSTOP00000032333

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936499	4,080,485 - 4,188,774 (-)	Ensembl

RefSeq Acc Id:

XM_005323348 ⟹ XP_005323405

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI
SpeTri2.0	NW_004936499	4,079,127 - 4,188,757 (-)	NCBI

Sequence:

show sequence

CTAGGGAGCGGTTGGCAAGCAAGAGCTCTATCGCGGGCGGGCAGCTGTGGCAGCGAACCGTTGG
GGATCTCACACTGGGGGCTACAGCTTTTCCCCTCCGGGAGTGAGTGAGCTGGGGCGGGAGAAGA
GCCGGGGAAGCGGGCTGGGCCCGGGGCTGCGGCTGCGGCCGCGGGGCTGCGGCTCCCCAGCCCC
GCCAGCCAGAACGTTTGGAGGTAGAGGAAAGGTCTTGACAGGGTGACTGGACCCGTGGCAGACT
CAAATCCAGGCCAACTGTATGGCTGTCTGAGGTCTTGGAACAGAAGGAGGTCCATTCCTGTTGG
TGACAACACTGTGGCCCTGTTCTGGGATGAGCAAGGTATAAAGGTTTCCCCCAAGCAAGACAAG
CTGAGTTCTTACATCTTGTGGCAGCTGTTGTGCTTAGTTTTGAGTCTGCCGGAGCTGAAGCCAG
CCCAGCCCCTTCTCATGGGCAGTTCCTACCTGTGCTGAGGTCCTGCAGCAGTGGCTGTGTGAGG
AGCTGTGAAATCAGTTACAACTGAAAATGTCTGACAGTCTGGATAATGAAGAAAAACCCCCAGC
TCCCCCATTGAGGATGAATAGTAACAATCGGGATTCTTCAGCACTCAACCACAGCTCCAAACCA
CTTCCCATGGCCCCTGAAGAGAAGAATAAGAAAGCCAGGCTTCGCTCTATCTTCCCAGGAGGAG
GGGATAAAACCAATAAGAAGAAAGAGAAAGAGCGCCCAGAGATCTCTCTTCCTTCAGACTTTGA
GCATACGATTCATGTGGGGTTTGATGCAGTCACCGGGGAATTCACTAACTCCCCTTTCCAGACC
TCTAGACCTGTGACGGTCGCTTCAAGTCAATCAGAGGGAAAAATGCCAGATCTCTATGGCTCAC
AGATGTGCCCAGGGAAGCTCCCAGAGGGAATTCCTGAGCAATGGGCAAGATTACTCCAAACCTC
CAACATAACAAAACTGGAACAAAAGAAGAACCCACAAGCCGTTCTTGATGTTCTCAAATTCTAT
GATTCCAAAGAAACCGTCAACAACCAGAAATACATGAGCTTTACATCAGGAGATAAAAGTGCAC
ATGGATACATAGCAGCACATCCTTCGAGTACAAAAACAGCATCTGAGCCTCCTTTAGCTCCTCC
TGTATCTGAAGAAGAAGATGAAGAAGAGGAGGAAGAAGAAGATGACAATGAGCCCCCACCAGTT
