Gja1 (gap junction protein, alpha 1) - Rat Genome Database

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Gene: Gja1 (gap junction protein, alpha 1) Rattus norvegicus
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Symbol: Gja1
Name: gap junction protein, alpha 1
RGD ID: 2690
Description: Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and positive regulation of cell communication. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); erythrokeratodermia variabilis (multiple); hypoplastic left heart syndrome; oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1); PARTICIPATES IN connexin signaling pathway; N-cadherin signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (-)-antofine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin 43; connexin k1; connexin-43; Cx43; Cxnk1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein alpha 1 43 kD; Gap junction protein alpha 1 43 kD (connexin 43); Gap junction protein, alpha 1, 43 kD (connexin 43); MGC93610
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,302,490 - 36,315,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2036,302,352 - 36,319,689 (+)EnsemblGRCr8
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)Ensemblrn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2037,095,121 - 37,107,568 (+)NCBICelera
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
adenoma  (ISO)
alcohol use disorder  (ISO)
amnestic disorder  (IMP)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial fibrillation  (IEP,ISO)
Atrioventricular Septal Defect 3  (ISO)
Atrioventricular Septal Defect and Common Atrioventricular Junction  (ISO)
autistic disorder  (ISO)
autoimmune thyroiditis  (IEP)
autosomal recessive craniometaphyseal dysplasia  (ISO)
Basaran Yilmaz Syndrome  (ISO)
borna disease  (IEP)
Brain Injuries  (IEP)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
Cardiac Arrhythmias  (IEP,ISO)
Cardiac Fibrosis  (IEP)
chronic kidney disease  (ISO)
Chylothorax  (ISO)
coronary aneurysm  (ISO)
Desbuquois dysplasia  (ISO)
Diabetic Foot  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Disease Progression  (ISO)
erythrokeratodermia variabilis  (ISO)
erythrokeratodermia variabilis et progressiva 3  (ISO)
Experimental Arthritis  (IMP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (IEP)
genetic disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IEP)
hereditary lymphedema IA  (ISO)
high grade glioma  (IMP)
Huntington's disease  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
hypertension  (IEP,ISO)
hypoplastic left heart syndrome  (ISO)
Hypoplastic Left Heart Syndrome 1  (ISO)
impotence  (IEP)
ischemia  (IEP)
Lung Neoplasms  (ISO)
Lymphatic Abnormalities  (ISO)
microphthalmia  (ISO)
myocardial infarction  (IEP,IMP)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Neuralgia  (ISO)
Nonsyndromic Sensorineural Hearing Loss  (ISO)
oculodentodigital dysplasia  (ISO,ISS)
Oculodentodigital Dysplasia, Autosomal Recessive  (ISO)
overactive bladder syndrome  (IEP)
palmoplantar keratoderma and congenital alopecia 1  (ISO)
palmoplantar keratosis  (ISO)
Parkinsonism  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP)
renovascular hypertension  (IEP)
Right Ventricular Hypertrophy  (ISO)
Schwartz-Lelek Syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP,IMP)
Sudden Cardiac Death  (ISO)
syndactyly  (ISO)
syndactyly type 3  (ISO)
syndactyly type 5  (ISO)
tetralogy of Fallot  (ISO)
tongue squamous cell carcinoma  (IEP)
transient cerebral ischemia  (IEP,ISO)
type 2 diabetes mellitus  (IEP)
urethral obstruction  (IEP)
Vascular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-antofine  (EXP)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexabromobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dibromo-4-hydroxybenzonitrile  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
ametryn  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anastrozole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apocynin  (EXP)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-amyrin  (EXP)
beta-carotene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
BQ 123  (EXP)
bucladesine  (EXP)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (EXP)
calciol  (EXP)
cantharidin  (ISO)
capsanthin  (EXP)
carbendazim  (EXP)
CARBENOXOLONE  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chaetoglobosin A  (EXP)
CHIR 99021  (EXP)
chloral hydrate  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
curcumin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (EXP)
endosulfan  (EXP,ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
ethidium  (EXP)
Ethylenethiourea  (ISO)
etoposide  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
Gastrodin  (EXP)
genistein  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutaraldehyde  (EXP)
glycerol  (EXP)
glyphosate  (EXP)
gossypol  (EXP)
griseofulvin  (ISO)
haloperidol  (EXP)
heptachlor  (ISO)
Heptachlor epoxide  (EXP,ISO)
heptan-1-ol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxyflutamide  (EXP)
imidacloprid  (EXP)
indoxyl sulfate  (EXP)
inulin  (ISO)
ioxynil  (EXP)
iprodione  (EXP)
irinotecan  (EXP,ISO)
isocarbophos  (EXP)
isoprenaline  (EXP,ISO)
