Gja1 (gap junction protein, alpha 1) - Rat Genome Database

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Gene: Gja1 (gap junction protein, alpha 1) Rattus norvegicus
Analyze
Symbol: Gja1
Name: gap junction protein, alpha 1
RGD ID: 2690
Description: Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and positive regulation of cell communication. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); erythrokeratodermia variabilis (multiple); hypoplastic left heart syndrome; oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1); PARTICIPATES IN connexin signaling pathway; N-cadherin signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (-)-antofine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin 43; connexin k1; connexin-43; Cx43; Cxnk1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein alpha 1 43 kD; Gap junction protein alpha 1 43 kD (connexin 43); Gap junction protein, alpha 1, 43 kD (connexin 43); MGC93610
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,302,490 - 36,315,010 (+)NCBIGRCr8
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Gja1RatAcute Lung Injury treatmentIEP 8662452 RGD 
Gja1Ratamnestic disorder  IMP 7207267 RGD 
Gja1Ratarrhythmogenic right ventricular cardiomyopathy  ISOGJA1 (Homo sapiens)11352402protein:altered expression:ventricleRGD 
Gja1Ratarrhythmogenic right ventricular cardiomyopathy  ISOGja1 (Mus musculus)265253172protein:decreased expression:cardiac ventricle (mouse)RGD 
Gja1Ratarrhythmogenic right ventricular cardiomyopathy  ISOGJA1 (Homo sapiens)13592599protein:decreased expression:buccal mucosaRGD 
Gja1Ratatrial fibrillation  IEP 7207850protein:increased localization:lateral plasma membrane and cardiac muscle cell RGD 
Gja1Ratatrial fibrillation susceptibilityISOGja1 (Mus musculus)12910123DNA:mutation:cds:p.G60S(mouse)RGD 
Gja1Ratatrial fibrillation  ISOGJA1 (Homo sapiens)8662373associated with Rheumatic Diseases and protein:decreased expression:myocardium of atriumRGD 
Gja1Ratatrial fibrillation  ISOGJA1 (Homo sapiens)8662382protein:decreased expression:myocardium of atriumRGD 
Gja1Ratautoimmune thyroiditis  IEP 7349390mRNA more ...RGD 
Gja1Ratborna disease  IEP 7364785 RGD 
Gja1RatBrain Injuries treatmentIEP 8662424 RGD 
Gja1Ratbrain ischemia  IEP 6480433protein:increased expression:cerebral cortexRGD 
Gja1RatCardiac Arrhythmias treatmentIEP 8662422 RGD 
Gja1RatCardiac Fibrosis  IEP 8662459protein:decreased expression:myocardiumRGD 
Gja1RatChylothorax  ISOGja1 (Mus musculus)13592598 RGD 
Gja1RatDiabetic Foot  ISOGJA1 (Homo sapiens)7207269protein:increased expression:dermisRGD 
Gja1Ratdilated cardiomyopathy  ISOGJA1 (Homo sapiens)1582667 RGD 
Gja1Ratdilated cardiomyopathy  IEP 264347602protein:decreased expression:heart (rat)RGD 
Gja1Raterythrokeratodermia variabilis  ISOGJA1 (Homo sapiens)11568612DNA:mutations:cds:p.E227D and p.A44V(human)RGD 
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Gja1RatAtrioventricular Septal Defect 3  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrioventricular septal defect 3ClinVarPMID:25741868 more ...
Gja1RatAtrioventricular Septal Defect and Common Atrioventricular Junction  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrioventricular septal defect and common atrioventricular junctionClinVarPMID:11470490 more ...
Gja1Ratautosomal recessive craniometaphyseal dysplasia  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Craniometaphyseal dysplasia and autosomal recessiveClinVarPMID:11146471 more ...
Gja1Raterythrokeratodermia variabilis et progressiva 3  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Erythrokeratodermia variabilis et progressiva 3ClinVarPMID:25398053 more ...
Gja1Ratgenetic disease  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11146276 more ...
Gja1Rathereditary lymphedema IA  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Edema of the dorsum of feetClinVarPMID:25741868
Gja1RatHypoplastic Left Heart Syndrome 1  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypoplastic left heart syndrome 1ClinVarPMID:11470490 more ...
Gja1Ratmicrophthalmia  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bilateral microphthalmosClinVarPMID:25741868
Gja1Ratoculodentodigital dysplasia  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Oculodentodigital dysplasiaClinVarPMID:10331943 more ...
