Npm1 (nucleophosmin 1) - Rat Genome Database

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Gene: Npm1 (nucleophosmin 1) Rattus norvegicus
Analyze
Symbol: Npm1 (Ensembl: AABR07041089.1)
Name: nucleophosmin 1
RGD ID: 3192
Description: Enables several functions, including anion binding activity; p53 binding activity; and protein kinase B binding activity. Involved in several processes, including cellular response to testosterone stimulus; negative regulation of apoptotic process; and rRNA metabolic process. Located in nuclear matrix and nucleoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B23NP; MGC108517; NPM; nucleolar phosphoprotein B23; nucleolar protein B23.1; nucleolar protein NO38; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); Nucleoplasmin-related protein (Nuclear protein B23; numatrin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Npm1-ps1   Npm1-ps12   Npm1-ps14   Npm1-ps19  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,245,739 - 18,255,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1018,245,740 - 18,256,024 (-)EnsemblGRCr8
GRCr8 EnsemblX116,366,774 - 116,369,327 (-)EnsemblGRCr8
mRatBN7.21017,741,512 - 17,751,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,739,941 - 17,751,645 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX111,554,752 - 111,557,411 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1022,489,548 - 22,499,561 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,978,148 - 21,988,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,466,819 - 17,476,835 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,080,949 - 18,091,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,080,950 - 18,090,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01017,965,977 - 17,975,978 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41018,051,990 - 18,062,714 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1017,382,029 - 17,392,033 (-)NCBICelera
RGSC_v3.11018,053,038 - 18,063,763 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bromobenzene  (EXP)
busulfan  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dihydroartemisinin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
idarubicin  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (ISO)
lanthanum trichloride  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
Nivalenol  (ISO)
nocodazole  (ISO)
NSC 23766  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quartz  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vitamin E  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle hypertrophy  (IEP)
cell volume homeostasis  (ISO)
cellular response to hypoxia  (IEP)
cellular response to testosterone stimulus  (IEP)
cellular response to UV  (ISO)
cellular senescence  (ISO,ISS)
centrosome cycle  (ISO,ISS)
chromatin remodeling  (IBA)
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  (IDA)
DNA repair  (ISO,ISS)
intracellular protein localization  (ISO)
liver regeneration  (IEP)
macrophage differentiation  (ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of centrosome duplication  (ISO)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of mRNA splicing, via spliceosome  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein kinase activity by regulation of protein phosphorylation  (ISO,ISS)
nucleocytoplasmic transport  (ISO)
nucleosome assembly  (ISO)
positive regulation of biosynthetic process  (ISO)
positive regulation of catalytic activity  (IDA)
positive regulation of cell cycle G2/M phase transition  (ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of centrosome duplication  (ISO)
positive regulation of DNA metabolic process  (IDA)
positive regulation of DNA replication  (IDA)
positive regulation of DNA-directed DNA polymerase activity  (IDA)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to nucleolus  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
positive regulation of translation  (ISO,ISS)
post-transcriptional regulation of gene expression  (ISO)
protein import into nucleus  (ISO)
protein stabilization  (ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO)
regulation of cell population proliferation  (IEA)
regulation of centriole replication  (ISO,ISS)
regulation of centrosome duplication  (IBA,ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of eIF2 alpha phosphorylation by dsRNA  (ISO,ISS)
regulation of mRNA stability involved in cellular response to UV  (ISO)
regulation of neuron apoptotic process  (IMP)
regulation of protein stability  (ISO)
ribosomal large subunit biogenesis  (IBA,IEA,ISO)
ribosomal large subunit export from nucleus  (IBA,ISO)
ribosomal small subunit biogenesis  (IBA,ISO)
ribosomal small subunit export from nucleus  (IBA,ISO)
rRNA transcription  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Ahn JY, etal., Mol Cell. 2005 May 13;18(4):435-45.
2. Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin. Avitabile D, etal., Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6145-50. doi: 10.1073/pnas.1017935108. Epub 2011 Mar 28.
3. A single gene codes for two forms of rat nucleolar protein B23 mRNA. Chang JH and Olson MO, J Biol Chem 1989 Jul 15;264(20):11732-7.