KN-93  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
letrozole  (ISO)
leupeptin  (ISO)
levetiracetam  (EXP)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
losartan  (EXP)
LY294002  (ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methoxychlor  (ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
Mitoquinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Muconic dialdehyde  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimodipine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP,ISO)
NMN zwitterion  (ISO)
Norfluoxetine  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
organophosphorus compound  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-cresol  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (ISO)
phenol  (EXP)
phenol red  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP)
protosappanin A  (ISO)
quercetin  (EXP,ISO)
radicicol  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Ro 31-8220  (EXP)
Ro 41-5253  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfur dioxide  (ISO)
Sunset Yellow FCF  (EXP)
tamoxifen  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
tolbutamide  (EXP)
toluene  (EXP)
topotecan  (EXP,ISO)
toxaphene  (ISO)
tramadol  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zardaverine  (EXP)
zearalenone  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (ISO)
ATP transport  (IMP)
atrial ventricular junction remodeling  (ISO)
blood vessel morphogenesis  (ISO)
bone development  (ISO,ISS)
bone remodeling  (ISO,ISS)
cardiac conduction  (ISO)
cell communication  (IEA)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (IBA,ISO)
cell-cell junction organization  (IEA,ISO)
cell-cell signaling  (IBA,IDA,IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to pH  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
chronic inflammatory response  (IMP)
decidualization  (IEP)
embryonic digit morphogenesis  (ISO)
embryonic heart tube development  (ISO)
endothelium development  (IEP)
epididymis development  (IEP)
epithelial cell maturation  (ISO)
establishment of mitotic spindle orientation  (ISO)
export across plasma membrane  (ISO)
gap junction assembly  (TAS)
glutamate secretion  (ISO)
glutathione transmembrane transport  (IEA)
heart development  (IBA,IEA,IEP,ISO)
heart looping  (ISO)
immune system process  (IEA)
in utero embryonic development  (ISO)
innate immune response  (IEA)
intracellular protein localization  (ISO)
lens development in camera-type eye  (ISO)
maintenance of protein localization in endoplasmic reticulum  (IDA)
male gonad development  (ISO)
microtubule-based transport  (ISO,ISS)
milk ejection reflex  (ISO)
monoatomic ion transmembrane transport  (ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell growth  (IEA,IMP,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of DNA biosynthetic process  (IDA)
negative regulation of endothelial cell proliferation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of gonadotropin secretion  (ISO)
negative regulation of trophoblast cell migration  (ISO)
neuron migration  (ISO)
neuron projection morphogenesis  (IMP)
osteoblast differentiation  (ISO)
positive regulation of behavioral fear response  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell communication by chemical coupling  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of establishment of Sertoli cell barrier  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glomerular filtration  (IMP)
positive regulation of insulin secretion  (IMP)
positive regulation of meiotic nuclear division  (IMP)
positive regulation of mesodermal cell differentiation  (ISO)
positive regulation of morphogenesis of an epithelium  (ISO)
positive regulation of protein catabolic process  (IDA)
positive regulation of smooth muscle cell chemotaxis  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of striated muscle tissue development  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (IMP)
regulation of actin filament organization  (IMP)
regulation of apoptotic process  (IMP)
regulation of atrial cardiac muscle cell membrane depolarization  (ISO)
regulation of bicellular tight junction assembly  (IMP)
regulation of blood circulation  (IEA)
regulation of body fluid levels  (IEA)
regulation of bone mineralization  (ISO)
regulation of bone remodeling  (ISO)
regulation of calcium ion transport  (IMP)
regulation of cell communication by electrical coupling  (IDA)
regulation of heart contraction  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to estradiol  (IEP)
response to fluid shear stress  (IEP)
response to glucose  (IEP)
response to ischemia  (IEP,ISO)
response to lipopolysaccharide  (IEP)
response to peptide hormone  (IEP)
response to pH  (IDA,IEA)
response to retinoic acid  (IEP)
response to wounding  (ISO)
signal transduction  (ISO)
skeletal muscle tissue regeneration  (ISO)
spermatogenesis  (IEA,IMP,ISO,ISS)
T cell activation  (ISO)
T cell proliferation  (ISO)
transmembrane transport  (IDA,IEA)
vascular transport  (IMP)
vasodilation  (IMP)
xenobiotic transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43). Ahmad Waza A, etal., Exp Cell Res. 2012 Dec 10;318(20):2559-66. doi: 10.1016/j.yexcr.2012.08.004. Epub 2012 Aug 30.
2. Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. Allard C, etal., J Cereb Blood Flow Metab. 2014 Feb;34(2):339-46. doi: 10.1038/jcbfm.2013.206. Epub 2013 Dec 4.
3. Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. Ambrosi C, etal., PLoS One. 2016 Jun 9;11(6):e0157073. doi: 10.1371/journal.pone.0157073. eCollection 2016.
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108. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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124. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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143. Antisense oligodeoxynucleotides targeting connexin43 reduce cerebral astrocytosis and edema in a rat model of traumatic brain injury. Wu Z, etal., Neurol Res. 2013 Apr;35(3):255-62. doi: 10.1179/1743132813Y.0000000165.
144. Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury. Xu Q, etal., Neurosci Lett. 2014 Apr 30;566:194-9. doi: 10.1016/j.neulet.2014.03.004. Epub 2014 Mar 12.
145. Membrane topology and quaternary structure of cardiac gap junction ion channels. Yeager M and Gilula NB, J Mol Biol. 1992 Feb 20;223(4):929-48.
146. Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment. Yeh HI, etal., Am J Hypertens. 2006 Feb;19(2):129-35.
147. Individual gap junction plaques contain multiple connexins in arterial endothelium. Yeh HI, etal., Circ Res. 1998 Dec 14-28;83(12):1248-63.
148. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. Yeh HI, etal., J Histochem Cytochem. 2000 Oct;48(10):1377-89.
149. Sildenafil improves long-term effect of endothelial progenitor cell-based treatment for monocrotaline-induced rat pulmonary arterial hypertension. Yen CH, etal., Cytotherapy. 2013 Feb;15(2):209-23. doi: 10.1016/j.jcyt.2012.09.002. Epub 2012 Dec 11.
150. Identification and functional analysis of novel phosphorylation sites in Cx43 in rat primary granulosa cells. Yogo K, etal., FEBS Lett 2002 Nov 6;531(2):132-6.
151. Spinal astrocyte gap junctions contribute to oxaliplatin-induced mechanical hypersensitivity. Yoon SY, etal., J Pain. 2013 Feb;14(2):205-14. doi: 10.1016/j.jpain.2012.11.002.
152. Antitumor effects of monoclonal antibodies to connexin 43 extracellular fragment in induced low-differentiated glioma. Yusubalieva GM, etal., Bull Exp Biol Med. 2012 May;153(1):163-9.
153. The gap junction-independent tumor-suppressing effect of connexin 43. Zhang YW, etal., J Biol Chem. 2003 Nov 7;278(45):44852-6. Epub 2003 Sep 2.
154. NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. Zheng YF, etal., J Pharm Pharmacol. 2010 May;62(5):615-21. doi: 10.1211/jpp/62.05.0009.
155. Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart. Zhou P, etal., PLoS One. 2013 Aug 12;8(8):e71567. doi: 10.1371/journal.pone.0071567. eCollection 2013.
156. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Zhu Y, etal., Cell Metab. 2016 Sep 13;24(3):420-433. doi: 10.1016/j.cmet.2016.08.005.
