Igf2 (insulin-like growth factor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Igf2 (insulin-like growth factor 2) Rattus norvegicus
Analyze
Symbol: Igf2
Name: insulin-like growth factor 2
RGD ID: 2870
Description: Predicted to enable protein kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2); PARTICIPATES IN insulin-like growth factor signaling pathway; INTERACTS WITH (S)-nicotine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF-II; IGFII; insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); insulin-like growth factor II isoform 2 variant 4 preprotein; MSA; multiplication-stimulating activity; multiplication-stimulating polypeptide; RNIGF2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv ; BB.SHR-(Acsm3-Igf2)/K
QTLs:   Bp30   Bp42   Thym4   Bw39  
Candidate Gene For: Niddm7 Hcar4 Iddm25
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,243,873 - 207,261,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,243,873 - 207,260,667 (-)EnsemblGRCr8
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,432,460 - 195,442,561 (-)NCBICelera
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Cytogenetic Map1q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
adrenocortical carcinoma  (ISO)
alcohol use disorder  (ISO)
alcohol-associated liver disease  (IEP)
alcoholic neuropathy  (IEP)
Alzheimer's disease  (IEP,ISO)
anemia  (ISO)
Animal Mammary Neoplasms  (IEP)
atherosclerosis  (ISO)
autistic disorder  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
bone development disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain infarction  (IEP)
Brain Injuries  (IEP)
breast cancer  (ISO)
choriocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
cognitive disorder  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
Desbuquois dysplasia  (ISO)
Diabetic Nephropathies  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
Embryo Loss  (IDA)
Ependymomas  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (IEP)
Experimental Radiation Injuries  (IEP)
Fetal Growth Retardation  (IEP,ISO)
gastrointestinal system disease  (ISO)
Growth Disorders  (ISO)
Hepatic Echinococcosis  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
hypoglycemia  (ISO)
inflammatory bowel disease  (IEP,ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
Lung Injury  (IEP)
Memory Disorders  (IEP,ISO)
meningitis  (ISO)
Metabolic Syndrome  (IAGP)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IDA)
Parkinson's disease  (ISO)
placenta disease  (ISO)
polyhydramnios  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
rhabdomyosarcoma  (ISO)
rheumatoid arthritis  (ISO)
Silver-Russell syndrome  (ISO)
Silver-Russell Syndrome 3  (ISO)
Spontaneous Abortions  (ISO)
type 1 diabetes mellitus  (IEP)
type 1 diabetes mellitus 2  (ISS)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
28-Homobrassinolide  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aluminium trifluoride  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ampullosporin  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Azoxymethane  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carmustine  (ISO)
choline  (EXP,ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
dantrolene  (ISO)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
escitalopram  (EXP)
estrone  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methimazole  (EXP)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylarsine oxide  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phthalic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethrin  (ISO)
thioacetamide  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
cellular response to mechanical stimulus  (IEP)
embryonic placenta development  (ISO,ISS)
embryonic placenta morphogenesis  (ISO)
exocrine pancreas development  (ISO)
female pregnancy  (IEP)
glucose metabolic process  (IEA)
in utero embryonic development  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
memory  (IMP)
negative regulation of muscle cell differentiation  (ISO,ISS)
negative regulation of natural killer cell mediated cytotoxicity  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
ossification  (IEA)
osteoblast differentiation  (ISO)
positive regulation of activated T cell proliferation  (IBA,ISO)
positive regulation of angiogenesis  (IGI)
positive regulation of blood vessel endothelial cell migration  (IGI)
positive regulation of cell division  (IEA)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of insulin receptor signaling pathway  (IBA,ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of mitotic nuclear division  (IBA,ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of steroid hormone biosynthetic process  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial cell proliferation  (IGI)
regulation of muscle cell differentiation  (ISO,ISS)
response to 2,3,7,8-tetrachlorodibenzodioxine  (IDA)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to nicotine  (IDA,IEP)
response to nutrient levels  (IEP)
response to xenobiotic stimulus  (IDA)
signal transduction  (IEA)
spongiotrophoblast cell proliferation  (ISO)
striated muscle cell differentiation  (ISO)

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oleic acid ameliorates amyloidosis in cellular and mouse models of Alzheimer's disease. Amtul Z, etal., Brain Pathol. 2011 May;21(3):321-9. doi: 10.1111/j.1750-3639.2010.00449.x. Epub 2010 Nov 11.
2. Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain. Armstrong CS, etal., J Neurosci Res. 2000 Mar 1;59(5):649-60.
