Gpi (glucose-6-phosphate isomerase) - Rat Genome Database

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Gene: Gpi (glucose-6-phosphate isomerase) Rattus norvegicus
Analyze
Symbol: Gpi
Name: glucose-6-phosphate isomerase
RGD ID: 2727
Description: Enables glucose-6-phosphate isomerase activity and monosaccharide binding activity. Involved in several processes, including response to estradiol; response to progesterone; and response to testosterone. Predicted to be located in ciliary membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 4; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Amf; autocrine motility factor; glucose phosphate isomerase; Gpi1; neuroleukin; Nlk; Pgi; Phi; phosphoglucose isomerase; phosphohexose isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,965,389 - 95,996,932 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,965,396 - 95,993,261 (-)EnsemblGRCr8
mRatBN7.2186,828,211 - 86,856,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx192,231,564 - 92,259,517 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,697,568 - 100,725,522 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,989,860 - 94,017,813 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,063,411 - 90,091,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)Ensemblrn6Rnor6.0
Rnor_5.0191,207,014 - 91,234,890 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4186,658,836 - 86,686,712 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,194,482 - 81,222,306 (-)NCBICelera
RGSC_v3.1186,736,946 - 86,764,823 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Pf-06840003  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prostaglandin A1  (ISO)
puerarin  (EXP)
quercetin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cumene peroxide and Fe(2+)-ascorbate-induced lipid peroxidation and effect of phosphoglucose isomerase. Agadjanyan ZS, etal., Mol Cell Biochem. 2006 Sep;289(1-2):49-53. Epub 2006 Apr 1.
2. Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA). Beutler E, etal., Blood Cells Mol Dis. 1997 Dec;23(3):402-9.
3. Time course of chronic oral cadmium nephrotoxicity in Wistar rats: excretion of urinary enzymes. Bomhard EM, etal., Drug Chem Toxicol. 1999 Nov;22(4):679-703.
4. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
5. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
6. Alterations in the mRNA levels of two metabolic enzymes in rat skeletal muscle during stretch-induced hypertrophy and disuse atrophy. Brownson C and Loughna P, Pflugers Arch. 1996 Apr;431(6):990-2.
7. Evidence for the participation of opioids in the regulation of carbohydrate metabolism in rat mammary glands. Deshpande N and Mitchell I, J Endocrinol. 1980 Jun;85(3):415-21.
8. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. Gaitonde MK, etal., J Neurochem. 1989 May;52(5):1348-52.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Plasma and intracellular levels of lactate dehydrogenase, phosphohexose isomerase and lysozyme activity in acute leukemia. Ho AD, etal., Blut. 1984 Jul;49(1):19-28.
11. Glycolytic enzyme levels in synaptosomes. Knull HR and Fillmore SJ, Comp Biochem Physiol B. 1985;81(2):349-51.
12. Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency. Kugler W, etal., Hum Genet. 1998 Oct;103(4):450-4.
13. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. Luo Y, etal., J Neurochem. 2002 Jan;80(2):354-61.
14. Comparative study of the effects of beta-sitosterol, estradiol and progesterone on selected biochemical parameters of the uterus of ovariectomised rats. Malini T and Vanithakumari G, J Ethnopharmacol. 1992 Feb;36(1):51-5.
15. Glucose-6-phosphate isomerase deficiency associated with nonspherocytic hemolytic anemia in the mouse: an animal model for the human disease. Merkle S and Pretsch W, Blood. 1993 Jan 1;81(1):206-13.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. Niinaka Y, etal., Cancer Res. 2010 Nov 15;70(22):9483-93. doi: 10.1158/0008-5472.CAN-09-3880. Epub 2010 Oct 26.
18. [Androgen regulation of aldolase and phosphohexose isomerase in the liver and seminal vesicles of white rats]. Nikulin AA, Vopr Med Khim. 1985 Mar-Apr;31(2):51-5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Pizzolla A, etal., Am J Pathol. 2013 Oct;183(4):1144-55. doi: 10.1016/j.ajpath.2013.06.019. Epub 2013 Jul 30.
23. Red cell glucose phosphate isomerase (GPI): a molecular study of three novel mutations associated with hereditary nonspherocytic hemolytic anemia. Repiso A, etal., Hum Mutat. 2006 Nov;27(11):1159.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis. Romagnoli A, etal., Biochem Biophys Res Commun. 2003 Mar 14;302(3):448-53.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia. Walker JA, etal., Eur J Immunol. 2012 Dec;42(12):3212-22. doi: 10.1002/eji.201242633. Epub 2012 Oct 16.
30. DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency. Walker JI, etal., Hum Mol Genet. 1993 Mar;2(3):327-9.
Additional References at PubMed
PMID:204065   PMID:1180875   PMID:1235912   PMID:1582174   PMID:1649192   PMID:2344351   PMID:3020690   PMID:3796661   PMID:7277315   PMID:7323947   PMID:7444718   PMID:8922529  
PMID:12054583   PMID:15155459   PMID:15665293   PMID:16229142   PMID:17634366   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20458337   PMID:22179047   PMID:22206666   PMID:22871113  
PMID:23376485   PMID:23533145   PMID:24006456   PMID:24810856   PMID:26459914   PMID:27103217   PMID:28803808  


Genomics

Comparative Map Data
Gpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,965,389 - 95,996,932 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl195,965,396 - 95,993,261 (-)EnsemblGRCr8
mRatBN7.2186,828,211 - 86,856,077 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx192,231,564 - 92,259,517 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,697,568 - 100,725,522 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,989,860 - 94,017,813 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,063,411 - 90,091,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)Ensemblrn6Rnor6.0
Rnor_5.0191,207,014 - 91,234,890 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4186,658,836 - 86,686,712 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera181,194,482 - 81,222,306 (-)NCBICelera
RGSC_v3.1186,736,946 - 86,764,823 (-)NCBI
Cytogenetic Map1q21NCBI
GPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381934,359,718 - 34,402,413 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1934,359,480 - 34,402,413 (+)Ensemblhg38GRCh38
GRCh371934,855,645 - 34,893,318 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361939,547,909 - 39,583,076 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341939,547,908 - 39,583,076NCBI
Celera1931,557,376 - 31,605,748 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1931,360,777 - 31,377,222 (+)NCBIHuRef
HuRef1931,390,807 - 31,399,974 (+)NCBIHuRef
CHM1_11934,857,156 - 34,895,165 (+)NCBICHM1_1
T2T-CHM13v2.01936,887,003 - 36,946,977 (+)NCBIT2T-CHM13v2.0
Gpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39733,900,752 - 33,929,761 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl733,900,755 - 33,929,761 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38734,201,327 - 34,230,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl734,201,330 - 34,230,336 (-)Ensemblmm10GRCm38
MGSCv37734,986,346 - 35,015,324 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36733,910,918 - 33,939,022 (-)NCBIMGSCv36mm8
MGSCv36724,688,418 - 24,717,214 (-)NCBIMGSCv36mm8
Celera729,335,681 - 29,371,931 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.46NCBI
Gpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554683,980,999 - 4,008,652 (+)Ensembl
ChiLan1.0NW_0049554683,980,999 - 4,007,553 (+)NCBIChiLan1.0ChiLan1.0
GPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22040,351,367 - 40,402,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11942,351,411 - 42,404,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01931,301,469 - 31,355,362 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,024,584 - 40,080,598 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,024,584 - 40,080,598 (+)EnsemblpanPan2panpan1.1
GPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,922,380 - 117,948,325 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,922,635 - 117,948,316 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1117,320,830 - 117,346,503 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01118,518,230 - 118,543,889 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1118,497,395 - 118,544,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11118,079,121 - 118,105,067 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,705,505 - 117,731,413 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,763,883 - 118,789,615 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,037,338 - 10,063,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,579,372 - 1,608,788 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,582,120 - 1,608,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,038,357 - 44,069,328 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1644,038,374 - 44,069,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2639,516,820 - 39,547,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q12NCBI
GPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1629,404,067 - 29,451,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl629,403,500 - 29,453,162 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660737,177,821 - 7,221,208 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,823,449 - 8,851,625 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247948,826,281 - 8,851,614 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpi
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12164,454,431 - 164,482,993 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpi
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:48