4. Structure of the gene for rat nucleolar protein B23. Chang JH and Olson MO, J Biol Chem 1990 Oct 25;265(30):18227-33.
5. cDNA and deduced primary structure of rat protein B23, a nucleolar protein containing highly conserved sequences. Chang JH, etal., J Biol Chem 1988 Sep 15;263(26):12824-7.
6. Disruption of ATP binding destabilizes NPM/B23 and inhibits anti-apoptotic function. Choi JW, etal., BMB Rep. 2008 Dec 31;41(12):840-5.
7. A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment. Chou SH, etal., PLoS One. 2012;7(11):e49769. doi: 10.1371/journal.pone.0049769. Epub 2012 Nov 30.
8. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. Falini B, etal., N Engl J Med. 2005 Jan 20;352(3):254-66.
9. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Gale RE, etal., Blood. 2008 Mar 1;111(5):2776-84. Epub 2007 Oct 23.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. NPM mutations in acute myelogenous leukemia. Grisendi S and Pandolfi PP, N Engl J Med. 2005 Jan 20;352(3):291-2.
13. Sedimentation analyses of the salt- and divalent metal ion-induced oligomerization of nucleolar protein B23. Herrera JE, etal., Biochemistry. 1996 Feb 27;35(8):2668-73.
14. Altered HLA Class I Profile Associated with Type A/D Nucleophosmin Mutation Points to Possible Anti-Nucleophosmin Immune Response in Acute Myeloid Leukemia. Kuzelova K, etal., PLoS One. 2015 May 20;10(5):e0127637. doi: 10.1371/journal.pone.0127637. eCollection 2015.
15. Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival. Lee SB, etal., Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16584-9. doi: 10.1073/pnas.0807668105. Epub 2008 Oct 17.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization. Nishimura Y, etal., Biosci Biotechnol Biochem. 2002 Oct;66(10):2239-42.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. Rau R, etal., Exp Hematol. 2014 Feb;42(2):101-13.e5. doi: 10.1016/j.exphem.2013.10.005. Epub 2013 Oct 29.
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease. Savkur RS and Olson MO, Nucleic Acids Res. 1998 Oct 1;26(19):4508-15.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Stimulation of calf thymus DNA polymerase alpha activity by nucleolar protein B23. Takemura M, etal., Biochem Biophys Res Commun. 1994 Feb 28;199(1):46-51.
28. Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity. Takemura M, etal., J Biochem. 1999 May;125(5):904-9.
29. Androgenic regulation of the expression and phosphorylation of prostatic nucleolar protein B23. Tawfic S, etal., Cell Mol Biol Res. 1993;39(1):43-51.
30. The carboxyl terminal sequence of nucleolar protein B23.1 is important in its DNA polymerase alpha-stimulatory activity. Umekawa H, etal., J Biochem (Tokyo). 2001 Aug;130(2):199-205.
31. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Vassiliou GS, etal., Nat Genet. 2011 May;43(5):470-5. doi: 10.1038/ng.796. Epub 2011 Mar 27.
32. Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cells. Wang G, etal., Biochemistry. 2010 May 11;49(18):3842-52. doi: 10.1021/bi9021928.
33. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix. Yun JP, etal., J Cell Biochem. 2003 Dec 15;90(6):1140-8.
34. Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells. Zou T, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C686-96. Epub 2005 May 4.