3. [Changes of serum and cerebrospinal fluid insulin-like growth factor-II levels in neonates with hypoxic-ischemic encephalopathy]. Bai B, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):187-90.
4. Gastrointestinal inflammation and the circulating IGF system in humans. Baricevic I, etal., Horm Metab Res. 2006 Jan;38(1):22-7.
5. Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain. Beilharz EJ, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):81-91.
6. In utero radiation-induced changes in growth factor levels in the developing rat brain. Benekou A, etal., Int J Radiat Biol. 2001 Jan;77(1):83-93.
7. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors. Brown AL, etal., J Biol Chem 1989 Mar 25;264(9):5148-54.
8. Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes. Calderari S, etal., Diabetologia. 2007 Jul;50(7):1463-71. Epub 2007 May 3.
9. Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring. Chen CM, etal., Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):62-7.
10. A critical role for IGF-II in memory consolidation and enhancement. Chen DY, etal., Nature. 2011 Jan 27;469(7331):491-7.
11. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
12. Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis. Conover CA, etal., Growth Horm IGF Res. 2002 Jun;12(3):178-83.
13. The insulin-like growth factor axis in children with inflammatory bowel disease. Corkins MR, etal., J Pediatr Gastroenterol Nutr. 2003 Feb;36(2):228-34.
14. Various components of the insulin-like growth factor system in tumor tissue, cerebrospinal fluid and peripheral blood of pediatric medulloblastoma and ependymoma patients. de Bont JM, etal., Int J Cancer. 2008 Aug 1;123(3):594-600.
15. Insulin resistance in experimental alcohol-induced liver disease. de la Monte SM, etal., J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 2):e477-86. Epub 2008 May 26.
16. Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. Devedjian JC, etal., J Clin Invest. 2000 Mar;105(6):731-40.
17. IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor. Diaz LE, etal., Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.
18. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
19. Insulin-like growth factor II precursor gene organization in relation to insulin gene family. Dull TJ, etal., Nature 1984 Aug 30-Sep 5;310(5980):777-81.
20. The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease. Eivindson M, etal., Horm Res. 2005;64(1):9-15. Epub 2005 Jul 25.
21. Elevated free IGF2 levels in localized, early-stage breast cancer in women. Espelund U, etal., Eur J Endocrinol. 2008 Nov;159(5):595-601. Epub 2008 Aug 21.
22. Comparative effects of probiotics, prebiotics, and synbiotics on growth factors in the large bowel in a rat model of formula-induced bowel inflammation. Fordjour L, etal., J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):507-13.
23. The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Francavilla A, etal., Hepatology. 1997 Feb;25(2):411-5.
24. Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters. Frunzio R, etal., J Biol Chem 1986 Dec 25;261(36):17138-49.
25. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Gaunt TR, etal., Hum Mol Genet. 2001 Jul 1;10(14):1491-501.
28. NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide. Giannakopoulou M, etal., Neuropathol Appl Neurobiol. 2000 Dec;26(6):513-21.
29. A simple in silico strategy identifies candidate biomarkers for the diagnosis of liver fibrosis in morbidly obese subjects. Giraudi PJ, etal., Liver Int. 2018 Jan;38(1):155-163. doi: 10.1111/liv.13505. Epub 2017 Jul 21.
30. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
31. Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Gonzalez-Parra S, etal., Horm Res 2002;57(1-2):10-4.
32. Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile. Gruslin A, etal., Reprod Sci. 2009 Sep;16(9):875-82. Epub 2009 Jun 3.
33. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
34. Insulin-like growth factors and binding proteins in multiple sclerosis plaques. Gveric D, etal., Neuropathol Appl Neurobiol. 1999 Jun;25(3):215-25.
35. Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro. Han HJ, etal., Clin Exp Pharmacol Physiol. 2006 Dec;33(12):1172-9.
36. The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy. Helle SI, etal., J Clin Endocrinol Metab. 2001 Jan;86(1):227-33.
37. Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer's disease: an observational study. Hertze J, etal., BMC Neurol. 2014 Apr 1;14:64. doi: 10.1186/1471-2377-14-64.
38. Insulin-Like growth factor-II (IGF-II) prevents proinflammatory cytokine-induced apoptosis and significantly improves islet survival after transplantation. Hughes A, etal., Transplantation. 2013 Mar 15;95(5):671-8. doi: 10.1097/TP.0b013e31827fa453.
39. The primary structure of the rat insulin-like growth factor II gene region. Ikejiri K, etal., Biochim Biophys Acta 1990 Jul 30;1049(3):350-3.
