Kcnn2 (potassium calcium-activated channel subfamily N member 2) - Rat Genome Database

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Gene: Kcnn2 (potassium calcium-activated channel subfamily N member 2) Rattus norvegicus
Analyze
Symbol: Kcnn2
Name: potassium calcium-activated channel subfamily N member 2
RGD ID: 2963
Description: Enables calmodulin binding activity and small conductance calcium-activated potassium channel activity. Involved in positive regulation of potassium ion transport; potassium ion transport; and regulation of neuronal synaptic plasticity. Located in dendritic spine; membrane; and neuronal cell body. Used to study essential tremor. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2); PARTICIPATES IN calcium/calcium-mediated signaling pathway; bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KCa2.2; LOC103690147; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnn2Trdk
Genetic Models: F344-Kcnn2Trdk/Kyo
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: The locus_ids 54262 and 103690147 are annotated independently on Rnor_6.0 (AR 105). [28 May 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81840,004,693 - 40,445,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1840,155,939 - 40,445,045 (+)EnsemblGRCr8
mRatBN7.21837,817,966 - 38,258,347 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1837,817,957 - 38,258,347 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1840,147,538 - 40,291,656 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01840,849,776 - 40,993,881 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01838,642,870 - 38,786,982 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01839,331,894 - 39,479,574 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)Ensemblrn6Rnor6.0
Rnor_5.01838,822,146 - 38,864,110 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41839,560,962 - 39,705,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1836,394,877 - 36,538,795 (+)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cyproheptadine  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
dequalinium  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
difenoconazole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
furan  (EXP)
gedunin  (ISO)
glucose  (ISO)
imipramine  (EXP)
indole-3-methanol  (EXP)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
organophosphorus compound  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
sunitinib  (ISO)
tacrine  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thallium atom  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trifluoperazine  (EXP)
tubocurarine  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
tremors  (IMP)
References

References - curated
# Reference Title Reference Citation
1. Small-conductance Ca2+-activated K+ channels: form and function. Adelman JP, etal., Annu Rev Physiol. 2012;74:245-69. doi: 10.1146/annurev-physiol-020911-153336. Epub 2011 Sep 19.
2. Chronic Intermittent Ethanol Exposure Selectively Increases Synaptic Excitability in the Ventral Domain of the Rat Hippocampus. Ewin SE, etal., Neuroscience. 2019 Feb 1;398:144-157. doi: 10.1016/j.neuroscience.2018.11.028. Epub 2018 Nov 24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. SK2 channel expression and function in cerebellar Purkinje cells. Hosy E, etal., J Physiol. 2011 Jul 15;589(Pt 14):3433-40. doi: 10.1113/jphysiol.2011.205823. Epub 2011 Apr 26.
6. Small-conductance, calcium-activated potassium channels from mammalian brain. Kohler M, etal., Science 1996 Sep 20;273(5282):1709-14.
7. Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel. Kuramoto T, etal., Brain Res. 2017 Dec 1;1676:38-45. doi: 10.1016/j.brainres.2017.09.012. Epub 2017 Sep 13.
8. Allosteric block of KCa2 channels by apamin. Lamy C, etal., J Biol Chem. 2010 Aug 27;285(35):27067-27077. doi: 10.1074/jbc.M110.110072. Epub 2010 Jun 18.
9. Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating. Maingret F, etal., Neuron. 2008 Aug 14;59(3):439-49. doi: 10.1016/j.neuron.2008.05.026.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. Monaghan AS, etal., J Biol Chem 2004 Jan 9;279(2):1003-9. Epub 2003 Oct 14.
12. The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system. Mongan LC, etal., Neuroscience. 2005;131(1):161-75.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Noble K, etal., Cell Calcium. 2010 Jan;47(1):47-54. doi: 10.1016/j.ceca.2009.11.004. Epub 2009 Dec 6.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Schumacher MA, etal., Nature. 2001 Apr 26;410(6832):1120-4.
20. Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Schumacher MA, etal., Structure. 2004 May;12(5):849-60.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Xia XM, etal., Nature. 1998 Oct 1;395(6701):503-7. doi: 10.1038/26758.
23. Structural basis for calmodulin as a dynamic calcium sensor. Zhang M, etal., Structure. 2012 May 9;20(5):911-23. doi: 10.1016/j.str.2012.03.019.
Additional References at PubMed
PMID:15356192   PMID:17110593   PMID:17347645   PMID:18624921   PMID:19139040   PMID:19144926   PMID:19254702   PMID:19815520   PMID:23129791   PMID:24096910   PMID:24381116   PMID:24951510  
PMID:26362340   PMID:27165696   PMID:27872234   PMID:28282037   PMID:31001092   PMID:34774547   PMID:36717104   PMID:37466411  