Additional References at PubMed
PMID:1651718   PMID:1652440   PMID:1696265   PMID:1852114   PMID:2987225   PMID:7593302   PMID:7691412   PMID:7892609   PMID:7930207   PMID:8165225   PMID:9109444   PMID:9438384  
PMID:9486664   PMID:9582296   PMID:9620080   PMID:10871288   PMID:10969038   PMID:11090614   PMID:11179202   PMID:11397787   PMID:11732910   PMID:11756680   PMID:11812132   PMID:11870059  
PMID:11896013   PMID:11922902   PMID:12064589   PMID:12064598   PMID:12064600   PMID:12064601   PMID:12064606   PMID:12397369   PMID:12429234   PMID:12483281   PMID:12577316   PMID:12606326  
PMID:12606457   PMID:12638734   PMID:12655594   PMID:12676745   PMID:12738802   PMID:12761501   PMID:12767974   PMID:12874275   PMID:14595769   PMID:14602580   PMID:14676187   PMID:14681032  
PMID:14684606   PMID:14732399   PMID:14970263   PMID:14973142   PMID:15016632   PMID:15028626   PMID:15033576   PMID:15084279   PMID:15128867   PMID:15137067   PMID:15272007   PMID:15328367  
PMID:15331631   PMID:15331634   PMID:15342787   PMID:15371442   PMID:15489334   PMID:15537869   PMID:15601660   PMID:15605384   PMID:15910768   PMID:15919068   PMID:15998674   PMID:16103109  
PMID:16127430   PMID:16195341   PMID:16240671   PMID:16328273   PMID:16341870   PMID:16352648   PMID:16443678   PMID:16474210   PMID:16624854   PMID:16685461   PMID:16703618   PMID:16790700  
PMID:16917092   PMID:16931598   PMID:16963503   PMID:17065216   PMID:17164264   PMID:17223729   PMID:17258854   PMID:17276456   PMID:17285859   PMID:17322640   PMID:17350281   PMID:17401374  
PMID:17450382   PMID:17480016   PMID:17513490   PMID:17541973   PMID:17558443   PMID:17561003   PMID:17584645   PMID:17591950   PMID:17632690   PMID:17690839   PMID:17693411   PMID:17713529  
PMID:17714073   PMID:17717278   PMID:17728094   PMID:17823969   PMID:17825302   PMID:17884088   PMID:17901047   PMID:17959141   PMID:17978847   PMID:18004727   PMID:18058800   PMID:18079109  
PMID:18097526   PMID:18163231   PMID:18172602   PMID:18178574   PMID:18239136   PMID:18373396   PMID:18378510   PMID:18380541   PMID:18556577   PMID:18593691   PMID:18601906   PMID:18629610  
PMID:18635599   PMID:18650245   PMID:18667438   PMID:18789391   PMID:18820645   PMID:18835920   PMID:19098115   PMID:19129462   PMID:19159354   PMID:19162006   PMID:19194037   PMID:19228792  
PMID:19232380   PMID:19232841   PMID:19242638   PMID:19297523   PMID:19321666   PMID:19386724   PMID:19423616   PMID:19438811   PMID:19439426   PMID:19460776   PMID:19460861   PMID:19465552  
PMID:19513369   PMID:19523531   PMID:19531903   PMID:19544087   PMID:19556520   PMID:19574999   PMID:19588758   PMID:19590141   PMID:19596827   PMID:19676129   PMID:19719782   PMID:19758135  
PMID:19896659   PMID:20086016   PMID:20089884   PMID:20167932   PMID:20361177   PMID:20378856   PMID:20379000   PMID:20412010   PMID:20466804   PMID:20484649   PMID:20497714   PMID:20513204  
PMID:20515445   PMID:20585956   PMID:20619143   PMID:20654614   PMID:20676131   PMID:20705586   PMID:20805582   PMID:20817946   PMID:20869426   PMID:20881055   PMID:20963625   PMID:20966593  
PMID:21038665   PMID:21157921   PMID:21296051   PMID:21346198   PMID:21423176   PMID:21453730   PMID:21454599   PMID:21548215   PMID:21606502   PMID:21700703   PMID:21708977   PMID:21749829  
PMID:21753256   PMID:21800912   PMID:21844382   PMID:21934140   PMID:21936631   PMID:21965676   PMID:22128836   PMID:22139843   PMID:22158029   PMID:22212640   PMID:22226601   PMID:22325386  
PMID:22384254   PMID:22411987   PMID:22470101   PMID:22519405   PMID:22549838   PMID:22558917   PMID:22561459   PMID:22568203   PMID:22623726   PMID:22642233   PMID:22796290   PMID:22811280  
PMID:22871113   PMID:22889254   PMID:22945766   PMID:23072709   PMID:23076176   PMID:23085979   PMID:23106098   PMID:23112846   PMID:23224291   PMID:23299500   PMID:23302960   PMID:23348765  
PMID:23376361   PMID:23376485   PMID:23381804   PMID:23403203   PMID:23455518   PMID:23460926   PMID:23494606   PMID:23553806   PMID:23620341   PMID:23659290   PMID:23712704   PMID:23827822  
PMID:23885125   PMID:23922949   PMID:24002703   PMID:24008412   PMID:24015194   PMID:24040453   PMID:24043768   PMID:24210816   PMID:24216131   PMID:24236049   PMID:24236122   PMID:24269759  
PMID:24383076   PMID:24433183   PMID:24481773   PMID:24654232   PMID:24872408   PMID:24883012   PMID:24938518   PMID:24940027   PMID:25023895   PMID:25065281   PMID:25086040   PMID:25115184  
PMID:25150797   PMID:25262337   PMID:25270829   PMID:25304966   PMID:25373717   PMID:25401388   PMID:25421413   PMID:25552354   PMID:25605500   PMID:25625334   PMID:25626126   PMID:25647175  
PMID:25731866   PMID:25748165   PMID:25791497   PMID:25988944   PMID:26031379   PMID:26095039   PMID:26111928   PMID:26115885   PMID:26138882   PMID:26154105   PMID:26169175   PMID:26200696  
PMID:26212436   PMID:26255026   PMID:26268619   PMID:26285688   PMID:26316108   PMID:26342084   PMID:26398314   PMID:26398676   PMID:26403541   PMID:26459193   PMID:26550940   PMID:26648560  
PMID:26830133   PMID:26841867   PMID:26869446   PMID:26926986   PMID:27030716   PMID:27078698   PMID:27122099   PMID:27138645   PMID:27156839   PMID:27235399   PMID:27323125   PMID:27391443  
PMID:27462070   PMID:27567473   PMID:27643942   PMID:27655723   PMID:27677282   PMID:27706732   PMID:27748857   PMID:27799555   PMID:27941941   PMID:28034749   PMID:28042145   PMID:28077322  
PMID:28081514   PMID:28096472   PMID:28122732   PMID:28342807   PMID:28424784   PMID:28459162   PMID:28561933   PMID:28637680   PMID:28716730   PMID:28974518   PMID:28978514   PMID:29065929  
PMID:29094045   PMID:29115377   PMID:29115504   PMID:29116012   PMID:29121655   PMID:29155206   PMID:29163229   PMID:29174980   PMID:29179175   PMID:29238079   PMID:29246788   PMID:29366904  
PMID:29476059   PMID:29664174   PMID:29678775   PMID:29763908   PMID:29867029   PMID:29882937   PMID:30049932   PMID:30054380   PMID:30070388   PMID:30242148   PMID:30347394   PMID:30448479  
PMID:30599359   PMID:30683822   PMID:30703072   PMID:30908945   PMID:30992345   PMID:31030416   PMID:31152853   PMID:31374823   PMID:31408542   PMID:31429423   PMID:31545399   PMID:31601792  
PMID:31712070   PMID:31730522   PMID:31826322   PMID:31888653   PMID:32088192   PMID:32124965   PMID:32138615   PMID:32188841   PMID:32213357   PMID:32258113   PMID:32401478   PMID:32436936  
PMID:32620936   PMID:32957719   PMID:33171391   PMID:33196322   PMID:33238452   PMID:33255329   PMID:33287729   PMID:33467936   PMID:33651309   PMID:33660186   PMID:34070699   PMID:34428599  
PMID:34698450   PMID:34716547   PMID:34769027   PMID:34831325   PMID:34931018   PMID:35008913   PMID:35061296   PMID:35066063   PMID:35279164   PMID:35608408   PMID:35799894   PMID:36077595  
PMID:36362410   PMID:36442284   PMID:36805498   PMID:37014755   PMID:37037067   PMID:37121428   PMID:37156321   PMID:37391124   PMID:37465947   PMID:37541575   PMID:37673049   PMID:37805009  
PMID:37904209   PMID:37904692   PMID:38517263   PMID:38583020   PMID:38599061   PMID:38653383   PMID:38967483   PMID:39049648  


Genomics

Comparative Map Data
Gja1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,302,490 - 36,315,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2036,302,352 - 36,319,689 (+)EnsemblGRCr8
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)Ensemblrn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2037,095,121 - 37,107,568 (+)NCBICelera
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Cytogenetic Map20q11NCBI
GJA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386121,435,646 - 121,449,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6121,435,577 - 121,449,727 (+)Ensemblhg38GRCh38
GRCh376121,756,792 - 121,770,873 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366121,798,444 - 121,812,572 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346121,798,486 - 121,812,571NCBI
Celera6122,501,175 - 122,515,303 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6119,340,180 - 119,354,307 (+)NCBIHuRef
CHM1_16122,020,550 - 122,034,679 (+)NCBICHM1_1
T2T-CHM13v2.06122,622,700 - 122,636,781 (+)NCBIT2T-CHM13v2.0
Gja1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391056,253,297 - 56,266,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1056,253,426 - 56,278,609 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381056,377,300 - 56,390,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1056,377,330 - 56,402,513 (+)Ensemblmm10GRCm38
MGSCv371056,097,106 - 56,110,225 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361056,065,762 - 56,078,833 (+)NCBIMGSCv36mm8
Celera1057,194,935 - 57,208,041 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1028.64NCBI
Gja1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554363,612,533 - 3,618,095 (+)Ensembl
ChiLan1.0NW_0049554363,612,533 - 3,618,095 (+)NCBIChiLan1.0ChiLan1.0