40. Gene Expression Profiling Distinguishes Between Spontaneous and Radiation-induced Rat Mammary Carcinomas. Imaoka T, etal., J Radiat Res (Tokyo). 2008 Apr 16;.
41. Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids. Kadlecova M, etal., Mol Cell Biochem. 2008 Jul;314(1-2):37-43. Epub 2008 Apr 17.
42. Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes. Kecha-Kamoun O, etal., Diabetes Metab Res Rev. 2001 Mar-Apr;17(2):146-52.
43. IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma. Kim YJ, etal., Biochem Biophys Res Commun. 2006 Jul 21;346(1):38-44. doi: 10.1016/j.bbrc.2006.05.080. Epub 2006 May 24.
44. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
45. Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. Kutasy B, etal., Pediatr Surg Int. 2014 Feb;30(2):137-42. doi: 10.1007/s00383-013-3449-7.
46. Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. Lester-Coll N, etal., J Alzheimers Dis. 2006 Mar;9(1):13-33.
47. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. Liu JG, etal., J Trace Elem Med Biol. 2012 Oct;26(4):255-61. doi: 10.1016/j.jtemb.2012.02.001. Epub 2012 Mar 16.
48. Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis. Ma YL, etal., J Bone Miner Res. 2006 Jun;21(6):855-64.
49. Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis. Martin-Trujillo A, etal., Ann Rheum Dis. 2010 Jun;69(6):1239-42. Epub 2009 Jun 24.
50. Functional analysis of multiple promoters of the rat insulin-like factor II gene. Matsuguchi T, etal., Biochim Biophys Acta 1990 Apr 6;1048(2-3):165-70.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
53. Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma in rats. Mukherjee B, etal., Eur J Cancer Prev. 2007 Aug;16(4):363-71.
54. Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis. Muller HL, etal., J Clin Endocrinol Metab. 1993 Nov;77(5):1113-9.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis. Nedic O, etal., Clin Chim Acta. 2003 Sep;335(1-2):83-8.
57. Changes in systemic levels of insulin-like growth factors and their binding proteins in patients with rheumatoid arthritis. Neidel J Clin Exp Rheumatol. 2001 Jan-Feb;19(1):81-4.
58. Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nguyen VA, etal., Nutrients. 2012 Aug;4(8):1042-57. Epub 2012 Aug 17.
59. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
60. Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. Pathak S, etal., Fertil Steril. 2009 May;91(5 Suppl):2253-63. Epub 2008 Sep 7.
61. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Pedros I, etal., Biochim Biophys Acta. 2014 Sep;1842(9):1556-66. doi: 10.1016/j.bbadis.2014.05.025. Epub 2014 Jun 2.
62. Multiple system atrophy is associated with changes in peripheral insulin-like growth factor system. Pellecchia MT, etal., Mov Disord. 2010 Nov 15;25(15):2621-6.
63. Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. Price WA, etal., Pediatr Res. 1992 Sep;32(3):291-5. doi: 10.1203/00006450-199209000-00009.
64. Expression of bone-related genes in bone marrow MSCs after cyclic mechanical strain: implications for distraction osteogenesis. Qi MC, etal., Int J Oral Sci. 2009 Sep;1(3):143-50.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer. Roy LD, etal., BMC Cancer. 2011 Aug 22;11:365.
69. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
70. Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice. Shao WJ, etal., Comp Med. 2008 Aug;58(4):341-6.
71. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Silva-Peña D, etal., Addict Biol. 2019 Sep;24(5):1019-1033. doi: 10.1111/adb.12668. Epub 2018 Sep 12.
72. Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA. Soares MB, etal., Nucleic Acids Res 1985 Feb 25;13(4):1119-34.
73. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9
74. Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions. Steck E, etal., J Mol Med (Berl). 2012 Oct;90(10):1185-95. doi: 10.1007/s00109-012-0895-y. Epub 2012 Apr 21.
75. Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus. Takeo C, etal., Endocr J. 2009 Mar;56(1):113-20. Epub 2008 Oct 22.
76. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
77. IGF-II and MMP9 as surgical repair indicators of ventricular septal defects. Tsai CY, etal., Clin Chim Acta. 2011 Apr 11;412(9-10):761-5. doi: 10.1016/j.cca.2011.01.005. Epub 2011 Jan 14.
78. A new leader exon identified in the rat insulin-like growth factor II gene. Ueno T, etal., Biochem Biophys Res Commun 1987 Oct 14;148(1):344-9.
79. Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats. Van Mieghem T, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1615-21. Epub 2009 Sep 23.