Genomics

Comparative Map Data
Kcnn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81840,004,693 - 40,445,043 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1840,155,939 - 40,445,045 (+)EnsemblGRCr8
mRatBN7.21837,817,966 - 38,258,347 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1837,817,957 - 38,258,347 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1840,147,538 - 40,291,656 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01840,849,776 - 40,993,881 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01838,642,870 - 38,786,982 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01839,331,894 - 39,479,574 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)Ensemblrn6Rnor6.0
Rnor_5.01838,822,146 - 38,864,110 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41839,560,962 - 39,705,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1836,394,877 - 36,538,795 (+)NCBICelera
Cytogenetic Map18q11NCBI
KCNN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385114,055,978 - 114,496,496 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5114,055,926 - 114,496,500 (+)Ensemblhg38GRCh38
GRCh375113,391,675 - 113,832,193 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365113,725,915 - 113,860,096 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345113,797,125 - 113,860,096NCBI
Celera5109,645,171 - 109,779,247 (+)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5108,880,682 - 109,014,440 (+)NCBIHuRef
CHM1_15113,130,747 - 113,264,917 (+)NCBICHM1_1
T2T-CHM13v2.05114,568,913 - 115,009,369 (+)NCBIT2T-CHM13v2.0
Kcnn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391845,401,754 - 45,818,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1845,401,927 - 45,818,950 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381845,268,750 - 45,685,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1845,268,860 - 45,686,024 (+)Ensemblmm10GRCm38
MGSCv371845,719,808 - 45,845,537 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361845,685,485 - 45,811,214 (+)NCBIMGSCv36mm8
Celera1846,932,460 - 47,057,444 (+)NCBICelera
Cytogenetic Map18B3- CNCBI
cM Map1824.34NCBI
Kcnn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540834,109,334 - 34,368,114 (+)Ensembl
ChiLan1.0NW_00495540834,223,523 - 34,366,191 (+)NCBIChiLan1.0ChiLan1.0
KCNN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24108,932,344 - 109,759,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15107,774,104 - 107,913,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05109,722,916 - 109,862,747 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15115,522,363 - 115,661,398 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5115,522,443 - 115,661,079 (+)EnsemblpanPan2panpan1.1
KCNN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,279,362 - 4,423,080 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,154,746 - 4,423,078 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha114,114,348 - 4,574,043 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0114,259,813 - 4,403,473 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,258,999 - 4,403,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,914,674 - 4,366,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,295,183 - 4,439,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,237,744 - 4,692,269 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213127,017,453 - 127,153,054 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937043134,301 - 161,686 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937043133,981 - 269,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2118,439,403 - 118,882,295 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12118,439,328 - 118,882,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22123,463,548 - 123,612,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12317,595,661 - 17,735,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2317,598,177 - 17,735,669 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603460,665,455 - 60,803,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247337,429,681 - 7,578,596 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247337,429,681 - 7,931,192 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnn2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11541,073,532 - 41,222,298 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnn2
2045 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000022530, ENSRNOT00000067262
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat


Genetic Models
This gene Kcnn2 is modified in the following models/strains:
F344-Kcnn2Trdk/Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 11 65 155 76 74 44 37 44 6 285 134 11 132 86 93 30 21 21