ATTGCACCAAGACCAGAGCATACAAAATCAATCTATACTCGTTCTGTGGTTGAATCTATTGCTT
CACCAGCAGCACCAAATAAAGAAGTCACACCACCTTCTGCGGAGAATGCCAACTCTAGTACTTT
GTACAGGAATACAGATCGGCAAAGGAAAAAATCAAAGATGACAGATGAGGAGATCCTAGAGAAG
CTAAGAAGCATTGTGAGTGTTGGAGACCCAAAGAAAAAGTACACAAGATTTGAAAAAATTGGTC
AAGGGGCATCGGGTACTGTTTATACAGCACTTGACATTGCAACAGGACAAGAGGTGGCCATAAA
GCAGATGAACCTTCAACAACAACCCAAAAAAGAATTAATTATTAATGAAATTCTGGTTATGAGG
GAAAATAAGAATCCCAATATTGTTAATTATTTAGATAGCTACTTAGTTGGTGATGAACTGTGGG
TGGTCATGGAATACTTGGCTGGTGGTTCTTTGACTGATGTGGTCACAGAGACCTGTATGGATGA
AGGACAGATAGCAGCTGTTTGCAGAGAGTGCCTCCAAGCTTTGGATTTCTTGCACTCAAACCAA
GTGATCCATAGAGACATAAAGAGTGACAATATTCTCCTCGGGATGGATGGCTCTGTTAAATTGA
CTGATTTTGGGTTCTGTGCCCAGATCACTCCTGAGCAAAGTAAACGAAGCACCATGGTGGGAAC
TCCCTATTGGATGGCACCTGAGGTGGTGACTCGCAAAGCTTATGGTCCAAAAGTTGATATATGG
TCTTTGGGAATTATGGCAATTGAAATGGTGGAAGGTGAACCCCCTTACCTTAATGAAAATCCAC
TCAGGGCATTATATCTGATAGCCACTAATGGAACCCCAGAGCTCCAGAATCCTGAGAGACTGTC
AGCTGTATTCCGTGACTTTTTAAATCGCTGTCTTGAGATGGATGTGGATAGGCGAGGATCTGCC
AAGGAGCTTTTGCAGCACCCATTTTTAAAACTAGCCAAGCCTCTCTCCAGCCTGACTCCTCTGA
TTATCGCTGCAAAGGAAGCGATTAAGAACAGCAGCCGCTAGGACTGCACGCCTTACCCCTCACC
ATCTCCCTCATGAGTAAGACTGAAATAAAACTCTGCTGCAGGAAAGATGAAAGAAAAGACAGTC
AAATAGGGTGGGGGTTCTTTAACTTTCAAATGAATAGAAACTTCTTATAAGCCTTTTCCTACTC
CCTCAGATTATGTAATTTATTTGTAAGCCTGAATCGCAGCCCAAACAGGGCAGCAATGTCGAAG
TGGCCATCAAGTGGTCACTTCCACCGTGAAGCGAAAGAGCCAGTAGTGAATCCCCTCATTTTGT
GCATTCACTTTGAAGAAAAAGATTTCTCAAAGATGCACATTCCCTCTTCATAGTGTTGTGTTTG
TTTTTAAGTTAGAGAGTAGTACCTCTTACATTCAAACCTCCTTCAAAACCCCTTACCCAATGTG
ATGTTTTTCACTTGCATTGTCATTAGATGTCCAGAAAAAAGATGTCAAGATGTTTTTTTAAAAA
AAAAGAAAGAAAAAAAAGCAAAGCAAAAAA

