Ntrk2 (neurotrophic receptor tyrosine kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ntrk2 (neurotrophic receptor tyrosine kinase 2) Rattus norvegicus
Analyze
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
RGD ID: 3213
Description: Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of intracellular signal transduction; and regulation of neuron projection development. Acts upstream of or within positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Used to study several diseases, including alcohol use disorder; brain disease (multiple); cognitive disorder (multiple); drug dependence (multiple); and glaucoma. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; anxiety disorder (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-AMPA; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; RATTRKB1; Tkrb; trk-B; trkB; trkB tyrosine kinase; TRKB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8175,560,558 - 5,875,899 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl175,564,570 - 5,874,628 (-)EnsemblGRCr8
mRatBN7.2175,558,992 - 5,870,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl175,559,043 - 5,869,136 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,584,315 - 5,894,662 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,120,448 - 7,429,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0175,580,732 - 5,891,094 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)Ensemblrn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,673,895 - 6,828,108 (-)NCBICelera
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (ISO)
alcohol use disorder  (IDA,IEP,ISO)
alcohol withdrawal syndrome  (IDA,IEP)
Alcohol-Related Disorders  (IEP)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (IEP,ISO)
amphetamine abuse  (IEP,ISO)
Anhedonia  (IEP)
anxiety disorder  (IEP,ISO)
attention deficit hyperactivity disorder  (IEP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (ISO)
Binge Drinking  (IEP)
bipolar disorder  (ISO)
borna disease  (IEP)
cannabis abuse  (IEP)
cerebral infarction  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Chronic Pain  (IEP)
cocaine abuse  (ISO)
cocaine dependence  (IMP)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (IMP)
colitis  (IEP)
congestive heart failure  (IEP)
depressive disorder  (IEP,IMP,ISO)
developmental and epileptic encephalopathy 58  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (IEP)
epilepsy  (IDA,ISO)
Escherichia Coli Infections  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Seizures  (IEP)
genetic disease  (ISO)
glaucoma  (IDA,IEP)
heroin dependence  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (IEP,ISO)
Hyperkinesis  (ISO)
Hyperphagia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (IEP)
intestinal disease  (IDA)
Lewy body dementia  (ISO)
major depressive disorder  (ISO)
malignant astrocytoma  (ISO)
Memory Disorders  (IDA)
middle cerebral artery infarction  (IDA,IEP)
morbid obesity  (ISO)
morphine dependence  (IEP,IMP,ISO)
morphine withdrawal syndrome  (IEP,IMP)
neuroblastoma  (ISO)
nicotine dependence  (IEP,ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
Obesity, Hyperphagia, and Developmental Delay  (ISO)
Oculomotor Nerve Injuries  (IEP)
opiate withdrawal syndrome  (IMP)
Optic Nerve Injuries  (IDA)
Parkinsonism  (IDA)
Pneumococcal Meningitis  (IEP)
post-traumatic stress disorder  (IEP)
Postherpetic Neuralgia  (IEP)
Postoperative Cognitive Dysfunction  (IEP,ISO)
Prenatal Exposure Delayed Effects  (IEP)
pulmonary fibrosis  (ISO)
schizophrenia  (ISO)
Spinal Cord Injuries  (IDA,IEP,IMP)
status epilepticus  (ISO)
stroke  (IEP)
Subarachnoid Hemorrhage  (IDA)
temporal lobe epilepsy  (IEP)
transient cerebral ischemia  (IEP)
traumatic brain injury  (IEP)
trigeminal neuralgia  (IEP)
vascular dementia  (IEP)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-hydroxynorketamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Solamarine  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
androgen antagonist  (EXP)
aniracetam  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsanilic acid  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buprenorphine  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
citalopram  (ISO)
Citreoviridin  (ISO)
clomipramine  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
echinacoside  (EXP,ISO)
endrin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
graphite  (EXP)
heroin  (ISO)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
imipramine  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
kainic acid  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
malathion  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
Nonylphenol  (EXP,ISO)
oleuropein  (ISO)
papaverine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
physostigmine  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
Ptaquiloside  (ISO)
quartz  (ISO)
reboxetine  (ISO)
reserpine  (ISO)
rivastigmine  (EXP)
rolipram  (EXP,ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tamibarotene  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
Tetrachlorobisphenol A  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
tranylcypromine  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zalcitabine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain-derived neurotrophic factor receptor signaling pathway  (IDA,IEA,IMP,ISO)
cell differentiation  (IEA)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
cellular response to amino acid stimulus  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IBA,IEP)
cellular response to growth factor stimulus  (IEA)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
central nervous system neuron development  (IEA,ISO,ISS)
cerebral cortex development  (IEA,ISO,ISS)
circadian rhythm  (IEA,ISO)
feeding behavior  (ISO)
glutamate secretion  (ISO)
learning  (IEA,ISO,ISS)
learning or memory  (IEA)
long-term memory  (IDA)
long-term synaptic potentiation  (IEA,ISO)
mechanoreceptor differentiation  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of anoikis  (IEA,ISO)
negative regulation of apoptotic process  (IEA,IMP)
negative regulation of neuron apoptotic process  (IMP)
nervous system development  (IEA)
neuromuscular junction development  (ISO)
neuron differentiation  (IEA,ISO,ISS)
neuron migration  (IEA,ISO,ISS)
neuronal action potential propagation  (ISO)
neurotrophin signaling pathway  (IEA)
oligodendrocyte differentiation  (IEA,ISO)
peripheral nervous system neuron development  (IEA,ISO)
positive regulation of axonogenesis  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of cell projection organization  (IEA)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of long-term synaptic depression  (IMP)
positive regulation of MAPK cascade  (IDA,IMP)
positive regulation of nervous system development  (IEA)
positive regulation of neuron projection development  (IBA,IEA,ISO,ISS)
positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway  (IGI)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA,IMP)
positive regulation of synapse assembly  (ISO)
positive regulation of synaptic transmission  (IEA)
positive regulation of synaptic transmission, glutamatergic  (IMP)
protein autophosphorylation  (IDA,IMP)
regulation of cytosolic calcium ion concentration  (IDA)
regulation of dendrite development  (IMP)
regulation of MAPK cascade  (IDA)
regulation of neuron projection development  (IEA)
regulation of neurotransmitter secretion  (IDA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of synaptic plasticity  (IEA)
response to auditory stimulus  (IEP)
response to ethanol  (IEP)
response to light stimulus  (IEP)
retina development in camera-type eye  (ISO)
retinal rod cell development  (ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (IEA,ISO)
vasculogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
2. Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring. Akbarabadi A, etal., Neuroscience. 2021 Jul 1;466:58-76. doi: 10.1016/j.neuroscience.2021.04.011. Epub 2021 Apr 26.