Sequence


Ensembl Acc Id: ENSRNOT00000022530   ⟹   ENSRNOP00000022530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1840,155,939 - 40,445,045 (+)Ensembl
mRatBN7.2 Ensembl1837,817,957 - 38,258,347 (+)Ensembl
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067262   ⟹   ENSRNOP00000060708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083642   ⟹   ENSRNOP00000069058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1840,299,477 - 40,445,045 (+)Ensembl
mRatBN7.2 Ensembl1837,818,045 - 38,258,347 (+)Ensembl
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086651   ⟹   ENSRNOP00000070118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1839,172,028 - 39,209,678 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158120   ⟹   ENSRNOP00000106518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1840,299,477 - 40,445,045 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167628   ⟹   ENSRNOP00000104994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1840,219,423 - 40,445,045 (+)Ensembl
RefSeq Acc Id: NM_001309404   ⟹   NP_001296333
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81840,300,927 - 40,445,043 (+)NCBI
mRatBN7.21838,114,226 - 38,258,347 (+)NCBI
Rnor_6.01839,335,377 - 39,479,574 (+)NCBI
Celera1836,394,877 - 36,538,795 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019314   ⟹   NP_062187
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81840,300,927 - 40,445,043 (+)NCBI
mRatBN7.21838,114,226 - 38,258,347 (+)NCBI
Rnor_6.01839,335,377 - 39,479,574 (+)NCBI
Rnor_5.01838,822,146 - 38,864,110 (+)NCBI
RGSC_v3.41839,560,962 - 39,705,037 (+)RGD
Celera1836,394,877 - 36,538,795 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063277519   ⟹   XP_063133589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81840,004,701 - 40,445,041 (+)NCBI
RefSeq Acc Id: XM_063277520   ⟹   XP_063133590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81840,299,382 - 40,444,493 (+)NCBI
RefSeq Acc Id: XM_063277521   ⟹   XP_063133591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81840,004,693 - 40,444,491 (+)NCBI
RefSeq Acc Id: NP_062187   ⟸   NM_019314
- Peptide Label: isoform 2
- UniProtKB: P70604 (UniProtKB/Swiss-Prot),   A6IWU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001296333   ⟸   NM_001309404
- Peptide Label: isoform 1
- UniProtKB: H6VQ94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060708   ⟸   ENSRNOT00000067262
Ensembl Acc Id: ENSRNOP00000022530   ⟸   ENSRNOT00000022530
Ensembl Acc Id: ENSRNOP00000069058   ⟸   ENSRNOT00000083642
Ensembl Acc Id: ENSRNOP00000070118   ⟸   ENSRNOT00000086651
RefSeq Acc Id: XP_063133591   ⟸   XM_063277521
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JUD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133589   ⟸   XM_063277519
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUD7 (UniProtKB/TrEMBL),   A0A8L2QBG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133590   ⟸   XM_063277520
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106518   ⟸   ENSRNOT00000158120
Ensembl Acc Id: ENSRNOP00000104994   ⟸   ENSRNOT00000167628
Protein Domains
Calmodulin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACB9-F1-model_v2 AlphaFold D4ACB9 1-335 view protein structure
AF-P70604-F1-model_v2 AlphaFold P70604 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2963 AgrOrtholog
BioCyc Gene G2FUF-7652 BioCyc
Ensembl Genes ENSRNOG00000016675 Ensembl, ENTREZGENE
  ENSRNOG00000051569 Ensembl
Ensembl Transcript ENSRNOT00000022530 ENTREZGENE
  ENSRNOT00000083642 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
InterPro CaM-bd_dom UniProtKB/Swiss-Prot
  CaM-bd_dom_sf UniProtKB/Swiss-Prot
  K_chnl_Ca-activ_SK UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
KEGG Report rno:54262 UniProtKB/Swiss-Prot
NCBI Gene 54262 ENTREZGENE
PANTHER PTHR10153 UniProtKB/Swiss-Prot
Pfam CaMBD UniProtKB/Swiss-Prot
  Ion_trans_2 UniProtKB/Swiss-Prot
  SK_channel UniProtKB/Swiss-Prot
PhenoGen Kcnn2 PhenoGen
PRINTS SKCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016675 RatGTEx
  ENSRNOG00000051569 RatGTEx
SMART CaMBD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81327 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC223303
UniProt A0A0G2JUD7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QBG6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8C0_RAT UniProtKB/TrEMBL
  A0ABK0LMQ9_RAT UniProtKB/TrEMBL
  A6IWU8 ENTREZGENE, UniProtKB/TrEMBL
  H6VQ94 ENTREZGENE, UniProtKB/TrEMBL
  KCNN2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Kcnn2  potassium calcium-activated channel subfamily N member 2  LOC103690147  small conductance calcium-activated potassium channel protein 2-like  Data merged from RGD:9234828 737654 PROVISIONAL
2016-02-11 Kcnn2  potassium calcium-activated channel subfamily N member 2  Kcnn2  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnn2  potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2  Kcnn2  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103690147  small conductance calcium-activated potassium channel protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Kcnn2  potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs shows sensitivity to apamin and tubocurare 69872
gene_process involved in afterhyperpolarization in central neurons 69872