RGD Reference Report - Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. - Rat Genome Database

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Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism.

Authors: Sander, T  Hildmann, T  Kretz, R  Furst, R  Sailer, U  Bauer, G  Schmitz, B  Beck-Mannagetta, G  Wienker, TF  Janz, D 
Citation: Sander T, etal., Am J Med Genet 1997 Jul 25;74(4):416-21.
RGD ID: 1358334
Pubmed: PMID:9259378   (View Abstract at PubMed)

Juvenile absence epilepsy (JAE) is a common subtype of idiopathic generalized epilepsy (IGE). Hereditary factors play a major role in its etiology. The important function of glutamate receptors (GluRs) in excitatory neurotransmission, synaptic plasticity, and neurodevelopment suggests their involvement in epileptogenesis. A tetranucleotide repeat polymorphism in the non-coding region of the kainate-selective GluR5 receptor gene (GRIK1) on chromosome 21q22.1 provides the tool to investigate this candidate gene. The present association and linkage study tested the hypothesis that allelic variants of GRIK1 confer genetic susceptibility to the pathogenesis of JAE. Our family-based association analysis using the haplotype-based haplotype relative risk statistic revealed an association of JAE with the nine-repeat containing allele of the GRIK1 tetranucleotide polymorphism (chi2 = 8.31, df = 1, P = 0.004). Supportive evidence for linkage to a JAE related IGE spectrum (Zmax = 1.67 at GRIK1) under an autosomal dominant mode of inheritance and significant allele sharing (P < 0.05) among the affected family members suggest that allelic variants of GRIK1 contribute a major genetic determinant to the pathogenesis of JAE-related phenotypes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
childhood absence epilepsy  IAGP 1358334 RGD 
childhood absence epilepsy  ISOGRIK1 (Homo sapiens)1358334; 1358334 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik1  (glutamate ionotropic receptor kainate type subunit 1)

Genes (Mus musculus)
Grik1  (glutamate receptor, ionotropic, kainate 1)

Genes (Homo sapiens)
GRIK1  (glutamate ionotropic receptor kainate type subunit 1)

Objects referenced in this article
Gene GRIK5 glutamate ionotropic receptor kainate type subunit 5 Homo sapiens
Gene Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) Mus musculus
Gene Grik5 glutamate ionotropic receptor kainate type subunit 5 Rattus norvegicus

Additional Information