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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3213
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntrk2increases expressionISONTRK2 (Homo sapiens)6480464CTDNicotine results in increased expression of NTRK2 proteinPMID:16790237
Ntrk2multiple interactionsISONtrk2 (Mus musculus)6480464CTD[Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein]PMID:36868510
Ntrk2multiple interactionsISONTRK2 (Homo sapiens)6480464CTDmethyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]PMID:16790237
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