3. A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy. Ali Shariati M, etal., Curr Eye Res. 2018 Dec;43(12):1489-1499. doi: 10.1080/02713683.2018.1508726. Epub 2018 Oct 1.
4. Association of contextual cues with morphine reward increases neural and synaptic plasticity in the ventral hippocampus of rats. Alvandi MS, etal., Addict Biol. 2017 Nov;22(6):1883-1894. doi: 10.1111/adb.12547. Epub 2017 Sep 22.
5. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Andero R, etal., Hippocampus. 2010 Dec 6.
6. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Andres-Alonso M, etal., Nat Commun. 2019 Nov 29;10(1):5448. doi: 10.1038/s41467-019-13224-z.
7. Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. Aoki C, etal., J Neurosci Res. 2000 Feb 1;59(3):454-63. doi: 10.1002/(SICI)1097-4547(20000201)59:3<454::AID-JNR21>3.0.CO;2-H.
8. Temporal and spatial differences in expression of TrkB isoforms in rat retina during constant light exposure. Asai N, etal., Exp Eye Res. 2007 Sep;85(3):346-55. Epub 2007 Jun 15.
9. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Atwal JK, etal., Neuron. 2000 Aug;27(2):265-77.
10. Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis. Avcuoglu S, etal., Am J Respir Cell Mol Biol. 2011 Oct;45(4):768-80. Epub 2011 Feb 17.
11. Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat. Avwenagha O, etal., Neuroscience. 2006 Jul 7;140(3):913-28. Epub 2006 Apr 19.
12. Up-regulation of high-affinity neurotrophin receptor, trk B-like protein on western blots of rat cortex after chronic ethanol treatment. Baek JK, etal., Brain Res Mol Brain Res. 1996 Aug;40(1):161-4. doi: 10.1016/0169-328x(96)00109-x.
13. An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma. Bai Y, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4722-31. Epub 2010 Mar 31.
14. Effects of cocaine base paste on anxiety-like behavior and immediate-early gene expression in nucleus accumbens and medial prefrontal cortex of female mice. Berardino BG, etal., Psychopharmacology (Berl). 2019 Dec;236(12):3525-3539. doi: 10.1007/s00213-019-05321-0. Epub 2019 Jul 6.
15. Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. Beuten J, etal., Biol Psychiatry. 2007 Jan 1;61(1):48-55. doi: 10.1016/j.biopsych.2006.02.023. Epub 2006 May 19.
16. Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis. Briones TL and Woods J, Neuroscience. 2013 Dec 19;254:324-34. doi: 10.1016/j.neuroscience.2013.09.031. Epub 2013 Sep 25.
17. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Cao XH, etal., J Neurochem. 2010 Sep 1;114(5):1460-75. Epub 2010 Jun 24.
18. Dysregulation of Nociceptin/Orphanin FQ and Dynorphin Systems in the Extended Amygdala of Alcohol Preferring Marchigian Sardinian (msP) Rats. Caputi FF, etal., Int J Mol Sci. 2021 Feb 28;22(5):2448. doi: 10.3390/ijms22052448.
19. Hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice. Che X, etal., Neuropharmacology. 2021 Sep 15;196:108717. doi: 10.1016/j.neuropharm.2021.108717. Epub 2021 Jul 15.
20. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
21. Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. Correia CT, etal., Genes Brain Behav. 2010 Oct;9(7):841-8. doi: 10.1111/j.1601-183X.2010.00627.x. Epub 2010 Aug 19.
22. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. Cortese GP, etal., J Neurosci. 2011 Mar 16;31(11):4274-9.
23. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
24. [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. Deng Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1373-8.
25. Adolescent cocaine self-administration induces habit behavior in adulthood: sex differences and structural consequences. DePoy LM, etal., Transl Psychiatry. 2016 Aug 30;6(8):e875. doi: 10.1038/tp.2016.150.
26. 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease. Devi L and Ohno M, Neuropsychopharmacology. 2012 Jan;37(2):434-44. doi: 10.1038/npp.2011.191. Epub 2011 Sep 7.
27. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Dong C, etal., Mol Psychiatry. 2009 Dec;14(12):1105-18. Epub 2009 Oct 20.
28. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
29. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. Eide FF, etal., J Neurosci. 1996 May 15;16(10):3123-9.
30. Anxiogenic-like effects of chronic cannabidiol administration in rats. ElBatsh MM, etal., Psychopharmacology (Berl). 2012 May;221(2):239-47. doi: 10.1007/s00213-011-2566-z. Epub 2011 Nov 15.
31. Alteration in messenger RNA neurotrophin 4 and tyrosine kinase receptors B expression levels following spinal cord injury. Esmaeili A, etal., J Neurosurg Sci. 2018 Apr;62(2):146-152. doi: 10.23736/S0390-5616.16.03106-4. Epub 2014 Dec 5.
32. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Fang X, etal., Eur Arch Psychiatry Clin Neurosci. 2020 Mar;270(2):195-205. doi: 10.1007/s00406-018-0909-z. Epub 2018 Jun 7.
33. A TrkB antibody agonist promotes plasticity following cervical spinal cord injury in adult rats. Fouad K, etal., J Neurotrauma. 2010 Jul 2.
34. Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. Fujita Y, etal., EMBO J. 2011 Apr 6;30(7):1389-401. doi: 10.1038/emboj.2011.55. Epub 2011 Mar 1.
35. BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses. Gangarossa G, etal., Cereb Cortex. 2020 Jan 10;30(1):197-214. doi: 10.1093/cercor/bhz081.
36. Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats. Garraway SM, etal., Neuroscience. 2011 Dec 29;199:86-102. Epub 2011 Oct 18.
37. 2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Garriga-Canut M, etal., Nat Neurosci. 2006 Nov;9(11):1382-7. doi: 10.1038/nn1791. Epub 2006 Oct 15.
38. Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro. Gascon E, etal., Eur J Neurosci. 2005 Jan;21(1):69-80.
39. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
40. Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression. Ge H, etal., Sci Rep. 2019 Oct 10;9(1):14619. doi: 10.1038/s41598-019-51124-w.
41. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
42. The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons. Gomes RA, etal., J Neurosci. 2006 Nov 1;26(44):11487-500.
43. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Graham DL, etal., Biol Psychiatry. 2009 Apr 15;65(8):696-701. doi: 10.1016/j.biopsych.2008.09.032. Epub 2008 Nov 6.
44. Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Gray J, etal., Int J Obes (Lond). 2007 Feb;31(2):359-64. Epub 2006 May 16.
45. Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. Gu F, etal., Food Funct. 2020 Jul 1;11(7):6148-6157. doi: 10.1039/d0fo00373e. Epub 2020 Jun 24.
46. Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. Gu F, etal., Neurobiol Dis. 2018 May;113:45-58. doi: 10.1016/j.nbd.2018.01.018. Epub 2018 Feb 2.
