Gnaz (G protein subunit alpha z) - Rat Genome Database

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Gene: Gnaz (G protein subunit alpha z) Rattus norvegicus
Analyze
Symbol: Gnaz
Name: G protein subunit alpha z
RGD ID: 2717
Description: Enables G protein-coupled serotonin receptor binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in cell body and dendrite. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm; plasma membrane; and synapse. Orthologous to human GNAZ (G protein subunit alpha z); PARTICIPATES IN endothelin signaling pathway; Hedgehog signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: g(x) alpha chain; guanine nucleotide binding protein (G protein), alpha z polypeptide; Guanine nucleotide binding protein alpha; guanine nucleotide binding protein, alpha z polypeptide; guanine nucleotide binding protein, alpha z subunit; guanine nucleotide-binding protein G(z) subunit alpha; GXA; gz-alpha; heterotrimeric guanine nucleotide-binding protein 1h; Hg1h
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,642,853 - 13,693,616 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2013,644,020 - 13,669,287 (-)EnsemblGRCr8
mRatBN7.22013,643,473 - 13,694,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,644,640 - 13,669,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2014,351,133 - 14,376,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,711,964 - 13,737,230 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02014,184,561 - 14,209,827 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,593,072 - 14,644,020 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,593,819 - 14,620,019 (-)Ensemblrn6Rnor6.0
Rnor_5.02016,776,281 - 16,801,749 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42014,148,003 - 14,174,136 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2015,127,777 - 15,153,073 (-)NCBICelera
RGSC_v3.12014,147,070 - 14,198,741 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
CGP 52608  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
gentamycin  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
ozone  (EXP)
paracetamol  (EXP)
pentanal  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell body  (IEA,ISO)
cytoplasm  (IBA)
dendrite  (IEA,ISO)
heterotrimeric G-protein complex  (IBA,TAS)
membrane  (IEA)
plasma membrane  (IEA,ISO,TAS)
synapse  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Endothelin-induced, long lasting, and Ca2+ influx-independent blockade of intrinsic secretion in pituitary cells by Gz subunits. Andric SA, etal., J Biol Chem. 2005 Jul 22;280(29):26896-903. Epub 2005 May 26.
2. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
3. Short-term cocaine treatment causes neuroadaptive changes in Galphaq and Galpha11 proteins in rats undergoing withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):349-55. Epub 2004 Jun 2.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. A role for G(z) in pancreatic islet beta-cell biology. Kimple ME, etal., J Biol Chem. 2005 Sep 9;280(36):31708-13. Epub 2005 Jul 6.
8. Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mannoury la Cour C, etal., Mol Pharmacol. 2006 Sep;70(3):1013-21. Epub 2006 Jun 13.
9. Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. Matsuoka M, etal., Proc Natl Acad Sci U S A 1988 Aug;85(15):5384-8.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Yang J, etal., Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9984-9.
Additional References at PubMed
PMID:1939224   PMID:11685543   PMID:18525017   PMID:22871113   PMID:23376485   PMID:29476059  


