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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
Acc ID: CHEBI:47499
Term: imipramine
Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Chemical ID: MESH:D007099
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntrk2increases phosphorylationISONtrk2 (Mus musculus)6480464CTDImipramine results in increased phosphorylation of NTRK2 proteinPMID:22396798
Ntrk2multiple interactionsISONtrk2 (Mus musculus)6480464CTDImipramine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]; Imipramine promotes the reaction [NTRK2 protein binds to PLCG1 protein modified form]; Imipramine results in increased phosphorylation of and results in increased activity of NTRK2 proteinPMID:21666748 PMID:22396798 PMID:31631060
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