47. Neuronal changes induced by Varicella Zoster Virus in a rat model of postherpetic neuralgia. Guedon JM, etal., Virology. 2015 Aug;482:167-80. doi: 10.1016/j.virol.2015.03.046. Epub 2015 Apr 11.
48. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
49. Physical Exercise Promotes Beneficial Changes on Neurotrophic Factors in Mesolimbic Brain Areas After AMPH Relapse: Involvement of the Endogenous Opioid System. H Z R, etal., Neurotox Res. 2023 Dec;41(6):741-751. doi: 10.1007/s12640-023-00675-y. Epub 2023 Oct 31.
50. Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury. Han F, etal., Neurobiol Dis. 2019 Jul;127:570-581. doi: 10.1016/j.nbd.2019.04.009. Epub 2019 Apr 11.
51. Rapid Activation of the Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Signaling Pathway by Electroconvulsive Shock in the Rat Prefrontal Cortex Is Not Associated with TrkB Neurotrophin Receptor Activation. Hansen HH, etal., Cell Mol Neurobiol. 2007 Apr 20;.
52. Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Hasegawa Y, etal., Stroke. 2011 Feb;42(2):477-83. Epub 2010 Dec 30.
53. Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. He XP, etal., J Neurosci. 2010 May 5;30(18):6188-96.
54. Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats. Hsu CC, etal., J Neuroimmune Pharmacol. 2020 Jun;15(2):326-339. doi: 10.1007/s11481-019-09903-9. Epub 2020 Jan 11.
55. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
56. Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats. Jeong HI, etal., J Exerc Rehabil. 2014 Jun 30;10(3):162-7. doi: 10.12965/jer.140111. eCollection 2014 Jun.
57. The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus. Jiang N, etal., J Ethnopharmacol. 2021 Mar 1;267:113625. doi: 10.1016/j.jep.2020.113625. Epub 2020 Nov 25.
58. Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression. Jiang Y, etal., Food Funct. 2020 Jan 29;11(1):378-391. doi: 10.1039/c9fo01780a.
59. Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats. Ju YY, etal., Acta Pharmacol Sin. 2015 Dec;36(12):1437-43. doi: 10.1038/aps.2015.94. Epub 2015 Nov 16.
60. Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors. Kato H, etal., FEBS Lett. 2004 Aug 13;572(1-3):123-8.
61. Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. Kim YI, etal., J Neurosci Res. 2006 Nov 15;84(7):1512-20.
62. Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats. Kishi T, etal., J Cardiol. 2012 Dec;60(6):489-94. doi: 10.1016/j.jjcc.2012.08.004. Epub 2012 Sep 2.
63. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Kohli MA, etal., Arch Gen Psychiatry. 2010 Apr;67(4):348-59. Epub 2010 Feb 1.
64. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Lambert WM, etal., Mol Cell Biol. 2013 Sep;33(18):3700-14. doi: 10.1128/MCB.00150-13. Epub 2013 Jul 22.
65. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Levran O, etal., Pharmacogenomics. 2013 May;14(7):755-68. doi: 10.2217/pgs.13.58.
66. Dynamic changes of TrkB gene expression in Streptococcus pneumoniae meningitis after treatment with antibiotics and dexamethasone. Li L, etal., World J Pediatr. 2011 Aug;7(3):250-6. Epub 2011 May 20.
67. Detecting genetic interactions for quantitative traits with U-statistics. Li M, etal., Genet Epidemiol. 2011 Sep;35(6):457-68. doi: 10.1002/gepi.20594. Epub 2011 May 26.
68. Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Li MD, etal., Biol Psychiatry. 2008 Dec 1;64(11):951-7. doi: 10.1016/j.biopsych.2008.04.026. Epub 2008 Jun 4.
69. Protection against acute cerebral ischemia/reperfusion injury by Leonuri Herba Total Alkali via modulation of BDNF-TrKB-PI3K/Akt signaling pathway in rats. Li Y, etal., Biomed Pharmacother. 2021 Jan;133:111021. doi: 10.1016/j.biopha.2020.111021. Epub 2020 Nov 20.
70. Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. Lin YT, etal., J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.
71. The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins. Lindsay JH and Prosser RA, Alcohol Clin Exp Res. 2018 Feb;42(2):315-328. doi: 10.1111/acer.13554. Epub 2017 Dec 27.
72. BDNF-TrkB pathway mediates antidepressant-like roles of H2 S in diabetic rats via promoting hippocampal autophagy. Liu HY, etal., Clin Exp Pharmacol Physiol. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. Epub 2019 Nov 24.
73. Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia. Liu L, etal., Sci Rep. 2020 Mar 19;10(1):4998. doi: 10.1038/s41598-020-61969-1.
74. Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. Liu Z, etal., Mol Pain. 2018 Jan-Dec;14:1744806918805902. doi: 10.1177/1744806918805902. Epub 2018 Sep 20.
75. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Lunden JW and Kirby LG, Neuroscience. 2013 Dec 19;254:160-72. doi: 10.1016/j.neuroscience.2013.08.071. Epub 2013 Sep 20.
76. 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents. Luo D, etal., Neurosci Lett. 2016 May 4;620:43-9. doi: 10.1016/j.neulet.2016.03.042. Epub 2016 Mar 24.
77. Histone Deacetylases May Mediate Surgery-Induced Impairment of Learning, Memory, and Dendritic Development. Luo F, etal., Mol Neurobiol. 2020 Sep;57(9):3702-3711. doi: 10.1007/s12035-020-01987-2. Epub 2020 Jun 20.
78. Activation of brain-derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation-induced fear memory impairments. Ma T, etal., Brain Behav. 2020 Apr;10(4):e01592. doi: 10.1002/brb3.1592. Epub 2020 Mar 10.
79. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. McCarty JH and Feinstein SC, Oncogene. 1998 Apr 2;16(13):1691-700.
80. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
81. Short-term ethanol exposure causes imbalanced neurotrophic factor allocation in the basal forebrain cholinergic system: a novel insight into understanding the initial processes of alcohol addiction. Miki T, etal., J Neural Transm (Vienna). 2014 Feb;121(2):201-10. doi: 10.1007/s00702-013-1085-y. Epub 2013 Sep 6.
82. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
83. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Miyamoto Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9. Epub 2006 Jun 26.
84. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):101-13. doi: 10.1002/neu.20009.
85. Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure. Moore DB, etal., J Neurobiol. 2004 Jul;60(1):114-26. doi: 10.1002/neu.20010.
86. Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion. Morcuende S, etal., J Comp Neurol. 2011 Aug 15;519(12):2335-52. doi: 10.1002/cne.22630.
87. Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. Moreira da Silva Santos A, etal., Neurosci Lett. 2020 Jan 10;715:134606. doi: 10.1016/j.neulet.2019.134606. Epub 2019 Nov 3.
88. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
89. Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway. Ni GX, etal., Biomed Pharmacother. 2020 Oct;130:110353. doi: 10.1016/j.biopha.2020.110353. Epub 2020 Jul 16.
90. Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Numakawa T, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):647-52. doi: 10.1073/pnas.0800888106. Epub 2009 Jan 6.
91. Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke. Okamura M, etal., J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105316. doi: 10.1016/j.jstrokecerebrovasdis.2020.105316. Epub 2020 Sep 28.
92. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
93. Lactobacillus Rhamnosus GG Affects the BDNF System in Brain Samples of Wistar Rats with Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy. Orlando A, etal., Nutrients. 2020 Feb 27;12(3):629. doi: 10.3390/nu12030629.
94. Effector immediate-early gene arc in the amygdala plays a critical role in alcoholism. Pandey SC, etal., J Neurosci. 2008 Mar 5;28(10):2589-600. doi: 10.1523/JNEUROSCI.4752-07.2008.
95. 7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence. Pandey SN, etal., Psychopharmacology (Berl). 2020 Jun;237(6):1827-1840. doi: 10.1007/s00213-020-05502-2. Epub 2020 Mar 23.
96. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Pease ME, etal., Invest Ophthalmol Vis Sci. 2000 Mar;41(3):764-74.
97. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Pereira DB, etal., J Neurosci Res. 2006 Apr;83(5):832-44.
98. Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation. Phillips RJ, etal., BMC Pregnancy Childbirth. 2014 Jul 22;14:241. doi: 10.1186/1471-2393-14-241.
99. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
100. Early intervention with gastrodin reduces striatal neurotoxicity in adult rats with experimentally‑induced diabetes mellitus. Qi YH, etal., Mol Med Rep. 2019 Apr;19(4):3114-3122. doi: 10.3892/mmr.2019.9954. Epub 2019 Feb 14.
101. Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport. Qiao LY and Grider JR, Pain. 2010 Oct;151(1):117-27. Epub 2010 Jul 16.
102. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
103. BDNF receptor antagonism during the induction of morphine dependence exacerbates the severity of physical dependence and ameliorates psychological dependence in rats. Rezamohammadi F, etal., Neurosci Lett. 2020 Oct 15;737:135332. doi: 10.1016/j.neulet.2020.135332. Epub 2020 Aug 26.
104. GOA pipeline RGD automated data pipeline
105. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
106. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
107. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
108. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. Saba J, etal., J Neurochem. 2018 Sep;146(6):686-702. doi: 10.1111/jnc.14476. Epub 2018 Aug 9.
109. TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Sahenk Z, etal., Exp Neurol. 2010 Aug;224(2):495-506. Epub 2010 May 27.
110. The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats. Schaser AJ, etal., Behav Brain Res. 2012 Jan 1;226(1):235-41. Epub 2011 Sep 21.
111. Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway. Seo SY, etal., Int J Mol Sci. 2021 Apr 14;22(8):4037. doi: 10.3390/ijms22084037.
112. Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats. Sequeira-Cordero A and Brenes JC, Eur J Pharmacol. 2021 Aug 5;904:174148. doi: 10.1016/j.ejphar.2021.174148. Epub 2021 May 5.
113. Functional Genetic Variation in the 3'-UTRNTRK2 is Associated with Risk of Ischemic Stroke. Shi J, etal., Pharmgenomics Pers Med. 2020 Nov 12;13:577-584. doi: 10.2147/PGPM.S270319. eCollection 2020.
114. Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats. Sim YJ J Exerc Rehabil. 2014 Apr 30;10(2):81-8. doi: 10.12965/jer.140102. eCollection 2014 Apr.
115. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Somkuwar SS, etal., Brain Struct Funct. 2016 Dec;221(9):4319-4335. doi: 10.1007/s00429-015-1163-z. Epub 2015 Dec 11.
116. Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder. Soontornniyomkij B, etal., J Affect Disord. 2011 Oct;133(3):646-54. Epub 2011 May 25.
117. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Soppet D, etal., Cell. 1991 May 31;65(5):895-903.
118. Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines. Sui WH, etal., J Cell Sci. 2015 Mar 15;128(6):1108-22. doi: 10.1242/jcs.160259. Epub 2015 Jan 27.
119. Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions. Sun D, etal., Neuropsychopharmacology. 2007 Jan;32(1):110-6. doi: 10.1038/sj.npp.1301134. Epub 2006 Jun 21.
120. Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor. Suzuki S, etal., Biochem Biophys Res Commun. 2002 Jun 28;294(5):1087-92. doi: 10.1016/S0006-291X(02)00606-X.
121. Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats. Takahashi Y, etal., Toxicology. 2021 Oct;462:152958. doi: 10.1016/j.tox.2021.152958. Epub 2021 Sep 20.
122. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. Takei S, etal., J Psychiatr Res. 2011 Apr;45(4):460-8. Epub 2010 Sep 21.
123. Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis. Tauber SC, etal., J Neuropathol Exp Neurol. 2005 Sep;64(9):806-15.
124. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
125. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. Thompson Ray M, etal., J Psychiatry Neurosci. 2011 May;36(3):195-203.
126. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent. Tucker K and Fadool DA, J Physiol 2002 Jul 15;542(Pt 2):413-29.
127. BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions. Vargas-Perez H, etal., J Neurosci. 2014 Jun 4;34(23):7899-909. doi: 10.1523/JNEUROSCI.3776-13.2014.
128. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. Verheij MM, etal., J Neurosci. 2016 Aug 3;36(31):8149-59. doi: 10.1523/JNEUROSCI.2711-14.2016.
129. Systemic treatment with 7,8-Dihydroxiflavone activates TtkB and affords protection of two different retinal ganglion cell populations against axotomy in adult rats. Vidal-Villegas B, etal., Exp Eye Res. 2021 Sep;210:108694. doi: 10.1016/j.exer.2021.108694. Epub 2021 Jul 8.
130. Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure. Wang H, etal., Neuroscience. 2011 Jan 13;172:453-9. Epub 2010 Oct 27.
131. 7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala. Wang N, etal., Mol Neurobiol. 2021 Jan;58(1):92-105. doi: 10.1007/s12035-020-02111-0. Epub 2020 Sep 7.
132. Bushenhuoxue improves cognitive function and activates brain-derived neurotrophic factor-mediated signaling in a rat model of vascular dementia. Wang W, etal., J Tradit Chin Med. 2020 Feb;40(1):49-58.
133. Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of NF-κB Signaling Pathway in Aged Rats. Wei P, etal., Nicotine Tob Res. 2018 Mar 6;20(4):515-522. doi: 10.1093/ntr/ntx157.
134. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
135. Neuroprotection of Retinal Ganglion Cells with AAV2-BDNF Pretreatment Restoring Normal TrkB Receptor Protein Levels in Glaucoma. Wójcik-Gryciuk A, etal., Int J Mol Sci. 2020 Aug 29;21(17):6262. doi: 10.3390/ijms21176262.
136. Decreased spasticity of Baishaoluoshi Decoction through the BDNF/TrKB-KCC2 pathway on poststroke spasticity rats. Xie L, etal., Neuroreport. 2021 Oct 6;32(14):1183-1191. doi: 10.1097/WNR.0000000000001709.
137. Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain. Xu HW, etal., Acta Pharmacol Sin. 2000 Jul;21(7):600-4.
138. Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. Xu K, etal., Pharmacogenomics J. 2007 Dec;7(6):368-79. doi: 10.1038/sj.tpj.6500430. Epub 2007 Jan 2.
139. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Xu X, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19126-31. Epub 2010 Oct 18.
140. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Yajima Y, etal., Brain Res. 2002 Dec 27;958(2):338-46.
141. Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. Yang HC, etal., Sci Rep. 2017 May 16;7(1):1975. doi: 10.1038/s41598-017-01791-4.
142. Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins. Yang J, etal., Exploration (Beijing). 2021 Sep 1;1(1):61-74. doi: 10.1002/EXP.20210004. eCollection 2021 Aug.
143. The contribution of rare and common variants in 30 genes to risk nicotine dependence. Yang J, etal., Mol Psychiatry. 2015 Nov;20(11):1467-78. doi: 10.1038/mp.2014.156. Epub 2014 Dec 2.
144. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Yeo GS, etal., Nat Neurosci. 2004 Nov;7(11):1187-9. Epub 2004 Oct 24.
145. Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism. Yousuf H, etal., Front Behav Neurosci. 2019 Jul 31;13:168. doi: 10.3389/fnbeh.2019.00168. eCollection 2019.
146. [Alteration of ion channel gene expression profile in rat model of post-myocardial infarction heart failure]. Zhang DM, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jan;30(1):53-7.
147. Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference. Zhang H, etal., Cell Mol Neurobiol. 2021 Jul;41(5):961-975. doi: 10.1007/s10571-020-00848-9. Epub 2020 Apr 22.
148. Effects of chronic ethanol administration on expression of BDNF and trkB mRNAs in rat hippocampus after experimental brain injury. Zhang L, etal., Brain Res Mol Brain Res. 2000 Jun 23;79(1-2):174-9. doi: 10.1016/s0169-328x(00)00124-8.
149. Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease. Zhao HL, etal., J Ethnopharmacol. 2021 Apr 6;269:113725. doi: 10.1016/j.jep.2020.113725. Epub 2020 Dec 25.
150. Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia. Zhao Y, etal., Biomed Pharmacother. 2021 Jun;138:111387. doi: 10.1016/j.biopha.2021.111387. Epub 2021 Mar 13.
151. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Zhou XP, etal., Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17181-6. Epub 2008 Oct 28.
152. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. Zocher M, etal., J Neurovirol. 2000 Dec;6(6):462-77.
Additional References at PubMed
PMID:1846020   PMID:8106527   PMID:8402890   PMID:9856458   PMID:10196222   PMID:10486198   PMID:10516311   PMID:10571233   PMID:10595510   PMID:10908605   PMID:11083466   PMID:11248116  
PMID:11251075   PMID:11389170   PMID:11738045   PMID:11860191   PMID:12049326   PMID:12367511   PMID:12373512   PMID:12471037   PMID:12605901   PMID:12646573   PMID:12796784   PMID:12798291  
PMID:12858046   PMID:14603320   PMID:14642449   PMID:15014113   PMID:15231696   PMID:15282267   PMID:15329723   PMID:15372074   PMID:15376326   PMID:15384067   PMID:15507485   PMID:15518646  
PMID:15601948   PMID:15665879   PMID:15703388   PMID:15721221   PMID:16173113   PMID:16175575   PMID:16264195   PMID:16357196   PMID:16399679   PMID:16500620   PMID:16612579   PMID:16769156  
PMID:16781670   PMID:16819522   PMID:16877354   PMID:16996037   PMID:17072373   PMID:17168119   PMID:17394529   PMID:17445239   PMID:17463054   PMID:17492691   PMID:17584746   PMID:17647101  
PMID:17828750   PMID:17959796   PMID:17967490   PMID:18063479   PMID:18063676   PMID:18338800   PMID:18353779   PMID:18381284   PMID:18420184   PMID:18432062   PMID:18446825   PMID:18474605  
PMID:18511210   PMID:18515408   PMID:18550280   PMID:18559670   PMID:18957307   PMID:19036963   PMID:19141250   PMID:19159346   PMID:19179431   PMID:19222991   PMID:19224567   PMID:19332029  
PMID:19351881   PMID:19424097   PMID:19460344   PMID:19546592   PMID:19549834   PMID:19551874   PMID:19583705   PMID:19585233   PMID:19671665   PMID:19686240   PMID:19726361   PMID:20047714  
PMID:20064930   PMID:20146080   PMID:20333308   PMID:20407211   PMID:20610389   PMID:20615547   PMID:20635439   PMID:21044076   PMID:21187387   PMID:21210848   PMID:21279681   PMID:21474450  
PMID:21756980   PMID:21849472   PMID:21945647   PMID:21946312   PMID:22022509   PMID:22128160   PMID:22345308   PMID:22374757   PMID:22563458   PMID:22649026   PMID:22678720   PMID:22710915  
PMID:22806574   PMID:22841916   PMID:22878065   PMID:22961271   PMID:23017014   PMID:23058367   PMID:23086941   PMID:23382219   PMID:23392678   PMID:23526925   PMID:23550026   PMID:23785138  
PMID:23844255   PMID:23867621   PMID:23975404   PMID:24021607   PMID:24035762   PMID:24045895   PMID:24069373   PMID:24103847   PMID:24198040   PMID:24271058   PMID:24316227   PMID:24361450  
PMID:24372023   PMID:24465591   PMID:24484474   PMID:24599793   PMID:24613359   PMID:24714156   PMID:24830751   PMID:24934279   PMID:24991961   PMID:25072185   PMID:25143381   PMID:25226925  
PMID:25453757   PMID:25542970   PMID:25661191   PMID:25665281   PMID:25761522   PMID:25886766   PMID:26019338   PMID:26088421   PMID:26094765   PMID:26222433   PMID:26339375   PMID:26574547  
PMID:26712630   PMID:26899129   PMID:27151332   PMID:27334657   PMID:27438618   PMID:27735948   PMID:27771283   PMID:27830679   PMID:27926876   PMID:27984178   PMID:28004953   PMID:28500221  
PMID:28607168   PMID:28705440   PMID:28757509   PMID:28821448   PMID:28821608   PMID:28890399   PMID:29075579   PMID:29098710   PMID:29420916   PMID:29425916   PMID:29468822   PMID:29611441  
PMID:29680698   PMID:29694277   PMID:29704115   PMID:30076998   PMID:30266684   PMID:30373907   PMID:30472367   PMID:30477252   PMID:30489133   PMID:30710509   PMID:30741614   PMID:31014242  
PMID:31114979   PMID:31219215   PMID:31430955   PMID:32043504   PMID:32194188   PMID:32507324   PMID:33043964   PMID:33130041   PMID:33206632   PMID:33359781   PMID:33571451   PMID:33616872  