80. Re-emergence of a fetal pattern of insulin-like growth factor expression during hyperoxic rat lung injury. Veness-Meehan KA, etal., Am J Respir Cell Mol Biol. 1997 May;16(5):538-48.
81. [The role of insulin-like growth factor-2 gene differentially methylated regions in TCDD-induced malformation] Wang J, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Apr;24(2):162-6.
82. Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors. Wang JF, etal., Biochem Biophys Res Commun. 1988 Dec 15;157(2):718-26.
83. Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Wang X, etal., Neuropharmacology. 2014 Jan;76 Pt A:80-7. doi: 10.1016/j.neuropharm.2013.08.022. Epub 2013 Sep 4.
84. Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation. Wang Y, etal., Cells Tissues Organs. 2007;186(3):192-203. Epub 2007 Jul 12.
85. Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor. Whitfield HJ, etal., Nature. 1984 Nov 15-21;312(5991):277-80.
86. Brain insulin-like growth factor-II mRNA content is reduced in insulin-dependent and non-insulin-dependent diabetes mellitus. Wuarin L, etal., J Neurochem. 1996 Aug;67(2):742-51.
87. MicroRNA-193-5p modulates angiogenesis through IGF2 in type 2 diabetic cardiomyopathy. Yi F, etal., Biochem Biophys Res Commun. 2017 Sep 30;491(4):876-882. doi: 10.1016/j.bbrc.2017.07.108. Epub 2017 Jul 20.
88. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
89. Insulin-like growth factor (IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus, and IGF treatment ameliorates diabetic neuropathy. Zhuang HX, etal., J Pharmacol Exp Ther. 1997 Oct;283(1):366-74.
Additional References at PubMed
PMID:2438416   PMID:2477062   PMID:2967174   PMID:3167060   PMID:3221878   PMID:7016879   PMID:9203585   PMID:11500939   PMID:12087403   PMID:12101187   PMID:12138094   PMID:12532445  
PMID:14566968   PMID:15694994   PMID:15833775   PMID:16311053   PMID:16448778   PMID:16825605   PMID:16901893   PMID:17393425   PMID:17628003   PMID:17724018   PMID:18693177   PMID:18762576  
PMID:19592596   PMID:19648158   PMID:19683557   PMID:19764351   PMID:19919529   PMID:20032056   PMID:20671425   PMID:21598309   PMID:21613208   PMID:21959847   PMID:22434232   PMID:22562201  
PMID:23016132   PMID:23229416   PMID:23376485   PMID:24667322   PMID:24845189   PMID:25268143   PMID:26276081   PMID:26455773   PMID:26495851   PMID:28362134   PMID:28417351   PMID:28522536  
PMID:28812967   PMID:28867213   PMID:28873464   PMID:28910276   PMID:28916632   PMID:30956007   PMID:32934005   PMID:33781005   PMID:33915127   PMID:37788670  


Genomics

Comparative Map Data
Igf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,243,873 - 207,261,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1207,243,873 - 207,260,667 (-)EnsemblGRCr8
mRatBN7.21197,814,409 - 197,831,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,828,102 - 215,839,081 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)Ensemblrn6Rnor6.0
Rnor_5.01222,722,921 - 222,733,868 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1195,432,460 - 195,442,561 (-)NCBICelera
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Cytogenetic Map1q41NCBI
IGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,129,117 - 2,149,566 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,129,112 - 2,158,391 (-)Ensemblhg38GRCh38
GRCh37112,150,347 - 2,170,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,106,923 - 2,127,409 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34112,110,531 - 2,116,578NCBI
Celera112,186,838 - 2,207,338 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,940,869 - 1,961,095 (-)NCBIHuRef
CHM1_1112,148,973 - 2,169,786 (-)NCBICHM1_1
T2T-CHM13v2.0112,216,758 - 2,237,216 (-)NCBIT2T-CHM13v2.0
Igf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,204,505 - 142,220,566 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,204,503 - 142,220,553 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387142,650,768 - 142,666,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,650,766 - 142,666,816 (-)Ensemblmm10GRCm38
MGSCv377149,836,673 - 149,846,940 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367142,460,158 - 142,468,879 (-)NCBIMGSCv36mm8
Celera7142,407,105 - 142,417,364 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.99NCBI
Igf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542213,880,471 - 13,888,566 (-)Ensembl
ChiLan1.0NW_00495542213,880,525 - 13,907,963 (-)NCBIChiLan1.0ChiLan1.0
IGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,555,470 - 4,584,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,767,218 - 3,777,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,170,190 - 2,199,442 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,202,764 - 2,228,890 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl112,202,743 - 2,228,890 (-)EnsemblpanPan2panpan1.1
IGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,294,036 - 46,311,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,294,019 - 46,311,982 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1844,906,773 - 44,921,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01846,973,499 - 46,991,455 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,973,482 - 47,002,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,425,198 - 46,440,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,005,530 - 46,020,544 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,751,952 - 46,766,988 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Igf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,719,158 - 1,727,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816972,282 - 979,167 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936816972,902 - 981,232 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.121,469,183 - 1,496,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap2pNCBI
IGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,937,414 - 1,951,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,936,830 - 1,945,388 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603899,135,565 - 99,144,253 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476714,969,866 - 14,979,026 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476714,969,977 - 14,997,577 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Igf2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v126,810,703 - 6,819,348 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Igf2
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1270
Count of miRNA genes:302
Interacting mature miRNAs:417
Transcripts:ENSRNOT00000050760, ENSRNOT00000073850
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1201915593208479939Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480777Insul17Insulin level QTL 173.86blood insulin amount (VT:0001560)blood insulin level area under curve (AUC) (CMO:0000351)1206690418207509562Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
D1Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41202,908,570 - 202,908,720RGDRGSC3.4
RGSC_v3.41202,908,571 - 202,908,720UniSTSRGSC3.4
Celera1195,434,394 - 195,434,543UniSTS
RGSC_v3.11203,096,636 - 203,096,786RGD
Cytogenetic Map1q41UniSTS
D1Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,378 - 197,816,499 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,072 - 215,830,192NCBIRnor6.0
Rnor_5.01222,724,891 - 222,725,011UniSTSRnor5.0
RGSC_v3.41202,908,592 - 202,908,713RGDRGSC3.4
RGSC_v3.41202,908,593 - 202,908,713UniSTSRGSC3.4
Celera1195,434,416 - 195,434,536UniSTS
RGSC_v3.11203,096,658 - 203,096,779RGD
RH 2.0 Map11070.1RGD
Cytogenetic Map1q41UniSTS
D1Arb24  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,245,771 - 207,246,036 (+)Marker Load Pipeline
mRatBN7.21197,816,307 - 197,816,572 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,001 - 215,830,265NCBIRnor6.0
Rnor_5.01222,724,820 - 222,725,084UniSTSRnor5.0
RGSC_v3.41202,908,521 - 202,908,786RGDRGSC3.4
RGSC_v3.41202,908,522 - 202,908,786UniSTSRGSC3.4
Celera1195,434,345 - 195,434,609UniSTS
RGSC_v3.11203,096,587 - 203,096,852RGD
SHRSP x BN Map1104.9599UniSTS
SHRSP x BN Map1104.9599RGD
Cytogenetic Map1q41UniSTS
D1Hmgc8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,245,812 - 207,246,077 (+)Marker Load Pipeline
mRatBN7.21197,816,348 - 197,816,613 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,042 - 215,830,306NCBIRnor6.0
Rnor_5.01222,724,861 - 222,725,125UniSTSRnor5.0
RGSC_v3.41202,908,563 - 202,908,827UniSTSRGSC3.4
RGSC_v3.41202,908,562 - 202,908,827RGDRGSC3.4
Celera1195,434,386 - 195,434,650UniSTS
RH 3.4 Map11436.7UniSTS
RH 3.4 Map11436.7RGD
Cytogenetic Map1q41UniSTS
D1Mco27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,331 - 197,816,504 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,025 - 215,830,197NCBIRnor6.0
Rnor_5.01222,724,844 - 222,725,016UniSTSRnor5.0
RGSC_v3.41202,908,546 - 202,908,718UniSTSRGSC3.4
Celera1195,434,369 - 195,434,541UniSTS
Cytogenetic Map1q41UniSTS
D1Wox58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,375 - 197,816,551 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,069 - 215,830,244NCBIRnor6.0
Rnor_5.01222,724,888 - 222,725,063UniSTSRnor5.0
RGSC_v3.41202,908,590 - 202,908,765UniSTSRGSC3.4
Celera1195,434,413 - 195,434,588UniSTS
Cytogenetic Map1q41UniSTS
AW742446  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,244,319 - 207,244,567 (+)Marker Load Pipeline
mRatBN7.21197,814,854 - 197,815,103 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,548 - 215,828,796NCBIRnor6.0
