Gene:	Irs1 ( Rattus norvegicus ) insulin receptor substrate 1
Description:	a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism
Synonyms:	IRS1IRM;
ArrayIDs:	6565382; 6633705; 5663853; 1369771_at; 5894666; 6354816; X58375_at; 6661509; 6513987; 6311870; 6708333; rc_AA963662_s_at; 6190292; GE22141; 6367253;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: IRS1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Irs1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Irs1 genome assembly 3.1 9 81768669 - 81821490     Rat Celera Assembly 9 80997490 - 81050250     RGSC genome assembly v3.4 9 81585251 - 81638071     Cytogenetic 9 q34 Mus musculus Irs1 Mouse genome assembly build 36.1 1 82233185 - 82287991     Cytogenetic 1 1 C5 Homo sapiens IRS1 human genome assembly 2 227425442 - 227489980     Human genome assembly build 36.2 2 227308182 - 227372719     Cytogenetic 2 q36   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology SH2 domain binding,  transmembrane receptor protein tyrosine kinase docking protein activity,  protein kinase binding ...  (details...)
Biological Process	Gene Ontology mammary gland development,  negative regulation of insulin receptor signaling pathway,  signal transduction ...  (details...)
Cellular Component	Gene Ontology nucleus,  cytoplasm,  caveola ...  (details...)
Disease	Ontology Insulin Resistance,  Coronary Arteriosclerosis,  Diabetes Mellitus, Non-Insulin-Dependent (details...)
Pathway	Ontology leptin system pathway,  insulin-like growth factor signaling pathway,  insulin signaling pathway (details...)
Protein	Note Reference phosphorylated on tyrosines following insulin stimulation 728920
Physical interaction	Note Reference binds phosphatidylinositol 3-kinase 728920
External Links
Databases	DATABASE ID SOURCE SMART: PTBI IPI SMART: PH IPI PROSITE: PH_DOMAIN IPI PROSITE: IRS_PTB IPI UNIPARC: UPI000012D8C0 IPI KEGG Report: rno:25467 ENTREZGENE HomoloGene Group ID: 4049 ENTREZGENE Germonline: 2922 Pfam: PH IPI Pfam: IRS IPI KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: Pleckstrin_homology. IPI InterPro: PH_type. IPI InterPro: Insln_rcpt_S1. IPI IPI: IPI00199662 IPI Ensembl Protein: ENSRNOP00000019579 IPI Gene3D-CATH: PH_type IPI Entrez Gene: Irs1 ENTREZGENE TIGR: TC236234 UniProt: IRS1_RAT IPI Ensembl Genes: ENSRNOG00000014597 IPI RatMap: 41352 ENTREZGENE PRINTS: INSULINRSI. IPI
Sequences	Nucleotide: X58375 Get FASTA Search GEO Profiles Nucleotide: CH474004 Get FASTA Search GEO Profiles Nucleotide: NM_012969 Get FASTA Search GEO Profiles (View all 3 Nucleotide Accessions) Protein: P35570 Get FASTA Protein: CAA41264 Get FASTA Protein: EDL75502 Get FASTA Protein: NP_037101 Get FASTA (View all 4 Protein Accessions)
Clusters	UniGene: 10476
References
Curated References	20 references in RGD related to Irs1
Other References	69 other references at PubMed related to Irs1
Database Information
RGD ID	2922
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Irs1 Insulin receptor substrate 1 APPROVED Symbol and Name status set to approved 70586