PMID:33874962   PMID:33954182   PMID:34695541   PMID:34728386   PMID:36233065   PMID:36375307   PMID:36499323   PMID:36565982   PMID:36622548   PMID:36725696   PMID:36958643   PMID:37252844  
PMID:37298449   PMID:38347284  


Genomics

Comparative Map Data
Ntrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8175,560,558 - 5,875,899 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl175,564,570 - 5,874,628 (-)EnsemblGRCr8
mRatBN7.2175,558,992 - 5,870,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl175,559,043 - 5,869,136 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,584,315 - 5,894,662 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,120,448 - 7,429,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0175,580,732 - 5,891,094 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)Ensemblrn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera175,673,895 - 6,828,108 (-)NCBICelera
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Cytogenetic Map17p14NCBI
NTRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38984,668,522 - 85,027,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl984,668,375 - 85,095,751 (+)Ensemblhg38GRCh38
GRCh37987,283,437 - 87,641,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36986,473,286 - 86,828,325 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34984,514,246 - 84,866,963NCBI
Celera957,854,390 - 58,209,019 (+)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef957,108,647 - 57,463,914 (+)NCBIHuRef
CHM1_1987,429,973 - 87,785,074 (+)NCBICHM1_1
T2T-CHM13v2.0996,818,888 - 97,177,857 (+)NCBIT2T-CHM13v2.0
Ntrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,954,363 - 59,281,782 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,954,383 - 59,281,784 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381358,806,472 - 59,133,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,806,569 - 59,133,970 (+)Ensemblmm10GRCm38
MGSCv371358,907,957 - 59,231,337 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361358,816,219 - 59,139,599 (+)NCBIMGSCv36mm8
Celera1359,869,829 - 60,184,466 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.2NCBI
Ntrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)Ensembl
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBIChiLan1.0ChiLan1.0
NTRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,829,141 - 84,374,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1983,835,183 - 84,380,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0939,663,986 - 40,208,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1984,022,677 - 84,378,307 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl984,021,837 - 84,372,678 (+)EnsemblpanPan2panpan1.1
NTRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1174,447,927 - 74,777,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl174,449,060 - 74,777,032 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha175,211,260 - 75,538,451 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0174,754,263 - 75,081,259 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl174,755,372 - 75,083,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1174,562,918 - 74,890,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0174,331,860 - 74,658,907 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0175,035,216 - 75,362,564 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936680267,596 - 615,928 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1030,033,405 - 30,429,882 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11030,030,050 - 30,429,938 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21034,211,939 - 34,350,822 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11295,477,612 - 95,836,734 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1295,479,447 - 95,620,364 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603883,830,767 - 84,200,895 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248098,276,951 - 8,616,765 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248098,274,736 - 8,622,287 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntrk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11479,014,321 - 79,328,636 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ntrk2
1765 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:545
Count of miRNA genes:254
Interacting mature miRNAs:310
Transcripts:ENSRNOT00000042145
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
D17Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0178,464,362 - 8,464,522NCBIRnor5.0
RGSC_v3.41711,811,510 - 11,811,669RGDRGSC3.4
RGSC_v3.11711,811,510 - 11,811,669RGD
RH 3.4 Map1753.5UniSTS
RH 3.4 Map1753.5RGD
RH 2.0 Map1743.9RGD
Cytogenetic Map17p14UniSTS
D17Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,705,480 - 5,705,653 (+)MAPPERmRatBN7.2
Rnor_6.0176,081,441 - 6,081,613NCBIRnor6.0
Rnor_5.0178,303,029 - 8,303,201UniSTSRnor5.0
RGSC_v3.41711,642,373 - 11,642,546RGDRGSC3.4
RGSC_v3.41711,642,374 - 11,642,546UniSTSRGSC3.4
Celera175,819,628 - 5,819,800UniSTS
RGSC_v3.11711,642,374 - 11,642,546RGD
RH 3.4 Map1753.6UniSTS
RH 3.4 Map1753.6RGD
RH 2.0 Map1741.7RGD
SHRSP x BN Map175.9601RGD
Cytogenetic Map17p14UniSTS
D17Got7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8175,852,358 - 5,852,472 (+)Marker Load Pipeline
mRatBN7.2175,846,851 - 5,846,967 (+)MAPPERmRatBN7.2
Rnor_6.0176,222,036 - 6,222,149NCBIRnor6.0
Rnor_5.0178,441,931 - 8,442,044UniSTSRnor5.0
RGSC_v3.41711,789,391 - 11,789,504UniSTSRGSC3.4
RGSC_v3.41711,789,390 - 11,789,504RGDRGSC3.4
Celera175,959,620 - 5,959,733UniSTS
RGSC_v3.11711,789,391 - 11,789,504RGD
RH 3.4 Map1773.7RGD
RH 3.4 Map1773.7UniSTS
RH 2.0 Map1738.2RGD
Cytogenetic Map17p14UniSTS
D17Arb15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,868,983 - 5,869,137 (+)MAPPERmRatBN7.2
Rnor_6.0176,244,475 - 6,244,628NCBIRnor6.0
Rnor_5.0178,464,370 - 8,464,523UniSTSRnor5.0
RGSC_v3.41711,811,516 - 11,811,669RGDRGSC3.4
RGSC_v3.41711,811,517 - 11,811,670UniSTSRGSC3.4
Celera175,981,709 - 5,981,850UniSTS
RGSC_v3.11711,811,516 - 11,811,669RGD
Cytogenetic Map17p14UniSTS
BF388200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,683,917 - 5,684,106 (+)MAPPERmRatBN7.2
Rnor_6.0176,060,589 - 6,060,777NCBIRnor6.0
Rnor_5.0178,282,177 - 8,282,365UniSTSRnor5.0
RGSC_v3.41711,620,134 - 11,620,322UniSTSRGSC3.4
Celera175,798,149 - 5,798,337UniSTS
RH 3.4 Map1773.7UniSTS
Cytogenetic Map17p14UniSTS
RH135318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,835,067 - 5,835,260 (+)MAPPERmRatBN7.2
