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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnn2
Name: potassium calcium-activated channel subfamily N member 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnn2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of KCNN2 mRNAPMID:21839799
Kcnn2decreases expressionISOKCNN2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of KCNN2 mRNAPMID:21802500
Kcnn2increases methylationISOKCNN2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KCNN2 exon; Benzo(a)pyrene results in increased methylation of KCNN2 promoterPMID:27901495
Kcnn2increases methylationISOKcnn2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of KCNN2 intronPMID:27901495
Kcnn2increases mutagenesisISOKCNN2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of KCNN2 genePMID:25435355
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