Rnor_5.01222,723,367 - 222,723,615UniSTSRnor5.0
RGSC_v3.41202,907,069 - 202,907,317UniSTSRGSC3.4
Celera1195,432,906 - 195,433,154UniSTS
Cytogenetic Map1q41UniSTS
RH94794  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,244,656 - 207,245,017 (+)Marker Load Pipeline
mRatBN7.21197,815,192 - 197,815,553 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,886 - 215,829,246NCBIRnor6.0
Rnor_5.01222,723,705 - 222,724,065UniSTSRnor5.0
RGSC_v3.41202,907,407 - 202,907,767UniSTSRGSC3.4
Celera1195,433,244 - 195,433,604UniSTS
Cytogenetic Map1q41UniSTS
BE098867  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,245,105 - 207,245,261 (+)Marker Load Pipeline
mRatBN7.21197,815,641 - 197,815,797 (+)MAPPERmRatBN7.2
Rnor_6.01215,829,335 - 215,829,490NCBIRnor6.0
Rnor_5.01222,724,154 - 222,724,309UniSTSRnor5.0
RGSC_v3.41202,907,856 - 202,908,011UniSTSRGSC3.4
Celera1195,433,693 - 195,433,848UniSTS
Cytogenetic Map1q41UniSTS
RH128370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,814,588 - 197,814,805 (+)MAPPERmRatBN7.2
Rnor_6.01215,828,282 - 215,828,498NCBIRnor6.0
Rnor_5.01222,723,101 - 222,723,317UniSTSRnor5.0
RGSC_v3.41202,906,803 - 202,907,019UniSTSRGSC3.4
Celera1195,432,640 - 195,432,856UniSTS
Cytogenetic Map1q41UniSTS
RH94585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,823,685 - 197,823,868 (+)MAPPERmRatBN7.2
Rnor_6.01215,837,378 - 215,837,560NCBIRnor6.0
Rnor_5.01222,732,197 - 222,732,379UniSTSRnor5.0
RGSC_v3.41202,915,899 - 202,916,081UniSTSRGSC3.4
Celera1195,441,730 - 195,441,912UniSTS
Cytogenetic Map1q41UniSTS
PMC151856P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,246,958 - 207,247,299 (+)Marker Load Pipeline
mRatBN7.21197,817,495 - 197,817,836 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,188 - 215,831,528NCBIRnor6.0
Rnor_5.01222,726,007 - 222,726,347UniSTSRnor5.0
RGSC_v3.41202,909,709 - 202,910,049UniSTSRGSC3.4
Celera1195,435,532 - 195,435,872UniSTS
Cytogenetic Map1q41UniSTS
ECD21742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,821,931 - 197,822,164 (+)MAPPERmRatBN7.2
Rnor_6.01215,835,624 - 215,835,856NCBIRnor6.0
Rnor_5.01222,730,443 - 222,730,675UniSTSRnor5.0
RGSC_v3.41202,914,145 - 202,914,377UniSTSRGSC3.4
Celera1195,440,092 - 195,440,324UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,882 - 197,819,233 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,575 - 215,832,925NCBIRnor6.0
Rnor_5.01222,726,394 - 222,727,744UniSTSRnor5.0
RGSC_v3.41202,910,096 - 202,911,446UniSTSRGSC3.4
Celera1195,435,919 - 195,437,393UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:276141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,819,139 - 197,819,224 (+)MAPPERmRatBN7.2
Rnor_6.01215,832,832 - 215,832,916NCBIRnor6.0
Rnor_5.01222,727,651 - 222,727,735UniSTSRnor5.0
RGSC_v3.41202,911,353 - 202,911,437UniSTSRGSC3.4
Celera1195,437,300 - 195,437,384UniSTS
Cytogenetic Map1q41UniSTS
D1Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,816,356 - 197,816,506 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,050 - 215,830,199NCBIRnor6.0
Rnor_5.01222,724,869 - 222,725,018UniSTSRnor5.0
RGSC_v3.41202,908,571 - 202,908,720UniSTSRGSC3.4
Celera1195,434,394 - 195,434,543UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,246,776 - 207,247,331 (+)Marker Load Pipeline
mRatBN7.21197,817,313 - 197,817,868 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,006 - 215,831,560NCBIRnor6.0
Rnor_5.01222,725,825 - 222,726,379UniSTSRnor5.0
RGSC_v3.41202,909,527 - 202,910,081UniSTSRGSC3.4
Celera1195,435,350 - 195,435,904UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,230 - 197,817,837 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,923 - 215,831,529NCBIRnor6.0
Rnor_5.01222,725,742 - 222,726,348UniSTSRnor5.0
RGSC_v3.41202,909,444 - 202,910,050UniSTSRGSC3.4
Celera1195,435,267 - 195,435,873UniSTS
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,507 - 197,819,204 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,200 - 215,832,896NCBIRnor6.0
Rnor_5.01222,726,019 - 222,727,715UniSTSRnor5.0
RGSC_v3.41202,909,721 - 202,911,417UniSTSRGSC3.4
Cytogenetic Map1q41UniSTS
Igf2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,246,509 - 207,247,252 (+)Marker Load Pipeline
mRatBN7.21197,817,046 - 197,817,789 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,739 - 215,831,481NCBIRnor6.0
Rnor_5.01222,725,558 - 222,726,300UniSTSRnor5.0
RGSC_v3.41202,909,260 - 202,910,002UniSTSRGSC3.4
Celera1195,435,083 - 195,435,825UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:532138  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81207,246,201 - 207,246,785 (+)Marker Load Pipeline
mRatBN7.21197,816,737 - 197,817,322 (+)MAPPERmRatBN7.2
Rnor_6.01215,830,431 - 215,831,014NCBIRnor6.0
Rnor_5.01222,725,250 - 222,725,833UniSTSRnor5.0