Rnor_6.0176,210,245 - 6,210,437NCBIRnor6.0
Rnor_5.0178,430,140 - 8,430,332UniSTSRnor5.0
RGSC_v3.41711,777,573 - 11,777,765UniSTSRGSC3.4
Celera175,947,917 - 5,948,109UniSTS
RH 3.4 Map1753.5UniSTS
Cytogenetic Map17p14UniSTS
RH140355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,559,068 - 5,559,315 (+)MAPPERmRatBN7.2
Rnor_6.0175,934,716 - 5,934,962NCBIRnor6.0
Rnor_5.0178,156,458 - 8,156,704UniSTSRnor5.0
RGSC_v3.41711,494,489 - 11,494,735UniSTSRGSC3.4
Celera175,673,921 - 5,674,167UniSTS
Cytogenetic Map17p14UniSTS
RH129925  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,739,292 - 5,739,485 (+)MAPPERmRatBN7.2
Rnor_6.0176,114,720 - 6,114,912NCBIRnor6.0
Rnor_5.0178,335,513 - 8,335,705UniSTSRnor5.0
RGSC_v3.41711,676,780 - 11,676,972UniSTSRGSC3.4
Celera175,852,552 - 5,852,744UniSTS
RH 3.4 Map1754.5UniSTS
Cytogenetic Map17p14UniSTS
RH133106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,743,832 - 5,744,018 (+)MAPPERmRatBN7.2
Rnor_6.0176,119,115 - 6,119,300NCBIRnor6.0
Rnor_5.0178,339,908 - 8,340,093UniSTSRnor5.0
RGSC_v3.41711,681,320 - 11,681,505UniSTSRGSC3.4
Celera175,857,092 - 5,857,277UniSTS
RH 3.4 Map1773.3UniSTS
Cytogenetic Map17p14UniSTS
BF386266  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,715,697 - 5,715,860 (+)MAPPERmRatBN7.2
Rnor_6.0176,091,659 - 6,091,821NCBIRnor6.0
Rnor_5.0178,312,470 - 8,312,632UniSTSRnor5.0
RGSC_v3.41711,652,039 - 11,652,201UniSTSRGSC3.4
Celera175,828,923 - 5,829,085UniSTS
RH 3.4 Map1773.4UniSTS
Cytogenetic Map17p14UniSTS
BE097527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,703,161 - 5,703,376 (+)MAPPERmRatBN7.2
Rnor_6.0176,079,122 - 6,079,336NCBIRnor6.0
Rnor_5.0178,300,710 - 8,300,924UniSTSRnor5.0
RGSC_v3.41711,640,055 - 11,640,269UniSTSRGSC3.4
Celera175,817,362 - 5,817,576UniSTS
RH 3.4 Map1772.8UniSTS
Cytogenetic Map17p14UniSTS
RH138199  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,667,249 - 5,667,431 (+)MAPPERmRatBN7.2
Rnor_6.0176,043,939 - 6,044,120NCBIRnor6.0
Rnor_5.0178,265,619 - 8,265,800UniSTSRnor5.0
RGSC_v3.41711,603,648 - 11,603,829UniSTSRGSC3.4
Celera175,781,473 - 5,781,654UniSTS
RH 3.4 Map1753.4UniSTS
Cytogenetic Map17p14UniSTS
RH138872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,701,329 - 5,701,568 (+)MAPPERmRatBN7.2
Rnor_6.0176,077,290 - 6,077,528NCBIRnor6.0
Rnor_5.0178,298,878 - 8,299,116UniSTSRnor5.0
RGSC_v3.41711,638,223 - 11,638,461UniSTSRGSC3.4
Celera175,815,530 - 5,815,768UniSTS
RH 3.4 Map1752.5UniSTS
Cytogenetic Map17p14UniSTS
RH139520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,559,212 - 5,559,432 (+)MAPPERmRatBN7.2
Rnor_6.0175,934,860 - 5,935,079NCBIRnor6.0
Rnor_5.0178,156,602 - 8,156,821UniSTSRnor5.0
RGSC_v3.41711,494,633 - 11,494,852UniSTSRGSC3.4
Celera175,674,065 - 5,674,284UniSTS
RH 3.4 Map1755.0UniSTS
Cytogenetic Map17p14UniSTS
BF390725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,748,331 - 5,748,504 (+)MAPPERmRatBN7.2
Rnor_6.0176,123,562 - 6,123,734NCBIRnor6.0
Rnor_5.0178,344,193 - 8,344,365UniSTSRnor5.0
RGSC_v3.41711,686,081 - 11,686,253UniSTSRGSC3.4
Celera175,861,597 - 5,861,769UniSTS
RH 3.4 Map1773.7UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 67 165 78 77 46 38 46 6 275 138 11 144 71 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY265419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY266346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC855568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042145   ⟹   ENSRNOP00000045635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl175,564,570 - 5,874,628 (-)Ensembl
mRatBN7.2 Ensembl175,559,043 - 5,869,121 (-)Ensembl
Rnor_6.0 Ensembl175,934,690 - 6,244,612 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082611   ⟹   ENSRNOP00000073595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl175,564,570 - 5,874,628 (-)Ensembl
mRatBN7.2 Ensembl175,559,043 - 5,869,121 (-)Ensembl
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090914   ⟹   ENSRNOP00000070128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl175,744,682 - 5,874,628 (-)Ensembl
mRatBN7.2 Ensembl175,739,171 - 5,869,136 (-)Ensembl
Rnor_6.0 Ensembl176,114,598 - 6,244,627 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100565   ⟹   ENSRNOP00000082641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl175,790,177 - 5,874,628 (-)Ensembl
mRatBN7.2 Ensembl175,784,667 - 5,869,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101783   ⟹   ENSRNOP00000078799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl175,790,027 - 5,874,628 (-)Ensembl
mRatBN7.2 Ensembl175,784,517 - 5,869,136 (-)Ensembl
RefSeq Acc Id: NM_001163168   ⟹   NP_001156640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,744,682 - 5,874,628 (-)NCBI
mRatBN7.2175,739,171 - 5,869,126 (-)NCBI
Rnor_6.0176,114,598 - 6,244,627 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
RGSC_v3.41711,494,463 - 11,811,654 (-)RGD
Celera175,852,430 - 6,828,108 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012731   ⟹   NP_036863
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,564,570 - 5,874,628 (-)NCBI
mRatBN7.2175,559,043 - 5,869,126 (-)NCBI
Rnor_6.0175,934,690 - 6,244,612 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
RGSC_v3.41711,494,463 - 11,811,654 (-)RGD
Celera175,673,895 - 6,828,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253507   ⟹   XP_006253569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,689,411 - 5,874,756 (-)NCBI
mRatBN7.2175,683,893 - 5,868,087 (-)NCBI
Rnor_6.0176,060,564 - 6,244,716 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771425   ⟹   XP_008769647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,874,756 (-)NCBI
mRatBN7.2175,560,666 - 5,869,126 (-)NCBI
Rnor_6.0175,934,651 - 6,244,725 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771426   ⟹   XP_008769648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,875,798 (-)NCBI
mRatBN7.2175,560,666 - 5,870,171 (-)NCBI
Rnor_6.0175,934,651 - 6,245,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771427   ⟹   XP_008769649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,689,411 - 5,874,756 (-)NCBI
mRatBN7.2175,689,623 - 5,868,087 (-)NCBI
Rnor_6.0176,060,564 - 6,244,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600456   ⟹   XP_017455945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,875,801 (-)NCBI
mRatBN7.2175,560,666 - 5,870,299 (-)NCBI
Rnor_6.0175,934,651 - 6,245,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095370   ⟹   XP_038951298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,874,971 (-)NCBI