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000032613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
PMC164521P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,830,299 - 86,831,706 (+)MAPPERmRatBN7.2
Rnor_6.0190,065,500 - 90,066,906NCBIRnor6.0
Rnor_5.0191,209,103 - 91,210,509UniSTSRnor5.0
RGSC_v3.4186,660,925 - 86,662,331UniSTSRGSC3.4
Celera181,196,529 - 81,197,935UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032613   ⟹   ENSRNOP00000029515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,965,396 - 95,993,261 (-)Ensembl
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
Rnor_6.0 Ensembl190,063,411 - 90,091,287 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097410   ⟹   ENSRNOP00000087782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101765   ⟹   ENSRNOP00000085356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,965,396 - 95,993,261 (-)Ensembl
mRatBN7.2 Ensembl186,828,216 - 86,856,086 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112795   ⟹   ENSRNOP00000080691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl195,965,396 - 95,992,739 (-)Ensembl
mRatBN7.2 Ensembl186,828,216 - 86,855,568 (-)Ensembl
RefSeq Acc Id: NM_207592   ⟹   NP_997475
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,393 - 95,993,261 (-)NCBI
mRatBN7.2186,828,211 - 86,856,077 (-)NCBI
Rnor_6.0190,063,411 - 90,091,287 (-)NCBI
Rnor_5.0191,207,014 - 91,234,890 (-)NCBI
RGSC_v3.4186,658,836 - 86,686,712 (-)RGD
Celera181,194,482 - 81,222,306 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283685   ⟹   XP_063139755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,389 - 95,996,883 (-)NCBI
RefSeq Acc Id: XM_063283691   ⟹   XP_063139761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8195,965,389 - 95,996,932 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997475 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139755 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139761 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62005 (Get FASTA)   NCBI Sequence Viewer  
  EDM07646 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029515
  ENSRNOP00000029515.3
  ENSRNOP00000087782.1
GenBank Protein Q6P6V0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997475   ⟸   NM_207592
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029515   ⟸   ENSRNOT00000032613
Ensembl Acc Id: ENSRNOP00000080691   ⟸   ENSRNOT00000112795
Ensembl Acc Id: ENSRNOP00000085356   ⟸   ENSRNOT00000101765
Ensembl Acc Id: ENSRNOP00000087782   ⟸   ENSRNOT00000097410
RefSeq Acc Id: XP_063139761   ⟸   XM_063283691
- Peptide Label: isoform X1
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139755   ⟸   XM_063283685
- Peptide Label: isoform X1
- UniProtKB: Q6P6V0 (UniProtKB/Swiss-Prot),   A0A8I6A243 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6V0-F1-model_v2 AlphaFold Q6P6V0 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689949
Promoter ID:EPDNEW_R473
Type:multiple initiation site
Name:Gpi_1
Description:glucose-6-phosphate isomerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0190,091,293 - 90,091,353EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2727 AgrOrtholog
BioCyc Gene G2FUF-60019 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY-5659 [GDP-mannose biosynthesis] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
  UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY-5659 BioCyc
  PWY66-399 BioCyc
  UDPNACETYLGALSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000023150 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032613 ENTREZGENE
  ENSRNOT00000032613.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097410.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1390.10 UniProtKB/Swiss-Prot
  Glucose-6-phosphate isomerase like protein, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599776 IMAGE-MGC_LOAD
InterPro G6P_Isomerase UniProtKB/Swiss-Prot
  G6P_Isomerase_C UniProtKB/Swiss-Prot
  Phosphoglucose_isomerase_CS UniProtKB/Swiss-Prot
  SIS_dom_sf UniProtKB/Swiss-Prot
  SIS_PGI_1 UniProtKB/Swiss-Prot
  SIS_PGI_2 UniProtKB/Swiss-Prot
KEGG Report rno:292804 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72563 IMAGE-MGC_LOAD
NCBI Gene Gpi ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATE ISOMERASE UniProtKB/Swiss-Prot
  PTHR11469 UniProtKB/Swiss-Prot
Pfam PGI UniProtKB/Swiss-Prot
PhenoGen Gpi PhenoGen
PRINTS G6PISOMERASE UniProtKB/Swiss-Prot
PROSITE P_GLUCOSE_ISOMERASE_1 UniProtKB/Swiss-Prot
  P_GLUCOSE_ISOMERASE_2 UniProtKB/Swiss-Prot
  P_GLUCOSE_ISOMERASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023150 RatGTEx
Superfamily-SCOP SSF53697 UniProtKB/Swiss-Prot
UniProt A0A8I6A243 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6Z4_RAT UniProtKB/TrEMBL
  A6JA88_RAT UniProtKB/TrEMBL
  G6PI_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Gpi  glucose-6-phosphate isomerase  Gpi  glucose phosphate isomerase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gpi  glucose phosphate isomerase    Glucose phosphate isomerase  Name updated 625702 APPROVED
2002-06-10 Gpi  Glucose phosphate isomerase      Symbol and Name status set to approved 70586 APPROVED