RGD Reference Report - Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro. - Rat Genome Database

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Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro.

Authors: Gascon, E  Vutskits, L  Zhang, H  Barral-Moran, MJ  Kiss, PJ  Mas, C  Kiss, JZ 
Citation: Gascon E, etal., Eur J Neurosci. 2005 Jan;21(1):69-80.
RGD ID: 1626132
Pubmed: PMID:15654844   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1460-9568.2004.03849.x   (Journal Full-text)

Dendritic arbor development of subventricular zone-derived interneurons is a critical step in their integration into functional circuits of the postnatal olfactory bulb. However, the mechanism and molecular control of this process remain unknown. In this study, we have developed a culture model where dendritic development of purified subventricular zone cells proceeds under serum-free conditions in the absence of added growth factors and non-neural cells. We demonstrate that the large majority of these cells in culture express GABA and elaborate dendritic arbors with spine-like protrusions but they do not possess axons. These neurons expressed receptors for neurotrophins including p75, TrkB and TrkC but not TrkA. Application of exogenous neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and nerve growth factor (NGF), to cultures stimulated dendritic growth and led to more complex dendritic arbors during the initial 3 days in culture. Our results suggest that these effects are independent of Trk receptors and mediated by the p75/ceramide signaling pathway. We also show that brain-derived neurotrophic factor is the only neurotrophin that is able to influence late-phase dendritic development via TrkB receptor activation. These results suggest that dendritic arbor development of subventricular zone-derived cells may be regulated by neurotrophins through the activation of p75 and the TrkB receptor signaling pathways in a sequentially defined temporal pattern.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain-derived neurotrophic factor receptor signaling pathway  IMP 1626132 RGD 
regulation of dendrite development  IMP 1626132 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ntrk2  (neurotrophic receptor tyrosine kinase 2)


Additional Information