Gja1RatOculodentodigital Dysplasia, Autosomal Recessive  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Oculodentodigital dysplasia and autosomal recessiveClinVarPMID:11146471 more ...
Gja1Ratpalmoplantar keratoderma and congenital alopecia 1  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant palmoplantar keratoderma and congenital alopeciaClinVarPMID:12457340 more ...
Gja1Ratsyndactyly  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: SyndactylyClinVarPMID:25741868 and PMID:28492532
Gja1Ratsyndactyly type 3  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndactyly type 3ClinVarPMID:11470490 more ...
Gja1Ratsyndactyly type 5  ISOGJA1 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndactyly type 5ClinVar 
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Gja1Ratadenoma  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16926031
Gja1Ratautistic disorder  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18435417
Gja1Ratautosomal recessive craniometaphyseal dysplasia  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gja1RatBasaran Yilmaz Syndrome  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gja1RatBreast Neoplasms  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29180066
Gja1RatCardiac Arrhythmias  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18003637 and PMID:18077386
Gja1Ratchronic kidney disease  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32045570
Gja1Ratcoronary aneurysm  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15548583
Gja1RatDiaphragmatic Hernia  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16292552 and PMID:16720372
Gja1RatDisease Progression  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29180066
Gja1RatExperimental Liver Cirrhosis  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Gja1RatHyperalgesia  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34286406
Gja1Rathypertension  ISOGJA1 (Homo sapiens)11554173CTD more ...CTDPMID:16448880 and PMID:36720419
Gja1RatLung Neoplasms  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15166089 and PMID:16926031
Gja1RatMyocardial Reperfusion Injury  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17445419
Gja1Ratoculodentodigital dysplasia  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12457340 more ...
Gja1RatOculodentodigital Dysplasia, Autosomal Recessive  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Gja1RatProstatic Neoplasms  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17199135
Gja1RatRight Ventricular Hypertrophy  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:36720419
Gja1RatSkin Neoplasms  ISOGJA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7586191
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Gja1Ratoculodentodigital dysplasia  ISSGja1 (Mus musculus)13592920OMIM:164200 more ...MouseDO 

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Gja1Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of GJA1 proteinCTDPMID:21177194
Gja1Rat(+)-pilocarpine affects localizationEXP 6480464Pilocarpine affects the localization of GJA1 proteinCTDPMID:21177194
Gja1Rat(-)-antofine multiple interactionsEXP 64804641 more ...CTDPMID:23403203
Gja1Rat(-)-antofine decreases expressionEXP 6480464antofine results in decreased expression of GJA1 proteinCTDPMID:23403203
Gja1Rat(R)-carnitine multiple interactionsISOGja1 (Mus musculus)6480464Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GJA1 mRNA]CTDPMID:37863343
Gja1Rat(R)-carnitine increases expressionISOGja1 (Mus musculus)6480464Carnitine results in increased expression of GJA1 mRNACTDPMID:37863343
Gja1Rat(R)-lipoic acid multiple interactionsISOGja1 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]CTDPMID:27260466
Gja1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein] and Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]CTDPMID:26165643
Gja1Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of GJA1 mRNACTDPMID:14618266
Gja1Rat(R,R)-tramadol multiple interactionsEXP 6480464Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]CTDPMID:33645892
Gja1Rat(S)-colchicine multiple interactionsEXP 6480464Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form] and Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]CTDPMID:8824497
Gja1Rat(S)-nicotine increases expressionISOGja1 (Mus musculus)6480464Nicotine results in increased expression of GJA1 mRNA and Nicotine results in increased expression of GJA1 proteinCTDPMID:36720419
Gja1Rat1,3-dinitrobenzene decreases expressionEXP 64804643-dinitrobenzene results in decreased expression of GJA1 protein and 3-dinitrobenzene results in decreased expression of GJA1 protein modified formCTDPMID:15082077
Gja1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GJA1 mRNACTDPMID:20551477 and PMID:25380136
Gja1Rat1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine increases phosphorylationEXP 64804641-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 proteinCTDPMID:24079413
Gja1Rat1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine multiple interactionsEXP 6480464AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] and resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]CTDPMID:24079413
Gja1Rat17alpha-ethynylestradiol multiple interactionsISOGJA1 (Homo sapiens)6480464Ethinyl Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GJA1 protein]CTDPMID:10633228
Gja1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of GJA1 mRNACTDPMID:16174780 and PMID:17351261
Gja1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of GJA1 mRNACTDPMID:12075121 more ...
Gja1Rat17alpha-ethynylestradiol multiple interactionsISOGja1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GJA1 mRNACTDPMID:17942748

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Biological Process
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Gja1Ratadult heart development acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291MGI:1857177 PMID:9486664RGDPMID:9486664
Gja1RatATP transport  IMP 1582674 RGD 
Gja1Ratatrial ventricular junction remodeling acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291MGI:95716 PMID:10969038RGDPMID:10969038
Gja1Ratblood vessel morphogenesis acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291MGI:2386570 more ...RGDPMID:16624854
Gja1Ratbone development involved_inISOGja1 (Mus musculus)1624291 PMID:25270829RGDPMID:25270829
Gja1Ratbone development involved_inISSUniProtKB:P232421600115GO_REF:0000024UniProtGO_REF:0000024
Gja1Ratbone remodeling involved_inISSUniProtKB:P232421600115GO_REF:0000024UniProtGO_REF:0000024
Gja1Ratbone remodeling involved_inISOGja1 (Mus musculus)1624291 PMID:25270829RGDPMID:25270829
Gja1Ratcardiac conduction acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291MGI:1857177 PMID:10969038 and PMID:9109444RGDPMID:10969038 and PMID:9109444
Gja1Ratcell communication involved_inIEAInterPro:IPR000500 and InterPro:IPR0179901600115GO_REF:0000002InterProGO_REF:0000002
Gja1Ratcell communication by chemical coupling acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291 PMID:15084279RGDPMID:15084279
Gja1Ratcell communication by electrical coupling involved_inISOGJA1 (Homo sapiens)1624291 PMID:16790700 more ...RGDPMID:16790700 more ...
Gja1Ratcell communication by electrical coupling acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291 PMID:15084279RGDPMID:15084279
Gja1Ratcell communication by electrical coupling involved_inIBAMGI:95713 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja1Ratcell-cell junction organization acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291MGI:1857177 PMID:9620080RGDPMID:9620080
Gja1Ratcell-cell signaling  IDA 1580399 RGD 
Gja1Ratcell-cell signaling acts_upstream_of_or_withinISOGja1 (Mus musculus)1624291 PMID:11397787RGDPMID:11397787
Gja1Ratcell-cell signaling involved_inIBAMGI:1334209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja1Ratcell-cell signaling involved_inIEAInterPro:IPR0022611600115GO_REF:0000002InterProGO_REF:0000002
Gja1Ratcell-cell signaling involved_inISOGJA1 (Homo sapiens)1624291 PMID:1696265RGDPMID:1696265
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Cellular Component
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Gja1Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Gja1Ratapical plasma membrane located_inISSUniProtKB:P232421600115GO_REF:0000024UniProtGO_REF:0000024
Gja1Ratapical plasma membrane located_inISOGja1 (Mus musculus)1624291 PMID:29366904 and PMID:9620080RGDPMID:29366904 and PMID:9620080
Gja1Ratapical plasma membrane located_inISOGJA1 (Sus scrofa)1624291 PMID:22470101 and PMID:7593302RGDPMID:22470101 and PMID:7593302
Gja1Ratcell junction located_inISOGJA1 (Homo sapiens)1624291 PMID:29366904RGDGO_REF:0000052 and PMID:29366904
Gja1Ratcell junction located_inISOGja1 (Mus musculus)1624291 PMID:15601660RGDPMID:15601660
Gja1Ratcell-cell contact zone located_inISOGJA1 (Homo sapiens)1624291 PMID:11090614RGDPMID:11090614
Gja1Ratcell-cell junction located_inISOGJA1 (Sus scrofa)1624291 PMID:7593302RGDPMID:7593302
Gja1Ratcell-cell junction located_inISOGja1 (Mus musculus)1624291 PMID:15084279 more ...RGDPMID:15084279 more ...
Gja1Ratconnexin complex  IDA 1580399 RGD 
Gja1Ratconnexin complex part_ofIBAMGI:2384150 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja1Ratconnexin complex part_ofIEAInterPro:IPR000500 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Gja1Ratconnexin complex part_ofISOGJA1 (Canis lupus familiaris)1624291 PMID:7930207RGDPMID:7930207
Gja1Ratconnexin complex part_ofIDA 14397551PMID:1371548UniProt 
Gja1Ratconnexin complex part_ofIMP 12793009PMID:19808665CAFA 
Gja1Ratconnexin complex part_ofIDA 12793029PMID:15284189CAFA 
Gja1Ratconnexin complex  IDA 1582674 RGD 
Gja1Ratconnexin complex  IDA 1598435 RGD 
Gja1Ratcontractile muscle fiber located_inISOGja1 (Mus musculus)1624291 PMID:21708977RGDPMID:21708977
Gja1Ratcytoplasm located_inISOGJA1 (Sus scrofa)1624291 PMID:22470101 and PMID:23827822RGDPMID:22470101 and PMID:23827822
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Molecular Function
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Gja1Ratalpha-tubulin binding enablesISOGJA1 (Homo sapiens) and UniProtKB:P17302-51624291 PMID:29163229RGDPMID:29163229
Gja1Ratbeta-catenin binding enablesISOGJA1 (Homo sapiens)1624291UniProtKB:P35222 and PMID:30992345RGDPMID:30992345
Gja1Ratbeta-tubulin binding enablesISOGja1 (Mus musculus)1624291 PMID:15084279RGDPMID:15084279
Gja1Ratchannel activity enablesTAS 1600115Reactome:R-RNO-9858424ReactomeReactome:R-RNO-9858424
Gja1Ratconnexin binding  IPIGja5 (Rattus norvegicus)7207849 RGD 
Gja1Ratdisordered domain specific binding enablesIPIUniProtKB:P2823412793009PMID:19808665CAFA 
Gja1Ratefflux transmembrane transporter activity enablesISOGja1 (Mus musculus)1624291 PMID:26200696RGDPMID:26200696
Gja1Ratgap junction channel activity  IDA 1580399 RGD 
Gja1Ratgap junction channel activity enablesIBAMGI:1339969 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gja1Ratgap junction channel activity enablesISOGJA1 (Homo sapiens) and UniProtKB:P17302-51624291 PMID:29366904RGDPMID:29366904
Gja1Ratgap junction channel activity enablesISOGJA1 (Homo sapiens)1624291 PMID:16790700 more ...RGDPMID:16790700 more ...
Gja1Ratgap junction channel activity enablesIDA 12793029PMID:15284189CAFA 
Gja1Ratgap junction channel activity enablesISOGja1 (Mus musculus)1624291 PMID:11397787 more ...RGDPMID:11397787 more ...
Gja1Ratgap junction channel activity  IDA 1582674 RGD 
Gja1Ratgap junction channel activity involved in cell communication by electrical coupling enablesISOGJA1 (Homo sapiens)1624291 PMID:1696265RGDPMID:1696265
Gja1Ratgap junction hemi-channel activity enablesISSUniProtKB:P173021600115GO_REF:0000024UniProtGO_REF:0000024
Gja1Ratgap junction hemi-channel activity enablesISOGJA1 (Homo sapiens)1624291 PMID:29366904RGDPMID:29366904
Gja1Ratglutathione transmembrane transporter activity enablesISOGja1 (Mus musculus)1624291 PMID:26200696RGDPMID:26200696
Gja1Ratmonoatomic ion transmembrane transporter activity enablesISOGJA1 (Homo sapiens)1624291 PMID:1696265RGDPMID:1696265
Gja1RatPDZ domain binding  IPITjp2 (Rattus norvegicus)1582683 RGD 
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RGD Manual Annotations


  
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Gja1Ratconnexin signaling pathway  ISOGJA1 (Homo sapiens)1580398 RGD 

Imported Annotations - KEGG (archival)

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Gja1Ratarrhythmogenic right ventricular cardiomyopathy pathway  IEA 6907045 KEGGrno:05412

Imported Annotations - PID (archival)

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Gja1RatN-cadherin signaling pathway  ISOGJA1 (Homo sapiens)6484113 PIDPID:200209

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Reference Title
Reference Citation
1. Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43). Ahmad Waza A, etal., Exp Cell Res. 2012 Dec 10;318(20):2559-66. doi: 10.1016/j.yexcr.2012.08.004. Epub 2012 Aug 30.
2. Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. Allard C, etal., J Cereb Blood Flow Metab. 2014 Feb;34(2):339-46. doi: 10.1038/jcbfm.2013.206. Epub 2013 Dec 4.
3. Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. Ambrosi C, etal., PLoS One. 2016 Jun 9;11(6):e0157073. doi: 10.1371/journal.pone.0157073. eCollection 2016.
4. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Asimaki A, etal., Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e003688. doi: 10.1161/CIRCEP.115.003688.
5. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. Ball KK, etal., J Neurosci Res. 2011 Dec;89(12):2052-67. doi: 10.1002/jnr.22663. Epub 2011 May 2.
6. [Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin43 remodeling in isoprenaline-treated rats]. Bao HG, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Apr;41(4):320-6.
7. Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP. Belliveau DJ, etal., J Biol Chem. 2006 Jul 28;281(30):20920-31. Epub 2006 May 26.
8. Heteromeric mixing of connexins: compatibility of partners and functional consequences. Beyer EC, etal., Cell Commun Adhes. 2001;8(4-6):199-204.
9. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. Beyer EC, etal., J Cell Biol 1987 Dec;105(6 Pt 1):2621-9.
10. Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Billaud M, etal., Respir Res. 2011 Mar 17;12:30. doi: 10.1186/1465-9921-12-30.
11. Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Bobbie MW, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3758-63. doi: 10.1167/iovs.09-4489. Epub 2010 Feb 3.
12. Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. Bouvier D, etal., J Biol Chem. 2009 Dec 4;284(49):34257-71. doi: 10.1074/jbc.M109.039594. Epub 2009 Oct 5.
13. Dominant De Novo Mutations in GJA1 Cause Erythrokeratodermia Variabilis et Progressiva, without Features of Oculodentodigital Dysplasia. Boyden LM, etal., J Invest Dermatol. 2015 Jun;135(6):1540-7. doi: 10.1038/jid.2014.485. Epub 2014 Nov 14.
14. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Chen MJ, etal., Glia. 2012 Nov;60(11):1660-70. doi: 10.1002/glia.22384. Epub 2012 Aug 1.
15. Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells. Condorelli DF, etal., Eur J Neurosci 2003 Oct;18(7):1807-27.
16. Casein kinase 1 regulates connexin-43 gap junction assembly. Cooper CD and Lampe PD, J Biol Chem 2002 Nov 22;277(47):44962-8.
17. Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE). Dasgupta C, etal., Mutat Res. 2001 Aug 8;479(1-2):173-86.
18. Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. De Maio A, etal., Shock. 2000 Jul;14(1):53-9.
19. Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. Desplantez T, etal., Pflugers Arch. 2004 Jul;448(4):363-75. Epub 2004 Mar 27.
20. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. Doble BW, etal., J Cell Sci. 2004 Jan 26;117(Pt 3):507-14.
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1 to 10 of 37 rows
PMID:1651718   PMID:1652440   PMID:1696265   PMID:1852114   PMID:2987225   PMID:7593302   PMID:7691412   PMID:7892609   PMID:7930207   PMID:8165225   PMID:9109444   PMID:9438384  
PMID:9486664   PMID:9582296   PMID:9620080   PMID:10871288   PMID:10969038   PMID:11090614   PMID:11179202   PMID:11397787   PMID:11732910   PMID:11756680   PMID:11812132   PMID:11870059  
PMID:11896013   PMID:11922902   PMID:12064589   PMID:12064598   PMID:12064600   PMID:12064601   PMID:12064606   PMID:12397369   PMID:12429234   PMID:12483281   PMID:12577316   PMID:12606326  
PMID:12606457   PMID:12638734   PMID:12655594   PMID:12676745   PMID:12738802   PMID:12761501   PMID:12767974   PMID:12874275   PMID:14595769   PMID:14602580   PMID:14676187   PMID:14681032  
PMID:14684606   PMID:14732399   PMID:14970263   PMID:14973142   PMID:15016632   PMID:15028626   PMID:15033576   PMID:15084279   PMID:15128867   PMID:15137067   PMID:15272007   PMID:15328367  
PMID:15331631   PMID:15331634   PMID:15342787   PMID:15371442   PMID:15489334   PMID:15537869   PMID:15601660   PMID:15605384   PMID:15910768   PMID:15919068   PMID:15998674   PMID:16103109  
PMID:16127430   PMID:16195341   PMID:16240671   PMID:16328273   PMID:16341870   PMID:16352648   PMID:16443678   PMID:16474210   PMID:16624854   PMID:16685461   PMID:16703618   PMID:16790700  
PMID:16917092   PMID:16931598   PMID:16963503   PMID:17065216   PMID:17164264   PMID:17223729   PMID:17258854   PMID:17276456   PMID:17285859   PMID:17322640   PMID:17350281   PMID:17401374  
PMID:17450382   PMID:17480016   PMID:17513490   PMID:17541973   PMID:17558443   PMID:17561003   PMID:17584645   PMID:17591950   PMID:17632690   PMID:17690839   PMID:17693411   PMID:17713529  
PMID:17714073   PMID:17717278   PMID:17728094   PMID:17823969   PMID:17825302   PMID:17884088   PMID:17901047   PMID:17959141   PMID:17978847   PMID:18004727   PMID:18058800   PMID:18079109  
1 to 10 of 37 rows



Gja1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82036,302,490 - 36,315,010 (+)NCBIGRCr8
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
GJA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386121,435,646 - 121,449,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6121,435,595 - 121,449,727 (+)EnsemblGRCh38hg38GRCh38
GRCh376121,756,792 - 121,770,873 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366121,798,444 - 121,812,572 (+)NCBINCBI36Build 36hg18NCBI36
Build 346121,798,486 - 121,812,571NCBI
Celera6122,501,175 - 122,515,303 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6119,340,180 - 119,354,307 (+)NCBIHuRef
CHM1_16122,020,550 - 122,034,679 (+)NCBICHM1_1
T2T-CHM13v2.06122,622,700 - 122,636,781 (+)NCBIT2T-CHM13v2.0
Gja1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391056,253,297 - 56,266,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1056,253,426 - 56,278,609 (+)EnsemblGRCm39 Ensembl
GRCm381056,377,300 - 56,390,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1056,377,330 - 56,402,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv371056,097,106 - 56,110,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361056,065,762 - 56,078,833 (+)NCBIMGSCv36mm8
Celera1057,194,935 - 57,208,041 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1028.64NCBI
Gja1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554363,612,533 - 3,618,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554363,612,533 - 3,618,095 (+)NCBIChiLan1.0ChiLan1.0
GJA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25141,418,977 - 141,433,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16139,315,632 - 139,329,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16123,348,744 - 123,360,887 (+)NCBIpanpan1.1PanPan1.1panPan2
GJA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1160,941,772 - 60,944,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl160,929,097 - 60,942,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,750,272 - 61,753,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,130,176 - 61,143,784 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,130,100 - 61,143,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,052,769 - 61,055,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0160,868,101 - 60,871,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,515,138 - 61,518,103 (+)NCBIUU_Cfam_GSD_1.0
Gja1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946111,813,180 - 111,826,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366583,920,043 - 3,932,987 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366583,920,043 - 3,932,987 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl140,988,528 - 41,002,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1140,988,818 - 41,002,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2145,543,880 - 45,557,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11352,397,291 - 52,410,341 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1352,396,109 - 52,410,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604024,676,777 - 24,690,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247989,359,004 - 9,364,313 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247989,358,996 - 9,364,413 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Gja1
78 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
20 35419326 35419327 G C snv FHL/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:137
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000001054
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

1 to 10 of 16 rows
D18Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,377,615 - 60,377,755 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,290 - 62,570,429NCBIRnor6.0
Rnor_5.01861,757,051 - 61,757,190UniSTSRnor5.0
RGSC_v3.41862,660,084 - 62,660,224RGDRGSC3.4
RGSC_v3.41862,660,085 - 62,660,224UniSTSRGSC3.4
RGSC_v3.11862,733,285 - 62,733,425RGD
Celera1858,484,925 - 58,485,064UniSTS
Cytogenetic Map20q11UniSTS
D18Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81862,647,557 - 62,647,720 (+)Marker Load Pipeline
mRatBN7.21860,377,590 - 60,377,753 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,265 - 62,570,427NCBIRnor6.0
Rnor_5.01861,757,026 - 61,757,188UniSTSRnor5.0
Celera1858,484,900 - 58,485,062UniSTS
RH 3.4 Map18610.4RGD
RH 3.4 Map18610.4UniSTS
RH 2.0 Map18301.2RGD
Cytogenetic Map20q11UniSTS
RH128006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,306 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,922NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,380UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,087UniSTSRGSC3.4
Celera2037,107,187 - 37,107,393UniSTS
RH 3.4 Map20375.01UniSTS
Cytogenetic Map20q11UniSTS
RH135241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,307 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,923NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,381UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,088UniSTSRGSC3.4
Celera2037,107,187 - 37,107,394UniSTS
RH 3.4 Map20372.51UniSTS
Cytogenetic Map20q11UniSTS
PMC151788P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,766,348 - 35,766,681 (+)MAPPERmRatBN7.2
Rnor_6.02037,886,965 - 37,887,297NCBIRnor6.0
Rnor_5.02039,622,423 - 39,622,755UniSTSRnor5.0
RGSC_v3.42035,420,130 - 35,420,462UniSTSRGSC3.4
Celera2037,105,436 - 37,105,768UniSTS
Cytogenetic Map20q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_001429427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY324140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT990403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000001054   ⟹   ENSRNOP00000001054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,756,029 - 35,768,475 (+)Ensembl
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100494   ⟹   ENSRNOP00000093256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)Ensembl
RefSeq Acc Id: NM_012567   ⟹   NP_036699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,302,564 - 36,315,010 (+)NCBI
mRatBN7.22035,756,035 - 35,768,481 (+)NCBI
Rnor_6.02037,876,650 - 37,889,097 (+)NCBI
Rnor_5.02039,612,080 - 39,624,555 (+)NCBI
RGSC_v3.42035,409,815 - 35,422,262 (+)RGD
Celera2037,095,121 - 37,107,568 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098413   ⟹   XP_038954341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,302,490 - 36,315,010 (+)NCBI
mRatBN7.22035,756,007 - 35,768,481 (+)NCBI
RefSeq Acc Id: XM_063278953   ⟹   XP_063135023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,303,757 - 36,315,010 (+)NCBI
RefSeq Acc Id: XM_063278954   ⟹   XP_063135024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82036,303,757 - 36,315,010 (+)NCBI
RefSeq Acc Id: NP_036699   ⟸   NM_012567
- UniProtKB: Q53ZE1 (UniProtKB/Swiss-Prot),   P08050 (UniProtKB/Swiss-Prot),   A0A654ICE6 (UniProtKB/TrEMBL),   A0A8L2UHE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001054   ⟸   ENSRNOT00000001054
RefSeq Acc Id: XP_038954341   ⟸   XM_039098413
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093256   ⟸   ENSRNOT00000100494
RefSeq Acc Id: XP_063135023   ⟸   XM_063278953
- Peptide Label: isoform X1
Connexin N-terminal   Gap junction protein cysteine-rich

Name Modeler Protein Id AA Range Protein Structure
AF-P08050-F1-model_v2 AlphaFold P08050 1-382 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701633
Promoter ID:EPDNEW_R12157
Type:multiple initiation site
Name:Gja1_1
Description:gap junction protein, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02037,876,642 - 37,876,702EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3605 BioCyc
Ensembl Genes ENSRNOG00000000805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001054 ENTREZGENE
  ENSRNOT00000100494 ENTREZGENE
  ENSRNOT00000100494.1 UniProtKB/Swiss-Prot
  ENSRNOT00000134128 ENTREZGENE
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
  1.20.5.1130 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105924 IMAGE-MGC_LOAD
InterPro Alpha_helix_dom_sf UniProtKB/Swiss-Prot
  Connexin UniProtKB/Swiss-Prot
  Connexin43 UniProtKB/Swiss-Prot
  Connexin43_C UniProtKB/Swiss-Prot
  Connexin_C UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
KEGG Report rno:24392 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93610 IMAGE-MGC_LOAD
NCBI Gene 24392 ENTREZGENE
PANTHER PTHR11984 UniProtKB/Swiss-Prot
  PTHR11984:SF33 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
  Connexin43 UniProtKB/Swiss-Prot
PharmGKB GJA1 RGD
PhenoGen Gja1 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
  CONNEXINA1 UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000805 RatGTEx
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF118220 UniProtKB/Swiss-Prot
TIGR TC230392
UniProt A0A654ICE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHE4 ENTREZGENE, UniProtKB/TrEMBL
  A6K4B5_RAT UniProtKB/TrEMBL
  CXA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Gja1  gap junction protein, alpha 1  Gja1  gap junction membrane channel protein alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gja1  gap junction membrane channel protein alpha 1    Gap junction protein, alpha 1, 43 kD (connexin 43)  Name updated 625702 APPROVED
2002-06-10 Gja1  Gap junction protein, alpha 1, 43 kD (connexin 43)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease decreased expression is assocaited with impaired cell-cell communication in heart failure 728855
gene_expression expressed in adult epididymis 628541
gene_physical_interaction forms gap junctions between principal and basal cells but not between adjacent principal cells 628541