Additional References at PubMed
PMID:2100262   PMID:9094689   PMID:9121481   PMID:10211837   PMID:10716735   PMID:11051553   PMID:11420665   PMID:11602260   PMID:12058066   PMID:12080348   PMID:12374805   PMID:12511551  
PMID:12882984   PMID:15087454   PMID:15485902   PMID:15489334   PMID:15596447   PMID:15607978   PMID:15615785   PMID:15989966   PMID:16007073   PMID:16027046   PMID:16041368   PMID:16099430  
PMID:16129783   PMID:16199867   PMID:16297385   PMID:16376875   PMID:16641100   PMID:16648475   PMID:16690610   PMID:16854843   PMID:16855206   PMID:17015463   PMID:17475909   PMID:17951246  
PMID:18023416   PMID:18420587   PMID:18625840   PMID:18809582   PMID:19160485   PMID:19188445   PMID:19208757   PMID:19581374   PMID:19946888   PMID:20352051   PMID:21423176   PMID:21630459  
PMID:22166220   PMID:22528486   PMID:22658674   PMID:22681889   PMID:22720776   PMID:23027902   PMID:24616519   PMID:24625528   PMID:25931508   PMID:25956029   PMID:27510036   PMID:31904090  
PMID:33450132   PMID:35352799  


Genomics

Comparative Map Data
Npm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,245,739 - 18,255,913 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1018,245,740 - 18,256,024 (-)EnsemblGRCr8
GRCr8 EnsemblX116,366,774 - 116,369,327 (-)EnsemblGRCr8
mRatBN7.21017,741,512 - 17,751,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,739,941 - 17,751,645 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX111,554,752 - 111,557,411 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1022,489,548 - 22,499,561 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,978,148 - 21,988,161 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,466,819 - 17,476,835 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,080,949 - 18,091,062 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,080,950 - 18,090,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01017,965,977 - 17,975,978 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41018,051,990 - 18,062,714 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1017,382,029 - 17,392,033 (-)NCBICelera
RGSC_v3.11018,053,038 - 18,063,763 (-)NCBI
Cytogenetic Map10q12NCBI
NPM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385171,387,116 - 171,410,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5171,387,086 - 171,411,810 (+)Ensemblhg38GRCh38
GRCh375170,814,120 - 170,837,904 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365170,747,403 - 170,770,493 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345170,747,461 - 170,770,492NCBI
Celera5166,847,258 - 166,870,233 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5165,912,826 - 165,935,666 (+)NCBIHuRef
CHM1_15170,247,232 - 170,270,413 (+)NCBICHM1_1
T2T-CHM13v2.05171,927,442 - 171,951,228 (+)NCBIT2T-CHM13v2.0
Npm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,102,498 - 33,114,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,102,287 - 33,113,206 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381133,152,498 - 33,164,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,152,287 - 33,163,206 (-)Ensemblmm10GRCm38
MGSCv371133,052,511 - 33,063,056 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361133,052,511 - 33,063,056 (-)NCBIMGSCv36mm8
Celera1135,564,831 - 35,575,324 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.21NCBI
Npm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540824,208,686 - 24,218,466 (+)Ensembl
ChiLan1.0NW_00495540824,151,070 - 24,218,783 (+)NCBIChiLan1.0ChiLan1.0
NPM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24166,524,239 - 166,544,710 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15164,663,846 - 164,684,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05166,735,904 - 166,756,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15173,490,197 - 173,510,657 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5173,490,197 - 173,510,656 (+)EnsemblpanPan2panpan1.1
NPM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,756,464 - 40,770,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,756,465 - 40,770,175 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha440,705,264 - 40,718,971 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0441,134,159 - 41,147,850 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,134,159 - 41,147,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1440,949,115 - 40,962,816 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,139,397 - 41,153,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0441,649,467 - 41,663,173 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,989,965 - 95,002,964 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366093,712,962 - 3,725,505 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366093,712,628 - 3,725,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,765,298 - 52,781,771 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11652,767,263 - 52,781,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,963,998 - 56,978,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12373,555,020 - 73,575,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2373,555,260 - 73,575,925 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660345,065,310 - 5,086,261 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473318,645,269 - 18,655,073 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v195,980,484 - 5,990,573 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npm1