Celera1195,434,775 - 195,435,358UniSTS
Cytogenetic Map1q41UniSTS
UniSTS:532139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21197,817,514 - 197,819,181 (+)MAPPERmRatBN7.2
Rnor_6.01215,831,207 - 215,832,873NCBIRnor6.0
Rnor_5.01222,726,026 - 222,727,692UniSTSRnor5.0
Cytogenetic Map1q41UniSTS


Related Rat Strains
The following Strains have been annotated to Igf2
BB.SHR-(Acsm3-Igf2)/K     SHR.BN-(D1Mit2-Igf2)     SHR.BN-(D1Mit3-Igf2)/Ipcv     SHR.BN-(D1Mit3-Igf2)/Jr    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 85 165 91 90 59 73 59 6 349 191 11 144 78 100 31 19 19

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ408382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M38688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X00911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050760   ⟹   ENSRNOP00000047037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,828,102 - 215,838,209 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073850   ⟹   ENSRNOP00000066983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,828,102 - 215,834,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080246   ⟹   ENSRNOP00000068633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,243,874 - 207,252,481 (-)Ensembl
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)Ensembl
Rnor_6.0 Ensembl1215,828,102 - 215,836,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089171   ⟹   ENSRNOP00000070557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1215,830,983 - 215,846,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164793   ⟹   ENSRNOP00000099605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,246,754 - 207,260,667 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171629   ⟹   ENSRNOP00000107112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,243,873 - 207,248,751 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172623   ⟹   ENSRNOP00000110891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1207,243,873 - 207,254,595 (-)Ensembl
RefSeq Acc Id: NM_001190162   ⟹   NP_001177091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,250,475 (-)NCBI
mRatBN7.21197,814,409 - 197,821,012 (-)NCBI
Rnor_6.01215,828,102 - 215,834,704 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
Celera1195,432,460 - 195,439,172 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001190163   ⟹   NP_001177092
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,253,980 (-)NCBI
mRatBN7.21197,814,409 - 197,824,517 (-)NCBI
Rnor_6.01215,828,102 - 215,838,209 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031511   ⟹   NP_113699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,252,412 (-)NCBI
mRatBN7.21197,814,409 - 197,822,949 (-)NCBI
Rnor_6.01215,828,102 - 215,836,641 (-)NCBI
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
RGSC_v3.41202,906,624 - 202,915,231 (-)RGD
Celera1195,432,460 - 195,441,052 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760074   ⟹   XP_008758296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,254,820 (-)NCBI
mRatBN7.21197,814,409 - 197,825,357 (-)NCBI
Rnor_6.01215,828,102 - 215,838,991 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096378   ⟹   XP_038952306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,261,263 (-)NCBI
mRatBN7.21197,814,409 - 197,831,802 (-)NCBI
RefSeq Acc Id: NP_113699   ⟸   NM_031511
- Peptide Label: isoform 1 preproprotein
- UniProtKB: A6HY76 (UniProtKB/TrEMBL),   Q63265 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177092   ⟸   NM_001190163
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P01346 (UniProtKB/Swiss-Prot),   M9NW49 (UniProtKB/TrEMBL),   Q63265 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177091   ⟸   NM_001190162
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P01346 (UniProtKB/Swiss-Prot),   M9NW49 (UniProtKB/TrEMBL),   Q63265 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758296   ⟸   XM_008760074
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000068633   ⟸   ENSRNOT00000080246
Ensembl Acc Id: ENSRNOP00000070557   ⟸   ENSRNOT00000089171
Ensembl Acc Id: ENSRNOP00000066983   ⟸   ENSRNOT00000073850
Ensembl Acc Id: ENSRNOP00000047037   ⟸   ENSRNOT00000050760
RefSeq Acc Id: XP_038952306   ⟸   XM_039096378
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000099605   ⟸   ENSRNOT00000164793
Ensembl Acc Id: ENSRNOP00000110891   ⟸   ENSRNOT00000172623
Ensembl Acc Id: ENSRNOP00000107112   ⟸   ENSRNOT00000171629
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01346-F1-model_v2 AlphaFold P01346 1-180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850064
Promoter ID:EP25033
Type:single initiation site
Name:RN_IGF2_3
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 155; Mammalian insulin-like growth factor 2 E3/E4.