mRatBN7.2175,560,666 - 5,869,466 (-)NCBI
RefSeq Acc Id: XM_063276069   ⟹   XP_063132139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,875,798 (-)NCBI
RefSeq Acc Id: XM_063276070   ⟹   XP_063132140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,875,816 (-)NCBI
RefSeq Acc Id: XM_063276071   ⟹   XP_063132141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,560,558 - 5,872,206 (-)NCBI
RefSeq Acc Id: XM_063276072   ⟹   XP_063132142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,744,684 - 5,875,899 (-)NCBI
RefSeq Acc Id: XM_063276073   ⟹   XP_063132143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,744,684 - 5,875,816 (-)NCBI
RefSeq Acc Id: XM_063276074   ⟹   XP_063132144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8175,744,684 - 5,874,957 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001156640 (Get FASTA)   NCBI Sequence Viewer  
  NP_036863 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253569 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769647 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769648 (Get FASTA)   NCBI Sequence Viewer  
  XP_008769649 (Get FASTA)   NCBI Sequence Viewer  
  XP_017455945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951298 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132139 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132140 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132141 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132142 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132143 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42279 (Get FASTA)   NCBI Sequence Viewer  
  AAA42280 (Get FASTA)   NCBI Sequence Viewer  
  AAA42281 (Get FASTA)   NCBI Sequence Viewer  
  AAP21832 (Get FASTA)   NCBI Sequence Viewer  
  AAP46138 (Get FASTA)   NCBI Sequence Viewer  
  AGR50959 (Get FASTA)   NCBI Sequence Viewer  
  EDL93899 (Get FASTA)   NCBI Sequence Viewer  
  EDL93900 (Get FASTA)   NCBI Sequence Viewer  
  EDL93901 (Get FASTA)   NCBI Sequence Viewer  
  EDL93902 (Get FASTA)   NCBI Sequence Viewer  
  EDL93903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045635
  ENSRNOP00000045635.1
  ENSRNOP00000070128
  ENSRNOP00000070128.1
  ENSRNOP00000073595
GenBank Protein Q63604 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036863   ⟸   NM_012731
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63605 (UniProtKB/Swiss-Prot),   Q63606 (UniProtKB/Swiss-Prot),   Q63604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156640   ⟸   NM_001163168
- Peptide Label: isoform 2 precursor
- UniProtKB: A6KAJ1 (UniProtKB/TrEMBL),   A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253569   ⟸   XM_006253507
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769648   ⟸   XM_008771426
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769647   ⟸   XM_008771425
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769649   ⟸   XM_008771427
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZVM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455945   ⟸   XM_017600456
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073595   ⟸   ENSRNOT00000082611
Ensembl Acc Id: ENSRNOP00000070128   ⟸   ENSRNOT00000090914
Ensembl Acc Id: ENSRNOP00000045635   ⟸   ENSRNOT00000042145
RefSeq Acc Id: XP_038951298   ⟸   XM_039095370
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082641   ⟸   ENSRNOT00000100565
Ensembl Acc Id: ENSRNOP00000078799   ⟸   ENSRNOT00000101783
RefSeq Acc Id: XP_063132140   ⟸   XM_063276070
- Peptide Label: isoform X2
- UniProtKB: Q63606 (UniProtKB/Swiss-Prot),   Q63605 (UniProtKB/Swiss-Prot),   Q63604 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132139   ⟸   XM_063276069
- Peptide Label: isoform X2
- UniProtKB: Q63606 (UniProtKB/Swiss-Prot),   Q63605 (UniProtKB/Swiss-Prot),   Q63604 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063132141   ⟸   XM_063276071
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132142   ⟸   XM_063276072
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVM2 (UniProtKB/TrEMBL),   A6KAJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132143   ⟸   XM_063276073
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVM2 (UniProtKB/TrEMBL),   A6KAJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132144   ⟸   XM_063276074
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVM2 (UniProtKB/TrEMBL),   A6KAJ1 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   LRRNT   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63604-F1-model_v2 AlphaFold Q63604 1-821 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3213 AgrOrtholog
BioCyc Gene G2FUF-10400 BioCyc
Ensembl Genes ENSRNOG00000018839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042145 ENTREZGENE
  ENSRNOT00000042145.3 UniProtKB/Swiss-Prot
  ENSRNOT00000082611 ENTREZGENE
  ENSRNOT00000090914 ENTREZGENE
  ENSRNOT00000090914.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  NTRK_C2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kin_neurotrophic_rcpt_2 UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report rno:25054 UniProtKB/Swiss-Prot
NCBI Gene 25054 ENTREZGENE
PANTHER BDNF/NT-3 GROWTH FACTORS RECEPTOR UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot
PharmGKB NTRK2 RGD
PhenoGen Ntrk2 PhenoGen
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot
  NTKRECEPTOR2 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018839 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC207397
  TC233755
UniProt A0A0G2K5X6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLZ3_RAT UniProtKB/TrEMBL
  A0A8I5ZVM2 ENTREZGENE, UniProtKB/TrEMBL
  A6KAJ1 ENTREZGENE, UniProtKB/TrEMBL
  NTRK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63605 ENTREZGENE
  Q63606 ENTREZGENE
  Q7TSD7_RAT UniProtKB/TrEMBL
UniProt Secondary Q63605 UniProtKB/Swiss-Prot
  Q63606 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk2  neurotrophic receptor tyrosine kinase 2  Ntrk2  neurotrophic tyrosine kinase, receptor, type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Ntrk2  neurotrophic tyrosine kinase, receptor, type 2    Neural receptor protein-tyrosine kinase (trkB)  Name updated 625702 APPROVED
2002-06-10 Ntrk2  Neural receptor protein-tyrosine kinase (trkB)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function responsible for tyrosine phosphorylation of voltage-gated potassium channel Kv1.3 633084
gene_regulation activated by GM1 ganglioside 727459