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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922 Species: Rattus norvegicus RGD Object: Gene Symbol: Irs1 Name: insulin receptor substrate 1

Acc ID: CHEBI:33216 Term: bisphenol A Definition: A bisphenol that has formula C15H16O2. CasRN: 80-05-7 Chemical ID: MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	bisphenol A results in decreased expression of IRS1 protein	PMID:22142692
increases expression	ISO	RGD:733473	6480464	CTD	bisphenol A results in increased expression of IRS1 mRNA	PMID:16029874
increases expression	ISO	RGD:10816	6480464	CTD	bisphenol A results in increased expression of IRS1 protein	PMID:22470480