hide sequence

RefSeq Acc Id:

XM_021725207 ⟹ XP_021580882

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,214 - 83,584,851 (+)	NCBI
SpeTri2.0	NW_004936499	4,079,127 - 4,188,757 (-)	NCBI

Sequence:

show sequence

CTAGGGAGCGGTTGGCAAGCAAGAGCTCTATCGCGGGCGGGCAGCTGTGGCAGCGAACCGTTGG
GGATCTCACACTGGGGGCTACAGCTTTTCCCCTCCGGGAGTGAGTGAGCTGGGGCGGGAGAAGA
GCCGGGGAAGCGGGCTGGGCCCGGGGCTGCGGCTGCGGCCGCGGGGCTGCGGCTCCCCAGCCCC
GCCAGCCAGAACGTTTGGAGGTAGAGGAAAGGTCTTGACAGGGTGACTGGACCCGTGGCAGACT
CAAATCCAGGCCAACTGTATGGCTGTCTGAGGTCTTGGAACAGAAGGAGGTCCATTCCTGTTGG
TGACAACACTGTGGCCCTGTTCTGGGATGAGCAAGGTATAAAGGTTTCCCCCAAGCAAGACAAG
CTGAGTTCTTACATCTTGTGGCAGCTGTTGTGCTTAGTTTTGAGTCTGCCGGAGCTGAAGCCAG
CCCAGCCCCTTCTCATGGGCAGTTCCTACCTGTGCTGAGGTCCTGCAGCAGTGGCTGTGTGAGG
AGCTGTGAAATCAGTTACAACTGAAAATGTCTGACAGTCTGGATAATGAAGAAAAACCCCCAGC
TCCCCCATTGAGGATGAATAGTAACAATCGGGATTCTTCAGCACTCAACCACAGCTCCAAACCA
CTTCCCATGGCCCCTGAAGAGAAGAATAAGAAAGCCAGGCTTCGCTCTATCTTCCCAGGAGGAG
GGGATAAAACCAATAAGAAGAAAGAGAAAGAGCGCCCAGAGATCTCTCTTCCTTCAGACTTTGA
GCATACGATTCATGTGGGGTTTGATGCAGTCACCGGGGAATTCACTGGAATTCCTGAGCAATGG
GCAAGATTACTCCAAACCTCCAACATAACAAAACTGGAACAAAAGAAGAACCCACAAGCCGTTC
TTGATGTTCTCAAATTCTATGATTCCAAAGAAACCGTCAACAACCAGAAATACATGAGCTTTAC
ATCAGGAGATAAAAGTGCACATGGATACATAGCAGCACATCCTTCGAGTACAAAAACAGCATCT
GAGCCTCCTTTAGCTCCTCCTGTATCTGAAGAAGAAGATGAAGAAGAGGAGGAAGAAGAAGATG
ACAATGAGCCCCCACCAGTTATTGCACCAAGACCAGAGCATACAAAATCAATCTATACTCGTTC
TGTGGTTGAATCTATTGCTTCACCAGCAGCACCAAATAAAGAAGTCACACCACCTTCTGCGGAG
AATGCCAACTCTAGTACTTTGTACAGGAATACAGATCGGCAAAGGAAAAAATCAAAGATGACAG
ATGAGGAGATCCTAGAGAAGCTAAGAAGCATTGTGAGTGTTGGAGACCCAAAGAAAAAGTACAC
AAGATTTGAAAAAATTGGTCAAGGGGCATCGGGTACTGTTTATACAGCACTTGACATTGCAACA
GGACAAGAGGTGGCCATAAAGCAGATGAACCTTCAACAACAACCCAAAAAAGAATTAATTATTA
ATGAAATTCTGGTTATGAGGGAAAATAAGAATCCCAATATTGTTAATTATTTAGATAGCTACTT
AGTTGGTGATGAACTGTGGGTGGTCATGGAATACTTGGCTGGTGGTTCTTTGACTGATGTGGTC
ACAGAGACCTGTATGGATGAAGGACAGATAGCAGCTGTTTGCAGAGAGTGCCTCCAAGCTTTGG
ATTTCTTGCACTCAAACCAAGTGATCCATAGAGACATAAAGAGTGACAATATTCTCCTCGGGAT
GGATGGCTCTGTTAAATTGACTGATTTTGGGTTCTGTGCCCAGATCACTCCTGAGCAAAGTAAA
CGAAGCACCATGGTGGGAACTCCCTATTGGATGGCACCTGAGGTGGTGACTCGCAAAGCTTATG
GTCCAAAAGTTGATATATGGTCTTTGGGAATTATGGCAATTGAAATGGTGGAAGGTGAACCCCC
TTACCTTAATGAAAATCCACTCAGGGCATTATATCTGATAGCCACTAATGGAACCCCAGAGCTC
CAGAATCCTGAGAGACTGTCAGCTGTATTCCGTGACTTTTTAAATCGCTGTCTTGAGATGGATG
TGGATAGGCGAGGATCTGCCAAGGAGCTTTTGCAGCACCCATTTTTAAAACTAGCCAAGCCTCT
CTCCAGCCTGACTCCTCTGATTATCGCTGCAAAGGAAGCGATTAAGAACAGCAGCCGCTAGGAC
TGCACGCCTTACCCCTCACCATCTCCCTCATGAGTAAGACTGAAATAAAACTCTGCTGCAGGAA
AGATGAAAGAAAAGACAGTCAAATAGGGTGGGGGTTCTTTAACTTTCAAATGAATAGAAACTTC
TTATAAGCCTTTTCCTACTCCCTCAGATTATGTAATTTATTTGTAAGCCTGAATCGCAGCCCAA
ACAGGGCAGCAATGTCGAAGTGGCCATCAAGTGGTCACTTCCACCGTGAAGCGAAAGAGCCAGT
AGTGAATCCCCTCATTTTGTGCATTCACTTTGAAGAAAAAGATTTCTCAAAGATGCACATTCCC
TCTTCATAGTGTTGTGTTTGTTTTTAAGTTAGAGAGTAGTACCTCTTACATTCAAACCTCCTTC
AAAACCCCTTACCCAATGTGATGTTTTTCACTTGCATTGTCATTAGATGTCCAGAAAAAAGATG
TCAAGATGTTTTTTTAAAAAAAAAGAAAGAAAAAAAAGCAAAGCAAAAAA

hide sequence

RefSeq Acc Id:

XM_040284271 ⟹ XP_040140205

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284282 ⟹ XP_040140216

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284285 ⟹ XP_040140219

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284291 ⟹ XP_040140225

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,329,189 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284296 ⟹ XP_040140230

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,329,189 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284300 ⟹ XP_040140234

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,354,637 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284303 ⟹ XP_040140237

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284307 ⟹ XP_040140241

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,213 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284314 ⟹ XP_040140248

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,214 - 83,584,851 (+)	NCBI

RefSeq Acc Id:

XM_040284317 ⟹ XP_040140251

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	83,469,214 - 83,584,851 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005323405	(Get FASTA)	NCBI Sequence Viewer
	XP_021580882	(Get FASTA)	NCBI Sequence Viewer
	XP_040140205	(Get FASTA)	NCBI Sequence Viewer
	XP_040140216	(Get FASTA)	NCBI Sequence Viewer
	XP_040140219	(Get FASTA)	NCBI Sequence Viewer
	XP_040140225	(Get FASTA)	NCBI Sequence Viewer
	XP_040140230	(Get FASTA)	NCBI Sequence Viewer
	XP_040140234	(Get FASTA)	NCBI Sequence Viewer
	XP_040140237	(Get FASTA)	NCBI Sequence Viewer
	XP_040140241	(Get FASTA)	NCBI Sequence Viewer
	XP_040140248	(Get FASTA)	NCBI Sequence Viewer
	XP_040140251	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008494.3
	ENSSTOP00000015144.2
	ENSSTOP00000026466.1
	ENSSTOP00000028069.1
	ENSSTOP00000032333.1

RefSeq Acc Id:

XP_005323405 ⟸ XM_005323348

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKE
KERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQTSRPVTVASSQSEGKMPDLYGSQMCPGKLPE
GIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPS
STKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEV
TPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT
ALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG
SLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI
TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT
NGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAKEAIK
NSSR

hide sequence

RefSeq Acc Id:	XP_021580882 ⟸ XM_021725207
- Peptide Label:	isoform X4
- UniProtKB:	A0A287D3G5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKE KERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDS KETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIA PRPEHTKSIYTRSVVESIASPAAPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLR SIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVI HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL GIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKE LLQHPFLKLAKPLSSLTPLIIAAKEAIKNSSR hide sequence

RefSeq Acc Id:	XP_040140225 ⟸ XM_040284291
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140230 ⟸ XM_040284296
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140234 ⟸ XM_040284300
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140205 ⟸ XM_040284271
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140241 ⟸ XM_040284307
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040140219 ⟸ XM_040284285
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140216 ⟸ XM_040284282
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140237 ⟸ XM_040284303
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040140248 ⟸ XM_040284314
- Peptide Label:	isoform X3
- UniProtKB:	I3MDM0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040140251 ⟸ XM_040284317
- Peptide Label:	isoform X4
- UniProtKB:	A0A287D3G5 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000008494 ⟸ ENSSTOT00000009470

RefSeq Acc Id:

ENSSTOP00000032333 ⟸ ENSSTOT00000041499

RefSeq Acc Id:

ENSSTOP00000015144 ⟸ ENSSTOT00000027433

RefSeq Acc Id:

ENSSTOP00000028069 ⟸ ENSSTOT00000037475

RefSeq Acc Id:

ENSSTOP00000026466 ⟸ ENSSTOT00000036341

Protein Domains

CRIB Protein kinase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025028	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009470.3	UniProtKB/TrEMBL
	ENSSTOT00000027433.2	UniProtKB/TrEMBL
	ENSSTOT00000036341.1	UniProtKB/TrEMBL
	ENSSTOT00000037475.1	UniProtKB/TrEMBL
	ENSSTOT00000041499.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.810.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	CRIB_dom	UniProtKB/TrEMBL
	CRIB_dom_sf	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	PAK_BD	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
	STK_PAK3	UniProtKB/TrEMBL
NCBI Gene	Pak3	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE PAK 3	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TAO	UniProtKB/TrEMBL
Pfam	PBD	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PROSITE	CRIB	UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	PBD	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/TrEMBL
UniProt	A0A287D3G5	ENTREZGENE, UniProtKB/TrEMBL
	A0A287DFJ8_ICTTR	UniProtKB/TrEMBL
	I3MDM0	ENTREZGENE, UniProtKB/TrEMBL
	I3MSP9_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM