RGD Reference Report - Antitumor effects of monoclonal antibodies to connexin 43 extracellular fragment in induced low-differentiated glioma. - Rat Genome Database

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Antitumor effects of monoclonal antibodies to connexin 43 extracellular fragment in induced low-differentiated glioma.

Authors: Yusubalieva, GM  Baklaushev, VP  Gurina, OI  Gulyaev, MV  Pirogov, YA  Chekhonin, VP 
Citation: Yusubalieva GM, etal., Bull Exp Biol Med. 2012 May;153(1):163-9.
RGD ID: 7207264
Pubmed: PMID:22808518   (View Abstract at PubMed)

We studied the effect of intravenous administration of monoclonal antibodies to the second extracellular loop of connexin 43 (MAbE2Cx43) on the dynamics of glioma growth and survival of experimental animals. Morphometric analysis of magnetic resonance imaging data showed that weekly intravenous administration of MAbE2Cx43 in a dose of 5 mg/kg significantly reduced glioma volume starting from day 21 after tumor implantation. By day 29, the mean volume of glioma in the experimental group (therapy with specific antibodies) was 2-fold lower than in controls. Deceleration of glioma growth in rats receiving MAbE2Cx43 was accompanied by a significant prolongation of rat lifespan (according to Kaplan-Meier test) and even led to complete recovery without delayed relapses in 19.23% animals. The mechanism of tumor-suppressing effects of antibodies can be related to inhibition of specific functions of connexin 43 in glioma cells in the peritumoral zone.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GJA1Humanhigh grade glioma  ISOGja1 (Rattus norvegicus) RGD 
Gja1Rathigh grade glioma  IMP  RGD 
Gja1Mousehigh grade glioma  ISOGja1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gja1  (gap junction protein, alpha 1)

Genes (Mus musculus)
Gja1  (gap junction protein, alpha 1)

Genes (Homo sapiens)
GJA1  (gap junction protein alpha 1)


Additional Information