Ntrk2 (neurotrophic receptor tyrosine kinase 2) - Rat Genome Database

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Pathways
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Gene: Ntrk2 (neurotrophic receptor tyrosine kinase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
RGD ID: 12547522
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (ortholog); neurotrophin receptor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN brain-derived neurotrophic factor receptor signaling pathway (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to brain-derived neurotrophic factor stimulus (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); Alzheimer's disease (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BDNF/NT-3 growth factors receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936680267,596 - 615,928 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IEA)
brain-derived neurotrophic factor receptor signaling pathway  (IEA,ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IEA,ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
central nervous system neuron development  (IEA)
cerebral cortex development  (IEA)
circadian rhythm  (IEA)
feeding behavior  (IEA,ISO)
glutamate secretion  (IEA,ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
learning  (IEA)
long-term memory  (ISO)
long-term synaptic potentiation  (IEA)
mechanoreceptor differentiation  (IEA,ISO)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of anoikis  (IEA)
negative regulation of neuron apoptotic process  (ISO)
nervous system development  (IEA)
neuron differentiation  (IEA)
neuron migration  (IEA)
neuronal action potential propagation  (IEA,ISO)
neurotrophin signaling pathway  (IEA)
obsolete calcium-mediated signaling using intracellular calcium source  (ISO)
oligodendrocyte differentiation  (IEA)
peripheral nervous system neuron development  (IEA)
positive regulation of axonogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron projection development  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
protein autophosphorylation  (ISO)
regulation of dendrite development  (ISO)
regulation of MAPK cascade  (ISO)
regulation of metabolic process  (IEA,ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
response to auditory stimulus  (ISO)
response to ethanol  (ISO)
response to light stimulus  (ISO)
retina development in camera-type eye  (IEA,ISO)
retinal rod cell development  (IEA,ISO)
synapse organization  (IEA)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (IEA)
trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (IEA)
vasculogenesis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ntrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936680267,596 - 615,928 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38984,668,522 - 85,027,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl984,668,375 - 85,095,751 (+)EnsemblGRCh38hg38GRCh38
GRCh37987,283,437 - 87,641,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36986,473,286 - 86,828,325 (+)NCBINCBI36Build 36hg18NCBI36
Build 34984,514,246 - 84,866,963NCBI
Celera957,854,390 - 58,209,019 (+)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef957,108,647 - 57,463,914 (+)NCBIHuRef
CHM1_1987,429,973 - 87,785,074 (+)NCBICHM1_1
T2T-CHM13v2.0996,818,888 - 97,177,857 (+)NCBIT2T-CHM13v2.0
Ntrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391358,954,363 - 59,281,782 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,954,383 - 59,281,784 (+)EnsemblGRCm39 Ensembl
GRCm381358,806,472 - 59,133,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,806,569 - 59,133,970 (+)EnsemblGRCm38mm10GRCm38
MGSCv371358,907,957 - 59,231,337 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,816,219 - 59,139,599 (+)NCBIMGSCv36mm8
Celera1359,869,829 - 60,184,466 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.2NCBI
Ntrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8175,560,558 - 5,875,899 (-)NCBIGRCr8
mRatBN7.2175,558,992 - 5,870,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl175,559,043 - 5,869,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx175,584,315 - 5,894,662 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0177,120,448 - 7,429,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0175,580,732 - 5,891,094 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Celera175,673,895 - 6,828,108 (-)NCBICelera
Cytogenetic Map17p14NCBI
Ntrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBIChiLan1.0ChiLan1.0
NTRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,829,141 - 84,374,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1983,835,183 - 84,380,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0939,663,986 - 40,208,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1984,022,677 - 84,378,307 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl984,021,837 - 84,372,678 (+)Ensemblpanpan1.1panPan2
NTRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1174,447,927 - 74,777,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl174,449,060 - 74,777,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha175,211,260 - 75,538,451 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0174,754,263 - 75,081,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl174,755,372 - 75,083,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1174,562,918 - 74,890,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0174,331,860 - 74,658,907 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0175,035,216 - 75,362,564 (-)NCBIUU_Cfam_GSD_1.0
NTRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1030,033,405 - 30,429,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11030,030,050 - 30,429,938 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21034,211,939 - 34,350,822 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11295,477,612 - 95,836,734 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1295,479,447 - 95,620,364 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603883,830,767 - 84,200,895 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248098,276,951 - 8,616,765 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248098,274,736 - 8,622,287 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000008935   ⟹   ENSSTOP00000008008
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936680267,596 - 615,928 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000032838   ⟹   ENSSTOP00000024396
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936680267,596 - 404,221 (+)Ensembl
RefSeq Acc Id: XM_005337430   ⟹   XP_005337487
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,472,442 (-)NCBI
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734640   ⟹   XP_021590315
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,266,050 - 121,472,430 (-)NCBI
SpeTri2.0NW_004936680267,875 - 473,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040285609   ⟹   XP_040141543
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,468,739 (-)NCBI
RefSeq Acc Id: XM_040285610   ⟹   XP_040141544
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,468,736 (-)NCBI
RefSeq Acc Id: XM_040285611   ⟹   XP_040141545
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBI
RefSeq Acc Id: XM_040285612   ⟹   XP_040141546
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBI
RefSeq Acc Id: XM_040285613   ⟹   XP_040141547
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,116,646 - 121,471,469 (-)NCBI
RefSeq Acc Id: XM_040285615   ⟹   XP_040141549
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947121,266,050 - 121,472,432 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005337487   ⟸   XM_005337430
- Peptide Label: isoform X4
- UniProtKB: I3MCL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590315   ⟸   XM_021734640
- Peptide Label: isoform X6
- UniProtKB: A0A287CSX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040141545   ⟸   XM_040285611
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040141546   ⟸   XM_040285612
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040141547   ⟸   XM_040285613
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040141543   ⟸   XM_040285609
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040141544   ⟸   XM_040285610
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040141549   ⟸   XM_040285615
- Peptide Label: isoform X5
- UniProtKB: A0A287CSX5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000008008   ⟸   ENSSTOT00000008935
RefSeq Acc Id: ENSSTOP00000024396   ⟸   ENSSTOT00000032838
Protein Domains
Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008937 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008935.3 UniProtKB/TrEMBL
  ENSSTOT00000032838.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  NTRK_C2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kin_neurotrophic_rcpt_2 UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_NGF_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
NCBI Gene Ntrk2 ENTREZGENE
PANTHER BDNF/NT-3 GROWTH FACTORS RECEPTOR UniProtKB/TrEMBL
  CONTACTIN 5 UniProtKB/TrEMBL
  MUSCLE ASSOCIATED RECEPTOR TYROSINE KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  TPKR_C2 UniProtKB/TrEMBL
PRINTS NTKRECEPTOR UniProtKB/TrEMBL
  NTKRECEPTOR2 UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A287CSX5 ENTREZGENE, UniProtKB/TrEMBL
  I3MCL6 ENTREZGENE, UniProtKB/TrEMBL