GJA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25141,418,977 - 141,433,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16139,315,632 - 139,329,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16123,348,744 - 123,360,887 (+)NCBIPanPan1.1PanPan1.1panPan2
GJA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1160,941,772 - 60,944,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl160,929,097 - 60,942,936 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha161,750,272 - 61,753,194 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0161,130,176 - 61,143,784 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,130,100 - 61,143,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,052,769 - 61,055,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0160,868,101 - 60,871,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,515,138 - 61,518,103 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gja1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946111,813,180 - 111,826,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366583,920,043 - 3,932,987 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366583,920,043 - 3,932,987 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl140,988,528 - 41,002,156 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1140,988,818 - 41,002,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2145,543,880 - 45,557,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11352,397,291 - 52,410,341 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1352,396,109 - 52,410,339 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604024,676,777 - 24,690,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247989,359,004 - 9,364,313 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247989,358,996 - 9,364,413 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gja1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11833,164,405 - 33,176,064 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gja1
100 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:137
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000001054
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203215696745978663Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
D18Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,377,615 - 60,377,755 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,290 - 62,570,429NCBIRnor6.0
Rnor_5.01861,757,051 - 61,757,190UniSTSRnor5.0
RGSC_v3.41862,660,084 - 62,660,224RGDRGSC3.4
RGSC_v3.41862,660,085 - 62,660,224UniSTSRGSC3.4
Celera1858,484,925 - 58,485,064UniSTS
RGSC_v3.11862,733,285 - 62,733,425RGD
Cytogenetic Map20q11UniSTS
D18Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81862,647,557 - 62,647,720 (+)Marker Load Pipeline
mRatBN7.21860,377,590 - 60,377,753 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,265 - 62,570,427NCBIRnor6.0
Rnor_5.01861,757,026 - 61,757,188UniSTSRnor5.0
Celera1858,484,900 - 58,485,062UniSTS
RH 3.4 Map18610.4RGD
RH 3.4 Map18610.4UniSTS
RH 2.0 Map18301.2RGD
Cytogenetic Map20q11UniSTS
RH128006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,306 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,922NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,380UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,087UniSTSRGSC3.4
Celera2037,107,187 - 37,107,393UniSTS
RH 3.4 Map20375.01UniSTS
Cytogenetic Map20q11UniSTS
RH135241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,307 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,923NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,381UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,088UniSTSRGSC3.4
Celera2037,107,187 - 37,107,394UniSTS
RH 3.4 Map20372.51UniSTS
Cytogenetic Map20q11UniSTS
PMC151788P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,766,348 - 35,766,681 (+)MAPPERmRatBN7.2
Rnor_6.02037,886,965 - 37,887,297NCBIRnor6.0
Rnor_5.02039,622,423 - 39,622,755UniSTSRnor5.0
RGSC_v3.42035,420,130 - 35,420,462UniSTSRGSC3.4
Celera2037,105,436 - 37,105,768UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 72 59 6 336 172 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY324140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT990403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001054   ⟹   ENSRNOP00000001054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2036,305,092 - 36,315,002 (+)Ensembl
mRatBN7.2 Ensembl2035,756,029 - 35,768,475 (+)Ensembl
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100494   ⟹   ENSRNOP00000093256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2036,304,327 - 36,315,002 (+)Ensembl