107 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:48
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000006591, ENSRNOT00000064744
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101774978420796344Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101576223019737486Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC060579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006591   ⟹   ENSRNOP00000006591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1018,245,740 - 18,256,024 (-)Ensembl
mRatBN7.2 Ensembl1017,739,941 - 17,751,645 (-)Ensembl
Rnor_6.0 Ensembl1018,080,950 - 18,090,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064744   ⟹   ENSRNOP00000062356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1018,247,716 - 18,255,723 (-)Ensembl
mRatBN7.2 Ensembl1017,743,494 - 17,751,519 (-)Ensembl
Rnor_6.0 Ensembl1018,082,932 - 18,090,932 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118471   ⟹   ENSRNOP00000092710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1017,739,941 - 17,751,514 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164406   ⟹   ENSRNOP00000107011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1018,245,740 - 18,255,741 (-)Ensembl
RefSeq Acc Id: NM_012992   ⟹   NP_037124
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,245,739 - 18,255,741 (-)NCBI
mRatBN7.21017,741,512 - 17,751,514 (-)NCBI
Rnor_6.01018,080,949 - 18,090,950 (-)NCBI
Rnor_5.01017,965,977 - 17,975,978 (-)NCBI
RGSC_v3.41018,051,990 - 18,062,714 (-)RGD
Celera1017,382,029 - 17,392,033 (-)RGD
Sequence:
RefSeq Acc Id: XM_063268470   ⟹   XP_063124540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81018,247,717 - 18,255,913 (-)NCBI
RefSeq Acc Id: NP_037124   ⟸   NM_012992
- UniProtKB: Q63698 (UniProtKB/Swiss-Prot),   Q64269 (UniProtKB/Swiss-Prot),   P13084 (UniProtKB/Swiss-Prot),   A6HDG2 (UniProtKB/TrEMBL),   D3ZXI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006591   ⟸   ENSRNOT00000006591
Ensembl Acc Id: ENSRNOP00000062356   ⟸   ENSRNOT00000064744
Ensembl Acc Id: ENSRNOP00000092710   ⟸   ENSRNOT00000118471
RefSeq Acc Id: XP_063124540   ⟸   XM_063268470
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107011   ⟸   ENSRNOT00000164406
Protein Domains
Nucleophosmin C-terminal   Nucleoplasmin core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13084-F1-model_v2 AlphaFold P13084 1-292 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697094
Promoter ID:EPDNEW_R7619
Type:multiple initiation site
Name:Npm1_1
Description:nucleophosmin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01018,090,953 - 18,091,013EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3192 AgrOrtholog
BioCyc Gene G2FUF-25609 BioCyc
Ensembl Genes ENSRNOG00000004616 Ensembl, ENTREZGENE
  ENSRNOG00000018923 Ensembl
Ensembl Transcript ENSRNOT00000006591 ENTREZGENE
  ENSRNOT00000064744 ENTREZGENE
Gene3D-CATH 1.10.10.2100 UniProtKB/Swiss-Prot
  Nucleoplasmin core domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888417 IMAGE-MGC_LOAD
  IMAGE:7382200 IMAGE-MGC_LOAD
InterPro NPM1_C UniProtKB/Swiss-Prot
  Nucleoplasmin UniProtKB/Swiss-Prot
  Nucleoplasmin_core_dom UniProtKB/Swiss-Prot
  Nucleoplasmin_core_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25498 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108517 IMAGE-MGC_LOAD
  MGC:72897 IMAGE-MGC_LOAD
NCBI Gene 25498 ENTREZGENE
PANTHER NUCLEOPHOSMIN UniProtKB/Swiss-Prot
  PTHR22747 UniProtKB/Swiss-Prot
Pfam NPM1-C UniProtKB/Swiss-Prot
  Nucleoplasmin UniProtKB/Swiss-Prot
PhenoGen Npm1 PhenoGen
RatGTEx ENSRNOG00000004616 RatGTEx
  ENSRNOG00000018923 RatGTEx
Superfamily-SCOP SSF69203 UniProtKB/Swiss-Prot
UniProt A0A8L2Q2H9_RAT UniProtKB/TrEMBL
  A0A8L2QVX8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LYP1_RAT UniProtKB/TrEMBL
  A6HDG2 ENTREZGENE, UniProtKB/TrEMBL
  A6HDG3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXI2 ENTREZGENE, UniProtKB/TrEMBL
  NPM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63698 ENTREZGENE
  Q64269 ENTREZGENE
UniProt Secondary Q63698 UniProtKB/Swiss-Prot
  Q64269 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Npm1  nucleophosmin 1  Npm1  nucleophosmin (nucleolar phosphoprotein B23, numatrin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Npm1  nucleophosmin (nucleolar phosphoprotein B23, numatrin)  Npm1  nucleophosmin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Npm1  nucleophosmin 1    Nucleoplasmin-related protein (Nuclear protein B23  Name updated 625702 APPROVED
2002-06-10 Npm1  Nucleoplasmin-related protein (Nuclear protein B23      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction has a high affinity for silver ions 729271
gene_transcript has two alternative splice forms 728939