Genomics

Comparative Map Data
Gnaz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,642,853 - 13,693,616 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2013,644,020 - 13,669,287 (-)EnsemblGRCr8
mRatBN7.22013,643,473 - 13,694,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,644,640 - 13,669,907 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2014,351,133 - 14,376,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,711,964 - 13,737,230 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02014,184,561 - 14,209,827 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,593,072 - 14,644,020 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,593,819 - 14,620,019 (-)Ensemblrn6Rnor6.0
Rnor_5.02016,776,281 - 16,801,749 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42014,148,003 - 14,174,136 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2015,127,777 - 15,153,073 (-)NCBICelera
RGSC_v3.12014,147,070 - 14,198,741 (-)NCBI
Cytogenetic Map20p12NCBI
GNAZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,070,519 - 23,125,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,070,325 - 23,125,036 (+)Ensemblhg38GRCh38
GRCh372223,412,705 - 23,467,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,742,669 - 21,797,224 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342221,737,222 - 21,791,775NCBI
Celera227,227,239 - 7,281,792 (+)NCBICelera
Cytogenetic Map22q11.22-q11.23NCBI
HuRef226,380,502 - 6,434,961 (+)NCBIHuRef
CHM1_12223,424,953 - 23,479,508 (+)NCBICHM1_1
T2T-CHM13v2.02223,493,390 - 23,547,904 (+)NCBIT2T-CHM13v2.0
Gnaz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391074,803,009 - 74,852,739 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1074,803,009 - 74,852,739 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381074,967,177 - 75,016,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1074,967,177 - 75,016,907 (+)Ensemblmm10GRCm38
MGSCv371074,429,976 - 74,478,622 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361074,410,947 - 74,459,593 (+)NCBIMGSCv36mm8
Celera1076,015,010 - 76,063,654 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1038.48NCBI
Gnaz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,501,153 - 7,554,235 (+)Ensembl
ChiLan1.0NW_0049554557,501,153 - 7,554,235 (+)NCBIChiLan1.0ChiLan1.0
GNAZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22332,902,100 - 32,956,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12235,125,858 - 35,180,490 (-)NCBINHGRI_mPanPan1
PanPan1.12221,694,068 - 21,748,459 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2221,719,169 - 21,746,851 (+)EnsemblpanPan2panpan1.1
GNAZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12627,780,598 - 27,811,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2627,781,704 - 27,810,188 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2626,858,045 - 26,887,668 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02629,186,052 - 29,215,701 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,163,807 - 29,215,697 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,269,346 - 27,298,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02626,887,024 - 26,916,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02627,876,069 - 27,905,727 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnaz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,510,028 - 142,562,971 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619191,091 - 244,235 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936619191,097 - 244,034 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,132,013 - 49,174,108 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11449,132,012 - 49,174,114 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,573,000 - 52,597,219 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNAZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,758,097 - 2,812,306 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,757,819 - 2,788,076 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660854,314,170 - 4,368,661 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnaz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,425,775 - 9,480,162 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247479,425,720 - 9,479,571 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gnaz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11812,441,154 - 12,491,460 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gnaz
194 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:102
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000001779
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH94432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,644,784 - 13,644,981 (+)MAPPERmRatBN7.2
Rnor_6.02014,594,389 - 14,594,585NCBIRnor6.0
Rnor_5.02016,776,426 - 16,776,622UniSTSRnor5.0
RGSC_v3.42014,148,148 - 14,148,344UniSTSRGSC3.4
Celera2015,127,922 - 15,128,118UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 66 150 81 80 50 88 50 6 338 185 11 129 81 92 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001779   ⟹   ENSRNOP00000001779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2013,644,020 - 13,669,287 (-)Ensembl
mRatBN7.2 Ensembl2013,644,640 - 13,669,907 (-)Ensembl
Rnor_6.0 Ensembl2014,593,819 - 14,620,019 (-)Ensembl
RefSeq Acc Id: NM_013189   ⟹   NP_037321
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,644,020 - 13,669,287 (-)NCBI
mRatBN7.22013,644,640 - 13,669,907 (-)NCBI
Rnor_6.02014,594,244 - 14,619,511 (-)NCBI
Rnor_5.02016,776,281 - 16,801,749 (-)NCBI
RGSC_v3.42014,148,003 - 14,174,136 (-)RGD
Celera2015,127,777 - 15,153,073 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772867   ⟹   XP_008771089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,642,853 - 13,693,616 (-)NCBI
mRatBN7.22013,643,473 - 13,694,240 (-)NCBI
Rnor_6.02014,593,072 - 14,644,020 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037321   ⟸   NM_013189
- UniProtKB: P19627 (UniProtKB/Swiss-Prot),   A6JKM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771089   ⟸   XM_008772867
- Peptide Label: isoform X1
- UniProtKB: P19627 (UniProtKB/Swiss-Prot),   A6JKM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001779   ⟸   ENSRNOT00000001779
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19627-F1-model_v2 AlphaFold P19627 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2717 AgrOrtholog
BioCyc Gene G2FUF-4100 BioCyc
Ensembl Genes ENSRNOG00000001313 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001779 ENTREZGENE
  ENSRNOT00000001779.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot
  Gprotein_alpha_su UniProtKB/Swiss-Prot
  GproteinA_insert UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:25740 UniProtKB/Swiss-Prot
NCBI Gene 25740 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR10218 UniProtKB/Swiss-Prot
Pfam G-alpha UniProtKB/Swiss-Prot
PhenoGen Gnaz PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot
  GPROTEINAI UniProtKB/Swiss-Prot
PROSITE G_ALPHA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001313 RatGTEx
SMART G_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A6JKM2 ENTREZGENE, UniProtKB/TrEMBL
  GNAZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnaz  G protein subunit alpha z  Gnaz  guanine nucleotide binding protein (G protein), alpha z polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-18 Gnaz  guanine nucleotide binding protein (G protein), alpha z polypeptide  Gnaz  guanine nucleotide binding protein, alpha z polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Gnaz  guanine nucleotide binding protein, alpha z polypeptide  Gnaz  guanine nucleotide binding protein, alpha z subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gnaz  Guanine nucleotide binding protein, alpha      Symbol and Name status set to approved 70586 APPROVED