Alternative Promoters:alternative promoter #3 of 3; 5' exon 3; site 1; major promoter.; see alsoEP28008  EP25032  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection; Primer extension; Length measurement of an RNA product; RNA Pol II in vitro; system; Nuclease protection; RNA Pol II in vitro system
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,913,234 - 202,913,294EPD
RGD ID:6850058
Promoter ID:EP25032
Type:single initiation site
Name:RN_IGF2_2
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 137; Mammalian insulin-like growth factor 2 E2/E3.
Alternative Promoters:alternative promoter #2 of 3; 5' exon 2; site 1.; see alsoEP28008  EP25033  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection; Primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,915,229 - 202,915,289EPD
RGD ID:6850054
Promoter ID:EP28008
Type:initiation region
Name:RN_IGF2_1
Description:Insulin-like growth factor II, IGF2 or IGF-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 3; 5' exon 1; site 1.; see alsoEP25032  EP25033  
Tissues & Cell Lines:fetal and neonatal tissues, adult brain
Experiment Methods:Nuclease protection with homologous sequence ladder; Primer extension
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41202,916,987 - 202,917,047EPD
RGD ID:13690565
Promoter ID:EPDNEW_R1090
Type:single initiation site
Name:Igf2_2
Description:insulin-like growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1091  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,834,714 - 215,834,774EPDNEW
RGD ID:13690566
Promoter ID:EPDNEW_R1091
Type:single initiation site
Name:Igf2_1
Description:insulin-like growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1090  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01215,836,710 - 215,836,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2870 AgrOrtholog
BioCyc Gene G2FUF-56899 BioCyc
Ensembl Genes ENSRNOG00000020369 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000164793 ENTREZGENE
  ENSRNOT00000172623 ENTREZGENE
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot
InterPro IGF2 UniProtKB/Swiss-Prot
  IGF2_C UniProtKB/Swiss-Prot
  Insulin-like UniProtKB/Swiss-Prot
  Insulin-like_growth_factor UniProtKB/Swiss-Prot
  Insulin-like_sf UniProtKB/Swiss-Prot
  Insulin_CS UniProtKB/Swiss-Prot
  Insulin_family UniProtKB/Swiss-Prot
KEGG Report rno:24483 UniProtKB/Swiss-Prot
NCBI Gene 24483 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR II UniProtKB/Swiss-Prot
Pfam IGF2_C UniProtKB/Swiss-Prot
  Insulin UniProtKB/Swiss-Prot
PhenoGen Igf2 PhenoGen
PRINTS INSLNLIKEGF UniProtKB/Swiss-Prot
  INSLNLIKEGF2 UniProtKB/Swiss-Prot
  INSULINFAMLY UniProtKB/Swiss-Prot
PROSITE INSULIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020369 RatGTEx
SMART IlGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot
UniProt A0A0G2JTA6_RAT UniProtKB/TrEMBL
  A0ABK0L5X2_RAT UniProtKB/TrEMBL
  A0ABK0LQ56_RAT UniProtKB/TrEMBL
  A0ABK0M217_RAT UniProtKB/TrEMBL
  A6HY75_RAT UniProtKB/TrEMBL
  A6HY76 ENTREZGENE, UniProtKB/TrEMBL
  IGF2_RAT UniProtKB/Swiss-Prot
  M9NW49 ENTREZGENE, UniProtKB/TrEMBL
  P01346 ENTREZGENE
  Q63265 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igf2  Insulin-like growth factor II (somatomedin A)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript two alternative transcripts are transcribed from two distinct promoters 729153