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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2963
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnn2
Name: potassium calcium-activated channel subfamily N member 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnn2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of KCNN2 mRNAPMID:25181051
Kcnn2increases expressionEXP 6480464CTDbisphenol A results in increased expression of KCNN2 mRNAPMID:29552716 PMID:34947998
Kcnn2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KCNN2 promoter; [bisphenol A co-treated with Testosterone] results in decreased expression of KCNN2 mRNAPMID:23359474 PMID:26496021
Kcnn2increases expressionISOKCNN2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of KCNN2 mRNAPMID:29275510
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