KCNN2 (potassium calcium-activated channel subfamily N member 2) - Rat Genome Database

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Gene: KCNN2 (potassium calcium-activated channel subfamily N member 2) Canis lupus familiaris
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Symbol: KCNN2
Name: potassium calcium-activated channel subfamily N member 2
RGD ID: 12247289
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); calmodulin binding (ortholog); inward rectifier potassium channel activity (ortholog); INVOLVED IN membrane repolarization during atrial cardiac muscle cell action potential (ortholog); modulation of chemical synaptic transmission (ortholog); positive regulation of potassium ion transport (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN cell surface (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC111097984; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel protein 2-like; uncharacterized LOC111097984
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,279,362 - 4,423,080 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,154,746 - 4,423,078 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,114,348 - 4,574,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0114,259,813 - 4,403,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,258,999 - 4,403,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,914,674 - 4,366,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,295,183 - 4,439,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,237,744 - 4,692,269 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:23376397   PMID:30032202  


Genomics

Comparative Map Data
KCNN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1114,279,362 - 4,423,080 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl114,154,746 - 4,423,078 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha114,114,348 - 4,574,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0114,259,813 - 4,403,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl114,258,999 - 4,403,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,914,674 - 4,366,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0114,295,183 - 4,439,054 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0114,237,744 - 4,692,269 (+)NCBIUU_Cfam_GSD_1.0
KCNN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385114,055,978 - 114,496,496 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5114,055,926 - 114,496,500 (+)EnsemblGRCh38hg38GRCh38
GRCh375113,391,675 - 113,832,193 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365113,725,915 - 113,860,096 (+)NCBINCBI36Build 36hg18NCBI36
Build 345113,797,125 - 113,860,096NCBI
Celera5109,645,171 - 109,779,247 (+)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5108,880,682 - 109,014,440 (+)NCBIHuRef
CHM1_15113,130,747 - 113,264,917 (+)NCBICHM1_1
T2T-CHM13v2.05114,568,913 - 115,009,369 (+)NCBIT2T-CHM13v2.0
Kcnn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391845,401,754 - 45,818,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1845,401,927 - 45,818,950 (+)EnsemblGRCm39 Ensembl
GRCm381845,268,750 - 45,685,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1845,268,860 - 45,686,024 (+)EnsemblGRCm38mm10GRCm38
MGSCv371845,719,808 - 45,845,537 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361845,685,485 - 45,811,214 (+)NCBIMGSCv36mm8
Celera1846,932,460 - 47,057,444 (+)NCBICelera
Cytogenetic Map18B3- CNCBI
cM Map1824.34NCBI
Kcnn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81840,004,693 - 40,445,043 (+)NCBIGRCr8
mRatBN7.21837,817,966 - 38,258,347 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1837,817,957 - 38,258,347 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1840,147,538 - 40,291,656 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01840,849,776 - 40,993,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01838,642,870 - 38,786,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01839,331,894 - 39,479,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1839,335,377 - 39,479,257 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01838,822,146 - 38,864,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41839,560,962 - 39,705,037 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1836,394,877 - 36,538,795 (+)NCBICelera
Cytogenetic Map18q11NCBI
Kcnn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540834,109,334 - 34,368,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540834,223,523 - 34,366,191 (+)NCBIChiLan1.0ChiLan1.0
KCNN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24108,932,344 - 109,759,429 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15107,774,104 - 107,913,089 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05109,722,916 - 109,862,747 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15115,522,363 - 115,661,398 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5115,522,443 - 115,661,079 (+)Ensemblpanpan1.1panPan2
Kcnn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213127,017,453 - 127,153,054 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004937043133,981 - 269,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2118,439,403 - 118,882,295 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12118,439,328 - 118,882,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22123,463,548 - 123,612,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12317,595,661 - 17,735,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2317,598,177 - 17,735,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603460,665,455 - 60,803,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247337,429,681 - 7,578,596 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247337,429,681 - 7,931,192 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNN2
1169 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 10 5 5 6
Low 4 8 1 3 1 6 6 6
Below cutoff 1 5 4 3 6 6 2 4 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000351   ⟹   ENSCAFP00000000318
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl114,154,746 - 4,423,078 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019115   ⟹   ENSCAFP00845014933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl114,258,999 - 4,403,890 (+)Ensembl
RefSeq Acc Id: XM_022425125   ⟹   XP_022280833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1114,279,362 - 4,423,080 (+)NCBI
Dog10K_Boxer_Tasha114,430,356 - 4,574,043 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038489785   ⟹   XP_038345713
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1114,222,574 - 4,366,142 (+)NCBI
RefSeq Acc Id: XM_038489786   ⟹   XP_038345714
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1113,914,674 - 4,366,142 (+)NCBI
RefSeq Acc Id: XM_038551826   ⟹   XP_038407754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0114,548,580 - 4,692,269 (+)NCBI
RefSeq Acc Id: XM_038551827   ⟹   XP_038407755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0114,237,744 - 4,692,269 (+)NCBI
RefSeq Acc Id: XM_038615716   ⟹   XP_038471644
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0114,295,183 - 4,439,054 (+)NCBI
RefSeq Acc Id: XM_038662673   ⟹   XP_038518601
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha114,114,348 - 4,574,043 (+)NCBI
RefSeq Acc Id: XM_038681183   ⟹   XP_038537111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0114,259,813 - 4,403,473 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022280833   ⟸   XM_022425125
- Peptide Label: isoform X1
- UniProtKB: A0A8P0S674 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000318   ⟸   ENSCAFT00000000351
RefSeq Acc Id: XP_038345714   ⟸   XM_038489786
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038345713   ⟸   XM_038489785
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038471644   ⟸   XM_038615716
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038537111   ⟸   XM_038681183
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SBF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518601   ⟸   XM_038662673
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038407755   ⟸   XM_038551827
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038407754   ⟸   XM_038551826
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SBF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014933   ⟸   ENSCAFT00845019115
Protein Domains
Calmodulin-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000220 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004292 UniProtKB/TrEMBL
  ENSCAFG00040011597 UniProtKB/TrEMBL
  ENSCAFG00845010795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000351.6 UniProtKB/TrEMBL
  ENSCAFT00030007965.1 UniProtKB/TrEMBL
  ENSCAFT00040021529.1 UniProtKB/TrEMBL
  ENSCAFT00845019115 ENTREZGENE
  ENSCAFT00845019115.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro CaM-bd_dom UniProtKB/TrEMBL
  CaM-bd_dom_sf UniProtKB/TrEMBL
  K_chnl_Ca-activ_SK UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
NCBI Gene KCNN2 ENTREZGENE
PANTHER PTHR10153 UniProtKB/TrEMBL
  SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2 UniProtKB/TrEMBL
Pfam CaMBD UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
  SK_channel UniProtKB/TrEMBL
PRINTS SKCHANNEL UniProtKB/TrEMBL
SMART CaMBD UniProtKB/TrEMBL
Superfamily-SCOP SSF81327 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C0M6E5_CANLF UniProtKB/TrEMBL
  A0A8C0SBF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RW27_CANLF UniProtKB/TrEMBL
  A0A8P0S674 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42285 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 KCNN2  potassium calcium-activated channel subfamily N member 2  LOC111097984  uncharacterized LOC111097984  Data merged from RGD:13218905 737654 PROVISIONAL