glutamate ionotropic receptor kainate type subunit 5
RGD ID:
2735
Description:
Enables identical protein binding activity; kainate selective glutamate receptor activity; and protein domain specific binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron apoptotic process; and protein retention in ER lumen. Located in dendrite; perikaryon; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study visual epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; acetamide.
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GRIK5 protein
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GRIK5 protein
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GRIK5 protein
[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of GRIK5 mRNA
[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of GRIK5 protein
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] and PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]
Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density.
[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease].
plays a role in frequency facilitation and induction of long-term potentiation (LTP) in mossy fiber pathways and in excitatory drives of inhibitory CA1 interneurons