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000121800   ⟹   ENSRNOP00000100528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2036,306,147 - 36,315,183 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134128   ⟹   ENSRNOP00000107427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2036,302,352 - 36,319,689 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134365   ⟹   ENSRNOP00000103696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2036,302,550 - 36,316,676 (+)Ensembl
RefSeq Acc Id: NM_012567   ⟹   NP_036699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,302,564 - 36,315,010 (+)NCBI
mRatBN7.22035,756,035 - 35,768,481 (+)NCBI
Rnor_6.02037,876,650 - 37,889,097 (+)NCBI
Rnor_5.02039,612,080 - 39,624,555 (+)NCBI
RGSC_v3.42035,409,815 - 35,422,262 (+)RGD
Celera2037,095,121 - 37,107,568 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098413   ⟹   XP_038954341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,302,490 - 36,315,010 (+)NCBI
mRatBN7.22035,756,007 - 35,768,481 (+)NCBI
RefSeq Acc Id: XM_063278953   ⟹   XP_063135023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,303,757 - 36,315,010 (+)NCBI
RefSeq Acc Id: XM_063278954   ⟹   XP_063135024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,303,757 - 36,315,010 (+)NCBI
RefSeq Acc Id: NP_036699   ⟸   NM_012567
- UniProtKB: Q53ZE1 (UniProtKB/Swiss-Prot),   P08050 (UniProtKB/Swiss-Prot),   A0A654ICE6 (UniProtKB/TrEMBL),   A0A8L2UHE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001054   ⟸   ENSRNOT00000001054
RefSeq Acc Id: XP_038954341   ⟸   XM_039098413
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093256   ⟸   ENSRNOT00000100494
RefSeq Acc Id: XP_063135023   ⟸   XM_063278953
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135024   ⟸   XM_063278954
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107427   ⟸   ENSRNOT00000134128
Ensembl Acc Id: ENSRNOP00000100528   ⟸   ENSRNOT00000121800
Ensembl Acc Id: ENSRNOP00000103696   ⟸   ENSRNOT00000134365
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08050-F1-model_v2 AlphaFold P08050 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701633
Promoter ID:EPDNEW_R12157
Type:multiple initiation site
Name:Gja1_1
Description:gap junction protein, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02037,876,642 - 37,876,702EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2690 AgrOrtholog
BioCyc Gene G2FUF-3605 BioCyc
Ensembl Genes ENSRNOG00000000805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001054 ENTREZGENE
  ENSRNOT00000100494 ENTREZGENE
  ENSRNOT00000100494.1 UniProtKB/Swiss-Prot
  ENSRNOT00000134128 ENTREZGENE
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
  1.20.5.1130 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105924 IMAGE-MGC_LOAD
InterPro Alpha_helix_dom_sf UniProtKB/Swiss-Prot
  Connexin UniProtKB/Swiss-Prot
  Connexin43 UniProtKB/Swiss-Prot
  Connexin43_C UniProtKB/Swiss-Prot
  Connexin_C UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:24392 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93610 IMAGE-MGC_LOAD
NCBI Gene 24392 ENTREZGENE
PANTHER PTHR11984 UniProtKB/Swiss-Prot
  PTHR11984:SF33 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
  Connexin43 UniProtKB/Swiss-Prot
PharmGKB GJA1 RGD
PhenoGen Gja1 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
  CONNEXINA1 UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000805 RatGTEx
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF118220 UniProtKB/Swiss-Prot
TIGR TC230392
UniProt A0A654ICE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHE4 ENTREZGENE, UniProtKB/TrEMBL
  A6K4B5_RAT UniProtKB/TrEMBL
  CXA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53ZE1 ENTREZGENE
UniProt Secondary Q53ZE1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Gja1  gap junction protein, alpha 1  Gja1  gap junction membrane channel protein alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gja1  gap junction membrane channel protein alpha 1    Gap junction protein, alpha 1, 43 kD (connexin 43)  Name updated 625702 APPROVED
2002-06-10 Gja1  Gap junction protein, alpha 1, 43 kD (connexin 43)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease decreased expression is assocaited with impaired cell-cell communication in heart failure 728855
gene_expression expressed in adult epididymis 628541
gene_physical_interaction forms gap junctions between principal and basal cells but not between adjacent principal cells 628541